Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMW2_LEIMU

TriTrypDb:

LmxM.09.1110

Length:

456

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	183	185	PF00675	0.748
CLV_NRD_NRD_1	198	200	PF00675	0.628
CLV_NRD_NRD_1	241	243	PF00675	0.655
CLV_NRD_NRD_1	276	278	PF00675	0.551
CLV_NRD_NRD_1	303	305	PF00675	0.636
CLV_NRD_NRD_1	339	341	PF00675	0.611
CLV_NRD_NRD_1	355	357	PF00675	0.563
CLV_NRD_NRD_1	38	40	PF00675	0.697
CLV_NRD_NRD_1	395	397	PF00675	0.833
CLV_NRD_NRD_1	422	424	PF00675	0.791
CLV_NRD_NRD_1	435	437	PF00675	0.567
CLV_PCSK_FUR_1	274	278	PF00082	0.360
CLV_PCSK_KEX2_1	183	185	PF00082	0.748
CLV_PCSK_KEX2_1	198	200	PF00082	0.628
CLV_PCSK_KEX2_1	241	243	PF00082	0.655
CLV_PCSK_KEX2_1	274	276	PF00082	0.655
CLV_PCSK_KEX2_1	303	305	PF00082	0.636
CLV_PCSK_KEX2_1	339	341	PF00082	0.611
CLV_PCSK_KEX2_1	355	357	PF00082	0.563
CLV_PCSK_KEX2_1	38	40	PF00082	0.707
CLV_PCSK_KEX2_1	394	396	PF00082	0.828
CLV_PCSK_KEX2_1	435	437	PF00082	0.620
CLV_PCSK_SKI1_1	285	289	PF00082	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.680
DOC_CKS1_1	67	72	PF01111	0.760
DOC_MAPK_gen_1	339	345	PF00069	0.521
DOC_MAPK_gen_1	404	413	PF00069	0.677
DOC_PP2B_LxvP_1	116	119	PF13499	0.708
DOC_PP4_FxxP_1	147	150	PF00568	0.727
DOC_PP4_FxxP_1	328	331	PF00568	0.723
DOC_USP7_MATH_1	102	106	PF00917	0.692
DOC_USP7_MATH_1	107	111	PF00917	0.696
DOC_USP7_MATH_1	20	24	PF00917	0.667
DOC_USP7_MATH_1	246	250	PF00917	0.610
DOC_USP7_MATH_1	255	259	PF00917	0.520
DOC_USP7_MATH_1	287	291	PF00917	0.584
DOC_USP7_MATH_1	372	376	PF00917	0.643
DOC_WW_Pin1_4	148	153	PF00397	0.724
DOC_WW_Pin1_4	344	349	PF00397	0.653
DOC_WW_Pin1_4	356	361	PF00397	0.780
DOC_WW_Pin1_4	368	373	PF00397	0.689
DOC_WW_Pin1_4	387	392	PF00397	0.794
DOC_WW_Pin1_4	396	401	PF00397	0.696
DOC_WW_Pin1_4	436	441	PF00397	0.706
DOC_WW_Pin1_4	66	71	PF00397	0.810
LIG_14-3-3_CanoR_1	137	142	PF00244	0.753
LIG_14-3-3_CanoR_1	160	165	PF00244	0.695
LIG_14-3-3_CanoR_1	183	189	PF00244	0.607
LIG_14-3-3_CanoR_1	198	204	PF00244	0.558
LIG_14-3-3_CanoR_1	339	344	PF00244	0.686
LIG_14-3-3_CanoR_1	355	360	PF00244	0.677
LIG_14-3-3_CanoR_1	38	44	PF00244	0.702
LIG_14-3-3_CanoR_1	386	391	PF00244	0.826
LIG_14-3-3_CanoR_1	394	400	PF00244	0.810
LIG_14-3-3_CanoR_1	5	11	PF00244	0.738
LIG_BRCT_BRCA1_1	248	252	PF00533	0.469
LIG_BRCT_BRCA1_1	357	361	PF00533	0.594
LIG_BRCT_BRCA1_2	357	363	PF00533	0.520
LIG_DLG_GKlike_1	162	169	PF00625	0.777
LIG_FHA_1	184	190	PF00498	0.706
LIG_FHA_1	397	403	PF00498	0.708
LIG_FHA_2	119	125	PF00498	0.707
LIG_FHA_2	223	229	PF00498	0.579
LIG_FHA_2	38	44	PF00498	0.751
LIG_FHA_2	67	73	PF00498	0.760
LIG_HCF-1_HBM_1	84	87	PF13415	0.621
LIG_IBAR_NPY_1	330	332	PF08397	0.726
LIG_LIR_Apic_2	110	114	PF02991	0.526
LIG_LIR_Apic_2	144	150	PF02991	0.735
LIG_LIR_Nem_3	211	216	PF02991	0.466
LIG_LIR_Nem_3	414	419	PF02991	0.471
LIG_Pex14_2	56	60	PF04695	0.649
LIG_Rb_pABgroove_1	310	318	PF01858	0.556
LIG_RPA_C_Fungi	188	200	PF08784	0.633
LIG_SH2_CRK	111	115	PF00017	0.528
LIG_SH2_STAP1	316	320	PF00017	0.621
LIG_SH2_STAP1	332	336	PF00017	0.531
LIG_SH2_STAP1	341	345	PF00017	0.636
LIG_SH2_STAT3	240	243	PF00017	0.657
LIG_SH2_STAT5	272	275	PF00017	0.529
LIG_SH3_1	111	117	PF00018	0.525
LIG_SH3_3	111	117	PF00018	0.739
LIG_SH3_3	24	30	PF00018	0.550
LIG_SH3_3	64	70	PF00018	0.810
LIG_SH3_3	72	78	PF00018	0.723
LIG_TRAF2_1	10	13	PF00917	0.731
LIG_TRAF2_1	34	37	PF00917	0.711
LIG_TRAF2_1	59	62	PF00917	0.811
MOD_CDK_SPK_2	148	153	PF00069	0.733
MOD_CDK_SPK_2	368	373	PF00069	0.697
MOD_CDK_SPK_2	66	71	PF00069	0.760
MOD_CDK_SPxxK_3	356	363	PF00069	0.703
MOD_CDK_SPxxK_3	387	394	PF00069	0.814
MOD_CK1_1	142	148	PF00069	0.733
MOD_CK1_1	151	157	PF00069	0.759
MOD_CK1_1	167	173	PF00069	0.662
MOD_CK1_1	218	224	PF00069	0.635
MOD_CK1_1	371	377	PF00069	0.614
MOD_CK1_1	390	396	PF00069	0.819
MOD_CK1_1	398	404	PF00069	0.675
MOD_CK1_1	426	432	PF00069	0.719
MOD_CK2_1	118	124	PF00069	0.728
MOD_CK2_1	20	26	PF00069	0.767
MOD_CK2_1	222	228	PF00069	0.586
MOD_CK2_1	315	321	PF00069	0.646
MOD_CK2_1	56	62	PF00069	0.747
MOD_CK2_1	66	72	PF00069	0.633
MOD_DYRK1A_RPxSP_1	396	400	PF00069	0.738
MOD_GlcNHglycan	104	107	PF01048	0.666
MOD_GlcNHglycan	155	158	PF01048	0.712
MOD_GlcNHglycan	166	169	PF01048	0.554
MOD_GlcNHglycan	190	193	PF01048	0.641
MOD_GlcNHglycan	195	198	PF01048	0.625
MOD_GlcNHglycan	217	220	PF01048	0.572
MOD_GlcNHglycan	221	224	PF01048	0.532
MOD_GlcNHglycan	247	251	PF01048	0.568
MOD_GlcNHglycan	431	434	PF01048	0.782
MOD_GlcNHglycan	52	56	PF01048	0.694
MOD_GlcNHglycan	6	9	PF01048	0.815
MOD_GSK3_1	137	144	PF00069	0.679
MOD_GSK3_1	156	163	PF00069	0.608
MOD_GSK3_1	164	171	PF00069	0.601
MOD_GSK3_1	184	191	PF00069	0.635
MOD_GSK3_1	215	222	PF00069	0.597
MOD_GSK3_1	368	375	PF00069	0.651
MOD_GSK3_1	376	383	PF00069	0.741
MOD_GSK3_1	386	393	PF00069	0.672
MOD_GSK3_1	394	401	PF00069	0.684
MOD_GSK3_1	56	63	PF00069	0.819
MOD_N-GLC_1	132	137	PF02516	0.638
MOD_N-GLC_1	429	434	PF02516	0.498
MOD_NEK2_1	286	291	PF00069	0.619
MOD_NEK2_1	315	320	PF00069	0.655
MOD_NEK2_1	60	65	PF00069	0.759
MOD_PIKK_1	132	138	PF00454	0.648
MOD_PK_1	184	190	PF00069	0.738
MOD_PK_1	199	205	PF00069	0.625
MOD_PK_1	339	345	PF00069	0.735
MOD_PKA_1	183	189	PF00069	0.738
MOD_PKA_1	198	204	PF00069	0.626
MOD_PKA_1	339	345	PF00069	0.721
MOD_PKA_1	355	361	PF00069	0.573
MOD_PKA_1	394	400	PF00069	0.748
MOD_PKA_1	423	429	PF00069	0.780
MOD_PKA_2	183	189	PF00069	0.709
MOD_PKA_2	198	204	PF00069	0.587
MOD_PKA_2	219	225	PF00069	0.598
MOD_PKA_2	255	261	PF00069	0.522
MOD_PKA_2	295	301	PF00069	0.578
MOD_PKA_2	339	345	PF00069	0.713
MOD_PKA_2	354	360	PF00069	0.588
MOD_PKA_2	37	43	PF00069	0.751
MOD_PKA_2	372	378	PF00069	0.746
MOD_PKA_2	385	391	PF00069	0.756
MOD_PKA_2	394	400	PF00069	0.823
MOD_PKA_2	4	10	PF00069	0.814
MOD_PKB_1	137	145	PF00069	0.753
MOD_PKB_1	160	168	PF00069	0.781
MOD_Plk_1	21	27	PF00069	0.721
MOD_Plk_1	256	262	PF00069	0.458
MOD_Plk_4	184	190	PF00069	0.636
MOD_Plk_4	256	262	PF00069	0.534
MOD_Plk_4	268	274	PF00069	0.553
MOD_Plk_4	315	321	PF00069	0.569
MOD_ProDKin_1	148	154	PF00069	0.724
MOD_ProDKin_1	344	350	PF00069	0.653
MOD_ProDKin_1	356	362	PF00069	0.782
MOD_ProDKin_1	368	374	PF00069	0.691
MOD_ProDKin_1	387	393	PF00069	0.792
MOD_ProDKin_1	396	402	PF00069	0.694
MOD_ProDKin_1	436	442	PF00069	0.702
MOD_ProDKin_1	66	72	PF00069	0.810
TRG_AP2beta_CARGO_1	211	220	PF09066	0.467
TRG_ENDOCYTIC_2	316	319	PF00928	0.591
TRG_ENDOCYTIC_2	332	335	PF00928	0.498
TRG_ER_diArg_1	182	184	PF00400	0.682
TRG_ER_diArg_1	240	242	PF00400	0.660
TRG_ER_diArg_1	273	276	PF00400	0.653
TRG_ER_diArg_1	311	314	PF00400	0.662
TRG_ER_diArg_1	339	341	PF00400	0.626
TRG_ER_diArg_1	394	396	PF00400	0.836
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.352
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZG0	Leptomonas seymouri	40%	100%
A0A3S7WQV1	Leishmania donovani	86%	100%
A4H5T9	Leishmania braziliensis	63%	100%
A4HU33	Leishmania infantum	86%	100%
Q4QHR4	Leishmania major	80%	100%