Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMX4_LEIMU

TriTrypDb:

LmxM.09.1230

Length:

442

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMX4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.483
CLV_C14_Caspase3-7	128	132	PF00656	0.489
CLV_MEL_PAP_1	330	336	PF00089	0.506
CLV_NRD_NRD_1	285	287	PF00675	0.525
CLV_NRD_NRD_1	294	296	PF00675	0.564
CLV_NRD_NRD_1	332	334	PF00675	0.508
CLV_PCSK_KEX2_1	123	125	PF00082	0.657
CLV_PCSK_KEX2_1	285	287	PF00082	0.566
CLV_PCSK_KEX2_1	294	296	PF00082	0.603
CLV_PCSK_KEX2_1	332	334	PF00082	0.508
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.657
CLV_PCSK_SKI1_1	161	165	PF00082	0.630
CLV_PCSK_SKI1_1	286	290	PF00082	0.545
DEG_SPOP_SBC_1	349	353	PF00917	0.401
DEG_SPOP_SBC_1	46	50	PF00917	0.653
DOC_ANK_TNKS_1	294	301	PF00023	0.395
DOC_ANK_TNKS_1	366	373	PF00023	0.442
DOC_CDC14_PxL_1	198	206	PF14671	0.431
DOC_CDC14_PxL_1	306	314	PF14671	0.345
DOC_CYCLIN_yCln2_LP_2	204	210	PF00134	0.404
DOC_CYCLIN_yCln2_LP_2	58	64	PF00134	0.570
DOC_MAPK_gen_1	332	339	PF00069	0.321
DOC_MAPK_gen_1	77	87	PF00069	0.530
DOC_MAPK_MEF2A_6	154	162	PF00069	0.352
DOC_MAPK_MEF2A_6	80	89	PF00069	0.500
DOC_PP2B_LxvP_1	36	39	PF13499	0.644
DOC_PP2B_LxvP_1	58	61	PF13499	0.669
DOC_PP4_FxxP_1	99	102	PF00568	0.425
DOC_SPAK_OSR1_1	333	337	PF12202	0.313
DOC_USP7_MATH_1	234	238	PF00917	0.358
DOC_USP7_MATH_1	308	312	PF00917	0.357
DOC_USP7_MATH_1	379	383	PF00917	0.418
DOC_USP7_MATH_1	433	437	PF00917	0.441
DOC_USP7_MATH_1	47	51	PF00917	0.725
DOC_USP7_MATH_1	54	58	PF00917	0.626
DOC_WW_Pin1_4	196	201	PF00397	0.365
DOC_WW_Pin1_4	264	269	PF00397	0.434
DOC_WW_Pin1_4	8	13	PF00397	0.721
LIG_14-3-3_CanoR_1	124	130	PF00244	0.392
LIG_APCC_ABBA_1	160	165	PF00400	0.372
LIG_BIR_II_1	1	5	PF00653	0.637
LIG_BIR_III_2	194	198	PF00653	0.394
LIG_BIR_III_4	111	115	PF00653	0.487
LIG_BIR_III_4	252	256	PF00653	0.380
LIG_BRCT_BRCA1_1	91	95	PF00533	0.313
LIG_eIF4E_1	276	282	PF01652	0.314
LIG_EVH1_1	201	205	PF00568	0.409
LIG_EVH1_1	60	64	PF00568	0.593
LIG_FHA_1	114	120	PF00498	0.457
LIG_FHA_1	151	157	PF00498	0.370
LIG_FHA_1	259	265	PF00498	0.481
LIG_FHA_1	400	406	PF00498	0.491
LIG_FHA_1	88	94	PF00498	0.376
LIG_FHA_2	345	351	PF00498	0.376
LIG_GBD_Chelix_1	24	32	PF00786	0.391
LIG_LIR_Apic_2	165	170	PF02991	0.417
LIG_LIR_Apic_2	342	346	PF02991	0.381
LIG_LIR_Gen_1	267	277	PF02991	0.380
LIG_LIR_Gen_1	90	99	PF02991	0.305
LIG_LIR_Nem_3	267	272	PF02991	0.379
LIG_LIR_Nem_3	274	279	PF02991	0.364
LIG_LIR_Nem_3	414	420	PF02991	0.472
LIG_LIR_Nem_3	90	94	PF02991	0.399
LIG_LYPXL_yS_3	309	312	PF13949	0.378
LIG_MLH1_MIPbox_1	91	95	PF16413	0.313
LIG_MYND_1	15	19	PF01753	0.598
LIG_PCNA_yPIPBox_3	324	333	PF02747	0.306
LIG_Pex14_1	219	223	PF04695	0.295
LIG_Pex14_2	163	167	PF04695	0.383
LIG_Pex14_2	94	98	PF04695	0.360
LIG_Pex14_2	99	103	PF04695	0.428
LIG_PTAP_UEV_1	345	350	PF05743	0.394
LIG_PTB_Apo_2	263	270	PF02174	0.409
LIG_SH2_CRK	152	156	PF00017	0.353
LIG_SH2_CRK	276	280	PF00017	0.311
LIG_SH2_CRK	343	347	PF00017	0.412
LIG_SH2_NCK_1	343	347	PF00017	0.395
LIG_SH2_STAP1	152	156	PF00017	0.353
LIG_SH2_STAP1	321	325	PF00017	0.345
LIG_SH2_STAP1	81	85	PF00017	0.476
LIG_SH2_STAP1	91	95	PF00017	0.257
LIG_SH2_STAT3	321	324	PF00017	0.348
LIG_SH2_STAT5	152	155	PF00017	0.355
LIG_SH2_STAT5	343	346	PF00017	0.369
LIG_SH2_STAT5	355	358	PF00017	0.357
LIG_SH3_1	343	349	PF00018	0.390
LIG_SH3_2	310	315	PF14604	0.354
LIG_SH3_3	152	158	PF00018	0.347
LIG_SH3_3	16	22	PF00018	0.676
LIG_SH3_3	194	200	PF00018	0.520
LIG_SH3_3	307	313	PF00018	0.388
LIG_SH3_3	343	349	PF00018	0.390
LIG_SH3_3	58	64	PF00018	0.624
LIG_SH3_3	9	15	PF00018	0.683
LIG_SUMO_SIM_anti_2	322	329	PF11976	0.378
LIG_TRAF2_1	436	439	PF00917	0.399
LIG_TRAF2_1	50	53	PF00917	0.678
LIG_UBA3_1	280	289	PF00899	0.310
LIG_WW_2	202	205	PF00397	0.407
MOD_CK1_1	117	123	PF00069	0.391
MOD_CK1_1	186	192	PF00069	0.464
MOD_CK1_1	48	54	PF00069	0.637
MOD_CK2_1	344	350	PF00069	0.370
MOD_CK2_1	433	439	PF00069	0.430
MOD_CK2_1	47	53	PF00069	0.718
MOD_GlcNHglycan	1	4	PF01048	0.531
MOD_GlcNHglycan	185	188	PF01048	0.688
MOD_GlcNHglycan	236	239	PF01048	0.749
MOD_GlcNHglycan	422	425	PF01048	0.669
MOD_GSK3_1	113	120	PF00069	0.403
MOD_GSK3_1	335	342	PF00069	0.347
MOD_GSK3_1	344	351	PF00069	0.356
MOD_N-GLC_1	264	269	PF02516	0.638
MOD_NEK2_1	339	344	PF00069	0.457
MOD_NEK2_1	420	425	PF00069	0.466
MOD_NEK2_1	89	94	PF00069	0.455
MOD_PIKK_1	350	356	PF00454	0.299
MOD_PIKK_1	389	395	PF00454	0.337
MOD_PIKK_1	48	54	PF00454	0.591
MOD_PKA_2	225	231	PF00069	0.423
MOD_PKA_2	344	350	PF00069	0.401
MOD_PKA_2	379	385	PF00069	0.414
MOD_Plk_2-3	434	440	PF00069	0.390
MOD_Plk_4	323	329	PF00069	0.364
MOD_Plk_4	54	60	PF00069	0.562
MOD_Plk_4	89	95	PF00069	0.342
MOD_ProDKin_1	196	202	PF00069	0.354
MOD_ProDKin_1	264	270	PF00069	0.430
MOD_ProDKin_1	8	14	PF00069	0.720
MOD_SUMO_rev_2	117	125	PF00179	0.422
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.517
TRG_ENDOCYTIC_2	152	155	PF00928	0.355
TRG_ENDOCYTIC_2	276	279	PF00928	0.381
TRG_ENDOCYTIC_2	309	312	PF00928	0.378
TRG_ENDOCYTIC_2	91	94	PF00928	0.349
TRG_ER_diArg_1	284	286	PF00400	0.375
TRG_ER_diArg_1	331	333	PF00400	0.307
TRG_ER_diArg_1	377	380	PF00400	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P570	Leptomonas seymouri	43%	100%
A0A0S4JNP6	Bodo saltans	22%	100%
A0A3S7WQU3	Leishmania donovani	86%	100%
A4H5V1	Leishmania braziliensis	63%	99%
A4HU45	Leishmania infantum	86%	100%
Q4QHQ2	Leishmania major	85%	100%