RAB3GAP2_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMU8_LEIMU

TriTrypDb:

LmxM.09.0960

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.488
CLV_C14_Caspase3-7	38	42	PF00656	0.588
CLV_C14_Caspase3-7	391	395	PF00656	0.587
CLV_MEL_PAP_1	417	423	PF00089	0.680
CLV_NRD_NRD_1	227	229	PF00675	0.512
CLV_PCSK_KEX2_1	227	229	PF00082	0.512
CLV_PCSK_SKI1_1	207	211	PF00082	0.425
CLV_PCSK_SKI1_1	293	297	PF00082	0.631
CLV_PCSK_SKI1_1	576	580	PF00082	0.707
CLV_PCSK_SKI1_1	606	610	PF00082	0.522
CLV_PCSK_SKI1_1	67	71	PF00082	0.524
DEG_APCC_DBOX_1	322	330	PF00400	0.450
DEG_ODPH_VHL_1	247	260	PF01847	0.524
DEG_SPOP_SBC_1	51	55	PF00917	0.737
DEG_SPOP_SBC_1	521	525	PF00917	0.729
DOC_MAPK_MEF2A_6	251	260	PF00069	0.539
DOC_PP1_RVXF_1	435	442	PF00149	0.550
DOC_PP2B_LxvP_1	371	374	PF13499	0.573
DOC_PP2B_LxvP_1	581	584	PF13499	0.532
DOC_USP7_MATH_1	116	120	PF00917	0.569
DOC_USP7_MATH_1	314	318	PF00917	0.700
DOC_USP7_MATH_1	33	37	PF00917	0.469
DOC_USP7_MATH_1	372	376	PF00917	0.719
DOC_USP7_MATH_1	416	420	PF00917	0.531
DOC_USP7_MATH_1	521	525	PF00917	0.808
DOC_USP7_MATH_1	540	544	PF00917	0.693
DOC_USP7_MATH_1	586	590	PF00917	0.584
DOC_USP7_MATH_1	611	615	PF00917	0.550
DOC_WW_Pin1_4	342	347	PF00397	0.532
DOC_WW_Pin1_4	481	486	PF00397	0.639
DOC_WW_Pin1_4	517	522	PF00397	0.791
DOC_WW_Pin1_4	52	57	PF00397	0.738
DOC_WW_Pin1_4	60	65	PF00397	0.664
LIG_14-3-3_CanoR_1	198	204	PF00244	0.493
LIG_14-3-3_CanoR_1	220	226	PF00244	0.631
LIG_14-3-3_CanoR_1	227	234	PF00244	0.518
LIG_14-3-3_CanoR_1	323	327	PF00244	0.605
LIG_14-3-3_CanoR_1	452	456	PF00244	0.635
LIG_14-3-3_CanoR_1	576	582	PF00244	0.686
LIG_14-3-3_CanoR_1	585	591	PF00244	0.419
LIG_14-3-3_CanoR_1	67	75	PF00244	0.432
LIG_BIR_II_1	1	5	PF00653	0.651
LIG_BRCT_BRCA1_1	230	234	PF00533	0.496
LIG_BRCT_BRCA1_1	35	39	PF00533	0.692
LIG_BRCT_BRCA1_1	554	558	PF00533	0.303
LIG_Clathr_ClatBox_1	103	107	PF01394	0.508
LIG_DLG_GKlike_1	420	428	PF00625	0.684
LIG_FHA_1	375	381	PF00498	0.570
LIG_FHA_1	402	408	PF00498	0.494
LIG_FHA_1	494	500	PF00498	0.654
LIG_FHA_1	501	507	PF00498	0.629
LIG_FHA_1	578	584	PF00498	0.669
LIG_FHA_1	98	104	PF00498	0.543
LIG_FHA_2	127	133	PF00498	0.539
LIG_LIR_Gen_1	148	155	PF02991	0.315
LIG_LIR_Gen_1	589	597	PF02991	0.350
LIG_LIR_LC3C_4	259	264	PF02991	0.453
LIG_LIR_Nem_3	148	152	PF02991	0.271
LIG_LIR_Nem_3	438	444	PF02991	0.438
LIG_LIR_Nem_3	589	593	PF02991	0.554
LIG_LYPXL_SIV_4	601	609	PF13949	0.585
LIG_Pex14_2	234	238	PF04695	0.416
LIG_SH2_CRK	414	418	PF00017	0.758
LIG_SH2_SRC	4	7	PF00017	0.616
LIG_SH2_STAT3	347	350	PF00017	0.601
LIG_SH2_STAT5	273	276	PF00017	0.412
LIG_SH2_STAT5	4	7	PF00017	0.771
LIG_SH2_STAT5	567	570	PF00017	0.497
LIG_SH3_3	3	9	PF00018	0.619
LIG_SH3_3	580	586	PF00018	0.665
LIG_SH3_3	614	620	PF00018	0.454
LIG_SUMO_SIM_anti_2	100	105	PF11976	0.490
LIG_SUMO_SIM_anti_2	259	264	PF11976	0.400
LIG_SUMO_SIM_anti_2	86	97	PF11976	0.509
LIG_SUMO_SIM_par_1	102	107	PF11976	0.557
LIG_SUMO_SIM_par_1	157	162	PF11976	0.385
LIG_SUMO_SIM_par_1	261	267	PF11976	0.388
LIG_TRAF2_1	177	180	PF00917	0.786
LIG_TRAF2_1	562	565	PF00917	0.426
LIG_TRAF2_2	451	456	PF00917	0.687
LIG_TRFH_1	342	346	PF08558	0.527
LIG_TYR_ITIM	412	417	PF00017	0.675
LIG_WRC_WIRS_1	587	592	PF05994	0.589
MOD_CDK_SPxxK_3	60	67	PF00069	0.502
MOD_CK1_1	151	157	PF00069	0.439
MOD_CK1_1	302	308	PF00069	0.723
MOD_CK1_1	317	323	PF00069	0.565
MOD_CK1_1	516	522	PF00069	0.746
MOD_CK1_1	525	531	PF00069	0.715
MOD_CK1_1	535	541	PF00069	0.718
MOD_CK1_1	543	549	PF00069	0.574
MOD_CK1_1	57	63	PF00069	0.707
MOD_CK1_1	577	583	PF00069	0.631
MOD_CK1_1	589	595	PF00069	0.623
MOD_CK1_1	79	85	PF00069	0.609
MOD_CK2_1	116	122	PF00069	0.472
MOD_CK2_1	173	179	PF00069	0.710
MOD_CK2_1	234	240	PF00069	0.493
MOD_CK2_1	372	378	PF00069	0.670
MOD_CK2_1	455	461	PF00069	0.625
MOD_CK2_1	559	565	PF00069	0.522
MOD_CK2_1	589	595	PF00069	0.648
MOD_GlcNHglycan	124	127	PF01048	0.559
MOD_GlcNHglycan	153	156	PF01048	0.496
MOD_GlcNHglycan	169	172	PF01048	0.707
MOD_GlcNHglycan	175	178	PF01048	0.710
MOD_GlcNHglycan	207	210	PF01048	0.676
MOD_GlcNHglycan	221	224	PF01048	0.626
MOD_GlcNHglycan	305	308	PF01048	0.724
MOD_GlcNHglycan	31	34	PF01048	0.699
MOD_GlcNHglycan	311	315	PF01048	0.758
MOD_GlcNHglycan	359	362	PF01048	0.671
MOD_GlcNHglycan	374	377	PF01048	0.646
MOD_GlcNHglycan	456	460	PF01048	0.662
MOD_GlcNHglycan	515	518	PF01048	0.720
MOD_GlcNHglycan	534	537	PF01048	0.641
MOD_GlcNHglycan	545	548	PF01048	0.469
MOD_GlcNHglycan	561	564	PF01048	0.485
MOD_GlcNHglycan	576	579	PF01048	0.545
MOD_GlcNHglycan	70	73	PF01048	0.486
MOD_GSK3_1	118	125	PF00069	0.555
MOD_GSK3_1	167	174	PF00069	0.700
MOD_GSK3_1	199	206	PF00069	0.777
MOD_GSK3_1	29	36	PF00069	0.607
MOD_GSK3_1	298	305	PF00069	0.658
MOD_GSK3_1	310	317	PF00069	0.703
MOD_GSK3_1	318	325	PF00069	0.701
MOD_GSK3_1	372	379	PF00069	0.667
MOD_GSK3_1	416	423	PF00069	0.706
MOD_GSK3_1	431	438	PF00069	0.386
MOD_GSK3_1	451	458	PF00069	0.620
MOD_GSK3_1	481	488	PF00069	0.710
MOD_GSK3_1	50	57	PF00069	0.665
MOD_GSK3_1	513	520	PF00069	0.737
MOD_GSK3_1	521	528	PF00069	0.686
MOD_GSK3_1	79	86	PF00069	0.492
MOD_GSK3_1	93	100	PF00069	0.377
MOD_N-GLC_1	171	176	PF02516	0.674
MOD_NEK2_1	166	171	PF00069	0.383
MOD_NEK2_1	218	223	PF00069	0.601
MOD_NEK2_1	234	239	PF00069	0.350
MOD_NEK2_1	329	334	PF00069	0.723
MOD_NEK2_1	401	406	PF00069	0.570
MOD_NEK2_1	431	436	PF00069	0.444
MOD_NEK2_1	455	460	PF00069	0.623
MOD_NEK2_1	609	614	PF00069	0.536
MOD_PIKK_1	401	407	PF00454	0.500
MOD_PIKK_1	540	546	PF00454	0.560
MOD_PKA_2	167	173	PF00069	0.659
MOD_PKA_2	219	225	PF00069	0.624
MOD_PKA_2	226	232	PF00069	0.550
MOD_PKA_2	322	328	PF00069	0.562
MOD_PKA_2	451	457	PF00069	0.593
MOD_Plk_1	116	122	PF00069	0.515
MOD_Plk_1	455	461	PF00069	0.625
MOD_Plk_4	234	240	PF00069	0.531
MOD_Plk_4	589	595	PF00069	0.547
MOD_ProDKin_1	342	348	PF00069	0.536
MOD_ProDKin_1	481	487	PF00069	0.637
MOD_ProDKin_1	517	523	PF00069	0.794
MOD_ProDKin_1	52	58	PF00069	0.739
MOD_ProDKin_1	60	66	PF00069	0.654
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.595
TRG_ENDOCYTIC_2	414	417	PF00928	0.682
TRG_ER_diArg_1	226	228	PF00400	0.517
TRG_ER_diArg_1	291	294	PF00400	0.541
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H8	Leptomonas seymouri	48%	81%
A0A1X0NMF5	Trypanosomatidae	31%	100%
A0A3S7WQU1	Leishmania donovani	88%	100%
A4H5S4	Leishmania braziliensis	75%	100%
A4HU17	Leishmania infantum	88%	100%
D0A9I5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4QHS8	Leishmania major	88%	100%