Mitochondrial import inner membrane translocase subunit TIM22

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial import inner membrane translocase subunit TIM17, putative

Species:

Leishmania mexicana

UniProt:

E9AMW4_LEIMU

TriTrypDb:

LmxM.09.1130

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	11
GO:0032991	protein-containing complex	1	11
GO:0042721	TIM22 mitochondrial import inner membrane insertion complex	4	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11

Previous1 2Next

Expansion

Sequence features

E9AMW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMW4

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006839	mitochondrial transport	4	11
GO:0006886	intracellular protein transport	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0007007	inner mitochondrial membrane organization	6	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11

Previous1 2 3 4Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0005048	signal sequence binding	4	1
GO:0005215	transporter activity	1	11
GO:0005488	binding	1	1
GO:0008320	protein transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11
GO:0022884	macromolecule transmembrane transporter activity	3	11
GO:0030943	mitochondrion targeting sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0140318	protein transporter activity	2	11

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	96	98	PF00675	0.232
CLV_PCSK_KEX2_1	95	97	PF00082	0.231
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.195
DEG_SPOP_SBC_1	52	56	PF00917	0.259
DOC_USP7_MATH_1	21	25	PF00917	0.574
DOC_USP7_MATH_1	52	56	PF00917	0.294
LIG_14-3-3_CanoR_1	66	70	PF00244	0.217
LIG_BIR_III_4	145	149	PF00653	0.355
LIG_BRCT_BRCA1_1	136	140	PF00533	0.259
LIG_BRCT_BRCA1_1	77	81	PF00533	0.372

Previous1 2 3 4Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE0	Leptomonas seymouri	78%	100%
A0A0S4JSJ8	Bodo saltans	71%	100%
A0A1X0NHR3	Trypanosomatidae	70%	100%
A0A3Q8IAV3	Leishmania donovani	99%	100%
A0A3R7M8C5	Trypanosoma rangeli	78%	100%
A4HU35	Leishmania infantum	99%	100%
D0A9L3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
Q4QHR2	Leishmania major	98%	100%
Q5BIN4	Bos taurus	29%	78%
Q5U4U5	Xenopus laevis	29%	83%

Previous1 2Next