RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AMX2_LEIMU

TriTrypDb:

LmxM.09.1210

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 2
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AMX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMX2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	352	356	PF00656	0.754
CLV_NRD_NRD_1	139	141	PF00675	0.413
CLV_NRD_NRD_1	145	147	PF00675	0.383
CLV_NRD_NRD_1	152	154	PF00675	0.328
CLV_NRD_NRD_1	203	205	PF00675	0.216
CLV_NRD_NRD_1	375	377	PF00675	0.537
CLV_PCSK_KEX2_1	139	141	PF00082	0.411
CLV_PCSK_KEX2_1	147	149	PF00082	0.363
CLV_PCSK_KEX2_1	152	154	PF00082	0.326
CLV_PCSK_KEX2_1	203	205	PF00082	0.346
CLV_PCSK_KEX2_1	375	377	PF00082	0.541
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.389
CLV_PCSK_PC7_1	148	154	PF00082	0.345
CLV_PCSK_SKI1_1	157	161	PF00082	0.363
CLV_PCSK_SKI1_1	227	231	PF00082	0.316
DOC_CKS1_1	51	56	PF01111	0.500
DOC_CYCLIN_RxL_1	144	155	PF00134	0.623
DOC_CYCLIN_RxL_1	224	234	PF00134	0.619
DOC_MAPK_gen_1	18	28	PF00069	0.419
DOC_MAPK_MEF2A_6	21	30	PF00069	0.420
DOC_MAPK_NFAT4_5	21	29	PF00069	0.418
DOC_PP1_RVXF_1	128	135	PF00149	0.487
DOC_PP4_FxxP_1	219	222	PF00568	0.600
DOC_USP7_MATH_1	103	107	PF00917	0.472
DOC_USP7_MATH_1	283	287	PF00917	0.692
DOC_USP7_MATH_1	339	343	PF00917	0.679
DOC_WW_Pin1_4	187	192	PF00397	0.546
DOC_WW_Pin1_4	245	250	PF00397	0.830
DOC_WW_Pin1_4	368	373	PF00397	0.754
DOC_WW_Pin1_4	382	387	PF00397	0.665
DOC_WW_Pin1_4	50	55	PF00397	0.500
LIG_14-3-3_CanoR_1	21	27	PF00244	0.436
LIG_14-3-3_CanoR_1	315	322	PF00244	0.728
LIG_Actin_RPEL_3	123	142	PF02755	0.489
LIG_BRCT_BRCA1_1	289	293	PF00533	0.615
LIG_CtBP_PxDLS_1	249	253	PF00389	0.609
LIG_EH_1	337	341	PF12763	0.742
LIG_EH1_1	223	231	PF00400	0.609
LIG_eIF4E_1	224	230	PF01652	0.605
LIG_FHA_1	18	24	PF00498	0.467
LIG_FHA_1	378	384	PF00498	0.757
LIG_FHA_1	51	57	PF00498	0.500
LIG_FHA_1	92	98	PF00498	0.489
LIG_FHA_2	283	289	PF00498	0.734
LIG_LIR_Gen_1	25	35	PF02991	0.492
LIG_LIR_Gen_1	342	349	PF02991	0.722
LIG_LIR_Gen_1	58	66	PF02991	0.502
LIG_LIR_Nem_3	25	30	PF02991	0.475
LIG_LIR_Nem_3	342	347	PF02991	0.720
LIG_PCNA_PIPBox_1	125	134	PF02747	0.489
LIG_PTAP_UEV_1	1	6	PF05743	0.484
LIG_SH2_CRK	344	348	PF00017	0.758
LIG_SH2_CRK	51	55	PF00017	0.500
LIG_SH2_NCK_1	344	348	PF00017	0.758
LIG_SH2_PTP2	412	415	PF00017	0.649
LIG_SH2_STAP1	258	262	PF00017	0.609
LIG_SH2_STAT3	225	228	PF00017	0.603
LIG_SH2_STAT5	225	228	PF00017	0.603
LIG_SH2_STAT5	412	415	PF00017	0.674
LIG_SH2_STAT5	48	51	PF00017	0.511
LIG_SH3_3	380	386	PF00018	0.770
LIG_SH3_3	62	68	PF00018	0.531
LIG_SUMO_SIM_anti_2	113	118	PF11976	0.344
LIG_SUMO_SIM_par_1	115	122	PF11976	0.344
LIG_TRAF2_1	268	271	PF00917	0.704
LIG_TRAF2_1	393	396	PF00917	0.749
LIG_WW_3	320	324	PF00397	0.531
MOD_CDK_SPxxK_3	368	375	PF00069	0.653
MOD_CK1_1	243	249	PF00069	0.789
MOD_CK1_1	305	311	PF00069	0.559
MOD_CK1_1	342	348	PF00069	0.609
MOD_CK2_1	228	234	PF00069	0.514
MOD_CK2_1	245	251	PF00069	0.801
MOD_CK2_1	382	388	PF00069	0.657
MOD_GlcNHglycan	125	128	PF01048	0.356
MOD_GlcNHglycan	2	5	PF01048	0.645
MOD_GlcNHglycan	212	215	PF01048	0.405
MOD_GlcNHglycan	230	233	PF01048	0.335
MOD_GlcNHglycan	234	239	PF01048	0.594
MOD_GlcNHglycan	258	261	PF01048	0.564
MOD_GlcNHglycan	263	266	PF01048	0.491
MOD_GlcNHglycan	304	307	PF01048	0.602
MOD_GlcNHglycan	32	35	PF01048	0.668
MOD_GlcNHglycan	364	367	PF01048	0.645
MOD_GlcNHglycan	368	371	PF01048	0.726
MOD_GlcNHglycan	401	404	PF01048	0.692
MOD_GlcNHglycan	78	81	PF01048	0.681
MOD_GSK3_1	119	126	PF00069	0.405
MOD_GSK3_1	256	263	PF00069	0.583
MOD_GSK3_1	283	290	PF00069	0.624
MOD_GSK3_1	297	304	PF00069	0.575
MOD_GSK3_1	362	369	PF00069	0.745
MOD_GSK3_1	377	384	PF00069	0.630
MOD_N-GLC_1	91	96	PF02516	0.605
MOD_N-GLC_2	301	303	PF02516	0.549
MOD_NEK2_1	112	117	PF00069	0.450
MOD_NEK2_1	119	124	PF00069	0.429
MOD_NEK2_1	22	27	PF00069	0.568
MOD_NEK2_1	250	255	PF00069	0.498
MOD_NEK2_1	297	302	PF00069	0.483
MOD_NEK2_1	30	35	PF00069	0.631
MOD_NEK2_1	362	367	PF00069	0.653
MOD_NEK2_2	322	327	PF00069	0.605
MOD_OFUCOSY	83	90	PF10250	0.602
MOD_PKA_2	17	23	PF00069	0.533
MOD_PKA_2	314	320	PF00069	0.662
MOD_PKA_2	322	328	PF00069	0.704
MOD_PKA_2	342	348	PF00069	0.612
MOD_Plk_1	243	249	PF00069	0.551
MOD_Plk_1	250	256	PF00069	0.545
MOD_Plk_1	287	293	PF00069	0.619
MOD_Plk_2-3	287	293	PF00069	0.571
MOD_Plk_4	103	109	PF00069	0.322
MOD_Plk_4	112	118	PF00069	0.334
MOD_Plk_4	119	125	PF00069	0.262
MOD_Plk_4	22	28	PF00069	0.403
MOD_Plk_4	9	15	PF00069	0.572
MOD_ProDKin_1	187	193	PF00069	0.405
MOD_ProDKin_1	245	251	PF00069	0.800
MOD_ProDKin_1	368	374	PF00069	0.699
MOD_ProDKin_1	382	388	PF00069	0.574
MOD_ProDKin_1	50	56	PF00069	0.621
MOD_SUMO_for_1	159	162	PF00179	0.541
MOD_SUMO_rev_2	161	171	PF00179	0.522
MOD_SUMO_rev_2	64	73	PF00179	0.571
TRG_ENDOCYTIC_2	344	347	PF00928	0.774
TRG_ENDOCYTIC_2	412	415	PF00928	0.592
TRG_ENDOCYTIC_2	59	62	PF00928	0.626
TRG_ER_diArg_1	139	141	PF00400	0.495
TRG_ER_diArg_1	145	148	PF00400	0.454
TRG_ER_diArg_1	151	153	PF00400	0.391
TRG_ER_diArg_1	203	205	PF00400	0.223
TRG_ER_diArg_1	340	343	PF00400	0.638
TRG_ER_diArg_1	374	376	PF00400	0.673
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQW1	Leishmania donovani	84%	99%
A4H5U9	Leishmania braziliensis	66%	94%
A4HU43	Leishmania infantum	84%	99%
Q4QHQ4	Leishmania major	82%	100%