Putative paraflagellar rod component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

paraflagellar rod component, putative

Species:

Leishmania mexicana

UniProt:

E9AMY4_LEIMU

TriTrypDb:

LmxM.09.1320

Length:

605

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 8
Forrest at al. (procyclic)	no	yes: 8
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 26

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 37
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	38
GO:0031514	motile cilium	5	38
GO:0042995	cell projection	2	38
GO:0043226	organelle	2	38
GO:0043227	membrane-bounded organelle	3	38
GO:0110165	cellular anatomical entity	1	38
GO:0120025	plasma membrane bounded cell projection	3	38
GO:0005737	cytoplasm	2	3
GO:0031974	membrane-enclosed lumen	2	3
GO:0031981	nuclear lumen	5	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	3
GO:0043233	organelle lumen	3	3
GO:0070013	intracellular organelle lumen	4	3
GO:0097014	ciliary plasm	5	3
GO:0099568	cytoplasmic region	3	3

Expansion

Sequence features

E9AMY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMY4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	38
GO:0005515	protein binding	2	38
GO:0005516	calmodulin binding	3	38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	37	41	PF00656	0.600
CLV_C14_Caspase3-7	457	461	PF00656	0.357
CLV_NRD_NRD_1	301	303	PF00675	0.318
CLV_NRD_NRD_1	330	332	PF00675	0.329
CLV_NRD_NRD_1	372	374	PF00675	0.408
CLV_PCSK_FUR_1	370	374	PF00082	0.207
CLV_PCSK_KEX2_1	226	228	PF00082	0.386
CLV_PCSK_KEX2_1	301	303	PF00082	0.333
CLV_PCSK_KEX2_1	330	332	PF00082	0.320
CLV_PCSK_KEX2_1	352	354	PF00082	0.314
CLV_PCSK_KEX2_1	372	374	PF00082	0.312
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.417
CLV_PCSK_PC1ET2_1	301	303	PF00082	0.334
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.324
CLV_PCSK_SKI1_1	182	186	PF00082	0.498
CLV_PCSK_SKI1_1	294	298	PF00082	0.394
CLV_PCSK_SKI1_1	337	341	PF00082	0.362
CLV_PCSK_SKI1_1	352	356	PF00082	0.308
CLV_PCSK_SKI1_1	390	394	PF00082	0.426
CLV_PCSK_SKI1_1	540	544	PF00082	0.333
DOC_CDC14_PxL_1	100	108	PF14671	0.289
DOC_CYCLIN_RxL_1	223	234	PF00134	0.494
DOC_MAPK_gen_1	421	429	PF00069	0.194
DOC_PP1_RVXF_1	224	231	PF00149	0.475
DOC_PP4_FxxP_1	519	522	PF00568	0.313
DOC_USP7_MATH_1	143	147	PF00917	0.369
DOC_USP7_MATH_1	267	271	PF00917	0.398
DOC_USP7_MATH_1	586	590	PF00917	0.617
DOC_USP7_UBL2_3	182	186	PF12436	0.308
DOC_USP7_UBL2_3	265	269	PF12436	0.294
DOC_USP7_UBL2_3	348	352	PF12436	0.157
DOC_WW_Pin1_4	90	95	PF00397	0.497
LIG_14-3-3_CanoR_1	337	344	PF00244	0.359
LIG_14-3-3_CanoR_1	353	361	PF00244	0.187
LIG_14-3-3_CanoR_1	49	54	PF00244	0.640
LIG_14-3-3_CanoR_1	575	582	PF00244	0.567
LIG_Actin_WH2_2	315	332	PF00022	0.357
LIG_BIR_II_1	1	5	PF00653	0.553
LIG_DLG_GKlike_1	455	462	PF00625	0.334
LIG_FHA_1	143	149	PF00498	0.478
LIG_FHA_1	164	170	PF00498	0.457
LIG_FHA_1	338	344	PF00498	0.404
LIG_FHA_1	436	442	PF00498	0.319
LIG_FHA_1	533	539	PF00498	0.392
LIG_FHA_2	117	123	PF00498	0.406
LIG_FHA_2	183	189	PF00498	0.543
LIG_FHA_2	232	238	PF00498	0.511
LIG_FHA_2	35	41	PF00498	0.407
LIG_FHA_2	353	359	PF00498	0.325
LIG_FHA_2	360	366	PF00498	0.318
LIG_FHA_2	392	398	PF00498	0.331
LIG_FHA_2	42	48	PF00498	0.406
LIG_FHA_2	91	97	PF00498	0.445
LIG_LIR_Apic_2	516	522	PF02991	0.319
LIG_LIR_Gen_1	355	363	PF02991	0.261
LIG_LIR_Gen_1	498	509	PF02991	0.279
LIG_LIR_Gen_1	525	533	PF02991	0.174
LIG_LIR_Nem_3	355	360	PF02991	0.261
LIG_LIR_Nem_3	40	45	PF02991	0.518
LIG_LIR_Nem_3	463	469	PF02991	0.411
LIG_LIR_Nem_3	498	504	PF02991	0.279
LIG_LIR_Nem_3	525	531	PF02991	0.174
LIG_PDZ_Class_2	600	605	PF00595	0.721
LIG_SH2_NCK_1	528	532	PF00017	0.450
LIG_SH2_SRC	544	547	PF00017	0.563
LIG_SH2_STAP1	194	198	PF00017	0.445
LIG_SH2_STAP1	218	222	PF00017	0.407
LIG_SH2_STAP1	357	361	PF00017	0.169
LIG_SH2_STAP1	528	532	PF00017	0.440
LIG_SH2_STAT5	128	131	PF00017	0.507
LIG_SH2_STAT5	183	186	PF00017	0.288
LIG_SH2_STAT5	220	223	PF00017	0.393
LIG_SH2_STAT5	224	227	PF00017	0.417
LIG_SH2_STAT5	377	380	PF00017	0.279
LIG_SH2_STAT5	391	394	PF00017	0.264
LIG_SH2_STAT5	45	48	PF00017	0.419
LIG_SH2_STAT5	469	472	PF00017	0.157
LIG_SH2_STAT5	544	547	PF00017	0.431
LIG_SH3_2	9	14	PF14604	0.496
LIG_SH3_3	134	140	PF00018	0.456
LIG_SH3_3	594	600	PF00018	0.614
LIG_SH3_3	6	12	PF00018	0.460
LIG_SUMO_SIM_anti_2	133	139	PF11976	0.282
LIG_SUMO_SIM_par_1	145	153	PF11976	0.300
LIG_SUMO_SIM_par_1	202	207	PF11976	0.403
LIG_TRAF2_1	233	236	PF00917	0.623
LIG_TRAF2_1	356	359	PF00917	0.361
LIG_TRAF2_1	503	506	PF00917	0.288
LIG_TRAF2_1	522	525	PF00917	0.303
LIG_TRAF2_1	93	96	PF00917	0.494
LIG_TYR_ITIM	526	531	PF00017	0.157
MOD_CK1_1	307	313	PF00069	0.194
MOD_CK1_1	458	464	PF00069	0.368
MOD_CK2_1	229	235	PF00069	0.418
MOD_CK2_1	307	313	PF00069	0.369
MOD_CK2_1	352	358	PF00069	0.331
MOD_CK2_1	391	397	PF00069	0.297
MOD_CK2_1	41	47	PF00069	0.558
MOD_CK2_1	500	506	PF00069	0.326
MOD_CK2_1	90	96	PF00069	0.466
MOD_GlcNHglycan	269	272	PF01048	0.376
MOD_GlcNHglycan	3	6	PF01048	0.553
MOD_GlcNHglycan	577	580	PF01048	0.513
MOD_GSK3_1	231	238	PF00069	0.518
MOD_GSK3_1	431	438	PF00069	0.357
MOD_GSK3_1	454	461	PF00069	0.264
MOD_GSK3_1	508	515	PF00069	0.187
MOD_LATS_1	453	459	PF00433	0.334
MOD_N-GLC_1	538	543	PF02516	0.353
MOD_N-GLC_2	379	381	PF02516	0.157
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	150	155	PF00069	0.418
MOD_NEK2_1	304	309	PF00069	0.440
MOD_NEK2_2	431	436	PF00069	0.298
MOD_PIKK_1	337	343	PF00454	0.386
MOD_PIKK_1	490	496	PF00454	0.264
MOD_PKA_1	352	358	PF00069	0.392
MOD_PKA_2	352	358	PF00069	0.279
MOD_PKA_2	454	460	PF00069	0.268
MOD_PKA_2	48	54	PF00069	0.477
MOD_Plk_1	304	310	PF00069	0.396
MOD_Plk_1	431	437	PF00069	0.279
MOD_Plk_1	455	461	PF00069	0.334
MOD_Plk_1	538	544	PF00069	0.289
MOD_Plk_2-3	171	177	PF00069	0.435
MOD_Plk_2-3	359	365	PF00069	0.392
MOD_Plk_2-3	413	419	PF00069	0.187
MOD_Plk_4	133	139	PF00069	0.509
MOD_Plk_4	143	149	PF00069	0.540
MOD_Plk_4	220	226	PF00069	0.238
MOD_Plk_4	307	313	PF00069	0.362
MOD_Plk_4	391	397	PF00069	0.233
MOD_ProDKin_1	90	96	PF00069	0.500
MOD_SUMO_for_1	169	172	PF00179	0.557
MOD_SUMO_for_1	347	350	PF00179	0.271
MOD_SUMO_rev_2	262	267	PF00179	0.324
MOD_SUMO_rev_2	307	316	PF00179	0.440
MOD_SUMO_rev_2	345	354	PF00179	0.186
TRG_DiLeu_BaEn_1	415	420	PF01217	0.157
TRG_DiLeu_BaEn_1	561	566	PF01217	0.362
TRG_DiLeu_BaEn_1	569	574	PF01217	0.362
TRG_DiLeu_BaEn_3	471	477	PF01217	0.332
TRG_DiLeu_BaEn_4	95	101	PF01217	0.342
TRG_ENDOCYTIC_2	128	131	PF00928	0.507
TRG_ENDOCYTIC_2	218	221	PF00928	0.330
TRG_ENDOCYTIC_2	357	360	PF00928	0.242
TRG_ENDOCYTIC_2	423	426	PF00928	0.307
TRG_ENDOCYTIC_2	528	531	PF00928	0.174
TRG_ER_diArg_1	124	127	PF00400	0.431
TRG_ER_diArg_1	329	331	PF00400	0.323
TRG_ER_diArg_1	370	373	PF00400	0.384
TRG_ER_diArg_1	534	537	PF00400	0.298
TRG_Pf-PMV_PEXEL_1	563	567	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I5	Leptomonas seymouri	24%	100%
A0A0N0P573	Leptomonas seymouri	61%	99%
A0A0N1IFZ5	Leptomonas seymouri	22%	100%
A0A0S4IPM7	Bodo saltans	30%	100%
A0A0S4IZY8	Bodo saltans	22%	100%
A0A0S4JS20	Bodo saltans	24%	100%
A0A1X0NI51	Trypanosomatidae	43%	100%
A0A1X0NYU4	Trypanosomatidae	21%	100%
A0A1X0P0B7	Trypanosomatidae	23%	100%
A0A381MH18	Leishmania infantum	22%	100%
A0A381MN58	Leishmania infantum	23%	100%
A0A3Q8IAP5	Leishmania donovani	22%	100%
A0A3Q8IEH2	Leishmania donovani	23%	100%
A0A3R7KDB9	Trypanosoma rangeli	22%	100%
A0A3R7P0W8	Trypanosoma rangeli	46%	100%
A0A3S5IRI8	Trypanosoma rangeli	23%	100%
A0A3S7WQV4	Leishmania donovani	89%	100%
A0A3S7X2K1	Leishmania donovani	23%	100%
A4H5W0	Leishmania braziliensis	77%	100%
A4H8S1	Leishmania braziliensis	22%	100%
A4HIY0	Leishmania braziliensis	22%	100%
A4HU55	Leishmania infantum	88%	100%
A4HX40	Leishmania infantum	23%	100%
C9ZLC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZLC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
C9ZVV0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
D0A9N7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AE36	Leishmania major	23%	100%
E9AE37	Leishmania major	23%	100%
E9AHJ2	Leishmania infantum	23%	100%
E9ALP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
E9ALP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	100%
P22225	Trypanosoma brucei brucei	22%	100%
Q26789	Trypanosoma brucei brucei	22%	100%
Q4QEM2	Leishmania major	22%	100%
Q4QHP3	Leishmania major	88%	100%
V5BDF9	Trypanosoma cruzi	45%	100%
V5BDW8	Trypanosoma cruzi	23%	100%