Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMW7_LEIMU

TriTrypDb:

LmxM.09.1160

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AMW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMW7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.638
CLV_C14_Caspase3-7	697	701	PF00656	0.308
CLV_NRD_NRD_1	286	288	PF00675	0.481
CLV_NRD_NRD_1	341	343	PF00675	0.418
CLV_NRD_NRD_1	391	393	PF00675	0.301
CLV_NRD_NRD_1	479	481	PF00675	0.530
CLV_NRD_NRD_1	55	57	PF00675	0.479
CLV_NRD_NRD_1	678	680	PF00675	0.660
CLV_NRD_NRD_1	718	720	PF00675	0.645
CLV_PCSK_FUR_1	287	291	PF00082	0.464
CLV_PCSK_FUR_1	676	680	PF00082	0.624
CLV_PCSK_KEX2_1	114	116	PF00082	0.345
CLV_PCSK_KEX2_1	286	288	PF00082	0.482
CLV_PCSK_KEX2_1	289	291	PF00082	0.488
CLV_PCSK_KEX2_1	391	393	PF00082	0.331
CLV_PCSK_KEX2_1	479	481	PF00082	0.521
CLV_PCSK_KEX2_1	535	537	PF00082	0.454
CLV_PCSK_KEX2_1	678	680	PF00082	0.622
CLV_PCSK_KEX2_1	718	720	PF00082	0.605
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.345
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.494
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.491
CLV_PCSK_SKI1_1	213	217	PF00082	0.436
CLV_PCSK_SKI1_1	286	290	PF00082	0.598
CLV_PCSK_SKI1_1	429	433	PF00082	0.415
CLV_PCSK_SKI1_1	482	486	PF00082	0.460
CLV_PCSK_SKI1_1	617	621	PF00082	0.512
CLV_PCSK_SKI1_1	62	66	PF00082	0.369
CLV_PCSK_SKI1_1	97	101	PF00082	0.363
DEG_APCC_DBOX_1	549	557	PF00400	0.708
DEG_COP1_1	276	283	PF00400	0.593
DEG_COP1_1	626	634	PF00400	0.517
DEG_Nend_UBRbox_3	1	3	PF02207	0.693
DEG_SCF_FBW7_1	462	469	PF00400	0.600
DEG_SPOP_SBC_1	466	470	PF00917	0.750
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.372
DOC_MAPK_gen_1	114	122	PF00069	0.526
DOC_MAPK_gen_1	166	175	PF00069	0.635
DOC_MAPK_gen_1	427	434	PF00069	0.626
DOC_MAPK_gen_1	726	735	PF00069	0.442
DOC_MAPK_HePTP_8	163	175	PF00069	0.686
DOC_MAPK_MEF2A_6	166	175	PF00069	0.604
DOC_MAPK_MEF2A_6	427	434	PF00069	0.639
DOC_PP1_RVXF_1	60	67	PF00149	0.578
DOC_PP2B_LxvP_1	642	645	PF13499	0.372
DOC_PP4_FxxP_1	185	188	PF00568	0.639
DOC_USP7_MATH_1	15	19	PF00917	0.684
DOC_USP7_MATH_1	273	277	PF00917	0.618
DOC_USP7_MATH_1	360	364	PF00917	0.699
DOC_USP7_MATH_1	447	451	PF00917	0.640
DOC_USP7_MATH_1	466	470	PF00917	0.767
DOC_USP7_MATH_1	472	476	PF00917	0.757
DOC_USP7_MATH_1	575	579	PF00917	0.764
DOC_USP7_UBL2_3	409	413	PF12436	0.672
DOC_USP7_UBL2_3	485	489	PF12436	0.637
DOC_USP7_UBL2_3	529	533	PF12436	0.632
DOC_WW_Pin1_4	279	284	PF00397	0.733
DOC_WW_Pin1_4	462	467	PF00397	0.599
DOC_WW_Pin1_4	554	559	PF00397	0.749
DOC_WW_Pin1_4	81	86	PF00397	0.749
LIG_14-3-3_CanoR_1	20	26	PF00244	0.758
LIG_14-3-3_CanoR_1	230	236	PF00244	0.793
LIG_14-3-3_CanoR_1	342	346	PF00244	0.720
LIG_14-3-3_CanoR_1	482	492	PF00244	0.554
LIG_14-3-3_CanoR_1	506	512	PF00244	0.678
LIG_APCC_ABBAyCdc20_2	391	397	PF00400	0.545
LIG_BRCT_BRCA1_1	118	122	PF00533	0.552
LIG_BRCT_BRCA1_1	91	95	PF00533	0.645
LIG_Clathr_ClatBox_1	174	178	PF01394	0.602
LIG_CSL_BTD_1	642	645	PF09270	0.372
LIG_EH_1	186	190	PF12763	0.528
LIG_FHA_1	158	164	PF00498	0.778
LIG_FHA_1	471	477	PF00498	0.684
LIG_FHA_1	506	512	PF00498	0.736
LIG_FHA_1	654	660	PF00498	0.264
LIG_FHA_2	11	17	PF00498	0.737
LIG_FHA_2	325	331	PF00498	0.633
LIG_FHA_2	495	501	PF00498	0.735
LIG_FHA_2	600	606	PF00498	0.658
LIG_LIR_Apic_2	201	207	PF02991	0.693
LIG_LIR_Gen_1	129	140	PF02991	0.617
LIG_LIR_Gen_1	307	318	PF02991	0.643
LIG_LIR_Gen_1	415	426	PF02991	0.700
LIG_LIR_Gen_1	584	594	PF02991	0.634
LIG_LIR_Nem_3	129	135	PF02991	0.612
LIG_LIR_Nem_3	307	313	PF02991	0.612
LIG_LIR_Nem_3	330	336	PF02991	0.618
LIG_LIR_Nem_3	415	421	PF02991	0.698
LIG_LIR_Nem_3	584	590	PF02991	0.629
LIG_LIR_Nem_3	63	69	PF02991	0.583
LIG_LIR_Nem_3	633	638	PF02991	0.661
LIG_LIR_Nem_3	656	660	PF02991	0.408
LIG_LIR_Nem_3	661	665	PF02991	0.332
LIG_LYPXL_yS_3	574	577	PF13949	0.707
LIG_MYND_1	554	558	PF01753	0.712
LIG_NRBOX	170	176	PF00104	0.580
LIG_PCNA_yPIPBox_3	612	620	PF02747	0.540
LIG_Pex14_1	332	336	PF04695	0.583
LIG_Pex14_2	185	189	PF04695	0.607
LIG_Pex14_2	65	69	PF04695	0.621
LIG_Pex14_2	95	99	PF04695	0.633
LIG_SH2_CRK	587	591	PF00017	0.561
LIG_SH2_GRB2like	335	338	PF00017	0.669
LIG_SH2_GRB2like	638	641	PF00017	0.393
LIG_SH2_SRC	378	381	PF00017	0.762
LIG_SH2_SRC	405	408	PF00017	0.653
LIG_SH2_SRC	625	628	PF00017	0.665
LIG_SH2_SRC	638	641	PF00017	0.393
LIG_SH2_STAP1	395	399	PF00017	0.551
LIG_SH2_STAP1	587	591	PF00017	0.561
LIG_SH2_STAP1	91	95	PF00017	0.618
LIG_SH2_STAT3	358	361	PF00017	0.661
LIG_SH2_STAT3	407	410	PF00017	0.545
LIG_SH2_STAT3	492	495	PF00017	0.688
LIG_SH2_STAT3	75	78	PF00017	0.699
LIG_SH2_STAT5	132	135	PF00017	0.589
LIG_SH2_STAT5	405	408	PF00017	0.589
LIG_SH2_STAT5	597	600	PF00017	0.679
LIG_SH2_STAT5	618	621	PF00017	0.636
LIG_SH2_STAT5	638	641	PF00017	0.389
LIG_SH2_STAT5	658	661	PF00017	0.244
LIG_SH3_1	290	296	PF00018	0.688
LIG_SH3_2	293	298	PF14604	0.714
LIG_SH3_3	23	29	PF00018	0.608
LIG_SH3_3	233	239	PF00018	0.747
LIG_SH3_3	250	256	PF00018	0.680
LIG_SH3_3	277	283	PF00018	0.747
LIG_SH3_3	290	296	PF00018	0.622
LIG_SH3_3	548	554	PF00018	0.732
LIG_SUMO_SIM_par_1	220	229	PF11976	0.671
LIG_SUMO_SIM_par_1	324	330	PF11976	0.615
LIG_TRAF2_1	497	500	PF00917	0.682
LIG_TYR_ITIM	393	398	PF00017	0.632
LIG_TYR_ITIM	403	408	PF00017	0.702
LIG_UBA3_1	421	429	PF00899	0.661
LIG_UBA3_1	530	535	PF00899	0.723
LIG_WW_2	551	554	PF00397	0.733
MOD_CDK_SPxxK_3	279	286	PF00069	0.744
MOD_CK1_1	226	232	PF00069	0.725
MOD_CK1_1	282	288	PF00069	0.789
MOD_CK1_1	31	37	PF00069	0.779
MOD_CK1_1	467	473	PF00069	0.743
MOD_CK1_1	475	481	PF00069	0.612
MOD_CK1_1	7	13	PF00069	0.759
MOD_CK1_1	80	86	PF00069	0.669
MOD_CK2_1	10	16	PF00069	0.801
MOD_CK2_1	229	235	PF00069	0.764
MOD_CK2_1	448	454	PF00069	0.713
MOD_CK2_1	494	500	PF00069	0.679
MOD_CK2_1	599	605	PF00069	0.691
MOD_Cter_Amidation	54	57	PF01082	0.494
MOD_Cter_Amidation	727	730	PF01082	0.642
MOD_GlcNHglycan	231	234	PF01048	0.492
MOD_GlcNHglycan	30	33	PF01048	0.561
MOD_GlcNHglycan	346	349	PF01048	0.569
MOD_GlcNHglycan	400	403	PF01048	0.430
MOD_GlcNHglycan	53	56	PF01048	0.503
MOD_GlcNHglycan	577	580	PF01048	0.425
MOD_GlcNHglycan	587	590	PF01048	0.396
MOD_GlcNHglycan	6	9	PF01048	0.496
MOD_GlcNHglycan	702	705	PF01048	0.494
MOD_GlcNHglycan	79	82	PF01048	0.490
MOD_GlcNHglycan	86	89	PF01048	0.449
MOD_GSK3_1	189	196	PF00069	0.563
MOD_GSK3_1	27	34	PF00069	0.819
MOD_GSK3_1	3	10	PF00069	0.674
MOD_GSK3_1	461	468	PF00069	0.714
MOD_GSK3_1	470	477	PF00069	0.640
MOD_GSK3_1	511	518	PF00069	0.698
MOD_GSK3_1	713	720	PF00069	0.392
MOD_GSK3_1	77	84	PF00069	0.738
MOD_LATS_1	544	550	PF00433	0.681
MOD_N-GLC_1	447	452	PF02516	0.446
MOD_N-GLC_1	713	718	PF02516	0.693
MOD_NEK2_1	1	6	PF00069	0.798
MOD_NEK2_1	341	346	PF00069	0.703
MOD_NEK2_1	398	403	PF00069	0.651
MOD_NEK2_1	417	422	PF00069	0.720
MOD_NEK2_1	511	516	PF00069	0.727
MOD_NEK2_1	706	711	PF00069	0.473
MOD_NEK2_1	713	718	PF00069	0.352
MOD_NEK2_2	15	20	PF00069	0.717
MOD_PIKK_1	21	27	PF00454	0.721
MOD_PIKK_1	341	347	PF00454	0.661
MOD_PKA_1	718	724	PF00069	0.441
MOD_PKA_2	157	163	PF00069	0.731
MOD_PKA_2	21	27	PF00069	0.690
MOD_PKA_2	229	235	PF00069	0.795
MOD_PKA_2	341	347	PF00069	0.713
MOD_PKA_2	372	378	PF00069	0.747
MOD_PKA_2	505	511	PF00069	0.682
MOD_PKA_2	51	57	PF00069	0.671
MOD_PKA_2	717	723	PF00069	0.402
MOD_Plk_1	15	21	PF00069	0.600
MOD_Plk_1	193	199	PF00069	0.565
MOD_Plk_1	447	453	PF00069	0.690
MOD_Plk_1	713	719	PF00069	0.502
MOD_Plk_2-3	249	255	PF00069	0.605
MOD_Plk_4	116	122	PF00069	0.623
MOD_Plk_4	135	141	PF00069	0.492
MOD_Plk_4	193	199	PF00069	0.758
MOD_Plk_4	324	330	PF00069	0.616
MOD_Plk_4	417	423	PF00069	0.616
MOD_Plk_4	448	454	PF00069	0.561
MOD_Plk_4	630	636	PF00069	0.614
MOD_Plk_4	653	659	PF00069	0.293
MOD_ProDKin_1	279	285	PF00069	0.732
MOD_ProDKin_1	462	468	PF00069	0.600
MOD_ProDKin_1	554	560	PF00069	0.749
MOD_ProDKin_1	81	87	PF00069	0.748
MOD_SUMO_rev_2	693	701	PF00179	0.384
TRG_DiLeu_BaEn_1	526	531	PF01217	0.611
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.393
TRG_ENDOCYTIC_2	103	106	PF00928	0.560
TRG_ENDOCYTIC_2	132	135	PF00928	0.589
TRG_ENDOCYTIC_2	335	338	PF00928	0.641
TRG_ENDOCYTIC_2	395	398	PF00928	0.576
TRG_ENDOCYTIC_2	405	408	PF00928	0.605
TRG_ENDOCYTIC_2	414	417	PF00928	0.630
TRG_ENDOCYTIC_2	574	577	PF00928	0.690
TRG_ENDOCYTIC_2	587	590	PF00928	0.584
TRG_ENDOCYTIC_2	657	660	PF00928	0.493
TRG_ER_diArg_1	19	22	PF00400	0.746
TRG_ER_diArg_1	286	288	PF00400	0.681
TRG_ER_diArg_1	390	392	PF00400	0.517
TRG_ER_diArg_1	46	49	PF00400	0.678
TRG_ER_diArg_1	479	482	PF00400	0.724
TRG_ER_diArg_1	676	679	PF00400	0.373
TRG_ER_diArg_1	717	719	PF00400	0.399
TRG_NLS_Bipartite_1	718	733	PF00514	0.354
TRG_NLS_MonoExtC_3	728	734	PF00514	0.376
TRG_NLS_MonoExtN_4	726	733	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.400
TRG_Pf-PMV_PEXEL_1	438	442	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	536	540	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTV6	Leptomonas seymouri	54%	100%
A0A0S4JUS6	Bodo saltans	24%	100%
A0A3Q8IH12	Leishmania donovani	89%	100%
A0A422NZM2	Trypanosoma rangeli	31%	100%
A4H5U4	Leishmania braziliensis	77%	100%
A4HU38	Leishmania infantum	88%	100%
Q4QHQ9	Leishmania major	87%	100%
V5DEB6	Trypanosoma cruzi	32%	100%