Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMT8_LEIMU

TriTrypDb:

LmxM.09.0870

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	457	461	PF00656	0.570
CLV_NRD_NRD_1	117	119	PF00675	0.613
CLV_NRD_NRD_1	148	150	PF00675	0.616
CLV_NRD_NRD_1	385	387	PF00675	0.624
CLV_NRD_NRD_1	451	453	PF00675	0.482
CLV_NRD_NRD_1	478	480	PF00675	0.508
CLV_NRD_NRD_1	9	11	PF00675	0.609
CLV_PCSK_FUR_1	146	150	PF00082	0.425
CLV_PCSK_KEX2_1	116	118	PF00082	0.526
CLV_PCSK_KEX2_1	148	150	PF00082	0.615
CLV_PCSK_KEX2_1	385	387	PF00082	0.624
CLV_PCSK_KEX2_1	451	453	PF00082	0.597
CLV_PCSK_KEX2_1	515	517	PF00082	0.551
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.478
CLV_PCSK_PC1ET2_1	515	517	PF00082	0.551
CLV_PCSK_PC7_1	112	118	PF00082	0.531
CLV_PCSK_SKI1_1	117	121	PF00082	0.532
CLV_PCSK_SKI1_1	411	415	PF00082	0.557
DEG_Nend_Nbox_1	1	3	PF02207	0.569
DEG_SCF_FBW7_2	321	328	PF00400	0.533
DEG_SPOP_SBC_1	298	302	PF00917	0.525
DEG_SPOP_SBC_1	71	75	PF00917	0.641
DOC_MAPK_gen_1	515	521	PF00069	0.569
DOC_MAPK_RevD_3	438	452	PF00069	0.605
DOC_PP2B_LxvP_1	20	23	PF13499	0.657
DOC_PP2B_LxvP_1	440	443	PF13499	0.600
DOC_PP4_FxxP_1	368	371	PF00568	0.640
DOC_PP4_MxPP_1	436	439	PF00568	0.588
DOC_USP7_MATH_1	265	269	PF00917	0.519
DOC_USP7_MATH_1	290	294	PF00917	0.709
DOC_USP7_MATH_1	296	300	PF00917	0.601
DOC_USP7_MATH_1	331	335	PF00917	0.635
DOC_USP7_MATH_1	42	46	PF00917	0.563
DOC_USP7_MATH_1	72	76	PF00917	0.659
DOC_USP7_MATH_2	32	38	PF00917	0.514
DOC_WW_Pin1_4	299	304	PF00397	0.711
DOC_WW_Pin1_4	313	318	PF00397	0.555
DOC_WW_Pin1_4	321	326	PF00397	0.638
DOC_WW_Pin1_4	402	407	PF00397	0.575
LIG_14-3-3_CanoR_1	10	17	PF00244	0.496
LIG_14-3-3_CanoR_1	256	260	PF00244	0.555
LIG_Actin_WH2_2	85	101	PF00022	0.587
LIG_BRCT_BRCA1_1	333	337	PF00533	0.629
LIG_EVH1_1	437	441	PF00568	0.590
LIG_FHA_1	171	177	PF00498	0.419
LIG_FHA_1	376	382	PF00498	0.723
LIG_FHA_1	394	400	PF00498	0.578
LIG_FHA_1	412	418	PF00498	0.497
LIG_FHA_1	427	433	PF00498	0.428
LIG_FHA_1	71	77	PF00498	0.739
LIG_FHA_2	139	145	PF00498	0.501
LIG_FHA_2	345	351	PF00498	0.674
LIG_FHA_2	470	476	PF00498	0.509
LIG_LIR_Apic_2	366	371	PF02991	0.637
LIG_LIR_Gen_1	251	261	PF02991	0.492
LIG_LIR_Gen_1	488	497	PF02991	0.570
LIG_LIR_Nem_3	251	257	PF02991	0.494
LIG_LIR_Nem_3	488	492	PF02991	0.553
LIG_LIR_Nem_3	94	98	PF02991	0.449
LIG_MYND_1	438	442	PF01753	0.594
LIG_PDZ_Class_2	516	521	PF00595	0.566
LIG_PDZ_Wminus1_1	519	521	PF00595	0.609
LIG_PTAP_UEV_1	370	375	PF05743	0.490
LIG_PTB_Apo_2	56	63	PF02174	0.669
LIG_SH2_CRK	361	365	PF00017	0.591
LIG_SH2_CRK	489	493	PF00017	0.566
LIG_SH2_CRK	95	99	PF00017	0.624
LIG_SH2_NCK_1	427	431	PF00017	0.573
LIG_SH2_PTP2	254	257	PF00017	0.496
LIG_SH2_STAP1	2	6	PF00017	0.570
LIG_SH2_STAP1	427	431	PF00017	0.519
LIG_SH2_STAT3	188	191	PF00017	0.430
LIG_SH2_STAT5	188	191	PF00017	0.459
LIG_SH2_STAT5	254	257	PF00017	0.496
LIG_SH2_STAT5	361	364	PF00017	0.577
LIG_SH2_STAT5	367	370	PF00017	0.565
LIG_SH2_STAT5	489	492	PF00017	0.570
LIG_SH2_STAT5	77	80	PF00017	0.521
LIG_SH3_2	439	444	PF14604	0.644
LIG_SH3_3	307	313	PF00018	0.582
LIG_SH3_3	330	336	PF00018	0.600
LIG_SH3_3	368	374	PF00018	0.544
LIG_SH3_3	378	384	PF00018	0.644
LIG_SH3_3	38	44	PF00018	0.796
LIG_SH3_3	400	406	PF00018	0.602
LIG_SH3_3	435	441	PF00018	0.631
LIG_SH3_3	501	507	PF00018	0.646
LIG_SH3_3	75	81	PF00018	0.771
LIG_SH3_CIN85_PxpxPR_1	439	444	PF14604	0.644
LIG_TRAF2_1	136	139	PF00917	0.542
LIG_TRAF2_1	249	252	PF00917	0.512
LIG_TYR_ITIM	359	364	PF00017	0.591
LIG_TYR_ITIM	487	492	PF00017	0.554
LIG_UBA3_1	182	190	PF00899	0.377
LIG_WW_2	438	441	PF00397	0.593
LIG_WW_3	441	445	PF00397	0.651
MOD_CK1_1	12	18	PF00069	0.599
MOD_CK1_1	220	226	PF00069	0.535
MOD_CK1_1	235	241	PF00069	0.566
MOD_CK1_1	299	305	PF00069	0.651
MOD_CK1_1	311	317	PF00069	0.610
MOD_CK1_1	488	494	PF00069	0.563
MOD_CK1_1	5	11	PF00069	0.643
MOD_CK2_1	138	144	PF00069	0.458
MOD_CK2_1	344	350	PF00069	0.679
MOD_Cter_Amidation	513	516	PF01082	0.555
MOD_GlcNHglycan	11	14	PF01048	0.600
MOD_GlcNHglycan	16	20	PF01048	0.600
MOD_GlcNHglycan	234	237	PF01048	0.615
MOD_GlcNHglycan	292	295	PF01048	0.685
MOD_GlcNHglycan	310	313	PF01048	0.644
MOD_GlcNHglycan	333	336	PF01048	0.640
MOD_GlcNHglycan	371	374	PF01048	0.656
MOD_GSK3_1	216	223	PF00069	0.717
MOD_GSK3_1	232	239	PF00069	0.744
MOD_GSK3_1	297	304	PF00069	0.633
MOD_GSK3_1	30	37	PF00069	0.511
MOD_GSK3_1	313	320	PF00069	0.612
MOD_GSK3_1	342	349	PF00069	0.573
MOD_GSK3_1	5	12	PF00069	0.566
MOD_N-GLC_1	495	500	PF02516	0.639
MOD_NEK2_1	175	180	PF00069	0.313
MOD_NEK2_1	204	209	PF00069	0.610
MOD_NEK2_1	297	302	PF00069	0.528
MOD_NEK2_1	344	349	PF00069	0.615
MOD_NEK2_1	426	431	PF00069	0.420
MOD_NEK2_1	458	463	PF00069	0.509
MOD_NEK2_1	487	492	PF00069	0.554
MOD_NEK2_1	55	60	PF00069	0.560
MOD_NEK2_2	72	77	PF00069	0.647
MOD_PIKK_1	170	176	PF00454	0.420
MOD_PIKK_1	301	307	PF00454	0.662
MOD_PKA_2	170	176	PF00069	0.429
MOD_PKA_2	255	261	PF00069	0.555
MOD_PKA_2	384	390	PF00069	0.541
MOD_PKA_2	432	438	PF00069	0.664
MOD_PKA_2	458	464	PF00069	0.571
MOD_PKA_2	9	15	PF00069	0.559
MOD_Plk_1	102	108	PF00069	0.478
MOD_Plk_1	444	450	PF00069	0.655
MOD_Plk_2-3	469	475	PF00069	0.534
MOD_Plk_4	184	190	PF00069	0.453
MOD_Plk_4	359	365	PF00069	0.570
MOD_Plk_4	432	438	PF00069	0.664
MOD_Plk_4	458	464	PF00069	0.506
MOD_Plk_4	72	78	PF00069	0.646
MOD_Plk_4	91	97	PF00069	0.390
MOD_ProDKin_1	299	305	PF00069	0.713
MOD_ProDKin_1	313	319	PF00069	0.556
MOD_ProDKin_1	321	327	PF00069	0.637
MOD_ProDKin_1	402	408	PF00069	0.574
MOD_SUMO_for_1	126	129	PF00179	0.472
MOD_SUMO_rev_2	33	37	PF00179	0.649
MOD_SUMO_rev_2	475	482	PF00179	0.576
TRG_ENDOCYTIC_2	201	204	PF00928	0.402
TRG_ENDOCYTIC_2	254	257	PF00928	0.496
TRG_ENDOCYTIC_2	361	364	PF00928	0.591
TRG_ENDOCYTIC_2	489	492	PF00928	0.565
TRG_ENDOCYTIC_2	95	98	PF00928	0.604
TRG_ER_diArg_1	145	148	PF00400	0.607
TRG_ER_diArg_1	285	288	PF00400	0.656
TRG_ER_diArg_1	384	386	PF00400	0.607
TRG_ER_diArg_1	450	452	PF00400	0.605
TRG_NLS_MonoCore_2	114	119	PF00514	0.487
TRG_NLS_MonoExtN_4	112	119	PF00514	0.524
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	148	153	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J5	Leptomonas seymouri	43%	100%
A0A3Q8IBX4	Leishmania donovani	89%	100%
A4H5N6	Leishmania braziliensis	72%	100%
A4HU08	Leishmania infantum	89%	100%
Q4QHT7	Leishmania major	87%	100%