Mitochondrial import inner membrane translocase subunit TIM22

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial import inner membrane translocase subunit TIM17, putative

Species:

Leishmania mexicana

UniProt:

E9AMW4_LEIMU

TriTrypDb:

LmxM.09.1130

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0032991	protein-containing complex	1	11
GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	4	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AMW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMW4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006839	mitochondrial transport	4	11
GO:0006886	intracellular protein transport	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0007007	inner mitochondrial membrane organization	6	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016043	cellular component organization	3	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0045039	protein insertion into mitochondrial inner membrane	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051204	protein insertion into mitochondrial membrane	5	11
GO:0051205	protein insertion into membrane	5	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0051668	localization within membrane	3	11
GO:0061024	membrane organization	4	11
GO:0070585	protein localization to mitochondrion	6	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0072594	establishment of protein localization to organelle	4	11
GO:0072655	establishment of protein localization to mitochondrion	5	11
GO:0072657	protein localization to membrane	4	11
GO:0090150	establishment of protein localization to membrane	4	11
GO:0090151	establishment of protein localization to mitochondrial membrane	4	11

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0008320	protein transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022884	macromolecule transmembrane transporter activity	3	11
GO:0140318	protein transporter activity	2	11
GO:0005048	signal sequence binding	4	1
GO:0005488	binding	1	1
GO:0030943	mitochondrion targeting sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.232
CLV_PCSK_KEX2_1	95	97	PF00082	0.231
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.195
DEG_SPOP_SBC_1	52	56	PF00917	0.259
DOC_USP7_MATH_1	21	25	PF00917	0.574
DOC_USP7_MATH_1	52	56	PF00917	0.294
LIG_14-3-3_CanoR_1	66	70	PF00244	0.217
LIG_BIR_III_4	145	149	PF00653	0.355
LIG_BRCT_BRCA1_1	136	140	PF00533	0.259
LIG_BRCT_BRCA1_1	77	81	PF00533	0.372
LIG_BRCT_BRCA1_2	136	142	PF00533	0.318
LIG_FHA_1	26	32	PF00498	0.538
LIG_LIR_Apic_2	120	124	PF02991	0.459
LIG_LIR_Gen_1	137	147	PF02991	0.499
LIG_LIR_Gen_1	78	86	PF02991	0.259
LIG_LIR_Nem_3	78	84	PF02991	0.307
LIG_Pex14_2	136	140	PF04695	0.259
LIG_Pex14_2	82	86	PF04695	0.237
LIG_REV1ctd_RIR_1	62	70	PF16727	0.193
LIG_SH2_STAT5	37	40	PF00017	0.225
LIG_SH3_3	4	10	PF00018	0.582
MOD_CK1_1	48	54	PF00069	0.200
MOD_CK1_1	68	74	PF00069	0.112
MOD_Cter_Amidation	97	100	PF01082	0.207
MOD_GlcNHglycan	50	53	PF01048	0.432
MOD_GlcNHglycan	70	73	PF01048	0.312
MOD_GSK3_1	21	28	PF00069	0.559
MOD_GSK3_1	41	48	PF00069	0.112
MOD_NEK2_1	41	46	PF00069	0.315
MOD_NEK2_1	65	70	PF00069	0.193
MOD_NEK2_1	75	80	PF00069	0.225
MOD_PIKK_1	53	59	PF00454	0.193
MOD_PKA_2	65	71	PF00069	0.203
MOD_Plk_1	22	28	PF00069	0.529
MOD_Plk_4	45	51	PF00069	0.403
TRG_ER_diArg_1	96	99	PF00400	0.457
TRG_NES_CRM1_1	9	23	PF08389	0.587

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE0	Leptomonas seymouri	78%	100%
A0A0S4JSJ8	Bodo saltans	71%	100%
A0A1X0NHR3	Trypanosomatidae	70%	100%
A0A3Q8IAV3	Leishmania donovani	99%	100%
A0A3R7M8C5	Trypanosoma rangeli	78%	100%
A4HU35	Leishmania infantum	99%	100%
D0A9L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
Q4QHR2	Leishmania major	98%	100%
Q5BIN4	Bos taurus	29%	78%
Q5U4U5	Xenopus laevis	29%	83%
Q9JKW1	Rattus norvegicus	28%	79%
V5BDJ5	Trypanosoma cruzi	78%	100%