Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bromodomain factor 5

Species:

Leishmania mexicana

UniProt:

E9AMX7_LEIMU

TriTrypDb:

LmxM.09.1260

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMX7

PDB structure(s): 5tck_A , 5tck_B , 5tcm_A , 5tcm_B , 5tcm_C , 6bya_A , 6bya_B , 6bya_C , 6bya_D

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.524
CLV_C14_Caspase3-7	196	200	PF00656	0.415
CLV_NRD_NRD_1	179	181	PF00675	0.518
CLV_NRD_NRD_1	201	203	PF00675	0.492
CLV_NRD_NRD_1	276	278	PF00675	0.497
CLV_NRD_NRD_1	354	356	PF00675	0.718
CLV_NRD_NRD_1	407	409	PF00675	0.475
CLV_NRD_NRD_1	422	424	PF00675	0.457
CLV_NRD_NRD_1	50	52	PF00675	0.438
CLV_PCSK_KEX2_1	179	181	PF00082	0.518
CLV_PCSK_KEX2_1	276	278	PF00082	0.497
CLV_PCSK_KEX2_1	356	358	PF00082	0.777
CLV_PCSK_KEX2_1	406	408	PF00082	0.489
CLV_PCSK_KEX2_1	422	424	PF00082	0.457
CLV_PCSK_KEX2_1	50	52	PF00082	0.410
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.777
CLV_PCSK_PC7_1	418	424	PF00082	0.605
CLV_PCSK_SKI1_1	105	109	PF00082	0.526
CLV_PCSK_SKI1_1	407	411	PF00082	0.572
DEG_APCC_DBOX_1	104	112	PF00400	0.581
DEG_APCC_DBOX_1	407	415	PF00400	0.559
DEG_APCC_DBOX_1	417	425	PF00400	0.577
DEG_APCC_DBOX_1	622	630	PF00400	0.555
DEG_SPOP_SBC_1	151	155	PF00917	0.553
DEG_SPOP_SBC_1	305	309	PF00917	0.757
DEG_SPOP_SBC_1	458	462	PF00917	0.578
DOC_ANK_TNKS_1	371	378	PF00023	0.500
DOC_CDC14_PxL_1	34	42	PF14671	0.357
DOC_CYCLIN_RxL_1	404	412	PF00134	0.529
DOC_MAPK_gen_1	241	250	PF00069	0.438
DOC_MAPK_gen_1	422	428	PF00069	0.614
DOC_MAPK_gen_1	479	488	PF00069	0.494
DOC_MAPK_gen_1	620	628	PF00069	0.618
DOC_MAPK_MEF2A_6	241	250	PF00069	0.363
DOC_MAPK_MEF2A_6	507	515	PF00069	0.581
DOC_MAPK_NFAT4_5	243	251	PF00069	0.492
DOC_MAPK_RevD_3	409	423	PF00069	0.538
DOC_PP2B_LxvP_1	127	130	PF13499	0.732
DOC_PP2B_LxvP_1	371	374	PF13499	0.719
DOC_PP2B_LxvP_1	399	402	PF13499	0.518
DOC_PP2B_LxvP_1	433	436	PF13499	0.639
DOC_SPAK_OSR1_1	580	584	PF12202	0.528
DOC_USP7_MATH_1	130	134	PF00917	0.679
DOC_USP7_MATH_1	151	155	PF00917	0.724
DOC_USP7_MATH_1	163	167	PF00917	0.537
DOC_USP7_MATH_1	305	309	PF00917	0.811
DOC_USP7_MATH_1	314	318	PF00917	0.774
DOC_USP7_MATH_1	351	355	PF00917	0.820
DOC_USP7_MATH_1	443	447	PF00917	0.618
DOC_USP7_MATH_1	456	460	PF00917	0.684
DOC_USP7_MATH_1	470	474	PF00917	0.542
DOC_USP7_MATH_1	491	495	PF00917	0.556
DOC_USP7_MATH_1	548	552	PF00917	0.521
DOC_USP7_MATH_1	596	600	PF00917	0.588
DOC_USP7_MATH_1	614	618	PF00917	0.704
DOC_WD40_RPTOR_TOS_1	186	192	PF00400	0.543
DOC_WW_Pin1_4	1	6	PF00397	0.705
DOC_WW_Pin1_4	306	311	PF00397	0.713
DOC_WW_Pin1_4	327	332	PF00397	0.809
DOC_WW_Pin1_4	384	389	PF00397	0.691
DOC_WW_Pin1_4	390	395	PF00397	0.576
DOC_WW_Pin1_4	436	441	PF00397	0.654
DOC_WW_Pin1_4	594	599	PF00397	0.499
LIG_14-3-3_CanoR_1	251	257	PF00244	0.422
LIG_14-3-3_CanoR_1	290	295	PF00244	0.586
LIG_14-3-3_CanoR_1	363	371	PF00244	0.767
LIG_14-3-3_CanoR_1	406	412	PF00244	0.624
LIG_14-3-3_CanoR_1	423	429	PF00244	0.402
LIG_Actin_WH2_2	183	200	PF00022	0.475
LIG_Actin_WH2_2	275	292	PF00022	0.446
LIG_AP2alpha_1	498	502	PF02296	0.643
LIG_BIR_II_1	1	5	PF00653	0.744
LIG_deltaCOP1_diTrp_1	261	270	PF00928	0.448
LIG_EH1_1	206	214	PF00400	0.201
LIG_eIF4E_1	577	583	PF01652	0.512
LIG_FHA_1	165	171	PF00498	0.419
LIG_FHA_1	2	8	PF00498	0.648
LIG_FHA_1	253	259	PF00498	0.415
LIG_FHA_1	385	391	PF00498	0.722
LIG_FHA_1	461	467	PF00498	0.568
LIG_FHA_1	494	500	PF00498	0.673
LIG_LIR_Gen_1	261	270	PF02991	0.466
LIG_LIR_Gen_1	42	49	PF02991	0.358
LIG_LIR_Gen_1	509	520	PF02991	0.490
LIG_LIR_Gen_1	542	549	PF02991	0.545
LIG_LIR_Gen_1	572	583	PF02991	0.513
LIG_LIR_Gen_1	636	646	PF02991	0.562
LIG_LIR_Nem_3	192	197	PF02991	0.491
LIG_LIR_Nem_3	199	204	PF02991	0.357
LIG_LIR_Nem_3	261	266	PF02991	0.477
LIG_LIR_Nem_3	269	273	PF02991	0.391
LIG_LIR_Nem_3	35	40	PF02991	0.484
LIG_LIR_Nem_3	42	47	PF02991	0.330
LIG_LIR_Nem_3	509	515	PF02991	0.440
LIG_LIR_Nem_3	542	546	PF02991	0.539
LIG_LIR_Nem_3	572	578	PF02991	0.511
LIG_LIR_Nem_3	636	642	PF02991	0.555
LIG_LYPXL_yS_3	194	197	PF13949	0.489
LIG_LYPXL_yS_3	37	40	PF13949	0.357
LIG_OCRL_FandH_1	280	292	PF00620	0.416
LIG_PCNA_yPIPBox_3	251	264	PF02747	0.438
LIG_Pex14_2	498	502	PF04695	0.561
LIG_Pex14_2	581	585	PF04695	0.429
LIG_SH2_CRK	201	205	PF00017	0.415
LIG_SH2_CRK	44	48	PF00017	0.357
LIG_SH2_CRK	89	93	PF00017	0.438
LIG_SH2_NCK_1	8	12	PF00017	0.514
LIG_SH2_STAP1	66	70	PF00017	0.360
LIG_SH2_STAP1	96	100	PF00017	0.391
LIG_SH2_STAT5	223	226	PF00017	0.357
LIG_SH2_STAT5	39	42	PF00017	0.372
LIG_SH2_STAT5	44	47	PF00017	0.339
LIG_SH2_STAT5	512	515	PF00017	0.448
LIG_SH2_STAT5	575	578	PF00017	0.351
LIG_SH3_3	391	397	PF00018	0.664
LIG_SH3_3	580	586	PF00018	0.520
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.358
LIG_SUMO_SIM_anti_2	514	521	PF11976	0.457
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.393
LIG_TRAF2_1	134	137	PF00917	0.728
LIG_TRAF2_1	506	509	PF00917	0.477
LIG_TRAF2_1	645	648	PF00917	0.589
LIG_UBA3_1	211	219	PF00899	0.422
LIG_WRC_WIRS_1	499	504	PF05994	0.573
MOD_CDK_SPK_2	1	6	PF00069	0.730
MOD_CK1_1	150	156	PF00069	0.780
MOD_CK1_1	262	268	PF00069	0.543
MOD_CK1_1	306	312	PF00069	0.666
MOD_CK1_1	446	452	PF00069	0.722
MOD_CK1_1	459	465	PF00069	0.495
MOD_CK2_1	163	169	PF00069	0.509
MOD_CK2_1	426	432	PF00069	0.505
MOD_CK2_1	502	508	PF00069	0.569
MOD_GlcNHglycan	132	135	PF01048	0.791
MOD_GlcNHglycan	139	142	PF01048	0.778
MOD_GlcNHglycan	149	152	PF01048	0.705
MOD_GlcNHglycan	226	229	PF01048	0.457
MOD_GlcNHglycan	310	313	PF01048	0.829
MOD_GlcNHglycan	316	319	PF01048	0.659
MOD_GlcNHglycan	324	328	PF01048	0.736
MOD_GlcNHglycan	341	344	PF01048	0.684
MOD_GlcNHglycan	347	350	PF01048	0.767
MOD_GlcNHglycan	366	369	PF01048	0.497
MOD_GlcNHglycan	451	454	PF01048	0.657
MOD_GlcNHglycan	472	475	PF01048	0.459
MOD_GlcNHglycan	493	496	PF01048	0.588
MOD_GlcNHglycan	504	507	PF01048	0.594
MOD_GlcNHglycan	536	539	PF01048	0.466
MOD_GlcNHglycan	603	606	PF01048	0.655
MOD_GlcNHglycan	611	614	PF01048	0.511
MOD_GlcNHglycan	93	96	PF01048	0.422
MOD_GSK3_1	137	144	PF00069	0.798
MOD_GSK3_1	147	154	PF00069	0.692
MOD_GSK3_1	231	238	PF00069	0.364
MOD_GSK3_1	262	269	PF00069	0.577
MOD_GSK3_1	304	311	PF00069	0.811
MOD_GSK3_1	323	330	PF00069	0.678
MOD_GSK3_1	443	450	PF00069	0.724
MOD_GSK3_1	456	463	PF00069	0.592
MOD_GSK3_1	468	475	PF00069	0.530
MOD_GSK3_1	498	505	PF00069	0.644
MOD_GSK3_1	587	594	PF00069	0.499
MOD_GSK3_1	597	604	PF00069	0.577
MOD_GSK3_1	615	622	PF00069	0.647
MOD_N-GLC_1	303	308	PF02516	0.726
MOD_NEK2_1	173	178	PF00069	0.427
MOD_NEK2_1	197	202	PF00069	0.438
MOD_NEK2_1	266	271	PF00069	0.498
MOD_NEK2_1	289	294	PF00069	0.475
MOD_NEK2_1	40	45	PF00069	0.391
MOD_NEK2_1	481	486	PF00069	0.475
MOD_NEK2_1	498	503	PF00069	0.460
MOD_NEK2_1	511	516	PF00069	0.453
MOD_NEK2_1	591	596	PF00069	0.562
MOD_NEK2_1	81	86	PF00069	0.438
MOD_NEK2_2	548	553	PF00069	0.554
MOD_NEK2_2	615	620	PF00069	0.612
MOD_PIKK_1	132	138	PF00454	0.736
MOD_PIKK_1	630	636	PF00454	0.508
MOD_PKA_1	147	153	PF00069	0.743
MOD_PKA_1	407	413	PF00069	0.619
MOD_PKA_2	122	128	PF00069	0.628
MOD_PKA_2	130	136	PF00069	0.647
MOD_PKA_2	197	203	PF00069	0.438
MOD_PKA_2	289	295	PF00069	0.498
MOD_PKA_2	314	320	PF00069	0.567
MOD_PKA_2	362	368	PF00069	0.743
MOD_PKA_2	407	413	PF00069	0.554
MOD_PKA_2	481	487	PF00069	0.491
MOD_PKA_2	619	625	PF00069	0.536
MOD_Plk_1	447	453	PF00069	0.497
MOD_Plk_4	259	265	PF00069	0.542
MOD_Plk_4	481	487	PF00069	0.566
MOD_Plk_4	511	517	PF00069	0.496
MOD_ProDKin_1	1	7	PF00069	0.691
MOD_ProDKin_1	306	312	PF00069	0.712
MOD_ProDKin_1	327	333	PF00069	0.810
MOD_ProDKin_1	384	390	PF00069	0.688
MOD_ProDKin_1	436	442	PF00069	0.657
MOD_ProDKin_1	594	600	PF00069	0.510
MOD_SUMO_for_1	101	104	PF00179	0.534
MOD_SUMO_for_1	258	261	PF00179	0.512
MOD_SUMO_rev_2	439	446	PF00179	0.738
TRG_DiLeu_BaEn_1	169	174	PF01217	0.438
TRG_DiLeu_BaEn_1	244	249	PF01217	0.438
TRG_DiLeu_BaEn_2	637	643	PF01217	0.506
TRG_DiLeu_BaEn_4	508	514	PF01217	0.566
TRG_DiLeu_BaLyEn_6	400	405	PF01217	0.566
TRG_ENDOCYTIC_2	194	197	PF00928	0.489
TRG_ENDOCYTIC_2	201	204	PF00928	0.357
TRG_ENDOCYTIC_2	37	40	PF00928	0.357
TRG_ENDOCYTIC_2	44	47	PF00928	0.357
TRG_ENDOCYTIC_2	512	515	PF00928	0.454
TRG_ENDOCYTIC_2	575	578	PF00928	0.454
TRG_ER_diArg_1	126	129	PF00400	0.659
TRG_ER_diArg_1	276	278	PF00400	0.521
TRG_ER_diArg_1	405	408	PF00400	0.479
TRG_ER_diArg_1	421	423	PF00400	0.464
TRG_ER_diArg_1	49	51	PF00400	0.438
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3P5	Leptomonas seymouri	56%	98%
A0A3Q8I8I6	Leishmania donovani	94%	100%
A0A3R7RQU7	Trypanosoma rangeli	36%	92%
A4H5V4	Leishmania braziliensis	80%	100%
A4HU48	Leishmania infantum	93%	100%
D0A9M6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	80%
Q4QHP9	Leishmania major	93%	100%