Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 10

Species:

Leishmania mexicana

UniProt:

E9AMV3_LEIMU

TriTrypDb:

LmxM.09.1010

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0005929	cilium	4	1
GO:0016020	membrane	2	2
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031514	motile cilium	5	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AMV3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMV3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	97	101	PF00656	0.652
CLV_NRD_NRD_1	151	153	PF00675	0.468
CLV_NRD_NRD_1	246	248	PF00675	0.465
CLV_NRD_NRD_1	384	386	PF00675	0.535
CLV_NRD_NRD_1	595	597	PF00675	0.449
CLV_PCSK_KEX2_1	138	140	PF00082	0.616
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.616
CLV_PCSK_SKI1_1	139	143	PF00082	0.627
CLV_PCSK_SKI1_1	258	262	PF00082	0.380
CLV_PCSK_SKI1_1	302	306	PF00082	0.402
CLV_PCSK_SKI1_1	406	410	PF00082	0.368
CLV_PCSK_SKI1_1	434	438	PF00082	0.420
CLV_PCSK_SKI1_1	81	85	PF00082	0.672
DEG_APCC_DBOX_1	170	178	PF00400	0.707
DEG_SCF_FBW7_1	312	319	PF00400	0.673
DEG_SCF_FBW7_2	439	444	PF00400	0.696
DOC_CKS1_1	313	318	PF01111	0.678
DOC_MAPK_gen_1	152	160	PF00069	0.627
DOC_MAPK_gen_1	365	371	PF00069	0.568
DOC_MAPK_gen_1	385	395	PF00069	0.473
DOC_MAPK_MEF2A_6	153	162	PF00069	0.615
DOC_PP4_FxxP_1	41	44	PF00568	0.788
DOC_USP7_MATH_1	109	113	PF00917	0.786
DOC_USP7_MATH_1	123	127	PF00917	0.719
DOC_USP7_MATH_1	316	320	PF00917	0.676
DOC_USP7_MATH_1	435	439	PF00917	0.688
DOC_USP7_MATH_1	44	48	PF00917	0.845
DOC_USP7_MATH_1	63	67	PF00917	0.694
DOC_USP7_MATH_1	68	72	PF00917	0.855
DOC_USP7_MATH_1	73	77	PF00917	0.842
DOC_USP7_UBL2_3	134	138	PF12436	0.821
DOC_USP7_UBL2_3	223	227	PF12436	0.578
DOC_WW_Pin1_4	172	177	PF00397	0.625
DOC_WW_Pin1_4	312	317	PF00397	0.663
DOC_WW_Pin1_4	437	442	PF00397	0.650
DOC_WW_Pin1_4	494	499	PF00397	0.784
DOC_WW_Pin1_4	560	565	PF00397	0.752
LIG_14-3-3_CanoR_1	125	135	PF00244	0.818
LIG_14-3-3_CanoR_1	152	156	PF00244	0.669
LIG_14-3-3_CanoR_1	302	312	PF00244	0.655
LIG_14-3-3_CanoR_1	434	440	PF00244	0.678
LIG_14-3-3_CanoR_1	579	588	PF00244	0.604
LIG_APCC_ABBA_1	267	272	PF00400	0.618
LIG_BRCT_BRCA1_1	320	324	PF00533	0.663
LIG_BRCT_BRCA1_1	607	611	PF00533	0.578
LIG_deltaCOP1_diTrp_1	337	342	PF00928	0.592
LIG_eIF4E_1	410	416	PF01652	0.598
LIG_FHA_1	20	26	PF00498	0.460
LIG_FHA_1	236	242	PF00498	0.692
LIG_FHA_1	327	333	PF00498	0.571
LIG_FHA_1	460	466	PF00498	0.622
LIG_FHA_1	502	508	PF00498	0.631
LIG_FHA_1	524	530	PF00498	0.658
LIG_FHA_1	580	586	PF00498	0.578
LIG_FHA_1	8	14	PF00498	0.482
LIG_FHA_2	138	144	PF00498	0.769
LIG_FHA_2	313	319	PF00498	0.664
LIG_FHA_2	368	374	PF00498	0.620
LIG_FHA_2	512	518	PF00498	0.673
LIG_FHA_2	95	101	PF00498	0.660
LIG_IRF3_LxIS_1	155	161	PF10401	0.660
LIG_LIR_Apic_2	339	345	PF02991	0.582
LIG_LIR_Apic_2	38	44	PF02991	0.788
LIG_LIR_Gen_1	154	162	PF02991	0.650
LIG_LIR_Gen_1	189	198	PF02991	0.721
LIG_LIR_Gen_1	462	471	PF02991	0.686
LIG_LIR_Gen_1	607	616	PF02991	0.679
LIG_LIR_Nem_3	154	158	PF02991	0.603
LIG_LIR_Nem_3	189	193	PF02991	0.685
LIG_LIR_Nem_3	254	260	PF02991	0.661
LIG_LIR_Nem_3	321	327	PF02991	0.637
LIG_LIR_Nem_3	407	413	PF02991	0.602
LIG_LIR_Nem_3	462	466	PF02991	0.679
LIG_LIR_Nem_3	592	598	PF02991	0.647
LIG_LIR_Nem_3	607	612	PF02991	0.569
LIG_PCNA_PIPBox_1	420	429	PF02747	0.479
LIG_PCNA_yPIPBox_3	420	434	PF02747	0.479
LIG_PDZ_Class_3	611	616	PF00595	0.705
LIG_Pex14_1	186	190	PF04695	0.684
LIG_Pex14_1	340	344	PF04695	0.591
LIG_Pex14_2	605	609	PF04695	0.610
LIG_PTB_Apo_2	184	191	PF02174	0.683
LIG_REV1ctd_RIR_1	322	330	PF16727	0.663
LIG_SH2_CRK	301	305	PF00017	0.650
LIG_SH2_CRK	413	417	PF00017	0.574
LIG_SH2_STAP1	263	267	PF00017	0.567
LIG_SH2_STAP1	461	465	PF00017	0.659
LIG_SH2_STAP1	598	602	PF00017	0.673
LIG_SH2_STAT3	287	290	PF00017	0.549
LIG_SH2_STAT3	483	486	PF00017	0.657
LIG_SH2_STAT5	287	290	PF00017	0.561
LIG_SH2_STAT5	413	416	PF00017	0.581
LIG_SH2_STAT5	426	429	PF00017	0.560
LIG_SH2_STAT5	461	464	PF00017	0.624
LIG_SH3_2	489	494	PF14604	0.769
LIG_SH3_3	182	188	PF00018	0.640
LIG_SH3_3	238	244	PF00018	0.672
LIG_SH3_3	310	316	PF00018	0.666
LIG_SH3_3	413	419	PF00018	0.564
LIG_SH3_3	442	448	PF00018	0.677
LIG_SH3_3	479	485	PF00018	0.628
LIG_SH3_3	486	492	PF00018	0.713
LIG_SUMO_SIM_anti_2	22	28	PF11976	0.746
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.612
LIG_SUMO_SIM_anti_2	566	572	PF11976	0.696
LIG_SUMO_SIM_par_1	202	208	PF11976	0.581
LIG_TRAF2_1	129	132	PF00917	0.862
LIG_TRAF2_1	251	254	PF00917	0.658
LIG_TRAF2_1	497	500	PF00917	0.748
LIG_TRAF2_1	521	524	PF00917	0.652
LIG_WRC_WIRS_1	606	611	PF05994	0.617
MOD_CDK_SPK_2	560	565	PF00069	0.752
MOD_CDK_SPxxK_3	560	567	PF00069	0.748
MOD_CK1_1	126	132	PF00069	0.777
MOD_CK1_1	137	143	PF00069	0.847
MOD_CK1_1	425	431	PF00069	0.692
MOD_CK1_1	46	52	PF00069	0.834
MOD_CK1_1	490	496	PF00069	0.769
MOD_CK1_1	71	77	PF00069	0.824
MOD_CK2_1	109	115	PF00069	0.753
MOD_CK2_1	126	132	PF00069	0.752
MOD_CK2_1	137	143	PF00069	0.772
MOD_CK2_1	248	254	PF00069	0.649
MOD_CK2_1	367	373	PF00069	0.600
MOD_CK2_1	494	500	PF00069	0.775
MOD_CK2_1	518	524	PF00069	0.621
MOD_CK2_1	560	566	PF00069	0.721
MOD_GlcNHglycan	125	128	PF01048	0.629
MOD_GlcNHglycan	15	18	PF01048	0.442
MOD_GlcNHglycan	396	399	PF01048	0.429
MOD_GlcNHglycan	56	59	PF01048	0.566
MOD_GlcNHglycan	589	592	PF01048	0.451
MOD_GlcNHglycan	87	90	PF01048	0.602
MOD_GSK3_1	126	133	PF00069	0.777
MOD_GSK3_1	223	230	PF00069	0.644
MOD_GSK3_1	25	32	PF00069	0.810
MOD_GSK3_1	312	319	PF00069	0.621
MOD_GSK3_1	435	442	PF00069	0.598
MOD_GSK3_1	44	51	PF00069	0.824
MOD_GSK3_1	466	473	PF00069	0.678
MOD_GSK3_1	490	497	PF00069	0.809
MOD_GSK3_1	587	594	PF00069	0.697
MOD_GSK3_1	59	66	PF00069	0.775
MOD_N-GLC_1	477	482	PF02516	0.486
MOD_N-GLC_1	534	539	PF02516	0.509
MOD_N-GLC_1	579	584	PF02516	0.483
MOD_N-GLC_2	412	414	PF02516	0.407
MOD_NEK2_1	158	163	PF00069	0.597
MOD_NEK2_1	19	24	PF00069	0.327
MOD_NEK2_1	235	240	PF00069	0.602
MOD_NEK2_1	261	266	PF00069	0.589
MOD_NEK2_1	271	276	PF00069	0.553
MOD_NEK2_1	317	322	PF00069	0.626
MOD_NEK2_1	360	365	PF00069	0.599
MOD_NEK2_1	48	53	PF00069	0.840
MOD_NEK2_1	605	610	PF00069	0.585
MOD_NEK2_1	7	12	PF00069	0.524
MOD_NEK2_2	503	508	PF00069	0.610
MOD_PIKK_1	261	267	PF00454	0.617
MOD_PIKK_1	303	309	PF00454	0.674
MOD_PIKK_1	399	405	PF00454	0.673
MOD_PIKK_1	46	52	PF00454	0.834
MOD_PIKK_1	73	79	PF00454	0.849
MOD_PIKK_1	83	89	PF00454	0.819
MOD_PK_1	248	254	PF00069	0.673
MOD_PKA_1	247	253	PF00069	0.685
MOD_PKA_1	30	36	PF00069	0.841
MOD_PKA_1	52	58	PF00069	0.732
MOD_PKA_1	92	98	PF00069	0.653
MOD_PKA_2	151	157	PF00069	0.675
MOD_PKA_2	63	69	PF00069	0.855
MOD_Plk_1	227	233	PF00069	0.644
MOD_Plk_1	248	254	PF00069	0.649
MOD_Plk_1	271	277	PF00069	0.613
MOD_Plk_1	317	323	PF00069	0.628
MOD_Plk_1	336	342	PF00069	0.433
MOD_Plk_1	367	373	PF00069	0.574
MOD_Plk_1	386	392	PF00069	0.638
MOD_Plk_2-3	367	373	PF00069	0.620
MOD_Plk_4	109	115	PF00069	0.773
MOD_Plk_4	181	187	PF00069	0.615
MOD_Plk_4	271	277	PF00069	0.639
MOD_Plk_4	477	483	PF00069	0.657
MOD_Plk_4	550	556	PF00069	0.606
MOD_Plk_4	581	587	PF00069	0.571
MOD_ProDKin_1	172	178	PF00069	0.625
MOD_ProDKin_1	312	318	PF00069	0.672
MOD_ProDKin_1	437	443	PF00069	0.656
MOD_ProDKin_1	494	500	PF00069	0.783
MOD_ProDKin_1	560	566	PF00069	0.749
MOD_SUMO_for_1	364	367	PF00179	0.614
MOD_SUMO_for_1	91	94	PF00179	0.756
MOD_SUMO_rev_2	126	136	PF00179	0.855
MOD_SUMO_rev_2	148	155	PF00179	0.696
MOD_SUMO_rev_2	400	408	PF00179	0.638
TRG_DiLeu_BaEn_1	215	220	PF01217	0.646
TRG_DiLeu_BaEn_2	549	555	PF01217	0.627
TRG_DiLeu_BaEn_2	606	612	PF01217	0.629
TRG_ENDOCYTIC_2	301	304	PF00928	0.616
TRG_ENDOCYTIC_2	413	416	PF00928	0.563
TRG_Pf-PMV_PEXEL_1	258	262	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUN6	Leptomonas seymouri	69%	99%
A0A0S4JT82	Bodo saltans	45%	100%
A0A1X0NI07	Trypanosomatidae	50%	100%
A0A3R7MXK0	Trypanosoma rangeli	44%	100%
A0A3S7WQS4	Leishmania donovani	95%	100%
A4H5S9	Leishmania braziliensis	85%	100%
A4HU23	Leishmania infantum	95%	100%
D0A9K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QHS3	Leishmania major	94%	100%
V5CK09	Trypanosoma cruzi	52%	100%