Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMS4_LEIMU

TriTrypDb:

LmxM.09.0730

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	277	283	PF00089	0.578
CLV_NRD_NRD_1	114	116	PF00675	0.522
CLV_NRD_NRD_1	180	182	PF00675	0.643
CLV_NRD_NRD_1	186	188	PF00675	0.637
CLV_NRD_NRD_1	204	206	PF00675	0.424
CLV_NRD_NRD_1	33	35	PF00675	0.660
CLV_NRD_NRD_1	506	508	PF00675	0.569
CLV_NRD_NRD_1	582	584	PF00675	0.761
CLV_NRD_NRD_1	588	590	PF00675	0.681
CLV_PCSK_KEX2_1	114	116	PF00082	0.522
CLV_PCSK_KEX2_1	204	206	PF00082	0.432
CLV_PCSK_KEX2_1	33	35	PF00082	0.660
CLV_PCSK_KEX2_1	506	508	PF00082	0.569
CLV_PCSK_KEX2_1	582	584	PF00082	0.651
CLV_PCSK_KEX2_1	588	590	PF00082	0.648
CLV_PCSK_SKI1_1	308	312	PF00082	0.399
CLV_PCSK_SKI1_1	338	342	PF00082	0.467
CLV_PCSK_SKI1_1	353	357	PF00082	0.446
CLV_PCSK_SKI1_1	384	388	PF00082	0.582
CLV_PCSK_SKI1_1	52	56	PF00082	0.557
CLV_PCSK_SKI1_1	606	610	PF00082	0.569
DEG_APCC_DBOX_1	203	211	PF00400	0.439
DEG_APCC_DBOX_1	307	315	PF00400	0.389
DEG_APCC_DBOX_1	383	391	PF00400	0.446
DEG_Nend_UBRbox_2	1	3	PF02207	0.663
DEG_SPOP_SBC_1	523	527	PF00917	0.518
DOC_CKS1_1	258	263	PF01111	0.441
DOC_CYCLIN_RxL_1	335	344	PF00134	0.466
DOC_MAPK_gen_1	204	212	PF00069	0.447
DOC_MAPK_gen_1	33	42	PF00069	0.591
DOC_MAPK_MEF2A_6	205	214	PF00069	0.554
DOC_MAPK_MEF2A_6	338	345	PF00069	0.534
DOC_PP4_FxxP_1	258	261	PF00568	0.550
DOC_USP7_MATH_1	12	16	PF00917	0.591
DOC_USP7_MATH_1	168	172	PF00917	0.676
DOC_USP7_MATH_1	216	220	PF00917	0.477
DOC_USP7_MATH_1	437	441	PF00917	0.542
DOC_USP7_MATH_1	570	574	PF00917	0.627
DOC_USP7_MATH_1	66	70	PF00917	0.551
DOC_WW_Pin1_4	17	22	PF00397	0.543
DOC_WW_Pin1_4	257	262	PF00397	0.509
DOC_WW_Pin1_4	279	284	PF00397	0.534
DOC_WW_Pin1_4	290	295	PF00397	0.559
DOC_WW_Pin1_4	475	480	PF00397	0.544
DOC_WW_Pin1_4	566	571	PF00397	0.543
DOC_WW_Pin1_4	6	11	PF00397	0.609
DOC_WW_Pin1_4	613	618	PF00397	0.527
DOC_WW_Pin1_4	624	629	PF00397	0.571
LIG_14-3-3_CanoR_1	215	225	PF00244	0.506
LIG_14-3-3_CanoR_1	232	239	PF00244	0.588
LIG_14-3-3_CanoR_1	353	359	PF00244	0.450
LIG_14-3-3_CanoR_1	413	419	PF00244	0.587
LIG_14-3-3_CanoR_1	425	430	PF00244	0.443
LIG_14-3-3_CanoR_1	494	498	PF00244	0.604
LIG_14-3-3_CanoR_1	52	60	PF00244	0.562
LIG_14-3-3_CanoR_1	601	609	PF00244	0.542
LIG_14-3-3_CanoR_1	623	631	PF00244	0.593
LIG_Actin_WH2_2	348	364	PF00022	0.526
LIG_Actin_WH2_2	419	437	PF00022	0.559
LIG_AP2alpha_1	295	299	PF02296	0.573
LIG_BRCT_BRCA1_1	240	244	PF00533	0.517
LIG_eIF4E_1	330	336	PF01652	0.436
LIG_FHA_1	118	124	PF00498	0.494
LIG_FHA_1	158	164	PF00498	0.526
LIG_FHA_1	209	215	PF00498	0.680
LIG_FHA_1	264	270	PF00498	0.478
LIG_FHA_1	272	278	PF00498	0.436
LIG_FHA_1	30	36	PF00498	0.587
LIG_FHA_1	355	361	PF00498	0.549
LIG_FHA_1	389	395	PF00498	0.395
LIG_FHA_1	457	463	PF00498	0.535
LIG_FHA_2	527	533	PF00498	0.644
LIG_FHA_2	567	573	PF00498	0.531
LIG_FHA_2	92	98	PF00498	0.520
LIG_GBD_Chelix_1	306	314	PF00786	0.551
LIG_GBD_Chelix_1	331	339	PF00786	0.453
LIG_LIR_Gen_1	116	125	PF02991	0.538
LIG_LIR_Gen_1	618	629	PF02991	0.631
LIG_LIR_Gen_1	96	105	PF02991	0.408
LIG_LIR_Nem_3	116	121	PF02991	0.378
LIG_LIR_Nem_3	357	361	PF02991	0.448
LIG_LIR_Nem_3	50	54	PF02991	0.494
LIG_LIR_Nem_3	618	624	PF02991	0.563
LIG_LIR_Nem_3	96	102	PF02991	0.502
LIG_PAM2_1	8	20	PF00658	0.482
LIG_Pex14_2	295	299	PF04695	0.573
LIG_SH2_CRK	337	341	PF00017	0.469
LIG_SH2_STAT3	612	615	PF00017	0.518
LIG_SH2_STAT5	330	333	PF00017	0.468
LIG_SH2_STAT5	393	396	PF00017	0.483
LIG_SH2_STAT5	401	404	PF00017	0.543
LIG_SH2_STAT5	612	615	PF00017	0.518
LIG_SH2_STAT5	91	94	PF00017	0.569
LIG_SH3_3	15	21	PF00018	0.587
LIG_SH3_3	394	400	PF00018	0.517
LIG_Sin3_3	332	339	PF02671	0.453
LIG_SUMO_SIM_par_1	339	344	PF11976	0.540
LIG_TRAF2_1	300	303	PF00917	0.510
LIG_TYR_ITIM	335	340	PF00017	0.459
LIG_TYR_ITIM	49	54	PF00017	0.497
MOD_CDK_SPK_2	257	262	PF00069	0.494
MOD_CK1_1	29	35	PF00069	0.530
MOD_CK1_1	496	502	PF00069	0.469
MOD_CK1_1	527	533	PF00069	0.523
MOD_CK1_1	69	75	PF00069	0.561
MOD_CK2_1	297	303	PF00069	0.552
MOD_CK2_1	496	502	PF00069	0.493
MOD_CK2_1	526	532	PF00069	0.665
MOD_CK2_1	566	572	PF00069	0.539
MOD_CK2_1	91	97	PF00069	0.518
MOD_CMANNOS	197	200	PF00535	0.535
MOD_Cter_Amidation	586	589	PF01082	0.760
MOD_GlcNHglycan	10	13	PF01048	0.628
MOD_GlcNHglycan	166	169	PF01048	0.617
MOD_GlcNHglycan	170	173	PF01048	0.753
MOD_GlcNHglycan	218	221	PF01048	0.474
MOD_GlcNHglycan	240	244	PF01048	0.517
MOD_GlcNHglycan	27	31	PF01048	0.483
MOD_GlcNHglycan	299	302	PF01048	0.492
MOD_GlcNHglycan	371	374	PF01048	0.565
MOD_GlcNHglycan	439	442	PF01048	0.551
MOD_GlcNHglycan	532	535	PF01048	0.657
MOD_GlcNHglycan	597	600	PF01048	0.732
MOD_GlcNHglycan	74	77	PF01048	0.489
MOD_GSK3_1	13	20	PF00069	0.544
MOD_GSK3_1	164	171	PF00069	0.532
MOD_GSK3_1	2	9	PF00069	0.651
MOD_GSK3_1	408	415	PF00069	0.565
MOD_GSK3_1	421	428	PF00069	0.465
MOD_GSK3_1	448	455	PF00069	0.758
MOD_GSK3_1	493	500	PF00069	0.504
MOD_GSK3_1	522	529	PF00069	0.670
MOD_GSK3_1	566	573	PF00069	0.575
MOD_GSK3_1	590	597	PF00069	0.642
MOD_GSK3_1	611	618	PF00069	0.524
MOD_GSK3_1	65	72	PF00069	0.535
MOD_N-GLC_1	285	290	PF02516	0.536
MOD_NEK2_1	1	6	PF00069	0.653
MOD_NEK2_1	131	136	PF00069	0.521
MOD_NEK2_1	239	244	PF00069	0.489
MOD_NEK2_1	341	346	PF00069	0.479
MOD_NEK2_1	369	374	PF00069	0.709
MOD_NEK2_1	388	393	PF00069	0.429
MOD_NEK2_1	412	417	PF00069	0.538
MOD_NEK2_1	54	59	PF00069	0.562
MOD_NEK2_1	547	552	PF00069	0.662
MOD_NEK2_1	595	600	PF00069	0.610
MOD_NEK2_1	60	65	PF00069	0.529
MOD_NEK2_1	78	83	PF00069	0.429
MOD_PIKK_1	600	606	PF00454	0.577
MOD_PIKK_1	611	617	PF00454	0.482
MOD_PK_1	425	431	PF00069	0.389
MOD_PKA_2	216	222	PF00069	0.600
MOD_PKA_2	231	237	PF00069	0.541
MOD_PKA_2	412	418	PF00069	0.614
MOD_PKA_2	493	499	PF00069	0.514
MOD_PKA_2	600	606	PF00069	0.505
MOD_PKA_2	622	628	PF00069	0.637
MOD_PKB_1	213	221	PF00069	0.479
MOD_Plk_1	239	245	PF00069	0.482
MOD_Plk_1	285	291	PF00069	0.609
MOD_Plk_1	341	347	PF00069	0.545
MOD_Plk_1	388	394	PF00069	0.358
MOD_Plk_1	590	596	PF00069	0.647
MOD_Plk_1	69	75	PF00069	0.439
MOD_Plk_4	117	123	PF00069	0.492
MOD_Plk_4	13	19	PF00069	0.592
MOD_Plk_4	141	147	PF00069	0.474
MOD_Plk_4	3	9	PF00069	0.546
MOD_Plk_4	542	548	PF00069	0.628
MOD_Plk_4	590	596	PF00069	0.647
MOD_ProDKin_1	17	23	PF00069	0.544
MOD_ProDKin_1	257	263	PF00069	0.516
MOD_ProDKin_1	279	285	PF00069	0.537
MOD_ProDKin_1	290	296	PF00069	0.558
MOD_ProDKin_1	475	481	PF00069	0.543
MOD_ProDKin_1	566	572	PF00069	0.541
MOD_ProDKin_1	6	12	PF00069	0.609
MOD_ProDKin_1	613	619	PF00069	0.529
MOD_ProDKin_1	624	630	PF00069	0.570
MOD_SUMO_for_1	429	432	PF00179	0.549
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.449
TRG_ENDOCYTIC_2	337	340	PF00928	0.473
TRG_ENDOCYTIC_2	51	54	PF00928	0.498
TRG_ENDOCYTIC_2	610	613	PF00928	0.581
TRG_ENDOCYTIC_2	99	102	PF00928	0.500
TRG_ER_diArg_1	212	215	PF00400	0.584
TRG_ER_diArg_1	246	249	PF00400	0.497
TRG_ER_diArg_1	33	35	PF00400	0.660
TRG_ER_diArg_1	505	507	PF00400	0.513
TRG_ER_diArg_1	581	583	PF00400	0.632
TRG_ER_diArg_1	588	590	PF00400	0.669
TRG_NES_CRM1_1	389	403	PF08389	0.474
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	359	363	PF00026	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILV8	Leptomonas seymouri	39%	100%
A0A3S7WQR1	Leishmania donovani	81%	100%
A4H5Q4	Leishmania braziliensis	69%	100%
A4HTZ4	Leishmania infantum	81%	100%
Q4QHV1	Leishmania major	80%	96%