RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMY0_LEIMU

TriTrypDb:

LmxM.09.1290

Length:

571

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMY0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.528
CLV_C14_Caspase3-7	351	355	PF00656	0.666
CLV_C14_Caspase3-7	46	50	PF00656	0.556
CLV_NRD_NRD_1	333	335	PF00675	0.490
CLV_PCSK_KEX2_1	346	348	PF00082	0.705
CLV_PCSK_KEX2_1	560	562	PF00082	0.765
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.662
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.697
CLV_PCSK_SKI1_1	334	338	PF00082	0.540
CLV_PCSK_SKI1_1	433	437	PF00082	0.394
DEG_COP1_1	264	273	PF00400	0.691
DEG_SCF_FBW7_1	468	475	PF00400	0.512
DEG_SPOP_SBC_1	207	211	PF00917	0.516
DEG_SPOP_SBC_1	273	277	PF00917	0.679
DOC_ANK_TNKS_1	186	193	PF00023	0.405
DOC_CYCLIN_RxL_1	221	232	PF00134	0.576
DOC_MAPK_gen_1	484	492	PF00069	0.414
DOC_MAPK_MEF2A_6	384	393	PF00069	0.425
DOC_MAPK_MEF2A_6	484	492	PF00069	0.414
DOC_PP1_RVXF_1	222	229	PF00149	0.458
DOC_PP1_RVXF_1	482	488	PF00149	0.408
DOC_PP2B_LxvP_1	284	287	PF13499	0.545
DOC_PP2B_LxvP_1	490	493	PF13499	0.437
DOC_PP2B_LxvP_1	534	537	PF13499	0.439
DOC_PP4_FxxP_1	199	202	PF00568	0.583
DOC_USP7_MATH_1	14	18	PF00917	0.633
DOC_USP7_MATH_1	207	211	PF00917	0.541
DOC_USP7_MATH_1	323	327	PF00917	0.622
DOC_USP7_MATH_1	472	476	PF00917	0.519
DOC_USP7_MATH_1	48	52	PF00917	0.619
DOC_USP7_MATH_1	495	499	PF00917	0.487
DOC_USP7_MATH_1	508	512	PF00917	0.387
DOC_USP7_MATH_1	71	75	PF00917	0.484
DOC_WW_Pin1_4	197	202	PF00397	0.544
DOC_WW_Pin1_4	274	279	PF00397	0.688
DOC_WW_Pin1_4	340	345	PF00397	0.632
DOC_WW_Pin1_4	355	360	PF00397	0.584
DOC_WW_Pin1_4	415	420	PF00397	0.523
DOC_WW_Pin1_4	468	473	PF00397	0.603
DOC_WW_Pin1_4	67	72	PF00397	0.479
DOC_WW_Pin1_4	79	84	PF00397	0.509
LIG_14-3-3_CanoR_1	213	219	PF00244	0.480
LIG_14-3-3_CanoR_1	334	342	PF00244	0.603
LIG_Actin_WH2_2	214	229	PF00022	0.451
LIG_BIR_III_4	442	446	PF00653	0.433
LIG_BIR_III_4	553	557	PF00653	0.653
LIG_CSL_BTD_1	387	390	PF09270	0.403
LIG_deltaCOP1_diTrp_1	145	156	PF00928	0.496
LIG_EABR_CEP55_1	15	24	PF12180	0.575
LIG_FHA_1	107	113	PF00498	0.468
LIG_FHA_1	275	281	PF00498	0.667
LIG_FHA_2	311	317	PF00498	0.566
LIG_FHA_2	372	378	PF00498	0.432
LIG_FHA_2	44	50	PF00498	0.591
LIG_FHA_2	469	475	PF00498	0.604
LIG_LIR_Apic_2	196	202	PF02991	0.607
LIG_LIR_Gen_1	99	107	PF02991	0.564
LIG_LIR_LC3C_4	434	438	PF02991	0.385
LIG_LIR_Nem_3	146	152	PF02991	0.510
LIG_LIR_Nem_3	99	103	PF02991	0.521
LIG_MAD2	392	400	PF02301	0.443
LIG_MYND_1	278	282	PF01753	0.662
LIG_Pex14_2	152	156	PF04695	0.447
LIG_SH2_CRK	100	104	PF00017	0.532
LIG_SH2_NCK_1	100	104	PF00017	0.532
LIG_SH2_PTP2	302	305	PF00017	0.335
LIG_SH2_SRC	172	175	PF00017	0.440
LIG_SH2_STAP1	381	385	PF00017	0.417
LIG_SH2_STAP1	404	408	PF00017	0.330
LIG_SH2_STAT5	100	103	PF00017	0.525
LIG_SH2_STAT5	302	305	PF00017	0.475
LIG_SH2_STAT5	516	519	PF00017	0.354
LIG_SH2_STAT5	530	533	PF00017	0.386
LIG_SH3_3	267	273	PF00018	0.756
LIG_SH3_3	275	281	PF00018	0.585
LIG_SH3_3	283	289	PF00018	0.676
LIG_SH3_3	33	39	PF00018	0.494
LIG_SH3_3	408	414	PF00018	0.380
LIG_SH3_3	556	562	PF00018	0.597
LIG_SUMO_SIM_anti_2	434	439	PF11976	0.384
LIG_SUMO_SIM_par_1	30	35	PF11976	0.459
LIG_SUMO_SIM_par_1	302	307	PF11976	0.254
LIG_TRAF2_1	239	242	PF00917	0.506
LIG_TRAF2_1	52	55	PF00917	0.623
LIG_WRC_WIRS_1	107	112	PF05994	0.447
LIG_WW_3	287	291	PF00397	0.484
MOD_CDC14_SPxK_1	343	346	PF00782	0.643
MOD_CDK_SPK_2	274	279	PF00069	0.772
MOD_CDK_SPxK_1	340	346	PF00069	0.636
MOD_CDK_SPxxK_3	340	347	PF00069	0.639
MOD_CDK_SPxxK_3	415	422	PF00069	0.471
MOD_CDK_SPxxK_3	79	86	PF00069	0.424
MOD_CK1_1	102	108	PF00069	0.664
MOD_CK1_1	158	164	PF00069	0.538
MOD_CK1_1	211	217	PF00069	0.396
MOD_CK1_1	40	46	PF00069	0.577
MOD_CK1_1	418	424	PF00069	0.509
MOD_CK1_1	475	481	PF00069	0.561
MOD_CK2_1	48	54	PF00069	0.621
MOD_CK2_1	67	73	PF00069	0.500
MOD_CMANNOS	156	159	PF00535	0.459
MOD_Cter_Amidation	344	347	PF01082	0.714
MOD_DYRK1A_RPxSP_1	340	344	PF00069	0.629
MOD_GlcNHglycan	16	19	PF01048	0.621
MOD_GlcNHglycan	177	180	PF01048	0.604
MOD_GlcNHglycan	204	207	PF01048	0.720
MOD_GlcNHglycan	246	249	PF01048	0.699
MOD_GlcNHglycan	25	30	PF01048	0.493
MOD_GlcNHglycan	306	309	PF01048	0.439
MOD_GlcNHglycan	325	328	PF01048	0.632
MOD_GlcNHglycan	350	353	PF01048	0.731
MOD_GlcNHglycan	363	367	PF01048	0.634
MOD_GlcNHglycan	368	371	PF01048	0.509
MOD_GlcNHglycan	39	42	PF01048	0.446
MOD_GlcNHglycan	457	460	PF01048	0.453
MOD_GlcNHglycan	474	477	PF01048	0.591
MOD_GlcNHglycan	540	543	PF01048	0.511
MOD_GSK3_1	151	158	PF00069	0.575
MOD_GSK3_1	197	204	PF00069	0.623
MOD_GSK3_1	207	214	PF00069	0.505
MOD_GSK3_1	229	236	PF00069	0.426
MOD_GSK3_1	362	369	PF00069	0.638
MOD_GSK3_1	413	420	PF00069	0.584
MOD_GSK3_1	468	475	PF00069	0.597
MOD_GSK3_1	67	74	PF00069	0.430
MOD_GSK3_1	98	105	PF00069	0.647
MOD_NEK2_1	151	156	PF00069	0.381
MOD_NEK2_1	362	367	PF00069	0.643
MOD_NEK2_1	4	9	PF00069	0.641
MOD_PIKK_1	229	235	PF00454	0.475
MOD_PIKK_1	310	316	PF00454	0.440
MOD_PIKK_1	508	514	PF00454	0.415
MOD_PKA_1	334	340	PF00069	0.622
MOD_PKA_1	560	566	PF00069	0.755
MOD_PKA_2	560	566	PF00069	0.755
MOD_PKB_1	332	340	PF00069	0.475
MOD_Plk_1	195	201	PF00069	0.464
MOD_Plk_1	98	104	PF00069	0.556
MOD_Plk_4	151	157	PF00069	0.403
MOD_Plk_4	166	172	PF00069	0.507
MOD_Plk_4	495	501	PF00069	0.476
MOD_Plk_4	71	77	PF00069	0.460
MOD_ProDKin_1	197	203	PF00069	0.543
MOD_ProDKin_1	274	280	PF00069	0.684
MOD_ProDKin_1	340	346	PF00069	0.636
MOD_ProDKin_1	355	361	PF00069	0.583
MOD_ProDKin_1	415	421	PF00069	0.524
MOD_ProDKin_1	468	474	PF00069	0.604
MOD_ProDKin_1	67	73	PF00069	0.480
MOD_ProDKin_1	79	85	PF00069	0.521
MOD_SUMO_rev_2	351	358	PF00179	0.669
MOD_SUMO_rev_2	377	385	PF00179	0.410
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.470
TRG_ENDOCYTIC_2	100	103	PF00928	0.525
TRG_ENDOCYTIC_2	302	305	PF00928	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D8	Leptomonas seymouri	39%	89%
A0A1X0NIM5	Trypanosomatidae	27%	94%
A0A3Q8I7J7	Leishmania donovani	88%	99%
A4HU51	Leishmania infantum	88%	99%
Q4QHP6	Leishmania major	85%	100%