Dual specificity protein phosphatase 12

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMX6_LEIMU

TriTrypDb:

LmxM.09.1250

Length:

184

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMX6

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	70	72	PF00675	0.623
CLV_PCSK_KEX2_1	70	72	PF00082	0.623
CLV_PCSK_SKI1_1	65	69	PF00082	0.538
DEG_Nend_UBRbox_2	1	3	PF02207	0.743
DOC_CKS1_1	153	158	PF01111	0.408
DOC_PP4_FxxP_1	99	102	PF00568	0.360
DOC_USP7_MATH_1	115	119	PF00917	0.527
DOC_USP7_MATH_1	22	26	PF00917	0.639
DOC_USP7_MATH_1	74	78	PF00917	0.653
DOC_USP7_MATH_1	9	13	PF00917	0.639
DOC_USP7_UBL2_3	61	65	PF12436	0.510
DOC_WW_Pin1_4	102	107	PF00397	0.428
DOC_WW_Pin1_4	152	157	PF00397	0.411
DOC_WW_Pin1_4	169	174	PF00397	0.545
DOC_WW_Pin1_4	177	182	PF00397	0.626
DOC_WW_Pin1_4	87	92	PF00397	0.551
LIG_BIR_III_2	170	174	PF00653	0.378
LIG_FHA_1	103	109	PF00498	0.540
LIG_FHA_1	160	166	PF00498	0.364
LIG_FHA_1	5	11	PF00498	0.434
LIG_LIR_Apic_2	96	102	PF02991	0.370
LIG_SH2_STAT5	128	131	PF00017	0.379
LIG_SH3_3	118	124	PF00018	0.593
LIG_SH3_3	18	24	PF00018	0.617
LIG_SH3_3	85	91	PF00018	0.523
MOD_CDK_SPxxK_3	152	159	PF00069	0.404
MOD_CK1_1	146	152	PF00069	0.380
MOD_CK1_1	25	31	PF00069	0.633
MOD_CK2_1	87	93	PF00069	0.575
MOD_GlcNHglycan	11	14	PF01048	0.575
MOD_GlcNHglycan	117	120	PF01048	0.470
MOD_GlcNHglycan	174	177	PF01048	0.640
MOD_GlcNHglycan	4	7	PF01048	0.736
MOD_GlcNHglycan	85	88	PF01048	0.622
MOD_GSK3_1	139	146	PF00069	0.394
MOD_GSK3_1	83	90	PF00069	0.600
MOD_N-GLC_1	115	120	PF02516	0.572
MOD_N-GLC_1	63	68	PF02516	0.652
MOD_N-GLC_1	82	87	PF02516	0.500
MOD_NEK2_1	94	99	PF00069	0.518
MOD_NEK2_2	63	68	PF00069	0.700
MOD_PIKK_1	143	149	PF00454	0.394
MOD_Plk_1	63	69	PF00069	0.665
MOD_Plk_4	123	129	PF00069	0.419
MOD_Plk_4	94	100	PF00069	0.375
MOD_ProDKin_1	102	108	PF00069	0.425
MOD_ProDKin_1	152	158	PF00069	0.405
MOD_ProDKin_1	169	175	PF00069	0.554
MOD_ProDKin_1	177	183	PF00069	0.551
MOD_ProDKin_1	87	93	PF00069	0.551
TRG_ER_diArg_1	45	48	PF00400	0.401
TRG_ER_diArg_1	69	71	PF00400	0.679

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4S9	Leptomonas seymouri	62%	100%
A0A0S4JFW8	Bodo saltans	41%	100%
A0A1X0NI01	Trypanosomatidae	52%	100%
A0A3S7WQX0	Leishmania donovani	87%	100%
A0A422NZK2	Trypanosoma rangeli	49%	100%
A4H5V3	Leishmania braziliensis	72%	100%
A4HU47	Leishmania infantum	87%	100%
D0A9M5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	93%
Q4QHQ0	Leishmania major	88%	100%
Q570P7	Arabidopsis thaliana	28%	100%
V5BMP4	Trypanosoma cruzi	52%	100%