PPPDE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PPPDE putative peptidase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMY1_LEIMU

TriTrypDb:

LmxM.09.1300

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMY1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016579	protein deubiquitination	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070646	protein modification by small protein removal	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0008233	peptidase activity	3	17
GO:0016787	hydrolase activity	2	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:0019783	ubiquitin-like protein peptidase activity	4	2
GO:0101005	deubiquitinase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.545
CLV_NRD_NRD_1	156	158	PF00675	0.616
CLV_PCSK_KEX2_1	156	158	PF00082	0.564
CLV_PCSK_PC7_1	152	158	PF00082	0.285
CLV_PCSK_SKI1_1	157	161	PF00082	0.596
CLV_PCSK_SKI1_1	178	182	PF00082	0.252
DEG_Nend_UBRbox_2	1	3	PF02207	0.712
DEG_SPOP_SBC_1	21	25	PF00917	0.455
DOC_CYCLIN_yCln2_LP_2	146	149	PF00134	0.553
DOC_CYCLIN_yCln2_LP_2	184	187	PF00134	0.448
DOC_MAPK_DCC_7	46	56	PF00069	0.371
DOC_MAPK_MEF2A_6	178	185	PF00069	0.475
DOC_MAPK_MEF2A_6	32	41	PF00069	0.290
DOC_PP2B_LxvP_1	146	149	PF13499	0.554
DOC_PP2B_LxvP_1	184	187	PF13499	0.456
DOC_USP7_MATH_1	15	19	PF00917	0.475
DOC_USP7_MATH_1	159	163	PF00917	0.602
DOC_USP7_MATH_1	21	25	PF00917	0.541
DOC_USP7_MATH_1	3	7	PF00917	0.715
DOC_WW_Pin1_4	86	91	PF00397	0.500
LIG_14-3-3_CanoR_1	156	164	PF00244	0.439
LIG_AP2alpha_2	121	123	PF02296	0.371
LIG_eIF4E_1	179	185	PF01652	0.454
LIG_EVH1_2	90	94	PF00568	0.486
LIG_FHA_2	23	29	PF00498	0.423
LIG_LIR_Apic_2	47	53	PF02991	0.371
LIG_MAD2	82	90	PF02301	0.418
LIG_MYND_1	182	186	PF01753	0.432
LIG_Pex14_2	138	142	PF04695	0.481
LIG_Pex14_2	94	98	PF04695	0.558
LIG_SH2_CRK	128	132	PF00017	0.490
LIG_SH2_NCK_1	27	31	PF00017	0.436
LIG_SH2_SRC	27	30	PF00017	0.443
LIG_SH2_SRC	70	73	PF00017	0.572
LIG_SH2_STAP1	195	199	PF00017	0.626
LIG_SH2_STAP1	27	31	PF00017	0.436
LIG_SH2_STAP1	66	70	PF00017	0.562
LIG_SH2_STAT5	179	182	PF00017	0.246
LIG_SH2_STAT5	199	202	PF00017	0.549
LIG_SH3_3	180	186	PF00018	0.456
LIG_SH3_3	80	86	PF00018	0.543
MOD_CK1_1	6	12	PF00069	0.726
MOD_CK2_1	103	109	PF00069	0.483
MOD_CK2_1	22	28	PF00069	0.476
MOD_GlcNHglycan	105	108	PF01048	0.373
MOD_GlcNHglycan	11	14	PF01048	0.681
MOD_GlcNHglycan	165	168	PF01048	0.593
MOD_GlcNHglycan	5	8	PF01048	0.680
MOD_GlcNHglycan	76	81	PF01048	0.354
MOD_GSK3_1	11	18	PF00069	0.555
MOD_GSK3_1	155	162	PF00069	0.601
MOD_GSK3_1	3	10	PF00069	0.645
MOD_NEK2_1	1	6	PF00069	0.678
MOD_NEK2_1	11	16	PF00069	0.582
MOD_PIKK_1	100	106	PF00454	0.538
MOD_PKA_2	155	161	PF00069	0.439
MOD_Plk_4	195	201	PF00069	0.553
MOD_Plk_4	46	52	PF00069	0.553
MOD_ProDKin_1	86	92	PF00069	0.500
TRG_DiLeu_BaEn_1	109	114	PF01217	0.547
TRG_ENDOCYTIC_2	128	131	PF00928	0.481
TRG_ENDOCYTIC_2	42	45	PF00928	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVE7	Leptomonas seymouri	52%	89%
A0A0N1PCI8	Leptomonas seymouri	64%	97%
A0A0S4JCD5	Bodo saltans	26%	80%
A0A1X0NHT4	Trypanosomatidae	41%	75%
A0A3Q8IAW2	Leishmania donovani	92%	100%
A0A3S7WQX3	Leishmania donovani	59%	86%
A0A422NZN2	Trypanosoma rangeli	40%	89%
A4H5V8	Leishmania braziliensis	74%	100%
A4HU52	Leishmania infantum	93%	100%
A4HU53	Leishmania infantum	59%	86%
D0A9N3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	92%
E9AMY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	86%
Q4QHP4	Leishmania major	58%	100%
Q4QHP5	Leishmania major	90%	100%
V5BDG9	Trypanosoma cruzi	29%	69%