PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMV2_LEIMU

TriTrypDb:

LmxM.09.1000

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMV2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMV2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.433
CLV_NRD_NRD_1	30	32	PF00675	0.279
CLV_PCSK_KEX2_1	30	32	PF00082	0.279
CLV_PCSK_SKI1_1	127	131	PF00082	0.610
CLV_PCSK_SKI1_1	174	178	PF00082	0.478
CLV_PCSK_SKI1_1	182	186	PF00082	0.396
CLV_PCSK_SKI1_1	232	236	PF00082	0.491
CLV_PCSK_SKI1_1	294	298	PF00082	0.612
CLV_PCSK_SKI1_1	30	34	PF00082	0.309
CLV_PCSK_SKI1_1	46	50	PF00082	0.364
DEG_APCC_DBOX_1	29	37	PF00400	0.297
DEG_Nend_UBRbox_3	1	3	PF02207	0.588
DOC_CYCLIN_RxL_1	177	187	PF00134	0.457
DOC_MAPK_gen_1	30	38	PF00069	0.279
DOC_MAPK_HePTP_8	28	40	PF00069	0.357
DOC_MAPK_MEF2A_6	31	40	PF00069	0.357
DOC_PP1_RVXF_1	269	276	PF00149	0.511
DOC_PP4_FxxP_1	40	43	PF00568	0.410
DOC_USP7_MATH_1	161	165	PF00917	0.739
DOC_USP7_UBL2_3	290	294	PF12436	0.543
DOC_USP7_UBL2_3	49	53	PF12436	0.410
LIG_14-3-3_CanoR_1	181	185	PF00244	0.425
LIG_14-3-3_CanoR_1	57	63	PF00244	0.334
LIG_BRCT_BRCA1_1	265	269	PF00533	0.617
LIG_BRCT_BRCA1_1	72	76	PF00533	0.410
LIG_BRCT_BRCA1_2	265	271	PF00533	0.621
LIG_BRCT_BRCA1_2	72	78	PF00533	0.246
LIG_FHA_1	140	146	PF00498	0.614
LIG_FHA_1	185	191	PF00498	0.446
LIG_FHA_1	245	251	PF00498	0.536
LIG_FHA_1	295	301	PF00498	0.584
LIG_FHA_1	57	63	PF00498	0.407
LIG_FHA_1	87	93	PF00498	0.277
LIG_FHA_2	75	81	PF00498	0.421
LIG_HCF-1_HBM_1	255	258	PF13415	0.469
LIG_Integrin_isoDGR_2	283	285	PF01839	0.652
LIG_LIR_Apic_2	39	43	PF02991	0.410
LIG_LIR_Gen_1	223	234	PF02991	0.420
LIG_LIR_Gen_1	68	76	PF02991	0.391
LIG_LIR_Gen_1	8	18	PF02991	0.438
LIG_LIR_Nem_3	223	229	PF02991	0.387
LIG_LIR_Nem_3	68	74	PF02991	0.316
LIG_LIR_Nem_3	8	13	PF02991	0.522
LIG_NRBOX	32	38	PF00104	0.357
LIG_PDZ_Class_2	306	311	PF00595	0.398
LIG_PTB_Apo_2	189	196	PF02174	0.431
LIG_PTB_Apo_2	39	46	PF02174	0.378
LIG_REV1ctd_RIR_1	192	202	PF16727	0.482
LIG_SH2_CRK	260	264	PF00017	0.522
LIG_SH2_STAP1	236	240	PF00017	0.371
LIG_SH2_STAT5	101	104	PF00017	0.344
LIG_SH2_STAT5	301	304	PF00017	0.446
LIG_SH3_3	1	7	PF00018	0.467
LIG_TRAF2_1	152	155	PF00917	0.619
LIG_TYR_ITIM	234	239	PF00017	0.393
LIG_UBA3_1	70	78	PF00899	0.266
MOD_CK1_1	88	94	PF00069	0.355
MOD_CK2_1	161	167	PF00069	0.693
MOD_CK2_1	97	103	PF00069	0.389
MOD_GlcNHglycan	163	166	PF01048	0.737
MOD_GlcNHglycan	242	245	PF01048	0.489
MOD_GlcNHglycan	265	268	PF01048	0.588
MOD_GSK3_1	180	187	PF00069	0.405
MOD_GSK3_1	240	247	PF00069	0.395
MOD_GSK3_1	259	266	PF00069	0.530
MOD_GSK3_1	269	276	PF00069	0.514
MOD_GSK3_1	70	77	PF00069	0.277
MOD_NEK2_1	184	189	PF00069	0.422
MOD_NEK2_1	269	274	PF00069	0.479
MOD_NEK2_1	58	63	PF00069	0.378
MOD_NEK2_1	69	74	PF00069	0.273
MOD_PIKK_1	156	162	PF00454	0.653
MOD_PK_1	198	204	PF00069	0.420
MOD_PKA_2	180	186	PF00069	0.427
MOD_PKA_2	56	62	PF00069	0.391
MOD_Plk_1	102	108	PF00069	0.531
MOD_Plk_1	198	204	PF00069	0.505
MOD_Plk_4	180	186	PF00069	0.517
MOD_Plk_4	97	103	PF00069	0.497
MOD_SUMO_rev_2	288	296	PF00179	0.367
TRG_DiLeu_BaEn_1	282	287	PF01217	0.596
TRG_DiLeu_BaEn_4	8	14	PF01217	0.455
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.482
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.432
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.297
TRG_ENDOCYTIC_2	236	239	PF00928	0.412
TRG_ENDOCYTIC_2	260	263	PF00928	0.517
TRG_ER_diArg_1	29	31	PF00400	0.279
TRG_Pf-PMV_PEXEL_1	144	149	PF00026	0.649

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBQ0	Leptomonas seymouri	59%	99%
A0A1X0NI65	Trypanosomatidae	40%	100%
A0A3S7WQS2	Leishmania donovani	89%	100%
A0A422N3Q8	Trypanosoma rangeli	39%	100%
A4H5S8	Leishmania braziliensis	74%	100%
A4HU22	Leishmania infantum	90%	100%
D0A9J2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QHS4	Leishmania major	91%	100%
V5D6M9	Trypanosoma cruzi	41%	100%