LeishMANIAdb
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Lem3/Cdc50

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Lem3/Cdc50
Gene product:
LEM3 (ligand-effect modulator 3) family / CDC50 family, putative
Species:
Leishmania mexicana
UniProt:
E9AMV4_LEIMU
TriTrypDb:
LmxM.09.1020
Length:
595

Annotations

LeishMANIAdb annotations

Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 18
NetGPI no yes: 0, no: 18
Cellular components
Term Name Level Count
GO:0016020 membrane 2 19
GO:0110165 cellular anatomical entity 1 19
GO:0005783 endoplasmic reticulum 5 2
GO:0005794 Golgi apparatus 5 2
GO:0005886 plasma membrane 3 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1

Expansion

Sequence features

E9AMV4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMV4

Function

Biological processes
Term Name Level Count
GO:0033036 macromolecule localization 2 19
GO:0051179 localization 1 19
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 286 290 PF00656 0.275
CLV_C14_Caspase3-7 66 70 PF00656 0.798
CLV_NRD_NRD_1 322 324 PF00675 0.396
CLV_NRD_NRD_1 331 333 PF00675 0.367
CLV_NRD_NRD_1 447 449 PF00675 0.428
CLV_NRD_NRD_1 478 480 PF00675 0.459
CLV_NRD_NRD_1 558 560 PF00675 0.383
CLV_NRD_NRD_1 569 571 PF00675 0.356
CLV_NRD_NRD_1 85 87 PF00675 0.389
CLV_PCSK_FUR_1 104 108 PF00082 0.343
CLV_PCSK_FUR_1 556 560 PF00082 0.372
CLV_PCSK_KEX2_1 106 108 PF00082 0.442
CLV_PCSK_KEX2_1 331 333 PF00082 0.339
CLV_PCSK_KEX2_1 536 538 PF00082 0.376
CLV_PCSK_KEX2_1 558 560 PF00082 0.352
CLV_PCSK_KEX2_1 85 87 PF00082 0.389
CLV_PCSK_PC1ET2_1 106 108 PF00082 0.339
CLV_PCSK_PC1ET2_1 536 538 PF00082 0.376
CLV_PCSK_SKI1_1 107 111 PF00082 0.335
CLV_PCSK_SKI1_1 202 206 PF00082 0.527
CLV_PCSK_SKI1_1 293 297 PF00082 0.441
CLV_PCSK_SKI1_1 300 304 PF00082 0.508
CLV_PCSK_SKI1_1 323 327 PF00082 0.500
CLV_PCSK_SKI1_1 379 383 PF00082 0.479
DEG_ODPH_VHL_1 309 321 PF01847 0.259
DEG_SPOP_SBC_1 51 55 PF00917 0.704
DOC_CDC14_PxL_1 154 162 PF14671 0.142
DOC_CDC14_PxL_1 335 343 PF14671 0.177
DOC_CYCLIN_yCln2_LP_2 155 161 PF00134 0.317
DOC_CYCLIN_yCln2_LP_2 267 273 PF00134 0.181
DOC_MAPK_FxFP_2 140 143 PF00069 0.600
DOC_MAPK_gen_1 448 458 PF00069 0.218
DOC_MAPK_MEF2A_6 216 223 PF00069 0.278
DOC_MAPK_MEF2A_6 449 458 PF00069 0.180
DOC_MAPK_MEF2A_6 493 501 PF00069 0.220
DOC_PP1_RVXF_1 377 384 PF00149 0.223
DOC_PP2B_LxvP_1 155 158 PF13499 0.299
DOC_PP2B_LxvP_1 23 26 PF13499 0.570
DOC_PP4_FxxP_1 140 143 PF00568 0.600
DOC_USP7_MATH_1 190 194 PF00917 0.290
DOC_USP7_MATH_1 428 432 PF00917 0.223
DOC_USP7_MATH_1 51 55 PF00917 0.623
DOC_USP7_MATH_1 535 539 PF00917 0.575
DOC_USP7_MATH_1 56 60 PF00917 0.616
DOC_USP7_MATH_1 91 95 PF00917 0.661
DOC_USP7_UBL2_3 106 110 PF12436 0.538
DOC_WW_Pin1_4 141 146 PF00397 0.513
DOC_WW_Pin1_4 280 285 PF00397 0.272
DOC_WW_Pin1_4 29 34 PF00397 0.601
DOC_WW_Pin1_4 346 351 PF00397 0.275
DOC_WW_Pin1_4 35 40 PF00397 0.595
DOC_WW_Pin1_4 441 446 PF00397 0.180
LIG_14-3-3_CanoR_1 202 209 PF00244 0.388
LIG_14-3-3_CanoR_1 251 260 PF00244 0.292
LIG_14-3-3_CanoR_1 300 305 PF00244 0.364
LIG_14-3-3_CanoR_1 323 330 PF00244 0.180
LIG_14-3-3_CanoR_1 440 444 PF00244 0.212
LIG_14-3-3_CanoR_1 479 483 PF00244 0.257
LIG_14-3-3_CanoR_1 493 497 PF00244 0.292
LIG_14-3-3_CanoR_1 62 68 PF00244 0.619
LIG_14-3-3_CanoR_1 86 95 PF00244 0.589
LIG_Actin_WH2_2 443 461 PF00022 0.147
LIG_Actin_WH2_2 554 572 PF00022 0.625
LIG_AP2alpha_1 315 319 PF02296 0.217
LIG_BIR_III_4 289 293 PF00653 0.169
LIG_BIR_III_4 589 593 PF00653 0.513
LIG_EH1_1 514 522 PF00400 0.290
LIG_FHA_1 18 24 PF00498 0.574
LIG_FHA_1 316 322 PF00498 0.225
LIG_FHA_1 460 466 PF00498 0.322
LIG_FHA_1 512 518 PF00498 0.289
LIG_FHA_1 90 96 PF00498 0.636
LIG_FHA_2 215 221 PF00498 0.241
LIG_FHA_2 284 290 PF00498 0.273
LIG_FHA_2 324 330 PF00498 0.279
LIG_FHA_2 393 399 PF00498 0.196
LIG_FHA_2 407 413 PF00498 0.259
LIG_Integrin_isoDGR_2 249 251 PF01839 0.485
LIG_LIR_Apic_2 402 408 PF02991 0.255
LIG_LIR_Gen_1 144 154 PF02991 0.407
LIG_LIR_Gen_1 156 167 PF02991 0.212
LIG_LIR_Gen_1 172 180 PF02991 0.349
LIG_LIR_Gen_1 215 223 PF02991 0.300
LIG_LIR_Gen_1 388 396 PF02991 0.222
LIG_LIR_Gen_1 468 476 PF02991 0.300
LIG_LIR_Nem_3 144 149 PF02991 0.398
LIG_LIR_Nem_3 156 162 PF02991 0.214
LIG_LIR_Nem_3 172 176 PF02991 0.275
LIG_LIR_Nem_3 177 183 PF02991 0.252
LIG_LIR_Nem_3 215 221 PF02991 0.262
LIG_LIR_Nem_3 272 276 PF02991 0.196
LIG_LIR_Nem_3 317 322 PF02991 0.193
LIG_LIR_Nem_3 388 394 PF02991 0.231
LIG_LIR_Nem_3 398 404 PF02991 0.202
LIG_LIR_Nem_3 444 450 PF02991 0.207
LIG_LIR_Nem_3 468 474 PF02991 0.196
LIG_LIR_Nem_3 538 542 PF02991 0.567
LIG_LIR_Nem_3 546 552 PF02991 0.518
LIG_Pex14_1 400 404 PF04695 0.207
LIG_Pex14_2 315 319 PF04695 0.217
LIG_Pex14_2 443 447 PF04695 0.213
LIG_PTB_Apo_2 413 420 PF02174 0.186
LIG_PTB_Phospho_1 413 419 PF10480 0.189
LIG_SH2_CRK 186 190 PF00017 0.280
LIG_SH2_CRK 271 275 PF00017 0.300
LIG_SH2_CRK 322 326 PF00017 0.271
LIG_SH2_CRK 451 455 PF00017 0.242
LIG_SH2_CRK 471 475 PF00017 0.146
LIG_SH2_NCK_1 173 177 PF00017 0.216
LIG_SH2_NCK_1 471 475 PF00017 0.300
LIG_SH2_NCK_1 88 92 PF00017 0.575
LIG_SH2_SRC 173 176 PF00017 0.250
LIG_SH2_SRC 186 189 PF00017 0.277
LIG_SH2_STAP1 433 437 PF00017 0.206
LIG_SH2_STAT3 540 543 PF00017 0.580
LIG_SH2_STAT5 153 156 PF00017 0.332
LIG_SH2_STAT5 188 191 PF00017 0.315
LIG_SH2_STAT5 266 269 PF00017 0.279
LIG_SH2_STAT5 271 274 PF00017 0.257
LIG_SH2_STAT5 301 304 PF00017 0.300
LIG_SH2_STAT5 413 416 PF00017 0.245
LIG_SH2_STAT5 419 422 PF00017 0.245
LIG_SH2_STAT5 463 466 PF00017 0.234
LIG_SH2_STAT5 540 543 PF00017 0.516
LIG_SH3_3 292 298 PF00018 0.294
LIG_SH3_3 454 460 PF00018 0.303
LIG_SH3_3 538 544 PF00018 0.617
LIG_SH3_3 92 98 PF00018 0.700
LIG_SUMO_SIM_anti_2 349 355 PF11976 0.234
LIG_SUMO_SIM_par_1 282 289 PF11976 0.196
LIG_SUMO_SIM_par_1 462 469 PF11976 0.245
LIG_TRFH_1 146 150 PF08558 0.368
LIG_TYR_ITIM 320 325 PF00017 0.300
LIG_TYR_ITIM 340 345 PF00017 0.139
LIG_Vh1_VBS_1 496 514 PF01044 0.142
LIG_WRC_WIRS_1 473 478 PF05994 0.205
LIG_WW_3 1 5 PF00397 0.567
MOD_CDC14_SPxK_1 32 35 PF00782 0.591
MOD_CDK_SPxK_1 29 35 PF00069 0.598
MOD_CDK_SPxxK_3 441 448 PF00069 0.180
MOD_CK1_1 100 106 PF00069 0.628
MOD_CK1_1 132 138 PF00069 0.611
MOD_CK1_1 21 27 PF00069 0.711
MOD_CK1_1 29 35 PF00069 0.714
MOD_CK1_1 370 376 PF00069 0.243
MOD_CK1_1 50 56 PF00069 0.741
MOD_CK1_1 57 63 PF00069 0.754
MOD_CK1_1 65 71 PF00069 0.737
MOD_CK2_1 214 220 PF00069 0.201
MOD_CK2_1 323 329 PF00069 0.276
MOD_CK2_1 392 398 PF00069 0.221
MOD_CK2_1 406 412 PF00069 0.297
MOD_CK2_1 67 73 PF00069 0.797
MOD_Cter_Amidation 477 480 PF01082 0.459
MOD_DYRK1A_RPxSP_1 35 39 PF00069 0.559
MOD_GlcNHglycan 15 18 PF01048 0.556
MOD_GlcNHglycan 23 26 PF01048 0.466
MOD_GlcNHglycan 326 329 PF01048 0.451
MOD_GlcNHglycan 367 370 PF01048 0.474
MOD_GlcNHglycan 49 52 PF01048 0.546
MOD_GlcNHglycan 54 57 PF01048 0.571
MOD_GSK3_1 13 20 PF00069 0.734
MOD_GSK3_1 2 9 PF00069 0.727
MOD_GSK3_1 365 372 PF00069 0.223
MOD_GSK3_1 47 54 PF00069 0.683
MOD_GSK3_1 56 63 PF00069 0.803
MOD_GSK3_1 87 94 PF00069 0.616
MOD_N-GLC_1 191 196 PF02516 0.632
MOD_N-GLC_1 221 226 PF02516 0.490
MOD_N-GLC_1 315 320 PF02516 0.425
MOD_N-GLC_1 355 360 PF02516 0.422
MOD_N-GLC_1 392 397 PF02516 0.500
MOD_N-GLC_2 374 376 PF02516 0.390
MOD_NEK2_1 315 320 PF00069 0.225
MOD_NEK2_1 367 372 PF00069 0.189
MOD_NEK2_1 439 444 PF00069 0.230
MOD_NEK2_1 511 516 PF00069 0.318
MOD_NEK2_2 121 126 PF00069 0.621
MOD_PIKK_1 129 135 PF00454 0.609
MOD_PIKK_1 251 257 PF00454 0.196
MOD_PKA_1 323 329 PF00069 0.182
MOD_PKA_2 100 106 PF00069 0.697
MOD_PKA_2 439 445 PF00069 0.228
MOD_PKA_2 478 484 PF00069 0.238
MOD_PKA_2 492 498 PF00069 0.307
MOD_PKA_2 61 67 PF00069 0.634
MOD_Plk_1 178 184 PF00069 0.343
MOD_Plk_1 191 197 PF00069 0.314
MOD_Plk_1 315 321 PF00069 0.231
MOD_Plk_1 392 398 PF00069 0.300
MOD_Plk_4 315 321 PF00069 0.200
MOD_Plk_4 459 465 PF00069 0.329
MOD_Plk_4 478 484 PF00069 0.142
MOD_Plk_4 492 498 PF00069 0.226
MOD_Plk_4 505 511 PF00069 0.317
MOD_ProDKin_1 141 147 PF00069 0.511
MOD_ProDKin_1 280 286 PF00069 0.272
MOD_ProDKin_1 29 35 PF00069 0.602
MOD_ProDKin_1 346 352 PF00069 0.275
MOD_ProDKin_1 441 447 PF00069 0.180
MOD_SUMO_for_1 260 263 PF00179 0.139
TRG_DiLeu_BaLyEn_6 36 41 PF01217 0.563
TRG_ENDOCYTIC_2 173 176 PF00928 0.251
TRG_ENDOCYTIC_2 180 183 PF00928 0.225
TRG_ENDOCYTIC_2 186 189 PF00928 0.234
TRG_ENDOCYTIC_2 234 237 PF00928 0.222
TRG_ENDOCYTIC_2 244 247 PF00928 0.217
TRG_ENDOCYTIC_2 273 276 PF00928 0.196
TRG_ENDOCYTIC_2 322 325 PF00928 0.300
TRG_ENDOCYTIC_2 342 345 PF00928 0.154
TRG_ENDOCYTIC_2 451 454 PF00928 0.268
TRG_ENDOCYTIC_2 471 474 PF00928 0.131
TRG_ENDOCYTIC_2 529 532 PF00928 0.627
TRG_ENDOCYTIC_2 552 555 PF00928 0.525
TRG_ER_diArg_1 330 332 PF00400 0.204
TRG_ER_diArg_1 555 558 PF00400 0.588
TRG_ER_diArg_1 84 86 PF00400 0.559
TRG_NLS_MonoExtN_4 107 114 PF00514 0.609
TRG_Pf-PMV_PEXEL_1 530 534 PF00026 0.309

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0U8 Leptomonas seymouri 65% 95%
A0A0S4IMK4 Bodo saltans 33% 100%
A0A0S4JQR9 Bodo saltans 36% 100%
A0A1X0NHQ5 Trypanosomatidae 46% 100%
A0A1X0P5L3 Trypanosomatidae 34% 100%
A0A3Q8IBY5 Leishmania donovani 89% 100%
A0A3R7LIN7 Trypanosoma rangeli 45% 100%
A0A3S7X9N4 Leishmania donovani 33% 100%
A0A422NR22 Trypanosoma rangeli 33% 100%
A4H5T1 Leishmania braziliensis 77% 100%
A4HN07 Leishmania braziliensis 32% 100%
A4HU24 Leishmania infantum 89% 100%
A4IBN0 Leishmania infantum 33% 100%
D0A9K3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9AFG4 Leishmania major 33% 100%
E9B6L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
P42838 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 24% 100%
Q4QHS2 Leishmania major 84% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS