Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligopeptidase b

Species:

Leishmania mexicana

UniProt:

E9AMS8_LEIMU

TriTrypDb:

LmxM.09.0770

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005829	cytosol	2	1

Expansion

Sequence features

E9AMS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS8

PDB structure(s): 2xe4_A

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0070012	oligopeptidase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.500
CLV_NRD_NRD_1	366	368	PF00675	0.276
CLV_NRD_NRD_1	462	464	PF00675	0.429
CLV_NRD_NRD_1	55	57	PF00675	0.304
CLV_PCSK_KEX2_1	366	368	PF00082	0.291
CLV_PCSK_KEX2_1	462	464	PF00082	0.398
CLV_PCSK_KEX2_1	546	548	PF00082	0.302
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.302
CLV_PCSK_SKI1_1	113	117	PF00082	0.307
CLV_PCSK_SKI1_1	311	315	PF00082	0.246
CLV_PCSK_SKI1_1	463	467	PF00082	0.434
CLV_PCSK_SKI1_1	542	546	PF00082	0.317
CLV_PCSK_SKI1_1	595	599	PF00082	0.373
CLV_PCSK_SKI1_1	719	723	PF00082	0.336
CLV_Separin_Metazoa	292	296	PF03568	0.507
DEG_APCC_DBOX_1	366	374	PF00400	0.476
DEG_APCC_DBOX_1	589	597	PF00400	0.341
DOC_CKS1_1	425	430	PF01111	0.465
DOC_CKS1_1	565	570	PF01111	0.331
DOC_MAPK_gen_1	128	137	PF00069	0.390
DOC_MAPK_gen_1	18	25	PF00069	0.552
DOC_MAPK_gen_1	719	729	PF00069	0.517
DOC_MAPK_MEF2A_6	647	656	PF00069	0.342
DOC_MAPK_MEF2A_6	722	729	PF00069	0.407
DOC_MAPK_NFAT4_5	722	730	PF00069	0.280
DOC_PP1_RVXF_1	20	26	PF00149	0.525
DOC_PP2B_LxvP_1	328	331	PF13499	0.485
DOC_PP2B_PxIxI_1	651	657	PF00149	0.395
DOC_PP4_MxPP_1	38	41	PF00568	0.465
DOC_USP7_MATH_1	355	359	PF00917	0.485
DOC_USP7_MATH_1	74	78	PF00917	0.424
DOC_USP7_UBL2_3	542	546	PF12436	0.302
DOC_USP7_UBL2_3	672	676	PF12436	0.302
DOC_WW_Pin1_4	424	429	PF00397	0.465
DOC_WW_Pin1_4	432	437	PF00397	0.465
DOC_WW_Pin1_4	564	569	PF00397	0.331
DOC_WW_Pin1_4	638	643	PF00397	0.327
LIG_14-3-3_CanoR_1	22	26	PF00244	0.573
LIG_14-3-3_CanoR_1	236	245	PF00244	0.446
LIG_14-3-3_CanoR_1	372	377	PF00244	0.476
LIG_14-3-3_CanoR_1	462	468	PF00244	0.441
LIG_14-3-3_CanoR_1	547	551	PF00244	0.302
LIG_APCC_ABBA_1	242	247	PF00400	0.465
LIG_APCC_ABBAyCdc20_2	83	89	PF00400	0.567
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	694	698	PF00533	0.302
LIG_Clathr_ClatBox_1	688	692	PF01394	0.302
LIG_CtBP_PxDLS_1	474	478	PF00389	0.313
LIG_deltaCOP1_diTrp_1	205	215	PF00928	0.468
LIG_deltaCOP1_diTrp_1	621	625	PF00928	0.339
LIG_FHA_1	110	116	PF00498	0.493
LIG_FHA_1	260	266	PF00498	0.470
LIG_FHA_1	272	278	PF00498	0.461
LIG_FHA_1	288	294	PF00498	0.515
LIG_FHA_1	308	314	PF00498	0.460
LIG_FHA_1	373	379	PF00498	0.482
LIG_FHA_1	400	406	PF00498	0.514
LIG_FHA_1	722	728	PF00498	0.408
LIG_FHA_1	86	92	PF00498	0.516
LIG_FHA_2	192	198	PF00498	0.614
LIG_FHA_2	200	206	PF00498	0.503
LIG_FHA_2	217	223	PF00498	0.441
LIG_FHA_2	315	321	PF00498	0.394
LIG_FHA_2	464	470	PF00498	0.430
LIG_FHA_2	547	553	PF00498	0.302
LIG_FHA_2	607	613	PF00498	0.302
LIG_FHA_2	616	622	PF00498	0.335
LIG_LIR_Apic_2	623	628	PF02991	0.331
LIG_LIR_Gen_1	336	343	PF02991	0.516
LIG_LIR_Gen_1	371	380	PF02991	0.507
LIG_LIR_Gen_1	421	428	PF02991	0.496
LIG_LIR_Gen_1	549	557	PF02991	0.302
LIG_LIR_LC3C_4	358	363	PF02991	0.555
LIG_LIR_Nem_3	119	123	PF02991	0.491
LIG_LIR_Nem_3	213	218	PF02991	0.446
LIG_LIR_Nem_3	24	28	PF02991	0.438
LIG_LIR_Nem_3	336	341	PF02991	0.491
LIG_LIR_Nem_3	358	363	PF02991	0.517
LIG_LIR_Nem_3	421	425	PF02991	0.501
LIG_LIR_Nem_3	430	434	PF02991	0.462
LIG_LIR_Nem_3	549	553	PF02991	0.302
LIG_LIR_Nem_3	630	636	PF02991	0.302
LIG_LIR_Nem_3	650	654	PF02991	0.295
LIG_LYPXL_yS_3	651	654	PF13949	0.302
LIG_NRP_CendR_1	730	731	PF00754	0.533
LIG_PTB_Apo_2	246	253	PF02174	0.567
LIG_SH2_CRK	123	127	PF00017	0.576
LIG_SH2_CRK	422	426	PF00017	0.567
LIG_SH2_SRC	103	106	PF00017	0.520
LIG_SH2_SRC	27	30	PF00017	0.591
LIG_SH2_SRC	413	416	PF00017	0.519
LIG_SH2_SRC	521	524	PF00017	0.275
LIG_SH2_SRC	537	540	PF00017	0.378
LIG_SH2_STAP1	111	115	PF00017	0.496
LIG_SH2_STAP1	181	185	PF00017	0.513
LIG_SH2_STAP1	303	307	PF00017	0.476
LIG_SH2_STAP1	422	426	PF00017	0.555
LIG_SH2_STAP1	634	638	PF00017	0.445
LIG_SH2_STAP1	87	91	PF00017	0.557
LIG_SH2_STAT3	303	306	PF00017	0.567
LIG_SH2_STAT5	103	106	PF00017	0.475
LIG_SH2_STAT5	111	114	PF00017	0.496
LIG_SH2_STAT5	123	126	PF00017	0.513
LIG_SH2_STAT5	217	220	PF00017	0.465
LIG_SH2_STAT5	27	30	PF00017	0.541
LIG_SH2_STAT5	360	363	PF00017	0.567
LIG_SH2_STAT5	48	51	PF00017	0.580
LIG_SH2_STAT5	514	517	PF00017	0.328
LIG_SH2_STAT5	521	524	PF00017	0.445
LIG_SH2_STAT5	543	546	PF00017	0.350
LIG_SH2_STAT5	71	74	PF00017	0.496
LIG_SH2_STAT5	87	90	PF00017	0.465
LIG_SH3_2	37	42	PF14604	0.489
LIG_SH3_3	158	164	PF00018	0.460
LIG_SH3_3	204	210	PF00018	0.516
LIG_SH3_3	290	296	PF00018	0.390
LIG_SH3_3	34	40	PF00018	0.518
LIG_SH3_3	381	387	PF00018	0.390
LIG_SH3_3	610	616	PF00018	0.312
LIG_SH3_3	8	14	PF00018	0.425
LIG_SUMO_SIM_anti_2	290	295	PF11976	0.571
LIG_SUMO_SIM_par_1	312	317	PF11976	0.466
LIG_TRAF2_1	136	139	PF00917	0.597
LIG_UBA3_1	313	319	PF00899	0.215
LIG_WW_3	39	43	PF00397	0.317
MOD_CK1_1	269	275	PF00069	0.330
MOD_CK1_1	3	9	PF00069	0.727
MOD_CK1_1	336	342	PF00069	0.381
MOD_CK1_1	424	430	PF00069	0.318
MOD_CK1_1	77	83	PF00069	0.350
MOD_CK2_1	173	179	PF00069	0.336
MOD_CK2_1	199	205	PF00069	0.445
MOD_CK2_1	216	222	PF00069	0.445
MOD_CK2_1	615	621	PF00069	0.315
MOD_CMANNOS	622	625	PF00535	0.341
MOD_Cter_Amidation	364	367	PF01082	0.317
MOD_GlcNHglycan	174	178	PF01048	0.361
MOD_GlcNHglycan	199	202	PF01048	0.420
MOD_GlcNHglycan	2	5	PF01048	0.759
MOD_GlcNHglycan	576	579	PF01048	0.302
MOD_GlcNHglycan	694	697	PF01048	0.302
MOD_GlcNHglycan	698	701	PF01048	0.302
MOD_GlcNHglycan	709	712	PF01048	0.302
MOD_GlcNHglycan	96	102	PF01048	0.324
MOD_GSK3_1	169	176	PF00069	0.339
MOD_GSK3_1	191	198	PF00069	0.427
MOD_GSK3_1	216	223	PF00069	0.406
MOD_GSK3_1	268	275	PF00069	0.304
MOD_GSK3_1	3	10	PF00069	0.729
MOD_GSK3_1	368	375	PF00069	0.317
MOD_GSK3_1	420	427	PF00069	0.339
MOD_GSK3_1	495	502	PF00069	0.512
MOD_GSK3_1	542	549	PF00069	0.320
MOD_GSK3_1	611	618	PF00069	0.313
MOD_GSK3_1	692	699	PF00069	0.310
MOD_GSK3_1	73	80	PF00069	0.387
MOD_GSK3_1	85	92	PF00069	0.447
MOD_LATS_1	525	531	PF00433	0.445
MOD_N-GLC_1	432	437	PF02516	0.364
MOD_NEK2_1	307	312	PF00069	0.361
MOD_NEK2_1	314	319	PF00069	0.311
MOD_NEK2_1	361	366	PF00069	0.453
MOD_NEK2_1	405	410	PF00069	0.383
MOD_NEK2_1	420	425	PF00069	0.370
MOD_NEK2_1	483	488	PF00069	0.436
MOD_NEK2_1	721	726	PF00069	0.504
MOD_NEK2_2	399	404	PF00069	0.427
MOD_PIKK_1	266	272	PF00454	0.378
MOD_PIKK_1	405	411	PF00454	0.359
MOD_PIKK_1	483	489	PF00454	0.577
MOD_PIKK_1	566	572	PF00454	0.420
MOD_PIKK_1	77	83	PF00454	0.196
MOD_PKA_1	546	552	PF00069	0.302
MOD_PKA_2	21	27	PF00069	0.583
MOD_PKA_2	546	552	PF00069	0.302
MOD_Plk_1	210	216	PF00069	0.361
MOD_Plk_1	220	226	PF00069	0.378
MOD_Plk_1	336	342	PF00069	0.479
MOD_Plk_1	413	419	PF00069	0.402
MOD_Plk_1	420	426	PF00069	0.418
MOD_Plk_1	77	83	PF00069	0.196
MOD_Plk_4	211	217	PF00069	0.375
MOD_Plk_4	427	433	PF00069	0.321
MOD_Plk_4	473	479	PF00069	0.374
MOD_ProDKin_1	424	430	PF00069	0.302
MOD_ProDKin_1	432	438	PF00069	0.302
MOD_ProDKin_1	564	570	PF00069	0.331
MOD_ProDKin_1	638	644	PF00069	0.327
MOD_SUMO_for_1	65	68	PF00179	0.205
MOD_SUMO_rev_2	143	153	PF00179	0.335
MOD_SUMO_rev_2	179	188	PF00179	0.445
MOD_SUMO_rev_2	221	229	PF00179	0.317
MOD_SUMO_rev_2	53	59	PF00179	0.379
MOD_SUMO_rev_2	558	566	PF00179	0.306
MOD_SUMO_rev_2	675	682	PF00179	0.338
TRG_DiLeu_BaLyEn_6	723	728	PF01217	0.502
TRG_ENDOCYTIC_2	123	126	PF00928	0.451
TRG_ENDOCYTIC_2	360	363	PF00928	0.415
TRG_ENDOCYTIC_2	422	425	PF00928	0.302
TRG_ENDOCYTIC_2	48	51	PF00928	0.445
TRG_ENDOCYTIC_2	634	637	PF00928	0.313
TRG_ENDOCYTIC_2	640	643	PF00928	0.318
TRG_ENDOCYTIC_2	651	654	PF00928	0.302
TRG_ER_diArg_1	294	297	PF00400	0.274
TRG_ER_diArg_1	462	464	PF00400	0.432
TRG_ER_diArg_1	729	731	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	80%	100%
A0A0S4JND1	Bodo saltans	56%	98%
A0A1X0NKN5	Trypanosomatidae	22%	80%
A0A1X0NMH6	Trypanosomatidae	65%	100%
A0A3Q8IGZ3	Leishmania donovani	91%	100%
A0A3S5H5P5	Leishmania donovani	24%	81%
A0A422N761	Trypanosoma rangeli	66%	100%
A4H4J9	Leishmania braziliensis	24%	100%
A4H5Q8	Leishmania braziliensis	84%	100%
A4HSS5	Leishmania infantum	23%	81%
A4HTZ8	Leishmania infantum	91%	100%
A5LFV8	Macaca fascicularis	24%	100%
C9ZTC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	81%
D0A9G2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	100%
E2JFG1	Amanita bisporigera	22%	96%
E2JFG2	Amanita bisporigera	23%	100%
E9AKR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	81%
H2E7Q7	Galerina marginata (strain CBS 339.88)	22%	99%
H2E7Q8	Galerina marginata (strain CBS 339.88)	23%	100%
O07834	Pseudoxanthomonas mexicana	38%	100%
O70196	Rattus norvegicus	25%	100%
P23687	Sus scrofa	25%	100%
P24555	Escherichia coli (strain K12)	36%	100%
P27028	Elizabethkingia meningoseptica	28%	100%
P27195	Elizabethkingia miricola	27%	100%
P48147	Homo sapiens	24%	100%
P55627	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	28%	97%
P55656	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	27%	100%
Q06903	Aeromonas hydrophila	26%	100%
Q32N48	Xenopus laevis	27%	100%
Q4QHU7	Leishmania major	90%	100%
Q4QJ45	Leishmania major	23%	100%
Q59536	Moraxella lacunata	38%	100%
Q9QUR6	Mus musculus	25%	100%
Q9XTA2	Bos taurus	24%	100%
V5B860	Trypanosoma cruzi	64%	100%