Metal-dependent protein hydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0160), putative

Species:

Leishmania mexicana

UniProt:

E9AMT5_LEIMU

TriTrypDb:

LmxM.09.0840

Length:

398

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMT5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.478
CLV_NRD_NRD_1	282	284	PF00675	0.330
CLV_NRD_NRD_1	3	5	PF00675	0.478
CLV_NRD_NRD_1	345	347	PF00675	0.294
CLV_PCSK_KEX2_1	282	284	PF00082	0.373
CLV_PCSK_SKI1_1	296	300	PF00082	0.408
CLV_PCSK_SKI1_1	391	395	PF00082	0.296
CLV_PCSK_SKI1_1	64	68	PF00082	0.343
DEG_SPOP_SBC_1	337	341	PF00917	0.573
DOC_CKS1_1	114	119	PF01111	0.494
DOC_MAPK_MEF2A_6	246	253	PF00069	0.389
DOC_USP7_MATH_1	271	275	PF00917	0.550
DOC_USP7_MATH_1	32	36	PF00917	0.632
DOC_USP7_MATH_1	337	341	PF00917	0.563
DOC_USP7_UBL2_3	118	122	PF12436	0.541
DOC_WW_Pin1_4	113	118	PF00397	0.482
DOC_WW_Pin1_4	149	154	PF00397	0.506
LIG_14-3-3_CanoR_1	124	132	PF00244	0.495
LIG_14-3-3_CanoR_1	168	178	PF00244	0.543
LIG_APCC_ABBA_1	292	297	PF00400	0.504
LIG_APCC_ABBAyCdc20_2	291	297	PF00400	0.504
LIG_BIR_II_1	1	5	PF00653	0.540
LIG_BRCT_BRCA1_1	339	343	PF00533	0.573
LIG_Clathr_ClatBox_1	307	311	PF01394	0.507
LIG_FHA_2	172	178	PF00498	0.404
LIG_FHA_2	339	345	PF00498	0.573
LIG_LIR_Gen_1	181	191	PF02991	0.504
LIG_LIR_Gen_1	256	267	PF02991	0.492
LIG_LIR_Nem_3	181	187	PF02991	0.504
LIG_LIR_Nem_3	256	262	PF02991	0.497
LIG_LIR_Nem_3	263	267	PF02991	0.488
LIG_SH2_CRK	351	355	PF00017	0.597
LIG_SH2_GRB2like	184	187	PF00017	0.527
LIG_SH2_GRB2like	231	234	PF00017	0.564
LIG_SH2_SRC	103	106	PF00017	0.585
LIG_SH2_SRC	143	146	PF00017	0.524
LIG_SH2_STAP1	184	188	PF00017	0.573
LIG_SH2_STAT5	10	13	PF00017	0.423
LIG_SH2_STAT5	143	146	PF00017	0.494
LIG_SH2_STAT5	264	267	PF00017	0.546
LIG_SH2_STAT5	322	325	PF00017	0.494
LIG_SH3_2	150	155	PF14604	0.541
LIG_SH3_3	144	150	PF00018	0.595
LIG_SUMO_SIM_anti_2	16	23	PF11976	0.577
LIG_SUMO_SIM_anti_2	172	181	PF11976	0.529
LIG_SUMO_SIM_par_1	305	311	PF11976	0.539
LIG_TYR_ITIM	349	354	PF00017	0.597
LIG_WRC_WIRS_1	380	385	PF05994	0.541
MOD_CDC14_SPxK_1	152	155	PF00782	0.508
MOD_CDK_SPK_2	113	118	PF00069	0.494
MOD_CDK_SPxK_1	113	119	PF00069	0.573
MOD_CDK_SPxK_1	149	155	PF00069	0.515
MOD_CK1_1	160	166	PF00069	0.591
MOD_CK1_1	35	41	PF00069	0.614
MOD_CK2_1	160	166	PF00069	0.505
MOD_CK2_1	169	175	PF00069	0.466
MOD_CK2_1	271	277	PF00069	0.597
MOD_CK2_1	338	344	PF00069	0.546
MOD_GlcNHglycan	1	4	PF01048	0.585
MOD_GlcNHglycan	126	129	PF01048	0.294
MOD_GlcNHglycan	287	291	PF01048	0.301
MOD_GlcNHglycan	34	37	PF01048	0.619
MOD_GlcNHglycan	373	376	PF01048	0.290
MOD_GSK3_1	106	113	PF00069	0.490
MOD_GSK3_1	120	127	PF00069	0.471
MOD_GSK3_1	16	23	PF00069	0.515
MOD_GSK3_1	160	167	PF00069	0.546
MOD_GSK3_1	215	222	PF00069	0.486
MOD_GSK3_1	28	35	PF00069	0.513
MOD_GSK3_1	44	51	PF00069	0.347
MOD_N-GLC_1	219	224	PF02516	0.346
MOD_N-GLC_1	48	53	PF02516	0.283
MOD_NEK2_1	110	115	PF00069	0.491
MOD_NEK2_1	159	164	PF00069	0.523
MOD_NEK2_1	265	270	PF00069	0.525
MOD_NEK2_1	286	291	PF00069	0.553
MOD_PIKK_1	219	225	PF00454	0.559
MOD_PKA_2	123	129	PF00069	0.494
MOD_Plk_1	355	361	PF00069	0.389
MOD_Plk_4	16	22	PF00069	0.509
MOD_Plk_4	207	213	PF00069	0.597
MOD_Plk_4	260	266	PF00069	0.573
MOD_ProDKin_1	113	119	PF00069	0.482
MOD_ProDKin_1	149	155	PF00069	0.506
TRG_DiLeu_BaEn_2	365	371	PF01217	0.524
TRG_ENDOCYTIC_2	132	135	PF00928	0.494
TRG_ENDOCYTIC_2	184	187	PF00928	0.482
TRG_ENDOCYTIC_2	264	267	PF00928	0.507
TRG_ENDOCYTIC_2	322	325	PF00928	0.494
TRG_ENDOCYTIC_2	351	354	PF00928	0.597
TRG_ER_diArg_1	75	78	PF00400	0.489
TRG_ER_FFAT_1	252	263	PF00635	0.527
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK4	Leptomonas seymouri	79%	100%
A0A1X0NMG9	Trypanosomatidae	45%	92%
A0A3S7WQQ4	Leishmania donovani	97%	100%
A0A422N2F9	Trypanosoma rangeli	57%	100%
A4H5R5	Leishmania braziliensis	88%	100%
A4HU05	Leishmania infantum	97%	100%
D0A9H0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
O17606	Caenorhabditis elegans	44%	100%
P40093	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	100%
Q4QHU0	Leishmania major	92%	97%
Q55G91	Dictyostelium discoideum	40%	100%
Q58DG1	Bos taurus	43%	100%
Q641W2	Rattus norvegicus	42%	100%
Q9HB07	Homo sapiens	42%	100%
Q9JK81	Mus musculus	43%	100%
Q9P7T6	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
V5D8M5	Trypanosoma cruzi	56%	100%