Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMX0_LEIMU

TriTrypDb:

LmxM.09.1190

Length:

604

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMX0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	492	496	PF00656	0.736
CLV_C14_Caspase3-7	580	584	PF00656	0.549
CLV_C14_Caspase3-7	75	79	PF00656	0.793
CLV_NRD_NRD_1	263	265	PF00675	0.538
CLV_NRD_NRD_1	292	294	PF00675	0.579
CLV_NRD_NRD_1	393	395	PF00675	0.515
CLV_NRD_NRD_1	396	398	PF00675	0.586
CLV_NRD_NRD_1	465	467	PF00675	0.717
CLV_NRD_NRD_1	468	470	PF00675	0.609
CLV_NRD_NRD_1	479	481	PF00675	0.724
CLV_NRD_NRD_1	89	91	PF00675	0.772
CLV_PCSK_FUR_1	394	398	PF00082	0.590
CLV_PCSK_FUR_1	476	480	PF00082	0.706
CLV_PCSK_KEX2_1	263	265	PF00082	0.538
CLV_PCSK_KEX2_1	292	294	PF00082	0.579
CLV_PCSK_KEX2_1	393	395	PF00082	0.515
CLV_PCSK_KEX2_1	396	398	PF00082	0.586
CLV_PCSK_KEX2_1	465	467	PF00082	0.802
CLV_PCSK_KEX2_1	478	480	PF00082	0.529
CLV_PCSK_KEX2_1	89	91	PF00082	0.628
CLV_PCSK_PC7_1	259	265	PF00082	0.480
CLV_PCSK_SKI1_1	259	263	PF00082	0.567
CLV_PCSK_SKI1_1	42	46	PF00082	0.417
CLV_PCSK_SKI1_1	523	527	PF00082	0.689
CLV_PCSK_SKI1_1	89	93	PF00082	0.733
CLV_Separin_Metazoa	20	24	PF03568	0.645
CLV_Separin_Metazoa	390	394	PF03568	0.604
DEG_APCC_DBOX_1	258	266	PF00400	0.560
DEG_COP1_1	430	437	PF00400	0.529
DEG_Nend_UBRbox_3	1	3	PF02207	0.549
DEG_SCF_FBW7_2	13	20	PF00400	0.725
DEG_SPOP_SBC_1	61	65	PF00917	0.521
DOC_CYCLIN_yCln2_LP_2	452	458	PF00134	0.535
DOC_MAPK_gen_1	23	32	PF00069	0.626
DOC_MAPK_MEF2A_6	332	341	PF00069	0.625
DOC_PP2B_LxvP_1	334	337	PF13499	0.636
DOC_PP4_FxxP_1	545	548	PF00568	0.410
DOC_SPAK_OSR1_1	531	535	PF12202	0.471
DOC_USP7_MATH_1	126	130	PF00917	0.712
DOC_USP7_MATH_1	140	144	PF00917	0.536
DOC_USP7_MATH_1	15	19	PF00917	0.728
DOC_USP7_MATH_1	188	192	PF00917	0.712
DOC_USP7_MATH_1	257	261	PF00917	0.566
DOC_USP7_MATH_1	268	272	PF00917	0.450
DOC_USP7_MATH_1	291	295	PF00917	0.585
DOC_USP7_MATH_1	429	433	PF00917	0.654
DOC_USP7_MATH_1	507	511	PF00917	0.568
DOC_USP7_MATH_1	535	539	PF00917	0.608
DOC_USP7_MATH_1	60	64	PF00917	0.635
DOC_WW_Pin1_4	13	18	PF00397	0.807
DOC_WW_Pin1_4	433	438	PF00397	0.719
DOC_WW_Pin1_4	451	456	PF00397	0.478
LIG_14-3-3_CanoR_1	156	165	PF00244	0.655
LIG_14-3-3_CanoR_1	292	296	PF00244	0.514
LIG_14-3-3_CanoR_1	302	308	PF00244	0.417
LIG_14-3-3_CanoR_1	42	47	PF00244	0.617
LIG_14-3-3_CanoR_1	523	532	PF00244	0.572
LIG_Actin_WH2_2	558	574	PF00022	0.543
LIG_BIR_III_4	97	101	PF00653	0.601
LIG_BRCT_BRCA1_1	537	541	PF00533	0.441
LIG_BRCT_BRCA1_1	597	601	PF00533	0.459
LIG_CtBP_PxDLS_1	338	342	PF00389	0.636
LIG_CtBP_PxDLS_1	372	376	PF00389	0.548
LIG_FHA_1	246	252	PF00498	0.457
LIG_FHA_1	278	284	PF00498	0.523
LIG_FHA_1	298	304	PF00498	0.601
LIG_FHA_1	311	317	PF00498	0.457
LIG_FHA_1	406	412	PF00498	0.628
LIG_FHA_1	439	445	PF00498	0.604
LIG_FHA_1	541	547	PF00498	0.551
LIG_FHA_2	578	584	PF00498	0.552
LIG_FHA_2	81	87	PF00498	0.636
LIG_LIR_Apic_2	542	548	PF02991	0.404
LIG_LIR_Gen_1	157	166	PF02991	0.707
LIG_LIR_Gen_1	219	229	PF02991	0.398
LIG_LIR_Gen_1	41	47	PF02991	0.668
LIG_LIR_Nem_3	157	162	PF02991	0.692
LIG_LIR_Nem_3	219	224	PF02991	0.402
LIG_LIR_Nem_3	41	46	PF02991	0.668
LIG_LIR_Nem_3	538	544	PF02991	0.451
LIG_LIR_Nem_3	575	581	PF02991	0.550
LIG_PAM2_1	339	351	PF00658	0.606
LIG_Pex14_1	106	110	PF04695	0.663
LIG_Pex14_1	304	308	PF04695	0.538
LIG_Pex14_2	155	159	PF04695	0.663
LIG_Pex14_2	39	43	PF04695	0.546
LIG_Pex14_2	541	545	PF04695	0.361
LIG_Pex3_1	99	110	PF04882	0.662
LIG_SH2_CRK	226	230	PF00017	0.523
LIG_SH2_NCK_1	226	230	PF00017	0.523
LIG_SH2_STAP1	40	44	PF00017	0.545
LIG_SH2_STAT5	144	147	PF00017	0.471
LIG_SH2_STAT5	226	229	PF00017	0.396
LIG_SH2_STAT5	308	311	PF00017	0.546
LIG_SH2_STAT5	40	43	PF00017	0.607
LIG_SH2_STAT5	544	547	PF00017	0.381
LIG_SH2_STAT5	570	573	PF00017	0.523
LIG_SH3_1	179	185	PF00018	0.693
LIG_SH3_1	417	423	PF00018	0.525
LIG_SH3_3	179	185	PF00018	0.629
LIG_SH3_3	27	33	PF00018	0.802
LIG_SH3_3	417	423	PF00018	0.631
LIG_SH3_3	431	437	PF00018	0.727
LIG_SH3_3	550	556	PF00018	0.721
LIG_SUMO_SIM_par_1	337	342	PF11976	0.638
LIG_SUMO_SIM_par_1	371	377	PF11976	0.471
LIG_SUMO_SIM_par_1	408	415	PF11976	0.483
LIG_TRAF2_1	120	123	PF00917	0.620
LIG_TRAF2_1	253	256	PF00917	0.539
LIG_TRFH_1	144	148	PF08558	0.475
LIG_TYR_ITIM	224	229	PF00017	0.392
LIG_WW_3	20	24	PF00397	0.645
MOD_CDC14_SPxK_1	436	439	PF00782	0.509
MOD_CDK_SPxK_1	433	439	PF00069	0.522
MOD_CK1_1	157	163	PF00069	0.706
MOD_CK1_1	209	215	PF00069	0.618
MOD_CK1_1	3	9	PF00069	0.592
MOD_CK1_1	306	312	PF00069	0.403
MOD_CK1_1	403	409	PF00069	0.655
MOD_CK1_1	512	518	PF00069	0.620
MOD_CK1_1	519	525	PF00069	0.529
MOD_CK1_1	63	69	PF00069	0.685
MOD_CK1_1	73	79	PF00069	0.827
MOD_CK2_1	249	255	PF00069	0.689
MOD_CK2_1	268	274	PF00069	0.348
MOD_CK2_1	493	499	PF00069	0.654
MOD_Cter_Amidation	463	466	PF01082	0.651
MOD_Cter_Amidation	467	470	PF01082	0.630
MOD_GlcNHglycan	128	131	PF01048	0.748
MOD_GlcNHglycan	138	141	PF01048	0.495
MOD_GlcNHglycan	156	159	PF01048	0.434
MOD_GlcNHglycan	167	170	PF01048	0.599
MOD_GlcNHglycan	208	211	PF01048	0.434
MOD_GlcNHglycan	249	254	PF01048	0.549
MOD_GlcNHglycan	259	262	PF01048	0.406
MOD_GlcNHglycan	270	273	PF01048	0.404
MOD_GlcNHglycan	280	283	PF01048	0.583
MOD_GlcNHglycan	313	316	PF01048	0.518
MOD_GlcNHglycan	402	405	PF01048	0.653
MOD_GlcNHglycan	484	487	PF01048	0.571
MOD_GlcNHglycan	5	9	PF01048	0.600
MOD_GlcNHglycan	511	514	PF01048	0.675
MOD_GlcNHglycan	518	521	PF01048	0.535
MOD_GlcNHglycan	537	540	PF01048	0.610
MOD_GlcNHglycan	598	601	PF01048	0.461
MOD_GlcNHglycan	65	68	PF01048	0.713
MOD_GSK3_1	132	139	PF00069	0.674
MOD_GSK3_1	154	161	PF00069	0.676
MOD_GSK3_1	245	252	PF00069	0.690
MOD_GSK3_1	303	310	PF00069	0.502
MOD_GSK3_1	38	45	PF00069	0.615
MOD_GSK3_1	403	410	PF00069	0.739
MOD_GSK3_1	423	430	PF00069	0.663
MOD_GSK3_1	489	496	PF00069	0.637
MOD_GSK3_1	512	519	PF00069	0.774
MOD_GSK3_1	535	542	PF00069	0.604
MOD_GSK3_1	577	584	PF00069	0.562
MOD_GSK3_1	70	77	PF00069	0.832
MOD_LATS_1	398	404	PF00433	0.552
MOD_N-GLC_1	245	250	PF02516	0.475
MOD_N-GLC_1	572	577	PF02516	0.689
MOD_N-GLC_1	595	600	PF02516	0.459
MOD_NEK2_1	154	159	PF00069	0.545
MOD_NEK2_1	175	180	PF00069	0.819
MOD_NEK2_1	217	222	PF00069	0.420
MOD_NEK2_1	224	229	PF00069	0.470
MOD_NEK2_1	234	239	PF00069	0.420
MOD_NEK2_1	303	308	PF00069	0.538
MOD_NEK2_1	339	344	PF00069	0.523
MOD_NEK2_1	524	529	PF00069	0.555
MOD_NEK2_1	581	586	PF00069	0.557
MOD_NEK2_2	297	302	PF00069	0.527
MOD_OFUCOSY	222	228	PF10250	0.573
MOD_PIKK_1	235	241	PF00454	0.593
MOD_PIKK_1	45	51	PF00454	0.690
MOD_PIKK_1	524	530	PF00454	0.494
MOD_PIKK_1	581	587	PF00454	0.556
MOD_PKA_1	89	95	PF00069	0.609
MOD_PKA_2	175	181	PF00069	0.761
MOD_PKA_2	291	297	PF00069	0.480
MOD_PKA_2	3	9	PF00069	0.580
MOD_PKA_2	392	398	PF00069	0.426
MOD_PKA_2	438	444	PF00069	0.569
MOD_PKA_2	563	569	PF00069	0.561
MOD_PKA_2	581	587	PF00069	0.665
MOD_PKA_2	71	77	PF00069	0.660
MOD_PKA_2	89	95	PF00069	0.570
MOD_PKB_1	480	488	PF00069	0.566
MOD_Plk_1	350	356	PF00069	0.607
MOD_Plk_1	494	500	PF00069	0.833
MOD_Plk_2-3	489	495	PF00069	0.644
MOD_Plk_4	158	164	PF00069	0.576
MOD_Plk_4	229	235	PF00069	0.479
MOD_Plk_4	303	309	PF00069	0.473
MOD_Plk_4	339	345	PF00069	0.619
MOD_Plk_4	42	48	PF00069	0.650
MOD_Plk_4	540	546	PF00069	0.400
MOD_ProDKin_1	13	19	PF00069	0.804
MOD_ProDKin_1	433	439	PF00069	0.712
MOD_ProDKin_1	451	457	PF00069	0.483
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.511
TRG_ENDOCYTIC_2	226	229	PF00928	0.396
TRG_ENDOCYTIC_2	40	43	PF00928	0.546
TRG_ER_diArg_1	22	25	PF00400	0.648
TRG_ER_diArg_1	262	264	PF00400	0.487
TRG_ER_diArg_1	392	394	PF00400	0.505
TRG_ER_diArg_1	475	478	PF00400	0.731
TRG_ER_diArg_1	479	482	PF00400	0.807
TRG_ER_diArg_1	88	90	PF00400	0.620
TRG_Pf-PMV_PEXEL_1	588	593	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJF6	Leptomonas seymouri	31%	96%
A0A3S7WQU0	Leishmania donovani	82%	100%
A4H5U7	Leishmania braziliensis	65%	98%
A4HU41	Leishmania infantum	82%	100%
Q4QHQ6	Leishmania major	80%	97%