DNA-directed RNA polymerase III subunit,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase III subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AMV8_LEIMU

TriTrypDb:

LmxM.09.1060

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	9
GO:0030880	RNA polymerase complex	3	9
GO:0032991	protein-containing complex	1	9
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	9
GO:0140535	intracellular protein-containing complex	2	9
GO:1902494	catalytic complex	2	9
GO:1990234	transferase complex	3	9
GO:0005666	RNA polymerase III complex	4	1
GO:0016020	membrane	2	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9AMV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMV8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006352	DNA-templated transcription initiation	6	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009059	macromolecule biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0018130	heterocycle biosynthetic process	4	9
GO:0019438	aromatic compound biosynthetic process	4	9
GO:0032774	RNA biosynthetic process	5	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034654	nucleobase-containing compound biosynthetic process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044271	cellular nitrogen compound biosynthetic process	4	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901362	organic cyclic compound biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9
GO:0006384	transcription initiation at RNA polymerase III promoter	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.279
CLV_C14_Caspase3-7	25	29	PF00656	0.518
CLV_C14_Caspase3-7	258	262	PF00656	0.428
CLV_C14_Caspase3-7	264	268	PF00656	0.282
CLV_C14_Caspase3-7	53	57	PF00656	0.561
CLV_PCSK_SKI1_1	65	69	PF00082	0.458
DEG_Nend_Nbox_1	1	3	PF02207	0.465
DEG_SPOP_SBC_1	218	222	PF00917	0.362
DEG_SPOP_SBC_1	33	37	PF00917	0.622
DOC_CDC14_PxL_1	146	154	PF14671	0.428
DOC_PP4_FxxP_1	151	154	PF00568	0.313
DOC_USP7_MATH_1	104	108	PF00917	0.492
DOC_USP7_MATH_1	213	217	PF00917	0.382
DOC_USP7_MATH_1	218	222	PF00917	0.328
DOC_USP7_MATH_1	50	54	PF00917	0.644
LIG_14-3-3_CanoR_1	163	171	PF00244	0.362
LIG_14-3-3_CanoR_1	71	77	PF00244	0.376
LIG_BIR_III_4	259	263	PF00653	0.372
LIG_BIR_III_4	283	287	PF00653	0.405
LIG_BRCT_BRCA1_1	210	214	PF00533	0.228
LIG_eIF4E_1	140	146	PF01652	0.428
LIG_FHA_1	111	117	PF00498	0.419
LIG_FHA_1	140	146	PF00498	0.465
LIG_FHA_1	46	52	PF00498	0.599
LIG_FHA_1	8	14	PF00498	0.443
LIG_FHA_1	89	95	PF00498	0.345
LIG_FHA_2	61	67	PF00498	0.398
LIG_LIR_Gen_1	107	116	PF02991	0.389
LIG_LIR_Nem_3	107	112	PF02991	0.415
LIG_LIR_Nem_3	3	8	PF02991	0.376
LIG_MYND_1	150	154	PF01753	0.405
LIG_PDZ_Class_3	292	297	PF00595	0.645
LIG_Pex14_2	18	22	PF04695	0.553
LIG_SH2_CRK	8	12	PF00017	0.395
LIG_SH2_NCK_1	8	12	PF00017	0.442
LIG_SH2_STAP1	60	64	PF00017	0.524
LIG_SH2_STAP1	8	12	PF00017	0.395
LIG_SH2_STAT5	140	143	PF00017	0.405
LIG_SH2_STAT5	17	20	PF00017	0.433
LIG_SH2_STAT5	172	175	PF00017	0.415
LIG_SH2_STAT5	5	8	PF00017	0.364
LIG_SH2_STAT5	76	79	PF00017	0.375
LIG_SH3_3	115	121	PF00018	0.373
LIG_SH3_3	13	19	PF00018	0.393
LIG_SH3_3	144	150	PF00018	0.405
LIG_SUMO_SIM_par_1	9	14	PF11976	0.343
LIG_TYR_ITIM	6	11	PF00017	0.400
MOD_CK1_1	162	168	PF00069	0.428
MOD_CK1_1	217	223	PF00069	0.504
MOD_CK1_1	43	49	PF00069	0.678
MOD_CK1_1	97	103	PF00069	0.439
MOD_CK2_1	252	258	PF00069	0.385
MOD_CK2_1	286	292	PF00069	0.428
MOD_GlcNHglycan	106	109	PF01048	0.395
MOD_GlcNHglycan	164	167	PF01048	0.460
MOD_GlcNHglycan	184	188	PF01048	0.162
MOD_GlcNHglycan	201	204	PF01048	0.492
MOD_GlcNHglycan	216	219	PF01048	0.372
MOD_GlcNHglycan	254	257	PF01048	0.453
MOD_GlcNHglycan	263	266	PF01048	0.299
MOD_GlcNHglycan	28	31	PF01048	0.645
MOD_GlcNHglycan	42	45	PF01048	0.678
MOD_GlcNHglycan	95	99	PF01048	0.420
MOD_GSK3_1	104	111	PF00069	0.401
MOD_GSK3_1	213	220	PF00069	0.447
MOD_GSK3_1	35	42	PF00069	0.627
MOD_GSK3_1	45	52	PF00069	0.594
MOD_NEK2_1	1	6	PF00069	0.374
MOD_NEK2_1	110	115	PF00069	0.416
MOD_NEK2_1	214	219	PF00069	0.428
MOD_NEK2_1	276	281	PF00069	0.368
MOD_NEK2_1	7	12	PF00069	0.346
MOD_NEK2_2	60	65	PF00069	0.462
MOD_PKA_2	162	168	PF00069	0.428
MOD_PKA_2	70	76	PF00069	0.377
MOD_Plk_4	1	7	PF00069	0.368
MOD_Plk_4	276	282	PF00069	0.332
MOD_Plk_4	286	292	PF00069	0.442
TRG_ENDOCYTIC_2	140	143	PF00928	0.405
TRG_ENDOCYTIC_2	172	175	PF00928	0.405
TRG_ENDOCYTIC_2	8	11	PF00928	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P336	Leptomonas seymouri	53%	90%
A0A1X0NIF1	Trypanosomatidae	31%	97%
A0A3Q8I7I6	Leishmania donovani	92%	100%
A4H5T5	Leishmania braziliensis	79%	99%
A4HU28	Leishmania infantum	93%	100%
D0A9K8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QHR8	Leishmania major	93%	100%