MSP domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MSP (Major sperm protein) domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMV7_LEIMU

TriTrypDb:

LmxM.09.1050

Length:

241

Annotations

LeishMANIAdb annotations

As the MSP domain is involved in providing cell motility, this protein is likely involved in the same function.. Has a number of plant (E1ZCB1_CHLVA), fungal (G8B4Z0_CANPC) and animal orthologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

E9AMV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMV7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022406	membrane docking	2	1
GO:0051179	localization	1	1
GO:0051640	organelle localization	2	1
GO:0051643	endoplasmic reticulum localization	3	1
GO:0061024	membrane organization	4	1
GO:0061817	endoplasmic reticulum-plasma membrane tethering	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090158	endoplasmic reticulum membrane organization	5	1
GO:0140056	organelle localization by membrane tethering	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.647
CLV_NRD_NRD_1	173	175	PF00675	0.604
CLV_NRD_NRD_1	192	194	PF00675	0.407
CLV_PCSK_KEX2_1	190	192	PF00082	0.482
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.513
CLV_PCSK_SKI1_1	133	137	PF00082	0.386
CLV_PCSK_SKI1_1	175	179	PF00082	0.577
DEG_Nend_UBRbox_2	1	3	PF02207	0.729
DOC_PP2B_PxIxI_1	5	11	PF00149	0.616
DOC_USP7_MATH_1	120	124	PF00917	0.613
DOC_USP7_MATH_1	145	149	PF00917	0.735
DOC_USP7_UBL2_3	55	59	PF12436	0.496
LIG_14-3-3_CanoR_1	174	182	PF00244	0.791
LIG_14-3-3_CanoR_1	40	46	PF00244	0.483
LIG_BIR_III_4	156	160	PF00653	0.722
LIG_FHA_1	24	30	PF00498	0.568
LIG_FHA_1	42	48	PF00498	0.426
LIG_FHA_1	65	71	PF00498	0.554
LIG_FHA_1	87	93	PF00498	0.603
LIG_FHA_2	184	190	PF00498	0.663
LIG_FHA_2	72	78	PF00498	0.525
LIG_LIR_Gen_1	13	21	PF02991	0.636
LIG_LIR_Nem_3	13	18	PF02991	0.608
LIG_PTB_Apo_2	28	35	PF02174	0.483
LIG_PTB_Phospho_1	28	34	PF10480	0.578
LIG_SH2_STAP1	34	38	PF00017	0.595
LIG_SH2_STAT5	129	132	PF00017	0.624
LIG_SH2_STAT5	50	53	PF00017	0.498
LIG_SH2_STAT5	85	88	PF00017	0.532
LIG_TYR_ITIM	32	37	PF00017	0.578
MOD_CK2_1	183	189	PF00069	0.670
MOD_CK2_1	71	77	PF00069	0.581
MOD_Cter_Amidation	172	175	PF01082	0.508
MOD_GlcNHglycan	147	150	PF01048	0.535
MOD_GlcNHglycan	161	164	PF01048	0.456
MOD_GlcNHglycan	171	174	PF01048	0.557
MOD_GlcNHglycan	195	198	PF01048	0.596
MOD_GlcNHglycan	62	65	PF01048	0.347
MOD_GSK3_1	169	176	PF00069	0.748
MOD_GSK3_1	23	30	PF00069	0.580
MOD_GSK3_1	60	67	PF00069	0.532
MOD_N-GLC_1	120	125	PF02516	0.483
MOD_N-GLC_1	193	198	PF02516	0.624
MOD_N-GLC_1	60	65	PF02516	0.296
MOD_NEK2_1	27	32	PF00069	0.513
MOD_NEK2_1	51	56	PF00069	0.545
MOD_NEK2_2	64	69	PF00069	0.545
MOD_PKA_2	159	165	PF00069	0.768
MOD_PKA_2	173	179	PF00069	0.806
MOD_PKA_2	227	233	PF00069	0.354
MOD_PKA_2	41	47	PF00069	0.578
MOD_PKA_2	83	89	PF00069	0.606
MOD_PKB_1	191	199	PF00069	0.705
MOD_Plk_1	120	126	PF00069	0.628
MOD_Plk_1	23	29	PF00069	0.502
MOD_Plk_2-3	183	189	PF00069	0.670
MOD_Plk_2-3	23	29	PF00069	0.578
MOD_Plk_4	121	127	PF00069	0.604
MOD_SUMO_rev_2	162	171	PF00179	0.633
TRG_DiLeu_BaEn_1	13	18	PF01217	0.591
TRG_ENDOCYTIC_2	34	37	PF00928	0.578
TRG_ER_diArg_1	191	193	PF00400	0.753
TRG_ER_diArg_1	39	42	PF00400	0.578
TRG_Pf-PMV_PEXEL_1	133	137	PF00026	0.370

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W8	Leptomonas seymouri	63%	96%
A0A1X0NI22	Trypanosomatidae	27%	88%
A0A3S7WQS6	Leishmania donovani	92%	96%
A0A422MXK0	Trypanosoma rangeli	31%	100%
A4H5T4	Leishmania braziliensis	78%	100%
A4HU27	Leishmania infantum	91%	96%
D0A9K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QHR9	Leishmania major	86%	100%
V5BI56	Trypanosoma cruzi	32%	100%