Putative acyl-CoA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyl-CoA binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMS6_LEIMU

TriTrypDb:

LmxM.09.0750

Length:

999

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS6

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0000062	fatty-acyl-CoA binding	4	9
GO:0000166	nucleotide binding	3	9
GO:0005488	binding	1	9
GO:0008289	lipid binding	2	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0033218	amide binding	2	9
GO:0036094	small molecule binding	2	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0120227	acyl-CoA binding	3	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:1901567	fatty acid derivative binding	3	9
GO:1901681	sulfur compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.730
CLV_C14_Caspase3-7	174	178	PF00656	0.737
CLV_C14_Caspase3-7	681	685	PF00656	0.684
CLV_C14_Caspase3-7	735	739	PF00656	0.738
CLV_C14_Caspase3-7	976	980	PF00656	0.536
CLV_NRD_NRD_1	19	21	PF00675	0.473
CLV_NRD_NRD_1	320	322	PF00675	0.485
CLV_NRD_NRD_1	525	527	PF00675	0.721
CLV_NRD_NRD_1	701	703	PF00675	0.529
CLV_NRD_NRD_1	879	881	PF00675	0.537
CLV_NRD_NRD_1	994	996	PF00675	0.376
CLV_NRD_NRD_1	997	999	PF00675	0.437
CLV_PCSK_KEX2_1	319	321	PF00082	0.487
CLV_PCSK_KEX2_1	524	526	PF00082	0.738
CLV_PCSK_KEX2_1	701	703	PF00082	0.515
CLV_PCSK_KEX2_1	879	881	PF00082	0.537
CLV_PCSK_KEX2_1	981	983	PF00082	0.297
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.503
CLV_PCSK_PC1ET2_1	981	983	PF00082	0.336
CLV_PCSK_SKI1_1	301	305	PF00082	0.430
CLV_PCSK_SKI1_1	308	312	PF00082	0.402
CLV_PCSK_SKI1_1	702	706	PF00082	0.572
CLV_PCSK_SKI1_1	83	87	PF00082	0.447
CLV_PCSK_SKI1_1	879	883	PF00082	0.523
CLV_PCSK_SKI1_1	943	947	PF00082	0.279
DEG_APCC_DBOX_1	300	308	PF00400	0.649
DEG_APCC_DBOX_1	82	90	PF00400	0.640
DEG_COP1_1	182	190	PF00400	0.599
DEG_SPOP_SBC_1	243	247	PF00917	0.741
DEG_SPOP_SBC_1	748	752	PF00917	0.680
DOC_CKS1_1	230	235	PF01111	0.739
DOC_CYCLIN_RxL_1	305	313	PF00134	0.664
DOC_CYCLIN_RxL_1	654	664	PF00134	0.689
DOC_CYCLIN_RxL_1	877	887	PF00134	0.627
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.489
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.647
DOC_MAPK_gen_1	524	531	PF00069	0.518
DOC_MAPK_gen_1	701	712	PF00069	0.724
DOC_MAPK_MEF2A_6	502	510	PF00069	0.483
DOC_MAPK_MEF2A_6	596	605	PF00069	0.317
DOC_MAPK_MEF2A_6	83	91	PF00069	0.562
DOC_MAPK_MEF2A_6	929	938	PF00069	0.546
DOC_MAPK_RevD_3	305	320	PF00069	0.551
DOC_PP1_RVXF_1	500	506	PF00149	0.436
DOC_PP1_RVXF_1	700	707	PF00149	0.610
DOC_PP1_RVXF_1	933	939	PF00149	0.536
DOC_PP4_FxxP_1	592	595	PF00568	0.508
DOC_USP7_MATH_1	176	180	PF00917	0.741
DOC_USP7_MATH_1	243	247	PF00917	0.791
DOC_USP7_MATH_1	471	475	PF00917	0.558
DOC_USP7_MATH_1	743	747	PF00917	0.787
DOC_USP7_MATH_1	754	758	PF00917	0.689
DOC_USP7_MATH_1	897	901	PF00917	0.799
DOC_USP7_MATH_1	908	912	PF00917	0.635
DOC_WW_Pin1_4	146	151	PF00397	0.711
DOC_WW_Pin1_4	161	166	PF00397	0.777
DOC_WW_Pin1_4	190	195	PF00397	0.777
DOC_WW_Pin1_4	229	234	PF00397	0.746
DOC_WW_Pin1_4	235	240	PF00397	0.770
DOC_WW_Pin1_4	244	249	PF00397	0.634
DOC_WW_Pin1_4	345	350	PF00397	0.759
DOC_WW_Pin1_4	440	445	PF00397	0.577
DOC_WW_Pin1_4	452	457	PF00397	0.455
DOC_WW_Pin1_4	591	596	PF00397	0.503
DOC_WW_Pin1_4	638	643	PF00397	0.680
DOC_WW_Pin1_4	749	754	PF00397	0.765
DOC_WW_Pin1_4	783	788	PF00397	0.724
DOC_WW_Pin1_4	822	827	PF00397	0.764
LIG_14-3-3_CanoR_1	151	156	PF00244	0.726
LIG_14-3-3_CanoR_1	217	225	PF00244	0.735
LIG_14-3-3_CanoR_1	321	331	PF00244	0.739
LIG_14-3-3_CanoR_1	410	415	PF00244	0.754
LIG_14-3-3_CanoR_1	481	487	PF00244	0.441
LIG_14-3-3_CanoR_1	502	506	PF00244	0.407
LIG_14-3-3_CanoR_1	536	540	PF00244	0.470
LIG_14-3-3_CanoR_1	650	658	PF00244	0.696
LIG_14-3-3_CanoR_1	838	846	PF00244	0.622
LIG_14-3-3_CanoR_1	859	863	PF00244	0.778
LIG_14-3-3_CanoR_1	982	992	PF00244	0.580
LIG_BIR_III_4	177	181	PF00653	0.759
LIG_BRCT_BRCA1_1	598	602	PF00533	0.405
LIG_deltaCOP1_diTrp_1	784	792	PF00928	0.721
LIG_EVH1_1	486	490	PF00568	0.527
LIG_EVH1_2	487	491	PF00568	0.526
LIG_FHA_1	182	188	PF00498	0.752
LIG_FHA_1	326	332	PF00498	0.797
LIG_FHA_1	346	352	PF00498	0.725
LIG_FHA_1	38	44	PF00498	0.543
LIG_FHA_1	566	572	PF00498	0.389
LIG_FHA_1	774	780	PF00498	0.541
LIG_FHA_1	852	858	PF00498	0.634
LIG_FHA_2	100	106	PF00498	0.675
LIG_FHA_2	379	385	PF00498	0.718
LIG_FHA_2	651	657	PF00498	0.697
LIG_FHA_2	728	734	PF00498	0.655
LIG_FHA_2	758	764	PF00498	0.740
LIG_FHA_2	868	874	PF00498	0.725
LIG_FHA_2	944	950	PF00498	0.470
LIG_HCF-1_HBM_1	27	30	PF13415	0.490
LIG_HCF-1_HBM_1	79	82	PF13415	0.612
LIG_LIR_Gen_1	14	22	PF02991	0.680
LIG_LIR_Gen_1	27	38	PF02991	0.647
LIG_LIR_Gen_1	504	512	PF02991	0.326
LIG_LIR_Gen_1	578	584	PF02991	0.416
LIG_LIR_Gen_1	599	610	PF02991	0.402
LIG_LIR_Gen_1	687	696	PF02991	0.604
LIG_LIR_Gen_1	773	782	PF02991	0.546
LIG_LIR_Gen_1	861	868	PF02991	0.563
LIG_LIR_Gen_1	967	977	PF02991	0.470
LIG_LIR_Nem_3	111	116	PF02991	0.571
LIG_LIR_Nem_3	14	19	PF02991	0.689
LIG_LIR_Nem_3	27	33	PF02991	0.632
LIG_LIR_Nem_3	40	44	PF02991	0.595
LIG_LIR_Nem_3	402	408	PF02991	0.694
LIG_LIR_Nem_3	504	508	PF02991	0.327
LIG_LIR_Nem_3	578	583	PF02991	0.460
LIG_LIR_Nem_3	588	592	PF02991	0.445
LIG_LIR_Nem_3	599	605	PF02991	0.398
LIG_LIR_Nem_3	656	661	PF02991	0.643
LIG_LIR_Nem_3	664	670	PF02991	0.655
LIG_LIR_Nem_3	687	693	PF02991	0.737
LIG_LIR_Nem_3	711	717	PF02991	0.617
LIG_LIR_Nem_3	773	778	PF02991	0.547
LIG_LIR_Nem_3	79	85	PF02991	0.605
LIG_LIR_Nem_3	861	865	PF02991	0.561
LIG_LIR_Nem_3	967	972	PF02991	0.470
LIG_MYND_2	373	377	PF01753	0.676
LIG_Pex14_2	401	405	PF04695	0.655
LIG_Pex14_2	505	509	PF04695	0.435
LIG_Pex14_2	598	602	PF04695	0.405
LIG_Pex14_2	658	662	PF04695	0.639
LIG_Pex14_2	938	942	PF04695	0.552
LIG_SH2_CRK	30	34	PF00017	0.651
LIG_SH2_CRK	667	671	PF00017	0.578
LIG_SH2_CRK	82	86	PF00017	0.573
LIG_SH2_NCK_1	862	866	PF00017	0.563
LIG_SH2_PTP2	715	718	PF00017	0.559
LIG_SH2_STAT5	298	301	PF00017	0.678
LIG_SH2_STAT5	30	33	PF00017	0.644
LIG_SH2_STAT5	362	365	PF00017	0.698
LIG_SH2_STAT5	57	60	PF00017	0.609
LIG_SH2_STAT5	580	583	PF00017	0.472
LIG_SH2_STAT5	589	592	PF00017	0.458
LIG_SH2_STAT5	646	649	PF00017	0.650
LIG_SH2_STAT5	715	718	PF00017	0.607
LIG_SH2_STAT5	984	987	PF00017	0.470
LIG_SH3_1	227	233	PF00018	0.710
LIG_SH3_2	230	235	PF14604	0.715
LIG_SH3_3	227	233	PF00018	0.822
LIG_SH3_3	346	352	PF00018	0.691
LIG_SH3_3	367	373	PF00018	0.710
LIG_SH3_3	484	490	PF00018	0.538
LIG_SH3_3	613	619	PF00018	0.627
LIG_SH3_3	634	640	PF00018	0.662
LIG_SH3_3	750	756	PF00018	0.672
LIG_SH3_3	821	827	PF00018	0.741
LIG_SUMO_SIM_anti_2	390	395	PF11976	0.655
LIG_SUMO_SIM_anti_2	708	714	PF11976	0.682
LIG_SUMO_SIM_anti_2	88	94	PF11976	0.637
LIG_SUMO_SIM_par_1	373	378	PF11976	0.676
LIG_SUMO_SIM_par_1	563	568	PF11976	0.357
LIG_SUMO_SIM_par_1	85	90	PF11976	0.614
LIG_TRAF2_1	342	345	PF00917	0.607
LIG_TRAF2_1	515	518	PF00917	0.465
LIG_TRAF2_1	724	727	PF00917	0.705
LIG_TRAF2_1	802	805	PF00917	0.757
LIG_TRAF2_1	870	873	PF00917	0.643
LIG_TYR_ITIM	712	717	PF00017	0.673
LIG_TYR_ITIM	860	865	PF00017	0.561
LIG_UBA3_1	310	319	PF00899	0.516
LIG_UBA3_1	564	569	PF00899	0.479
LIG_UBA3_1	621	628	PF00899	0.678
LIG_UBA3_1	990	999	PF00899	0.636
MOD_CDC14_SPxK_1	641	644	PF00782	0.701
MOD_CDK_SPK_2	146	151	PF00069	0.559
MOD_CDK_SPK_2	244	249	PF00069	0.610
MOD_CDK_SPK_2	591	596	PF00069	0.473
MOD_CDK_SPxK_1	229	235	PF00069	0.814
MOD_CDK_SPxK_1	638	644	PF00069	0.707
MOD_CDK_SPxK_1	783	789	PF00069	0.712
MOD_CK1_1	14	20	PF00069	0.664
MOD_CK1_1	186	192	PF00069	0.624
MOD_CK1_1	228	234	PF00069	0.704
MOD_CK1_1	262	268	PF00069	0.676
MOD_CK1_1	364	370	PF00069	0.678
MOD_CK1_1	439	445	PF00069	0.543
MOD_CK1_1	454	460	PF00069	0.569
MOD_CK1_1	466	472	PF00069	0.565
MOD_CK1_1	480	486	PF00069	0.459
MOD_CK1_1	519	525	PF00069	0.489
MOD_CK1_1	757	763	PF00069	0.682
MOD_CK1_1	773	779	PF00069	0.668
MOD_CK1_1	793	799	PF00069	0.736
MOD_CK2_1	650	656	PF00069	0.663
MOD_CK2_1	705	711	PF00069	0.627
MOD_CK2_1	727	733	PF00069	0.716
MOD_CK2_1	757	763	PF00069	0.748
MOD_CK2_1	810	816	PF00069	0.830
MOD_CK2_1	867	873	PF00069	0.724
MOD_CK2_1	885	891	PF00069	0.652
MOD_CMANNOS	966	969	PF00535	0.270
MOD_Cter_Amidation	522	525	PF01082	0.741
MOD_DYRK1A_RPxSP_1	229	233	PF00069	0.728
MOD_GlcNHglycan	177	181	PF01048	0.539
MOD_GlcNHglycan	252	255	PF01048	0.585
MOD_GlcNHglycan	353	356	PF01048	0.465
MOD_GlcNHglycan	447	450	PF01048	0.764
MOD_GlcNHglycan	45	49	PF01048	0.462
MOD_GlcNHglycan	464	468	PF01048	0.801
MOD_GlcNHglycan	517	522	PF01048	0.693
MOD_GlcNHglycan	560	563	PF01048	0.640
MOD_GlcNHglycan	598	601	PF01048	0.370
MOD_GlcNHglycan	607	610	PF01048	0.393
MOD_GlcNHglycan	697	700	PF01048	0.522
MOD_GlcNHglycan	745	748	PF01048	0.610
MOD_GlcNHglycan	756	759	PF01048	0.466
MOD_GlcNHglycan	812	815	PF01048	0.647
MOD_GlcNHglycan	899	902	PF01048	0.579
MOD_GlcNHglycan	917	920	PF01048	0.343
MOD_GSK3_1	186	193	PF00069	0.660
MOD_GSK3_1	225	232	PF00069	0.744
MOD_GSK3_1	325	332	PF00069	0.746
MOD_GSK3_1	336	343	PF00069	0.759
MOD_GSK3_1	436	443	PF00069	0.539
MOD_GSK3_1	447	454	PF00069	0.622
MOD_GSK3_1	466	473	PF00069	0.516
MOD_GSK3_1	554	561	PF00069	0.459
MOD_GSK3_1	565	572	PF00069	0.365
MOD_GSK3_1	601	608	PF00069	0.405
MOD_GSK3_1	638	645	PF00069	0.680
MOD_GSK3_1	743	750	PF00069	0.784
MOD_GSK3_1	788	795	PF00069	0.810
MOD_GSK3_1	885	892	PF00069	0.723
MOD_LATS_1	836	842	PF00433	0.620
MOD_N-GLC_1	437	442	PF02516	0.728
MOD_N-GLC_1	850	855	PF02516	0.534
MOD_N-GLC_1	884	889	PF02516	0.471
MOD_NEK2_1	120	125	PF00069	0.659
MOD_NEK2_1	220	225	PF00069	0.779
MOD_NEK2_1	272	277	PF00069	0.664
MOD_NEK2_1	310	315	PF00069	0.644
MOD_NEK2_1	44	49	PF00069	0.622
MOD_NEK2_1	447	452	PF00069	0.520
MOD_NEK2_1	470	475	PF00069	0.607
MOD_NEK2_1	491	496	PF00069	0.471
MOD_NEK2_1	545	550	PF00069	0.510
MOD_NEK2_1	555	560	PF00069	0.452
MOD_NEK2_1	590	595	PF00069	0.530
MOD_NEK2_1	601	606	PF00069	0.359
MOD_NEK2_1	778	783	PF00069	0.746
MOD_NEK2_1	792	797	PF00069	0.709
MOD_NEK2_1	828	833	PF00069	0.847
MOD_NEK2_1	923	928	PF00069	0.540
MOD_NEK2_1	994	999	PF00069	0.653
MOD_PIKK_1	340	346	PF00454	0.623
MOD_PIKK_1	796	802	PF00454	0.778
MOD_PIKK_1	99	105	PF00454	0.694
MOD_PKA_1	20	26	PF00069	0.690
MOD_PKA_2	218	224	PF00069	0.728
MOD_PKA_2	228	234	PF00069	0.729
MOD_PKA_2	480	486	PF00069	0.502
MOD_PKA_2	501	507	PF00069	0.403
MOD_PKA_2	535	541	PF00069	0.504
MOD_PKA_2	649	655	PF00069	0.689
MOD_PKA_2	788	794	PF00069	0.744
MOD_PKA_2	858	864	PF00069	0.695
MOD_PKB_1	217	225	PF00069	0.730
MOD_Plk_1	14	20	PF00069	0.682
MOD_Plk_1	437	443	PF00069	0.530
MOD_Plk_1	555	561	PF00069	0.544
MOD_Plk_1	573	579	PF00069	0.369
MOD_Plk_1	87	93	PF00069	0.629
MOD_Plk_2-3	378	384	PF00069	0.701
MOD_Plk_2-3	727	733	PF00069	0.651
MOD_Plk_2-3	844	850	PF00069	0.700
MOD_Plk_4	310	316	PF00069	0.651
MOD_Plk_4	364	370	PF00069	0.722
MOD_Plk_4	378	384	PF00069	0.627
MOD_Plk_4	410	416	PF00069	0.734
MOD_Plk_4	454	460	PF00069	0.494
MOD_Plk_4	501	507	PF00069	0.385
MOD_Plk_4	535	541	PF00069	0.520
MOD_Plk_4	555	561	PF00069	0.437
MOD_Plk_4	585	591	PF00069	0.421
MOD_Plk_4	601	607	PF00069	0.316
MOD_Plk_4	628	634	PF00069	0.689
MOD_Plk_4	770	776	PF00069	0.528
MOD_Plk_4	87	93	PF00069	0.567
MOD_ProDKin_1	146	152	PF00069	0.714
MOD_ProDKin_1	161	167	PF00069	0.779
MOD_ProDKin_1	190	196	PF00069	0.773
MOD_ProDKin_1	229	235	PF00069	0.748
MOD_ProDKin_1	244	250	PF00069	0.775
MOD_ProDKin_1	345	351	PF00069	0.754
MOD_ProDKin_1	440	446	PF00069	0.577
MOD_ProDKin_1	452	458	PF00069	0.456
MOD_ProDKin_1	591	597	PF00069	0.503
MOD_ProDKin_1	638	644	PF00069	0.680
MOD_ProDKin_1	749	755	PF00069	0.766
MOD_ProDKin_1	783	789	PF00069	0.728
MOD_ProDKin_1	822	828	PF00069	0.766
MOD_SUMO_rev_2	930	936	PF00179	0.499
MOD_SUMO_rev_2	976	983	PF00179	0.536
MOD_SUMO_rev_2	986	991	PF00179	0.597
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.624
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.704
TRG_ENDOCYTIC_2	30	33	PF00928	0.644
TRG_ENDOCYTIC_2	580	583	PF00928	0.476
TRG_ENDOCYTIC_2	589	592	PF00928	0.450
TRG_ENDOCYTIC_2	667	670	PF00928	0.574
TRG_ENDOCYTIC_2	714	717	PF00928	0.613
TRG_ENDOCYTIC_2	82	85	PF00928	0.573
TRG_ENDOCYTIC_2	862	865	PF00928	0.653
TRG_ENDOCYTIC_2	939	942	PF00928	0.600
TRG_ENDOCYTIC_2	988	991	PF00928	0.563
TRG_ER_diArg_1	217	220	PF00400	0.769
TRG_ER_diArg_1	524	526	PF00400	0.540
TRG_ER_diArg_1	701	703	PF00400	0.746
TRG_ER_diArg_1	706	709	PF00400	0.684
TRG_ER_diArg_1	878	880	PF00400	0.735
TRG_NLS_Bipartite_1	981	999	PF00514	0.602
TRG_NLS_MonoExtC_3	994	999	PF00514	0.638
TRG_Pf-PMV_PEXEL_1	151	155	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	308	312	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	543	547	PF00026	0.711
TRG_Pf-PMV_PEXEL_1	659	664	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.273

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G9	Leptomonas seymouri	54%	100%
A0A3S7WQP7	Leishmania donovani	89%	100%
A0A422N766	Trypanosoma rangeli	29%	100%
A4H5Q6	Leishmania braziliensis	72%	100%
A4HTZ6	Leishmania infantum	89%	100%
D0A9G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4QHU9	Leishmania major	88%	100%