Phospholipid:diacylglycerol acyltransferase,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipid:diacylglycerol acyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AMV6_LEIMU

TriTrypDb:

LmxM.09.1040

Length:

692

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AMV6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMV6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008080	N-acetyltransferase activity	6	7
GO:0008374	O-acyltransferase activity	5	12
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	12
GO:0046027	phospholipid:diacylglycerol acyltransferase activity	7	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.733
CLV_C14_Caspase3-7	618	622	PF00656	0.254
CLV_NRD_NRD_1	122	124	PF00675	0.360
CLV_NRD_NRD_1	176	178	PF00675	0.494
CLV_NRD_NRD_1	29	31	PF00675	0.563
CLV_NRD_NRD_1	317	319	PF00675	0.517
CLV_NRD_NRD_1	320	322	PF00675	0.522
CLV_NRD_NRD_1	390	392	PF00675	0.525
CLV_NRD_NRD_1	45	47	PF00675	0.446
CLV_NRD_NRD_1	451	453	PF00675	0.486
CLV_NRD_NRD_1	552	554	PF00675	0.498
CLV_NRD_NRD_1	632	634	PF00675	0.585
CLV_NRD_NRD_1	654	656	PF00675	0.593
CLV_NRD_NRD_1	684	686	PF00675	0.657
CLV_NRD_NRD_1	93	95	PF00675	0.447
CLV_PCSK_KEX2_1	121	123	PF00082	0.410
CLV_PCSK_KEX2_1	176	178	PF00082	0.495
CLV_PCSK_KEX2_1	29	31	PF00082	0.596
CLV_PCSK_KEX2_1	322	324	PF00082	0.515
CLV_PCSK_KEX2_1	451	453	PF00082	0.486
CLV_PCSK_KEX2_1	552	554	PF00082	0.454
CLV_PCSK_KEX2_1	632	634	PF00082	0.585
CLV_PCSK_KEX2_1	686	688	PF00082	0.654
CLV_PCSK_KEX2_1	93	95	PF00082	0.458
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.518
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.554
CLV_PCSK_PC7_1	318	324	PF00082	0.393
CLV_PCSK_PC7_1	447	453	PF00082	0.475
CLV_PCSK_SKI1_1	204	208	PF00082	0.630
CLV_PCSK_SKI1_1	391	395	PF00082	0.430
CLV_PCSK_SKI1_1	557	561	PF00082	0.430
CLV_PCSK_SKI1_1	659	663	PF00082	0.652
DEG_APCC_DBOX_1	309	317	PF00400	0.255
DEG_Kelch_Keap1_1	621	626	PF01344	0.477
DEG_SCF_TRCP1_1	252	257	PF00400	0.325
DEG_SPOP_SBC_1	478	482	PF00917	0.203
DOC_CDC14_PxL_1	469	477	PF14671	0.255
DOC_CYCLIN_yClb1_LxF_4	310	316	PF00134	0.325
DOC_CYCLIN_yClb5_NLxxxL_5	645	654	PF00134	0.338
DOC_MAPK_gen_1	121	130	PF00069	0.464
DOC_MAPK_gen_1	176	182	PF00069	0.262
DOC_MAPK_gen_1	318	327	PF00069	0.297
DOC_MAPK_gen_1	93	104	PF00069	0.674
DOC_MAPK_HePTP_8	119	131	PF00069	0.513
DOC_MAPK_MEF2A_6	122	131	PF00069	0.440
DOC_MAPK_MEF2A_6	176	183	PF00069	0.346
DOC_PP1_RVXF_1	120	127	PF00149	0.520
DOC_PP2B_LxvP_1	102	105	PF13499	0.573
DOC_USP7_MATH_1	103	107	PF00917	0.629
DOC_USP7_MATH_1	23	27	PF00917	0.739
DOC_USP7_MATH_1	78	82	PF00917	0.693
DOC_USP7_UBL2_3	579	583	PF12436	0.324
DOC_USP7_UBL2_3	682	686	PF12436	0.340
DOC_WW_Pin1_4	16	21	PF00397	0.723
DOC_WW_Pin1_4	292	297	PF00397	0.241
DOC_WW_Pin1_4	507	512	PF00397	0.324
DOC_WW_Pin1_4	680	685	PF00397	0.400
LIG_14-3-3_CanoR_1	158	164	PF00244	0.377
LIG_14-3-3_CanoR_1	202	207	PF00244	0.385
LIG_14-3-3_CanoR_1	24	28	PF00244	0.734
LIG_14-3-3_CanoR_1	310	314	PF00244	0.316
LIG_14-3-3_CanoR_1	408	417	PF00244	0.248
LIG_14-3-3_CanoR_1	528	536	PF00244	0.325
LIG_14-3-3_CanoR_1	637	646	PF00244	0.294
LIG_Actin_WH2_2	560	578	PF00022	0.324
LIG_APCC_Cbox_2	352	358	PF00515	0.325
LIG_BRCT_BRCA1_1	311	315	PF00533	0.316
LIG_BRCT_BRCA1_1	515	519	PF00533	0.324
LIG_BRCT_BRCA1_1	63	67	PF00533	0.676
LIG_EH1_1	124	132	PF00400	0.363
LIG_EH1_1	590	598	PF00400	0.305
LIG_FHA_1	186	192	PF00498	0.315
LIG_FHA_1	332	338	PF00498	0.258
LIG_FHA_1	381	387	PF00498	0.269
LIG_FHA_1	440	446	PF00498	0.333
LIG_FHA_1	508	514	PF00498	0.318
LIG_FHA_1	533	539	PF00498	0.245
LIG_FHA_1	625	631	PF00498	0.430
LIG_FHA_2	150	156	PF00498	0.414
LIG_FHA_2	238	244	PF00498	0.230
LIG_FHA_2	3	9	PF00498	0.725
LIG_FHA_2	466	472	PF00498	0.383
LIG_FXI_DFP_1	72	76	PF00024	0.469
LIG_GBD_Chelix_1	127	135	PF00786	0.367
LIG_HP1_1	179	183	PF01393	0.291
LIG_Integrin_RGD_1	169	171	PF01839	0.589
LIG_LIR_Apic_2	257	263	PF02991	0.307
LIG_LIR_Gen_1	252	263	PF02991	0.302
LIG_LIR_Gen_1	407	418	PF02991	0.277
LIG_LIR_Gen_1	494	503	PF02991	0.203
LIG_LIR_Gen_1	57	67	PF02991	0.677
LIG_LIR_Gen_1	636	646	PF02991	0.295
LIG_LIR_Gen_1	70	80	PF02991	0.669
LIG_LIR_Nem_3	162	167	PF02991	0.385
LIG_LIR_Nem_3	205	210	PF02991	0.394
LIG_LIR_Nem_3	252	258	PF02991	0.302
LIG_LIR_Nem_3	303	309	PF02991	0.230
LIG_LIR_Nem_3	407	413	PF02991	0.260
LIG_LIR_Nem_3	422	428	PF02991	0.239
LIG_LIR_Nem_3	57	62	PF02991	0.683
LIG_LIR_Nem_3	636	642	PF02991	0.298
LIG_LIR_Nem_3	70	75	PF02991	0.711
LIG_OCRL_FandH_1	349	361	PF00620	0.325
LIG_PCNA_TLS_4	391	398	PF02747	0.264
LIG_Pex14_1	230	234	PF04695	0.325
LIG_Pex14_2	206	210	PF04695	0.361
LIG_Pex14_2	75	79	PF04695	0.740
LIG_REV1ctd_RIR_1	161	170	PF16727	0.396
LIG_REV1ctd_RIR_1	337	345	PF16727	0.325
LIG_SH2_GRB2like	358	361	PF00017	0.316
LIG_SH2_NCK_1	639	643	PF00017	0.227
LIG_SH2_PTP2	358	361	PF00017	0.325
LIG_SH2_SRC	358	361	PF00017	0.325
LIG_SH2_STAP1	290	294	PF00017	0.230
LIG_SH2_STAT3	280	283	PF00017	0.241
LIG_SH2_STAT5	173	176	PF00017	0.425
LIG_SH2_STAT5	221	224	PF00017	0.293
LIG_SH2_STAT5	260	263	PF00017	0.316
LIG_SH2_STAT5	358	361	PF00017	0.265
LIG_SH2_STAT5	512	515	PF00017	0.325
LIG_SH3_3	134	140	PF00018	0.453
LIG_SH3_3	17	23	PF00018	0.741
LIG_SH3_3	178	184	PF00018	0.329
LIG_SH3_3	470	476	PF00018	0.232
LIG_SH3_3	486	492	PF00018	0.223
LIG_SH3_3	606	612	PF00018	0.418
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.301
LIG_SUMO_SIM_par_1	14	19	PF11976	0.764
LIG_UBA3_1	233	239	PF00899	0.255
LIG_UBA3_1	593	599	PF00899	0.278
LIG_WRC_WIRS_1	394	399	PF05994	0.316
LIG_WRC_WIRS_1	62	67	PF05994	0.642
MOD_CDC14_SPxK_1	295	298	PF00782	0.255
MOD_CDC14_SPxK_1	683	686	PF00782	0.339
MOD_CDK_SPK_2	680	685	PF00069	0.336
MOD_CDK_SPxK_1	292	298	PF00069	0.255
MOD_CDK_SPxK_1	680	686	PF00069	0.338
MOD_CDK_SPxxK_3	680	687	PF00069	0.340
MOD_CK1_1	205	211	PF00069	0.354
MOD_CK1_1	517	523	PF00069	0.203
MOD_CK1_1	52	58	PF00069	0.746
MOD_CK2_1	149	155	PF00069	0.417
MOD_CK2_1	450	456	PF00069	0.319
MOD_GlcNHglycan	207	210	PF01048	0.612
MOD_GlcNHglycan	25	28	PF01048	0.549
MOD_GlcNHglycan	252	255	PF01048	0.486
MOD_GlcNHglycan	372	375	PF01048	0.432
MOD_GlcNHglycan	452	455	PF01048	0.505
MOD_GlcNHglycan	49	52	PF01048	0.518
MOD_GlcNHglycan	580	583	PF01048	0.413
MOD_GlcNHglycan	601	604	PF01048	0.470
MOD_GSK3_1	250	257	PF00069	0.300
MOD_GSK3_1	327	334	PF00069	0.273
MOD_GSK3_1	404	411	PF00069	0.325
MOD_GSK3_1	432	439	PF00069	0.349
MOD_GSK3_1	513	520	PF00069	0.139
MOD_GSK3_1	611	618	PF00069	0.395
MOD_GSK3_1	621	628	PF00069	0.370
MOD_GSK3_1	645	652	PF00069	0.330
MOD_LATS_1	635	641	PF00433	0.358
MOD_N-GLC_1	432	437	PF02516	0.512
MOD_N-GLC_1	514	519	PF02516	0.490
MOD_N-GLC_1	521	526	PF02516	0.506
MOD_N-GLC_1	563	568	PF02516	0.534
MOD_NEK2_1	393	398	PF00069	0.250
MOD_NEK2_1	406	411	PF00069	0.265
MOD_NEK2_1	49	54	PF00069	0.790
MOD_NEK2_1	563	568	PF00069	0.324
MOD_NEK2_1	645	650	PF00069	0.192
MOD_NEK2_2	159	164	PF00069	0.375
MOD_NEK2_2	514	519	PF00069	0.302
MOD_PIKK_1	396	402	PF00454	0.325
MOD_PIKK_1	52	58	PF00454	0.614
MOD_PIKK_1	88	94	PF00454	0.679
MOD_PKA_2	23	29	PF00069	0.715
MOD_PKA_2	309	315	PF00069	0.316
MOD_PKA_2	380	386	PF00069	0.324
MOD_PKA_2	439	445	PF00069	0.338
MOD_PKA_2	450	456	PF00069	0.297
MOD_PKA_2	527	533	PF00069	0.325
MOD_PKA_2	677	683	PF00069	0.333
MOD_Plk_1	194	200	PF00069	0.377
MOD_Plk_1	514	520	PF00069	0.290
MOD_Plk_1	532	538	PF00069	0.325
MOD_Plk_1	563	569	PF00069	0.303
MOD_Plk_1	615	621	PF00069	0.383
MOD_Plk_1	625	631	PF00069	0.363
MOD_Plk_2-3	615	621	PF00069	0.285
MOD_Plk_4	103	109	PF00069	0.639
MOD_Plk_4	159	165	PF00069	0.351
MOD_Plk_4	169	175	PF00069	0.417
MOD_Plk_4	202	208	PF00069	0.360
MOD_Plk_4	393	399	PF00069	0.317
MOD_Plk_4	412	418	PF00069	0.300
MOD_Plk_4	426	432	PF00069	0.295
MOD_Plk_4	514	520	PF00069	0.325
MOD_Plk_4	61	67	PF00069	0.589
MOD_ProDKin_1	16	22	PF00069	0.723
MOD_ProDKin_1	292	298	PF00069	0.241
MOD_ProDKin_1	507	513	PF00069	0.324
MOD_ProDKin_1	680	686	PF00069	0.402
MOD_SUMO_rev_2	243	249	PF00179	0.344
TRG_DiLeu_BaLyEn_6	534	539	PF01217	0.203
TRG_ENDOCYTIC_2	221	224	PF00928	0.269
TRG_ENDOCYTIC_2	358	361	PF00928	0.300
TRG_ENDOCYTIC_2	497	500	PF00928	0.351
TRG_ENDOCYTIC_2	591	594	PF00928	0.300
TRG_ENDOCYTIC_2	639	642	PF00928	0.293
TRG_ER_diArg_1	121	123	PF00400	0.560
TRG_ER_diArg_1	175	177	PF00400	0.324
TRG_ER_diArg_1	210	213	PF00400	0.239
TRG_ER_diArg_1	28	30	PF00400	0.703
TRG_ER_diArg_1	551	553	PF00400	0.298
TRG_ER_diArg_1	632	634	PF00400	0.385
TRG_ER_diArg_1	684	687	PF00400	0.453
TRG_NLS_MonoExtC_3	317	322	PF00514	0.139
TRG_NLS_MonoExtC_3	654	659	PF00514	0.416
TRG_NLS_MonoExtN_4	318	325	PF00514	0.317
TRG_NLS_MonoExtN_4	655	660	PF00514	0.432
TRG_NLS_MonoExtN_4	682	689	PF00514	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU70	Leptomonas seymouri	66%	91%
A0A0S4J6G5	Bodo saltans	37%	100%
A0A1X0NHY0	Trypanosomatidae	46%	87%
A0A3R7KCW2	Trypanosoma rangeli	42%	100%
A0A3S7WQS8	Leishmania donovani	93%	100%
A4H5T3	Leishmania braziliensis	83%	100%
A4HU26	Leishmania infantum	93%	100%
D0A9K5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
O94680	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
P40345	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q4QHS0	Leishmania major	91%	100%
V5BDI6	Trypanosoma cruzi	43%	100%