PITH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMW5_LEIMU

TriTrypDb:

LmxM.09.1140

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	11
GO:0030992	intraciliary transport particle B	2	11
GO:0032991	protein-containing complex	1	11
GO:0042995	cell projection	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	11
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1

Expansion

Sequence features

E9AMW5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMW5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11
GO:0010970	transport along microtubule	4	11
GO:0030705	cytoskeleton-dependent intracellular transport	4	11
GO:0031503	protein-containing complex localization	2	11
GO:0042073	intraciliary transport	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0099111	microtubule-based transport	4	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.480
CLV_NRD_NRD_1	14	16	PF00675	0.679
CLV_NRD_NRD_1	28	30	PF00675	0.783
CLV_NRD_NRD_1	40	42	PF00675	0.678
CLV_PCSK_KEX2_1	13	15	PF00082	0.683
CLV_PCSK_KEX2_1	28	30	PF00082	0.776
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.678
CLV_PCSK_PC7_1	24	30	PF00082	0.652
CLV_PCSK_SKI1_1	113	117	PF00082	0.516
CLV_PCSK_SKI1_1	29	33	PF00082	0.581
CLV_PCSK_SKI1_1	41	45	PF00082	0.662
CLV_PCSK_SKI1_1	51	55	PF00082	0.461
DEG_APCC_DBOX_1	27	35	PF00400	0.659
DOC_MAPK_gen_1	101	109	PF00069	0.556
DOC_MAPK_gen_1	158	167	PF00069	0.441
DOC_MAPK_MEF2A_6	101	109	PF00069	0.556
DOC_MAPK_MEF2A_6	158	167	PF00069	0.463
DOC_PP1_RVXF_1	156	163	PF00149	0.542
DOC_PP1_RVXF_1	49	55	PF00149	0.642
DOC_PP4_MxPP_1	1	4	PF00568	0.529
DOC_USP7_MATH_1	137	141	PF00917	0.697
LIG_14-3-3_CanoR_1	96	105	PF00244	0.548
LIG_BIR_III_4	181	185	PF00653	0.547
LIG_FHA_1	146	152	PF00498	0.583
LIG_FHA_1	76	82	PF00498	0.529
LIG_FHA_2	106	112	PF00498	0.398
LIG_FHA_2	124	130	PF00498	0.566
LIG_FHA_2	25	31	PF00498	0.773
LIG_FHA_2	35	41	PF00498	0.777
LIG_LIR_Gen_1	126	136	PF02991	0.511
LIG_LIR_Gen_1	159	168	PF02991	0.478
LIG_LIR_Gen_1	169	178	PF02991	0.369
LIG_LIR_Gen_1	55	66	PF02991	0.512
LIG_LIR_Nem_3	159	165	PF02991	0.481
LIG_LIR_Nem_3	169	174	PF02991	0.382
LIG_LIR_Nem_3	55	61	PF02991	0.467
LIG_Pex14_2	54	58	PF04695	0.635
LIG_SH2_STAP1	171	175	PF00017	0.487
LIG_SH2_STAP1	178	182	PF00017	0.477
LIG_SH3_3	1	7	PF00018	0.667
LIG_SH3_3	138	144	PF00018	0.575
LIG_SH3_3	71	77	PF00018	0.651
LIG_TRFH_1	149	153	PF08558	0.651
LIG_WRC_WIRS_1	58	63	PF05994	0.495
MOD_CK1_1	103	109	PF00069	0.485
MOD_CK1_1	169	175	PF00069	0.462
MOD_CK2_1	193	199	PF00069	0.617
MOD_CK2_1	24	30	PF00069	0.545
MOD_CK2_1	34	40	PF00069	0.503
MOD_GlcNHglycan	168	171	PF01048	0.430
MOD_GlcNHglycan	98	101	PF01048	0.476
MOD_GSK3_1	18	25	PF00069	0.686
MOD_GSK3_1	76	83	PF00069	0.533
MOD_GSK3_1	92	99	PF00069	0.495
MOD_NEK2_1	105	110	PF00069	0.462
MOD_NEK2_1	45	50	PF00069	0.748
MOD_NEK2_1	80	85	PF00069	0.490
MOD_PIKK_1	184	190	PF00454	0.549
MOD_PIKK_1	19	25	PF00454	0.684
MOD_PIKK_1	34	40	PF00454	0.508
MOD_PKA_2	137	143	PF00069	0.659
MOD_PKA_2	163	169	PF00069	0.520
MOD_Plk_1	132	138	PF00069	0.574
MOD_Plk_4	163	169	PF00069	0.491
MOD_Plk_4	76	82	PF00069	0.532
MOD_SUMO_rev_2	106	115	PF00179	0.513
TRG_ENDOCYTIC_2	171	174	PF00928	0.511
TRG_Pf-PMV_PEXEL_1	29	33	PF00026	0.663
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A8	Leptomonas seymouri	75%	100%
A0A1X0NHU5	Trypanosomatidae	49%	100%
A0A3S5H6E4	Leishmania donovani	82%	87%
A0A3S5ISF4	Trypanosoma rangeli	45%	100%
A4H5U2	Leishmania braziliensis	80%	100%
A4HU36	Leishmania infantum	83%	87%
D0A9L4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QHR1	Leishmania major	81%	100%
V5AY45	Trypanosoma cruzi	47%	100%