Ras family protein-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras family protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AMT6_LEIMU

TriTrypDb:

LmxM.09.0850

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AMT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMT6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0003924	GTPase activity	7	10
GO:0005488	binding	1	10
GO:0005525	GTP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0019001	guanyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032561	guanyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	179	181	PF00082	0.700
CLV_PCSK_KEX2_1	37	39	PF00082	0.347
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.700
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.347
CLV_PCSK_SKI1_1	111	115	PF00082	0.386
DEG_APCC_DBOX_1	18	26	PF00400	0.422
DOC_MAPK_MEF2A_6	47	56	PF00069	0.322
DOC_PP1_RVXF_1	96	102	PF00149	0.322
DOC_PP2B_PxIxI_1	49	55	PF00149	0.322
DOC_USP7_MATH_1	138	142	PF00917	0.463
DOC_USP7_MATH_1	154	158	PF00917	0.597
DOC_USP7_MATH_1	181	185	PF00917	0.730
DOC_WW_Pin1_4	74	79	PF00397	0.642
LIG_14-3-3_CanoR_1	131	137	PF00244	0.455
LIG_14-3-3_CanoR_1	180	184	PF00244	0.733
LIG_14-3-3_CanoR_1	72	78	PF00244	0.613
LIG_14-3-3_CanoR_1	86	95	PF00244	0.370
LIG_eIF4E_1	17	23	PF01652	0.511
LIG_FHA_1	49	55	PF00498	0.323
LIG_FHA_2	11	17	PF00498	0.620
LIG_HP1_1	205	209	PF01393	0.422
LIG_LIR_Gen_1	141	149	PF02991	0.286
LIG_LIR_LC3C_4	263	267	PF02991	0.463
LIG_LIR_Nem_3	107	113	PF02991	0.326
LIG_LIR_Nem_3	135	139	PF02991	0.323
LIG_LIR_Nem_3	14	20	PF02991	0.515
LIG_LIR_Nem_3	141	146	PF02991	0.324
LIG_LYPXL_yS_3	17	20	PF13949	0.528
LIG_PTB_Apo_2	112	119	PF02174	0.322
LIG_PTB_Phospho_1	112	118	PF10480	0.322
LIG_Rb_pABgroove_1	122	130	PF01858	0.463
LIG_SH2_NCK_1	118	122	PF00017	0.379
LIG_SH2_STAP1	248	252	PF00017	0.422
LIG_SH2_STAT5	149	152	PF00017	0.422
LIG_SH2_STAT5	39	42	PF00017	0.303
LIG_SH2_STAT5	48	51	PF00017	0.303
LIG_SH3_3	2	8	PF00018	0.598
LIG_SUMO_SIM_par_1	21	27	PF11976	0.322
LIG_SxIP_EBH_1	86	99	PF03271	0.544
LIG_TYR_ITIM	15	20	PF00017	0.564
MOD_CK1_1	251	257	PF00069	0.347
MOD_CK1_1	74	80	PF00069	0.601
MOD_CK2_1	138	144	PF00069	0.411
MOD_Cter_Amidation	177	180	PF01082	0.698
MOD_GlcNHglycan	103	107	PF01048	0.198
MOD_GlcNHglycan	156	159	PF01048	0.597
MOD_GlcNHglycan	188	191	PF01048	0.635
MOD_GlcNHglycan	249	253	PF01048	0.319
MOD_GlcNHglycan	78	81	PF01048	0.642
MOD_GlcNHglycan	90	93	PF01048	0.504
MOD_GSK3_1	134	141	PF00069	0.206
MOD_GSK3_1	181	188	PF00069	0.677
MOD_GSK3_1	247	254	PF00069	0.322
MOD_GSK3_1	70	77	PF00069	0.473
MOD_PK_1	179	185	PF00069	0.623
MOD_PKA_1	179	185	PF00069	0.693
MOD_PKA_2	179	185	PF00069	0.693
MOD_PKA_2	71	77	PF00069	0.620
MOD_PKB_1	226	234	PF00069	0.422
MOD_Plk_1	144	150	PF00069	0.380
MOD_Plk_4	138	144	PF00069	0.419
MOD_ProDKin_1	74	80	PF00069	0.646
TRG_ENDOCYTIC_2	110	113	PF00928	0.347
TRG_ENDOCYTIC_2	17	20	PF00928	0.520
TRG_ER_diArg_1	225	228	PF00400	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6P8	Leptomonas seymouri	27%	100%
A0A0N1I011	Leptomonas seymouri	26%	100%
A0A0N1I5E3	Leptomonas seymouri	26%	100%
A0A0N1I9K4	Leptomonas seymouri	25%	100%
A0A0N1PE58	Leptomonas seymouri	63%	100%
A0A0S4IRD6	Bodo saltans	27%	100%
A0A0S4J1G8	Bodo saltans	23%	100%
A0A0S4JR87	Bodo saltans	27%	100%
A0A0S4JRU1	Bodo saltans	26%	100%
A0A0S4KHE5	Bodo saltans	24%	100%
A0A1X0NN55	Trypanosomatidae	41%	100%
A0A1X0NVM5	Trypanosomatidae	24%	100%
A0A3Q8I8G7	Leishmania donovani	88%	100%
A0A3Q8ICX9	Leishmania donovani	25%	100%
A0A3Q8ID64	Leishmania donovani	27%	100%
A0A3R7N3U0	Trypanosoma rangeli	44%	100%
A0A3R7RHV7	Trypanosoma rangeli	29%	100%
A0A3S5H6H3	Leishmania donovani	26%	100%
A0A3S7WV84	Leishmania donovani	25%	100%
A0A422MUR1	Trypanosoma rangeli	26%	100%
A0A422P0L6	Trypanosoma rangeli	24%	100%
A4H5R6	Leishmania braziliensis	82%	100%
A4H6A5	Leishmania braziliensis	25%	89%
A4H9M3	Leishmania braziliensis	25%	93%
A4HK33	Leishmania braziliensis	25%	84%
A4HKJ3	Leishmania braziliensis	27%	87%
A4HU06	Leishmania infantum	88%	100%
A4HUM9	Leishmania infantum	26%	100%
A4HXY7	Leishmania infantum	25%	100%
A4I7N3	Leishmania infantum	25%	100%
A4I825	Leishmania infantum	27%	100%
A5D7F5	Bos taurus	31%	100%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
D0A9H1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
F1PTE3	Canis lupus familiaris	27%	100%
O00194	Homo sapiens	30%	100%
O04486	Arabidopsis thaliana	24%	100%
O14966	Homo sapiens	24%	100%
O24466	Arabidopsis thaliana	25%	100%
P05712	Rattus norvegicus	25%	100%
P10949	Bos taurus	25%	100%
P11023	Bos taurus	25%	100%
P19892	Arabidopsis thaliana	24%	100%
P20336	Homo sapiens	25%	100%
P23640	Rattus norvegicus	28%	100%
P28186	Arabidopsis thaliana	25%	100%
P35286	Rattus norvegicus	26%	100%
P36861	Volvox carteri	27%	100%
P51153	Homo sapiens	27%	100%
P51159	Homo sapiens	28%	100%
P53994	Mus musculus	25%	100%
P57729	Homo sapiens	24%	100%
P61019	Homo sapiens	25%	100%
P61105	Canis lupus familiaris	25%	100%
P62823	Mus musculus	25%	100%
P62824	Rattus norvegicus	25%	100%
P63011	Mus musculus	25%	100%
P63012	Rattus norvegicus	25%	100%
Q01971	Oryctolagus cuniculus	25%	100%
Q05975	Lymnaea stagnalis	26%	100%
Q06AU3	Sus scrofa	25%	100%
Q08DE8	Bos taurus	22%	100%
Q1HE58	Canis lupus familiaris	28%	100%
Q39433	Beta vulgaris	25%	100%
Q40723	Oryza sativa subsp. japonica	24%	100%
Q4LE85	Sus scrofa	28%	100%
Q4Q573	Leishmania major	27%	87%
Q4Q5N4	Leishmania major	26%	84%
Q4QDS9	Leishmania major	25%	93%
Q4QH97	Leishmania major	26%	90%
Q4QHT9	Leishmania major	88%	100%
Q4R4R9	Macaca fascicularis	25%	100%
Q4R4X6	Macaca fascicularis	25%	100%
Q58DS5	Bos taurus	27%	100%
Q5KTJ6	Mesocricetus auratus	26%	100%
Q5M7D1	Xenopus laevis	29%	99%
Q5R6B6	Pongo abelii	25%	100%
Q5R7A4	Pongo abelii	24%	100%
Q5RDE5	Pongo abelii	31%	100%
Q5ZIT5	Gallus gallus	24%	100%
Q63481	Rattus norvegicus	25%	100%
Q6IMK3	Danio rerio	33%	100%
Q6IML7	Rattus norvegicus	31%	100%
Q6IMM1	Gallus gallus	32%	100%
Q7T3A4	Danio rerio	26%	100%
Q7ZYF1	Xenopus laevis	29%	100%
Q8CFP6	Mus musculus	31%	100%
Q8HZJ5	Bos taurus	29%	100%
Q8QZZ8	Mus musculus	24%	100%
Q90965	Gallus gallus	25%	100%
Q91YQ1	Mus musculus	25%	100%
Q96283	Arabidopsis thaliana	24%	100%
Q96E17	Homo sapiens	25%	100%
Q99P58	Mus musculus	29%	100%
Q99P74	Rattus norvegicus	29%	100%
Q9DD03	Mus musculus	26%	100%
Q9ERI2	Mus musculus	28%	100%
Q9LFT9	Arabidopsis thaliana	24%	100%
Q9NZQ0	Homo sapiens	31%	100%
Q9SF91	Arabidopsis thaliana	25%	100%
Q9SF92	Arabidopsis thaliana	23%	100%
V5BBM5	Trypanosoma cruzi	26%	100%