Cilia- and flagella-associated protein 299

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4464), putative

Species:

Leishmania mexicana

UniProt:

E9AMS9_LEIMU

TriTrypDb:

LmxM.09.0780

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

E9AMS9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.489
CLV_C14_Caspase3-7	53	57	PF00656	0.472
CLV_NRD_NRD_1	208	210	PF00675	0.195
CLV_NRD_NRD_1	246	248	PF00675	0.195
CLV_NRD_NRD_1	58	60	PF00675	0.288
CLV_NRD_NRD_1	91	93	PF00675	0.232
CLV_PCSK_KEX2_1	116	118	PF00082	0.195
CLV_PCSK_KEX2_1	169	171	PF00082	0.195
CLV_PCSK_KEX2_1	206	208	PF00082	0.195
CLV_PCSK_KEX2_1	246	248	PF00082	0.195
CLV_PCSK_KEX2_1	90	92	PF00082	0.222
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.226
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.226
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.195
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.272
CLV_PCSK_SKI1_1	125	129	PF00082	0.265
CLV_PCSK_SKI1_1	164	168	PF00082	0.208
CLV_PCSK_SKI1_1	28	32	PF00082	0.219
CLV_PCSK_SKI1_1	69	73	PF00082	0.208
CLV_Separin_Metazoa	119	123	PF03568	0.380
DOC_CYCLIN_RxL_1	161	171	PF00134	0.471
DOC_MAPK_gen_1	122	132	PF00069	0.395
DOC_MAPK_gen_1	204	214	PF00069	0.395
DOC_MAPK_MEF2A_6	233	240	PF00069	0.430
DOC_USP7_MATH_1	168	172	PF00917	0.453
DOC_USP7_MATH_2	221	227	PF00917	0.449
DOC_USP7_UBL2_3	161	165	PF12436	0.461
DOC_USP7_UBL2_3	206	210	PF12436	0.395
DOC_WW_Pin1_4	105	110	PF00397	0.451
DOC_WW_Pin1_4	185	190	PF00397	0.489
DOC_WW_Pin1_4	215	220	PF00397	0.401
DOC_WW_Pin1_4	4	9	PF00397	0.661
LIG_14-3-3_CanoR_1	15	19	PF00244	0.622
LIG_14-3-3_CanoR_1	150	159	PF00244	0.395
LIG_APCC_ABBAyCdc20_2	209	215	PF00400	0.489
LIG_BRCT_BRCA1_1	152	156	PF00533	0.457
LIG_BRCT_BRCA1_1	187	191	PF00533	0.395
LIG_Clathr_ClatBox_1	49	53	PF01394	0.489
LIG_FHA_1	121	127	PF00498	0.489
LIG_FHA_1	178	184	PF00498	0.395
LIG_FHA_1	188	194	PF00498	0.395
LIG_FHA_1	196	202	PF00498	0.395
LIG_FHA_1	84	90	PF00498	0.510
LIG_FHA_2	33	39	PF00498	0.471
LIG_FHA_2	43	49	PF00498	0.395
LIG_KLC1_Yacidic_2	48	53	PF13176	0.451
LIG_LIR_Apic_2	3	9	PF02991	0.403
LIG_LIR_Gen_1	188	199	PF02991	0.416
LIG_LIR_Gen_1	234	241	PF02991	0.348
LIG_LIR_Nem_3	142	147	PF02991	0.423
LIG_LIR_Nem_3	153	159	PF02991	0.423
LIG_LIR_Nem_3	188	194	PF02991	0.416
LIG_LIR_Nem_3	234	238	PF02991	0.348
LIG_LIR_Nem_3	32	36	PF02991	0.405
LIG_Pex14_2	156	160	PF04695	0.395
LIG_SH2_CRK	6	10	PF00017	0.404
LIG_SH2_GRB2like	175	178	PF00017	0.395
LIG_SH2_NCK_1	241	245	PF00017	0.399
LIG_SH2_NCK_1	6	10	PF00017	0.404
LIG_SH2_SRC	241	244	PF00017	0.395
LIG_SH2_STAP1	36	40	PF00017	0.423
LIG_SH2_STAT3	39	42	PF00017	0.395
LIG_SH2_STAT5	135	138	PF00017	0.451
LIG_SH2_STAT5	144	147	PF00017	0.419
LIG_SH2_STAT5	159	162	PF00017	0.394
LIG_SH2_STAT5	235	238	PF00017	0.408
LIG_SH2_STAT5	39	42	PF00017	0.395
LIG_SH2_STAT5	51	54	PF00017	0.395
LIG_SH2_STAT5	6	9	PF00017	0.436
LIG_SH3_3	213	219	PF00018	0.437
LIG_SH3_5	231	235	PF00018	0.449
LIG_SxIP_EBH_1	5	18	PF03271	0.413
LIG_TRAF2_1	137	140	PF00917	0.415
LIG_TYR_ITIM	239	244	PF00017	0.489
LIG_UBA3_1	110	116	PF00899	0.449
LIG_WW_3	12	16	PF00397	0.411
MOD_CK1_1	171	177	PF00069	0.451
MOD_CK1_1	187	193	PF00069	0.458
MOD_CK2_1	134	140	PF00069	0.415
MOD_CK2_1	217	223	PF00069	0.449
MOD_CK2_1	31	37	PF00069	0.420
MOD_CK2_1	70	76	PF00069	0.395
MOD_GlcNHglycan	136	139	PF01048	0.213
MOD_GlcNHglycan	140	144	PF01048	0.197
MOD_GlcNHglycan	93	96	PF01048	0.284
MOD_GlcNHglycan	99	102	PF01048	0.239
MOD_GSK3_1	4	11	PF00069	0.675
MOD_N-GLC_1	185	190	PF02516	0.195
MOD_N-GLC_1	223	228	PF02516	0.213
MOD_NEK2_1	120	125	PF00069	0.451
MOD_NEK2_1	184	189	PF00069	0.497
MOD_NEK2_1	194	199	PF00069	0.520
MOD_NEK2_1	31	36	PF00069	0.442
MOD_NEK2_1	83	88	PF00069	0.491
MOD_PKA_1	91	97	PF00069	0.474
MOD_PKA_2	14	20	PF00069	0.574
MOD_PKA_2	22	28	PF00069	0.475
MOD_PKA_2	91	97	PF00069	0.504
MOD_Plk_1	139	145	PF00069	0.408
MOD_Plk_1	171	177	PF00069	0.413
MOD_Plk_1	195	201	PF00069	0.438
MOD_Plk_1	31	37	PF00069	0.430
MOD_Plk_2-3	22	28	PF00069	0.523
MOD_Plk_2-3	32	38	PF00069	0.391
MOD_Plk_4	125	131	PF00069	0.404
MOD_Plk_4	171	177	PF00069	0.410
MOD_Plk_4	179	185	PF00069	0.434
MOD_ProDKin_1	105	111	PF00069	0.451
MOD_ProDKin_1	185	191	PF00069	0.489
MOD_ProDKin_1	215	221	PF00069	0.401
MOD_ProDKin_1	4	10	PF00069	0.664
MOD_SUMO_for_1	115	118	PF00179	0.426
MOD_SUMO_for_1	160	163	PF00179	0.399
MOD_SUMO_rev_2	157	167	PF00179	0.489
TRG_DiLeu_BaLyEn_6	106	111	PF01217	0.408
TRG_ENDOCYTIC_2	235	238	PF00928	0.383
TRG_ENDOCYTIC_2	241	244	PF00928	0.410
TRG_ER_diArg_1	149	152	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.211

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0T4	Leptomonas seymouri	88%	100%
A0A0S4IMY7	Bodo saltans	67%	100%
A0A1X0NN64	Trypanosomatidae	67%	100%
A0A3S5H6D9	Leishmania donovani	95%	95%
A0A422N781	Trypanosoma rangeli	71%	100%
A2AVJ0	Danio rerio	47%	100%
A4H5Q9	Leishmania braziliensis	91%	100%
A4HTZ9	Leishmania infantum	95%	95%
D0A9G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
Q2YDG2	Bos taurus	50%	100%
Q4QHU6	Leishmania major	94%	100%
Q5PQ44	Xenopus laevis	51%	100%
Q6V702	Homo sapiens	48%	100%
Q810M1	Mus musculus	49%	100%