Dynactin domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMW1_LEIMU

TriTrypDb:

LmxM.09.1100

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	193	195	PF00675	0.509
CLV_PCSK_KEX2_1	122	124	PF00082	0.595
CLV_PCSK_KEX2_1	137	139	PF00082	0.440
CLV_PCSK_KEX2_1	195	197	PF00082	0.504
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.510
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.411
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.502
CLV_PCSK_SKI1_1	108	112	PF00082	0.555
CLV_PCSK_SKI1_1	196	200	PF00082	0.476
DEG_APCC_KENBOX_2	45	49	PF00400	0.486
DEG_SPOP_SBC_1	214	218	PF00917	0.404
DEG_SPOP_SBC_1	97	101	PF00917	0.506
DOC_PP2B_LxvP_1	167	170	PF13499	0.468
DOC_USP7_MATH_1	214	218	PF00917	0.586
DOC_USP7_MATH_1	220	224	PF00917	0.593
DOC_USP7_MATH_1	31	35	PF00917	0.513
DOC_USP7_MATH_1	75	79	PF00917	0.496
DOC_USP7_MATH_1	97	101	PF00917	0.482
DOC_USP7_UBL2_3	195	199	PF12436	0.478
DOC_WW_Pin1_4	224	229	PF00397	0.686
DOC_WW_Pin1_4	23	28	PF00397	0.780
LIG_14-3-3_CanoR_1	151	160	PF00244	0.466
LIG_14-3-3_CanoR_1	168	174	PF00244	0.450
LIG_14-3-3_CanoR_1	76	86	PF00244	0.492
LIG_Actin_WH2_2	174	192	PF00022	0.508
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_FHA_1	162	168	PF00498	0.557
LIG_FHA_1	225	231	PF00498	0.555
LIG_FHA_1	243	249	PF00498	0.275
LIG_FHA_1	39	45	PF00498	0.552
LIG_FHA_1	99	105	PF00498	0.515
LIG_FHA_2	134	140	PF00498	0.492
LIG_LIR_Gen_1	109	118	PF02991	0.453
LIG_LIR_Gen_1	158	167	PF02991	0.438
LIG_LIR_Nem_3	109	114	PF02991	0.480
LIG_LIR_Nem_3	158	163	PF02991	0.451
LIG_MYND_1	187	191	PF01753	0.548
LIG_SH2_SRC	212	215	PF00017	0.346
LIG_SH3_3	227	233	PF00018	0.550
LIG_SUMO_SIM_anti_2	41	47	PF11976	0.488
MOD_CK1_1	125	131	PF00069	0.508
MOD_CK1_1	95	101	PF00069	0.511
MOD_CK2_1	133	139	PF00069	0.490
MOD_GlcNHglycan	218	221	PF01048	0.605
MOD_GlcNHglycan	222	225	PF01048	0.588
MOD_GlcNHglycan	27	30	PF01048	0.598
MOD_GSK3_1	169	176	PF00069	0.503
MOD_GSK3_1	216	223	PF00069	0.593
MOD_GSK3_1	23	30	PF00069	0.527
MOD_GSK3_1	240	247	PF00069	0.553
MOD_GSK3_1	5	12	PF00069	0.649
MOD_GSK3_1	91	98	PF00069	0.483
MOD_N-GLC_1	144	149	PF02516	0.521
MOD_NEK2_1	173	178	PF00069	0.406
MOD_NEK2_1	242	247	PF00069	0.384
MOD_PIKK_1	151	157	PF00454	0.444
MOD_PIKK_1	85	91	PF00454	0.549
MOD_PKA_1	122	128	PF00069	0.509
MOD_PKA_2	122	128	PF00069	0.463
MOD_PKA_2	75	81	PF00069	0.529
MOD_Plk_1	38	44	PF00069	0.513
MOD_Plk_4	169	175	PF00069	0.420
MOD_Plk_4	244	250	PF00069	0.514
MOD_ProDKin_1	224	230	PF00069	0.678
MOD_ProDKin_1	23	29	PF00069	0.778
MOD_SUMO_for_1	249	252	PF00179	0.460
TRG_NLS_MonoExtC_3	194	199	PF00514	0.475
TRG_NLS_MonoExtN_4	194	199	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	140	144	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA21	Leptomonas seymouri	64%	93%
A0A3S7WQT3	Leishmania donovani	91%	100%
A0A422MTH2	Trypanosoma rangeli	29%	83%
A4H5T8	Leishmania braziliensis	83%	100%
A4HU32	Leishmania infantum	91%	100%
Q4QHR5	Leishmania major	91%	100%