AAA domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMT3_LEIMU

TriTrypDb:

LmxM.09.0820

Length:

530

Annotations

LeishMANIAdb annotations

Probably a secreted protein, similarly to its distant eukaryotic torsin homologs, involved in secretory processes. Also similar to bacterial ClpB ATPases, with chaperoning function.. Might be associated to known or unknown protein secretion pathways.. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 2
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMT3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMT3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016462	pyrophosphatase activity	5	10
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	10
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	10
GO:0016887	ATP hydrolysis activity	7	10
GO:0017076	purine nucleotide binding	4	10
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.300
CLV_C14_Caspase3-7	520	524	PF00656	0.607
CLV_NRD_NRD_1	115	117	PF00675	0.493
CLV_NRD_NRD_1	145	147	PF00675	0.341
CLV_NRD_NRD_1	447	449	PF00675	0.372
CLV_PCSK_KEX2_1	115	117	PF00082	0.446
CLV_PCSK_KEX2_1	145	147	PF00082	0.355
CLV_PCSK_KEX2_1	447	449	PF00082	0.372
CLV_PCSK_SKI1_1	486	490	PF00082	0.415
DEG_APCC_KENBOX_2	439	443	PF00400	0.396
DEG_SCF_FBW7_1	488	495	PF00400	0.506
DEG_SPOP_SBC_1	492	496	PF00917	0.498
DEG_SPOP_SBC_1	505	509	PF00917	0.502
DOC_CKS1_1	489	494	PF01111	0.499
DOC_CKS1_1	56	61	PF01111	0.414
DOC_MAPK_DCC_7	96	106	PF00069	0.532
DOC_MAPK_gen_1	129	138	PF00069	0.289
DOC_MAPK_gen_1	96	106	PF00069	0.584
DOC_MAPK_HePTP_8	126	138	PF00069	0.411
DOC_MAPK_MEF2A_6	129	138	PF00069	0.405
DOC_MAPK_MEF2A_6	152	159	PF00069	0.403
DOC_MAPK_MEF2A_6	469	478	PF00069	0.520
DOC_MAPK_MEF2A_6	99	108	PF00069	0.557
DOC_MAPK_RevD_3	134	147	PF00069	0.355
DOC_PP1_RVXF_1	473	479	PF00149	0.429
DOC_PP2B_LxvP_1	104	107	PF13499	0.516
DOC_USP7_MATH_1	26	30	PF00917	0.678
DOC_USP7_MATH_1	276	280	PF00917	0.570
DOC_USP7_MATH_1	292	296	PF00917	0.498
DOC_USP7_MATH_1	390	394	PF00917	0.372
DOC_USP7_MATH_1	42	46	PF00917	0.493
DOC_USP7_MATH_1	492	496	PF00917	0.568
DOC_USP7_MATH_1	505	509	PF00917	0.514
DOC_USP7_MATH_1	51	55	PF00917	0.330
DOC_USP7_UBL2_3	61	65	PF12436	0.463
DOC_WW_Pin1_4	325	330	PF00397	0.538
DOC_WW_Pin1_4	488	493	PF00397	0.483
DOC_WW_Pin1_4	499	504	PF00397	0.549
DOC_WW_Pin1_4	55	60	PF00397	0.469
LIG_14-3-3_CanoR_1	172	180	PF00244	0.276
LIG_14-3-3_CanoR_1	181	188	PF00244	0.276
LIG_14-3-3_CanoR_1	351	357	PF00244	0.541
LIG_14-3-3_CanoR_1	401	411	PF00244	0.475
LIG_APCC_ABBA_1	458	463	PF00400	0.463
LIG_FHA_1	168	174	PF00498	0.285
LIG_FHA_1	285	291	PF00498	0.625
LIG_FHA_1	80	86	PF00498	0.523
LIG_FHA_2	199	205	PF00498	0.300
LIG_FHA_2	235	241	PF00498	0.357
LIG_FHA_2	280	286	PF00498	0.643
LIG_FHA_2	359	365	PF00498	0.484
LIG_FHA_2	418	424	PF00498	0.418
LIG_Integrin_RGD_1	527	529	PF01839	0.528
LIG_LIR_Gen_1	370	379	PF02991	0.504
LIG_LIR_Gen_1	9	19	PF02991	0.573
LIG_LIR_Nem_3	201	206	PF02991	0.414
LIG_LIR_Nem_3	370	374	PF02991	0.450
LIG_LIR_Nem_3	383	389	PF02991	0.336
LIG_LIR_Nem_3	62	66	PF02991	0.428
LIG_LIR_Nem_3	9	15	PF02991	0.594
LIG_SH2_CRK	375	379	PF00017	0.417
LIG_SH2_SRC	73	76	PF00017	0.383
LIG_SH2_STAP1	382	386	PF00017	0.464
LIG_SH2_STAT5	382	385	PF00017	0.473
LIG_SH2_STAT5	66	69	PF00017	0.388
LIG_SH2_STAT5	73	76	PF00017	0.461
LIG_SH3_3	133	139	PF00018	0.410
LIG_SH3_3	148	154	PF00018	0.291
LIG_SH3_3	331	337	PF00018	0.584
LIG_SH3_3	384	390	PF00018	0.455
LIG_SH3_3	45	51	PF00018	0.423
LIG_Sin3_3	12	19	PF02671	0.568
LIG_SUMO_SIM_par_1	12	18	PF11976	0.463
LIG_SUMO_SIM_par_1	229	235	PF11976	0.276
LIG_SUMO_SIM_par_1	73	79	PF11976	0.395
LIG_UBA3_1	140	147	PF00899	0.455
MOD_CDK_SPxK_1	55	61	PF00069	0.477
MOD_CK1_1	242	248	PF00069	0.450
MOD_CK1_1	265	271	PF00069	0.621
MOD_CK1_1	279	285	PF00069	0.637
MOD_CK1_1	295	301	PF00069	0.523
MOD_CK1_1	31	37	PF00069	0.638
MOD_CK1_1	316	322	PF00069	0.566
MOD_CK1_1	328	334	PF00069	0.570
MOD_CK1_1	40	46	PF00069	0.558
MOD_CK1_1	402	408	PF00069	0.510
MOD_CK1_1	419	425	PF00069	0.463
MOD_CK1_1	495	501	PF00069	0.678
MOD_CK1_1	76	82	PF00069	0.581
MOD_CK2_1	204	210	PF00069	0.393
MOD_CK2_1	279	285	PF00069	0.536
MOD_CK2_1	356	362	PF00069	0.455
MOD_CK2_1	435	441	PF00069	0.609
MOD_CK2_1	504	510	PF00069	0.737
MOD_CK2_1	91	97	PF00069	0.624
MOD_GlcNHglycan	17	20	PF01048	0.706
MOD_GlcNHglycan	244	247	PF01048	0.375
MOD_GlcNHglycan	265	268	PF01048	0.609
MOD_GlcNHglycan	297	300	PF01048	0.649
MOD_GlcNHglycan	315	318	PF01048	0.520
MOD_GlcNHglycan	330	333	PF01048	0.586
MOD_GlcNHglycan	392	395	PF01048	0.412
MOD_GlcNHglycan	401	404	PF01048	0.386
MOD_GlcNHglycan	437	440	PF01048	0.442
MOD_GlcNHglycan	70	73	PF01048	0.489
MOD_GlcNHglycan	82	85	PF01048	0.577
MOD_GSK3_1	172	179	PF00069	0.276
MOD_GSK3_1	194	201	PF00069	0.386
MOD_GSK3_1	259	266	PF00069	0.639
MOD_GSK3_1	279	286	PF00069	0.677
MOD_GSK3_1	319	326	PF00069	0.656
MOD_GSK3_1	352	359	PF00069	0.448
MOD_GSK3_1	37	44	PF00069	0.565
MOD_GSK3_1	415	422	PF00069	0.470
MOD_GSK3_1	488	495	PF00069	0.609
MOD_GSK3_1	51	58	PF00069	0.380
MOD_GSK3_1	76	83	PF00069	0.589
MOD_NEK2_1	261	266	PF00069	0.520
MOD_NEK2_1	283	288	PF00069	0.632
MOD_NEK2_1	324	329	PF00069	0.756
MOD_NEK2_1	374	379	PF00069	0.421
MOD_NEK2_1	415	420	PF00069	0.457
MOD_NEK2_2	73	78	PF00069	0.542
MOD_PIKK_1	172	178	PF00454	0.372
MOD_PIKK_1	336	342	PF00454	0.498
MOD_PIKK_1	453	459	PF00454	0.459
MOD_PKA_2	262	268	PF00069	0.627
MOD_PKA_2	295	301	PF00069	0.694
MOD_Plk_1	234	240	PF00069	0.335
MOD_Plk_1	481	487	PF00069	0.446
MOD_Plk_2-3	204	210	PF00069	0.393
MOD_Plk_4	239	245	PF00069	0.416
MOD_Plk_4	374	380	PF00069	0.404
MOD_Plk_4	424	430	PF00069	0.348
MOD_ProDKin_1	325	331	PF00069	0.532
MOD_ProDKin_1	488	494	PF00069	0.493
MOD_ProDKin_1	499	505	PF00069	0.548
MOD_ProDKin_1	55	61	PF00069	0.471
TRG_DiLeu_BaEn_2	423	429	PF01217	0.408
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.438
TRG_ENDOCYTIC_2	375	378	PF00928	0.400
TRG_ENDOCYTIC_2	388	391	PF00928	0.389
TRG_ER_diArg_1	114	116	PF00400	0.361
TRG_ER_diArg_1	144	146	PF00400	0.385
TRG_ER_diArg_1	212	215	PF00400	0.300
TRG_ER_diArg_1	446	448	PF00400	0.372
TRG_ER_diArg_1	473	476	PF00400	0.514
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFB4	Leptomonas seymouri	63%	100%
A0A3Q8I8K7	Leishmania donovani	91%	100%
A0A3R7RCD3	Trypanosoma rangeli	38%	100%
A4H5R3	Leishmania braziliensis	79%	100%
A4HU03	Leishmania infantum	91%	100%
D0A9G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4QHU2	Leishmania major	90%	100%
V5B864	Trypanosoma cruzi	38%	100%