Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMT7_LEIMU

TriTrypDb:

LmxM.09.0860

Length:

106

Annotations

LeishMANIAdb annotations

A very small protein, that could also possibly be organellar (mitochondrial). A transit peptide cannot be excluded in the sequence.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0016020	membrane	2	8
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	8

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Expansion

Sequence features

E9AMT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMT7

Function

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Biological processes
Term	Name	Level	Count
GO:0008535	respiratory chain complex IV assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0017004	cytochrome complex assembly	6	1
GO:0022607	cellular component assembly	4	1
GO:0033108	mitochondrial respiratory chain complex assembly	6	1
GO:0033617	mitochondrial cytochrome c oxidase assembly	7	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	88	92	PF00656	0.493
CLV_NRD_NRD_1	27	29	PF00675	0.429
CLV_NRD_NRD_1	54	56	PF00675	0.613
CLV_PCSK_FUR_1	52	56	PF00082	0.635
CLV_PCSK_KEX2_1	22	24	PF00082	0.382
CLV_PCSK_KEX2_1	27	29	PF00082	0.415
CLV_PCSK_KEX2_1	54	56	PF00082	0.602
CLV_PCSK_KEX2_1	6	8	PF00082	0.510
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.483
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.518

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P760	Leptomonas seymouri	68%	100%
A0A0S4IM31	Bodo saltans	41%	85%
A0A3S5H6E0	Leishmania donovani	94%	100%
A4H5R7	Leishmania braziliensis	81%	100%
A4HU07	Leishmania infantum	94%	100%
D0A9H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4QHT8	Leishmania major	91%	100%

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