DEAD/DEAH box helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD/DEAH box helicase-like protein

Species:

Leishmania mexicana

UniProt:

E9AMT4_LEIMU

TriTrypDb:

LmxM.09.0830

Length:

776

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMT4

PDB structure(s): 7am2_BW

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003724	RNA helicase activity	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0008186	ATP-dependent activity, acting on RNA	2	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	273	277	PF00656	0.433
CLV_NRD_NRD_1	149	151	PF00675	0.234
CLV_NRD_NRD_1	189	191	PF00675	0.259
CLV_NRD_NRD_1	226	228	PF00675	0.251
CLV_NRD_NRD_1	260	262	PF00675	0.221
CLV_NRD_NRD_1	318	320	PF00675	0.300
CLV_NRD_NRD_1	326	328	PF00675	0.330
CLV_NRD_NRD_1	356	358	PF00675	0.606
CLV_NRD_NRD_1	369	371	PF00675	0.478
CLV_NRD_NRD_1	392	394	PF00675	0.475
CLV_NRD_NRD_1	407	409	PF00675	0.398
CLV_NRD_NRD_1	499	501	PF00675	0.517
CLV_NRD_NRD_1	507	509	PF00675	0.294
CLV_NRD_NRD_1	544	546	PF00675	0.238
CLV_NRD_NRD_1	635	637	PF00675	0.571
CLV_NRD_NRD_1	665	667	PF00675	0.517
CLV_NRD_NRD_1	719	721	PF00675	0.393
CLV_NRD_NRD_1	725	727	PF00675	0.414
CLV_PCSK_FUR_1	187	191	PF00082	0.221
CLV_PCSK_FUR_1	258	262	PF00082	0.221
CLV_PCSK_KEX2_1	189	191	PF00082	0.258
CLV_PCSK_KEX2_1	228	230	PF00082	0.229
CLV_PCSK_KEX2_1	260	262	PF00082	0.221
CLV_PCSK_KEX2_1	296	298	PF00082	0.215
CLV_PCSK_KEX2_1	356	358	PF00082	0.606
CLV_PCSK_KEX2_1	407	409	PF00082	0.426
CLV_PCSK_KEX2_1	499	501	PF00082	0.428
CLV_PCSK_KEX2_1	507	509	PF00082	0.229
CLV_PCSK_KEX2_1	719	721	PF00082	0.402
CLV_PCSK_KEX2_1	725	727	PF00082	0.428
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.221
CLV_PCSK_PC1ET2_1	296	298	PF00082	0.226
CLV_PCSK_SKI1_1	105	109	PF00082	0.379
CLV_PCSK_SKI1_1	192	196	PF00082	0.222
CLV_PCSK_SKI1_1	22	26	PF00082	0.568
CLV_PCSK_SKI1_1	236	240	PF00082	0.248
CLV_PCSK_SKI1_1	251	255	PF00082	0.274
CLV_PCSK_SKI1_1	260	264	PF00082	0.258
CLV_PCSK_SKI1_1	500	504	PF00082	0.314
CLV_PCSK_SKI1_1	621	625	PF00082	0.362
CLV_PCSK_SKI1_1	63	67	PF00082	0.482
CLV_PCSK_SKI1_1	685	689	PF00082	0.375
CLV_PCSK_SKI1_1	736	740	PF00082	0.574
DEG_APCC_DBOX_1	472	480	PF00400	0.340
DOC_CKS1_1	119	124	PF01111	0.435
DOC_CKS1_1	133	138	PF01111	0.287
DOC_CKS1_1	439	444	PF01111	0.476
DOC_CYCLIN_RxL_1	255	266	PF00134	0.433
DOC_CYCLIN_RxL_1	565	575	PF00134	0.516
DOC_MAPK_gen_1	177	186	PF00069	0.455
DOC_MAPK_gen_1	187	196	PF00069	0.502
DOC_MAPK_gen_1	255	264	PF00069	0.439
DOC_MAPK_gen_1	370	377	PF00069	0.387
DOC_MAPK_gen_1	507	513	PF00069	0.520
DOC_MAPK_gen_1	598	608	PF00069	0.620
DOC_MAPK_gen_1	710	718	PF00069	0.379
DOC_MAPK_MEF2A_6	370	379	PF00069	0.481
DOC_MAPK_MEF2A_6	568	576	PF00069	0.421
DOC_MAPK_RevD_3	245	261	PF00069	0.421
DOC_PP1_RVXF_1	478	485	PF00149	0.358
DOC_PP1_RVXF_1	506	513	PF00149	0.473
DOC_PP2B_LxvP_1	195	198	PF13499	0.421
DOC_PP2B_LxvP_1	59	62	PF13499	0.499
DOC_PP4_FxxP_1	494	497	PF00568	0.455
DOC_PP4_FxxP_1	580	583	PF00568	0.421
DOC_PP4_FxxP_1	768	771	PF00568	0.501
DOC_USP7_MATH_1	2	6	PF00917	0.739
DOC_USP7_MATH_1	277	281	PF00917	0.446
DOC_USP7_MATH_1	418	422	PF00917	0.457
DOC_USP7_UBL2_3	621	625	PF12436	0.458
DOC_WW_Pin1_4	118	123	PF00397	0.467
DOC_WW_Pin1_4	132	137	PF00397	0.343
DOC_WW_Pin1_4	438	443	PF00397	0.495
DOC_WW_Pin1_4	759	764	PF00397	0.603
DOC_WW_Pin1_4	90	95	PF00397	0.403
DOC_WW_Pin1_4	97	102	PF00397	0.279
LIG_14-3-3_CanoR_1	150	155	PF00244	0.587
LIG_14-3-3_CanoR_1	327	332	PF00244	0.367
LIG_14-3-3_CanoR_1	41	49	PF00244	0.533
LIG_14-3-3_CanoR_1	453	462	PF00244	0.527
LIG_14-3-3_CanoR_1	473	477	PF00244	0.380
LIG_14-3-3_CanoR_1	499	503	PF00244	0.362
LIG_14-3-3_CanoR_1	658	664	PF00244	0.342
LIG_APCC_ABBA_1	570	575	PF00400	0.421
LIG_APCC_ABBAyCdc20_2	499	505	PF00400	0.337
LIG_APCC_ABBAyCdc20_2	545	551	PF00400	0.421
LIG_BIR_II_1	1	5	PF00653	0.725
LIG_BIR_III_3	1	5	PF00653	0.520
LIG_BRCT_BRCA1_1	220	224	PF00533	0.433
LIG_BRCT_BRCA1_1	527	531	PF00533	0.591
LIG_eIF4E_1	232	238	PF01652	0.415
LIG_FHA_1	107	113	PF00498	0.362
LIG_FHA_1	119	125	PF00498	0.338
LIG_FHA_1	197	203	PF00498	0.470
LIG_FHA_1	257	263	PF00498	0.502
LIG_FHA_1	306	312	PF00498	0.439
LIG_FHA_1	316	322	PF00498	0.466
LIG_FHA_1	426	432	PF00498	0.584
LIG_FHA_1	493	499	PF00498	0.375
LIG_FHA_1	517	523	PF00498	0.482
LIG_FHA_1	555	561	PF00498	0.446
LIG_FHA_1	56	62	PF00498	0.482
LIG_FHA_1	582	588	PF00498	0.449
LIG_FHA_1	648	654	PF00498	0.387
LIG_FHA_2	140	146	PF00498	0.433
LIG_FHA_2	239	245	PF00498	0.449
LIG_FHA_2	439	445	PF00498	0.500
LIG_GBD_Chelix_1	616	624	PF00786	0.410
LIG_LIR_Apic_2	164	170	PF02991	0.453
LIG_LIR_Apic_2	180	185	PF02991	0.453
LIG_LIR_Gen_1	113	123	PF02991	0.329
LIG_LIR_Gen_1	308	317	PF02991	0.446
LIG_LIR_Gen_1	360	369	PF02991	0.451
LIG_LIR_Gen_1	520	531	PF02991	0.402
LIG_LIR_Gen_1	547	553	PF02991	0.505
LIG_LIR_Gen_1	659	664	PF02991	0.364
LIG_LIR_Nem_3	266	272	PF02991	0.421
LIG_LIR_Nem_3	308	313	PF02991	0.450
LIG_LIR_Nem_3	360	365	PF02991	0.394
LIG_LIR_Nem_3	469	474	PF02991	0.495
LIG_LIR_Nem_3	520	526	PF02991	0.437
LIG_LIR_Nem_3	547	552	PF02991	0.505
LIG_LIR_Nem_3	659	663	PF02991	0.360
LIG_LIR_Nem_3	683	687	PF02991	0.367
LIG_NRBOX	233	239	PF00104	0.367
LIG_NRBOX	364	370	PF00104	0.341
LIG_PCNA_yPIPBox_3	141	151	PF02747	0.516
LIG_Pex14_1	684	688	PF04695	0.369
LIG_Pex14_2	300	304	PF04695	0.421
LIG_REV1ctd_RIR_1	510	518	PF16727	0.516
LIG_SH2_CRK	182	186	PF00017	0.453
LIG_SH2_GRB2like	172	175	PF00017	0.421
LIG_SH2_PTP2	310	313	PF00017	0.446
LIG_SH2_PTP2	660	663	PF00017	0.336
LIG_SH2_SRC	677	680	PF00017	0.379
LIG_SH2_STAP1	549	553	PF00017	0.511
LIG_SH2_STAT5	167	170	PF00017	0.433
LIG_SH2_STAT5	269	272	PF00017	0.427
LIG_SH2_STAT5	302	305	PF00017	0.449
LIG_SH2_STAT5	310	313	PF00017	0.449
LIG_SH2_STAT5	323	326	PF00017	0.302
LIG_SH2_STAT5	474	477	PF00017	0.360
LIG_SH2_STAT5	589	592	PF00017	0.453
LIG_SH2_STAT5	660	663	PF00017	0.336
LIG_SH2_STAT5	677	680	PF00017	0.363
LIG_SH3_3	130	136	PF00018	0.419
LIG_SH3_3	244	250	PF00018	0.545
LIG_SH3_3	372	378	PF00018	0.489
LIG_SH3_3	436	442	PF00018	0.552
LIG_SH3_3	487	493	PF00018	0.352
LIG_SH3_3	684	690	PF00018	0.502
LIG_SH3_3	760	766	PF00018	0.490
LIG_SH3_3	768	774	PF00018	0.475
LIG_SH3_5	462	466	PF00018	0.450
LIG_SUMO_SIM_anti_2	244	249	PF11976	0.420
LIG_SUMO_SIM_anti_2	659	665	PF11976	0.358
LIG_SUMO_SIM_par_1	428	436	PF11976	0.576
LIG_TRAF2_1	441	444	PF00917	0.564
LIG_TYR_ITIM	267	272	PF00017	0.248
LIG_TYR_ITSM	306	313	PF00017	0.283
LIG_UBA3_1	193	200	PF00899	0.287
LIG_UBA3_1	365	371	PF00899	0.367
MOD_CDC14_SPxK_1	93	96	PF00782	0.391
MOD_CDK_SPxK_1	90	96	PF00069	0.372
MOD_CK1_1	134	140	PF00069	0.459
MOD_CK1_1	16	22	PF00069	0.578
MOD_CK1_1	29	35	PF00069	0.633
MOD_CK1_1	448	454	PF00069	0.539
MOD_CK1_1	554	560	PF00069	0.248
MOD_CK1_1	593	599	PF00069	0.368
MOD_CK1_1	659	665	PF00069	0.357
MOD_CK2_1	139	145	PF00069	0.248
MOD_CK2_1	395	401	PF00069	0.442
MOD_CK2_1	438	444	PF00069	0.493
MOD_CK2_1	452	458	PF00069	0.569
MOD_CK2_1	72	78	PF00069	0.361
MOD_Cter_Amidation	325	328	PF01082	0.332
MOD_Cter_Amidation	505	508	PF01082	0.287
MOD_GlcNHglycan	38	41	PF01048	0.584
MOD_GlcNHglycan	395	398	PF01048	0.382
MOD_GlcNHglycan	420	423	PF01048	0.638
MOD_GlcNHglycan	450	453	PF01048	0.687
MOD_GlcNHglycan	454	457	PF01048	0.665
MOD_GlcNHglycan	527	530	PF01048	0.398
MOD_GlcNHglycan	553	556	PF01048	0.248
MOD_GlcNHglycan	592	595	PF01048	0.359
MOD_GlcNHglycan	617	620	PF01048	0.326
MOD_GlcNHglycan	771	774	PF01048	0.672
MOD_GSK3_1	16	23	PF00069	0.534
MOD_GSK3_1	214	221	PF00069	0.290
MOD_GSK3_1	223	230	PF00069	0.270
MOD_GSK3_1	232	239	PF00069	0.264
MOD_GSK3_1	3	10	PF00069	0.688
MOD_GSK3_1	311	318	PF00069	0.307
MOD_GSK3_1	32	39	PF00069	0.557
MOD_GSK3_1	327	334	PF00069	0.496
MOD_GSK3_1	43	50	PF00069	0.543
MOD_GSK3_1	448	455	PF00069	0.672
MOD_GSK3_1	68	75	PF00069	0.378
MOD_GSK3_1	88	95	PF00069	0.361
MOD_N-GLC_1	113	118	PF02516	0.267
MOD_N-GLC_1	680	685	PF02516	0.366
MOD_NEK2_1	131	136	PF00069	0.364
MOD_NEK2_1	20	25	PF00069	0.704
MOD_NEK2_1	238	243	PF00069	0.264
MOD_NEK2_1	256	261	PF00069	0.299
MOD_NEK2_1	278	283	PF00069	0.258
MOD_NEK2_1	395	400	PF00069	0.502
MOD_NEK2_1	531	536	PF00069	0.279
MOD_NEK2_1	590	595	PF00069	0.370
MOD_NEK2_1	624	629	PF00069	0.452
MOD_NEK2_1	656	661	PF00069	0.470
MOD_NEK2_1	673	678	PF00069	0.369
MOD_NEK2_1	72	77	PF00069	0.380
MOD_NEK2_2	734	739	PF00069	0.564
MOD_PIKK_1	305	311	PF00454	0.248
MOD_PIKK_1	47	53	PF00454	0.516
MOD_PIKK_1	70	76	PF00454	0.431
MOD_PKA_1	150	156	PF00069	0.266
MOD_PKA_1	227	233	PF00069	0.393
MOD_PKA_1	327	333	PF00069	0.362
MOD_PKA_1	393	399	PF00069	0.458
MOD_PKA_2	27	33	PF00069	0.704
MOD_PKA_2	452	458	PF00069	0.733
MOD_PKA_2	472	478	PF00069	0.559
MOD_PKA_2	498	504	PF00069	0.498
MOD_PKA_2	506	512	PF00069	0.390
MOD_PKA_2	665	671	PF00069	0.499
MOD_Plk_1	673	679	PF00069	0.396
MOD_Plk_1	680	686	PF00069	0.430
MOD_Plk_2-3	425	431	PF00069	0.588
MOD_Plk_4	150	156	PF00069	0.248
MOD_Plk_4	531	537	PF00069	0.256
MOD_Plk_4	659	665	PF00069	0.342
MOD_ProDKin_1	118	124	PF00069	0.460
MOD_ProDKin_1	132	138	PF00069	0.340
MOD_ProDKin_1	438	444	PF00069	0.497
MOD_ProDKin_1	759	765	PF00069	0.600
MOD_ProDKin_1	90	96	PF00069	0.399
MOD_ProDKin_1	97	103	PF00069	0.274
MOD_SUMO_rev_2	244	253	PF00179	0.248
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.203
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.344
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.355
TRG_ENDOCYTIC_2	172	175	PF00928	0.248
TRG_ENDOCYTIC_2	269	272	PF00928	0.248
TRG_ENDOCYTIC_2	310	313	PF00928	0.283
TRG_ENDOCYTIC_2	549	552	PF00928	0.381
TRG_ENDOCYTIC_2	660	663	PF00928	0.336
TRG_ER_diArg_1	189	192	PF00400	0.291
TRG_ER_diArg_1	257	260	PF00400	0.251
TRG_ER_diArg_1	348	351	PF00400	0.446
TRG_ER_diArg_1	355	357	PF00400	0.541
TRG_ER_diArg_1	406	408	PF00400	0.352
TRG_ER_diArg_1	478	481	PF00400	0.384
TRG_ER_diArg_1	498	500	PF00400	0.251
TRG_ER_diArg_1	718	720	PF00400	0.408
TRG_NLS_MonoExtC_3	226	231	PF00514	0.264
TRG_NLS_MonoExtN_4	227	232	PF00514	0.264
TRG_Pf-PMV_PEXEL_1	200	204	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	260	265	PF00026	0.264
TRG_Pf-PMV_PEXEL_1	327	331	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	480	485	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ75	Leptomonas seymouri	80%	95%
A0A1X0NMI3	Trypanosomatidae	61%	97%
A0A3S7WQS0	Leishmania donovani	96%	100%
A0A422N2G7	Trypanosoma rangeli	64%	100%
A4H5R4	Leishmania braziliensis	88%	100%
A4H7Y3	Leishmania braziliensis	23%	100%
A4HU04	Leishmania infantum	96%	100%
D0A9G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q4QHU1	Leishmania major	96%	100%
V5ASP0	Trypanosoma cruzi	64%	100%