RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMS2_LEIMU

TriTrypDb:

LmxM.09.0710

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.530
CLV_C14_Caspase3-7	307	311	PF00656	0.714
CLV_NRD_NRD_1	116	118	PF00675	0.523
CLV_NRD_NRD_1	198	200	PF00675	0.526
CLV_NRD_NRD_1	303	305	PF00675	0.634
CLV_NRD_NRD_1	31	33	PF00675	0.597
CLV_NRD_NRD_1	313	315	PF00675	0.579
CLV_NRD_NRD_1	317	319	PF00675	0.586
CLV_NRD_NRD_1	417	419	PF00675	0.466
CLV_PCSK_KEX2_1	116	118	PF00082	0.523
CLV_PCSK_KEX2_1	198	200	PF00082	0.526
CLV_PCSK_KEX2_1	302	304	PF00082	0.637
CLV_PCSK_KEX2_1	31	33	PF00082	0.597
CLV_PCSK_KEX2_1	313	315	PF00082	0.576
CLV_PCSK_KEX2_1	356	358	PF00082	0.759
CLV_PCSK_KEX2_1	417	419	PF00082	0.466
CLV_PCSK_KEX2_1	509	511	PF00082	0.588
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.759
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.588
CLV_PCSK_SKI1_1	189	193	PF00082	0.521
CLV_PCSK_SKI1_1	198	202	PF00082	0.556
CLV_PCSK_SKI1_1	206	210	PF00082	0.520
CLV_PCSK_SKI1_1	280	284	PF00082	0.588
CLV_PCSK_SKI1_1	31	35	PF00082	0.592
CLV_PCSK_SKI1_1	93	97	PF00082	0.510
DEG_Nend_UBRbox_1	1	4	PF02207	0.789
DEG_SCF_FBW7_1	374	381	PF00400	0.708
DEG_SIAH_1	52	60	PF03145	0.537
DEG_SPOP_SBC_1	21	25	PF00917	0.688
DOC_CKS1_1	375	380	PF01111	0.774
DOC_CYCLIN_RxL_1	493	503	PF00134	0.474
DOC_MAPK_MEF2A_6	259	267	PF00069	0.464
DOC_MAPK_MEF2A_6	484	491	PF00069	0.449
DOC_MAPK_NFAT4_5	484	492	PF00069	0.456
DOC_PP1_RVXF_1	185	191	PF00149	0.510
DOC_PP1_RVXF_1	495	502	PF00149	0.553
DOC_PP1_SILK_1	260	265	PF00149	0.628
DOC_USP7_MATH_1	129	133	PF00917	0.665
DOC_USP7_MATH_1	137	141	PF00917	0.605
DOC_USP7_MATH_1	21	25	PF00917	0.555
DOC_USP7_MATH_1	258	262	PF00917	0.662
DOC_USP7_MATH_1	282	286	PF00917	0.640
DOC_USP7_MATH_1	432	436	PF00917	0.632
DOC_USP7_MATH_1	9	13	PF00917	0.768
DOC_WW_Pin1_4	155	160	PF00397	0.698
DOC_WW_Pin1_4	191	196	PF00397	0.514
DOC_WW_Pin1_4	254	259	PF00397	0.564
DOC_WW_Pin1_4	374	379	PF00397	0.691
DOC_WW_Pin1_4	384	389	PF00397	0.739
DOC_WW_Pin1_4	412	417	PF00397	0.458
DOC_WW_Pin1_4	49	54	PF00397	0.679
DOC_WW_Pin1_4	67	72	PF00397	0.656
DOC_WW_Pin1_4	7	12	PF00397	0.672
LIG_14-3-3_CanoR_1	189	195	PF00244	0.516
LIG_14-3-3_CanoR_1	31	38	PF00244	0.588
LIG_14-3-3_CanoR_1	69	79	PF00244	0.643
LIG_14-3-3_CanoR_1	93	99	PF00244	0.499
LIG_AP2alpha_1	210	214	PF02296	0.434
LIG_APCC_ABBA_1	498	503	PF00400	0.620
LIG_APCC_ABBAyCdc20_2	497	503	PF00400	0.620
LIG_BIR_III_4	133	137	PF00653	0.510
LIG_CtBP_PxDLS_1	439	443	PF00389	0.647
LIG_FHA_1	103	109	PF00498	0.629
LIG_FHA_1	156	162	PF00498	0.615
LIG_FHA_1	32	38	PF00498	0.585
LIG_FHA_1	83	89	PF00498	0.629
LIG_FHA_2	21	27	PF00498	0.643
LIG_FHA_2	347	353	PF00498	0.669
LIG_FHA_2	385	391	PF00498	0.773
LIG_FHA_2	452	458	PF00498	0.450
LIG_FHA_2	464	470	PF00498	0.503
LIG_LIR_Gen_1	176	186	PF02991	0.478
LIG_LIR_Gen_1	332	341	PF02991	0.642
LIG_LIR_Gen_1	453	464	PF02991	0.482
LIG_LIR_Nem_3	176	182	PF02991	0.498
LIG_LIR_Nem_3	332	338	PF02991	0.636
LIG_LIR_Nem_3	453	459	PF02991	0.482
LIG_Pex14_2	210	214	PF04695	0.525
LIG_RPA_C_Fungi	488	500	PF08784	0.362
LIG_SH2_STAT5	420	423	PF00017	0.464
LIG_SH3_3	156	162	PF00018	0.689
LIG_SH3_3	243	249	PF00018	0.571
LIG_SH3_3	252	258	PF00018	0.557
LIG_SH3_3	372	378	PF00018	0.666
LIG_SH3_3	395	401	PF00018	0.495
LIG_SH3_3	48	54	PF00018	0.683
LIG_SH3_3	65	71	PF00018	0.559
LIG_SH3_CIN85_PxpxPR_1	273	278	PF14604	0.527
LIG_SUMO_SIM_par_1	438	444	PF11976	0.643
LIG_TRAF2_1	387	390	PF00917	0.682
LIG_TRAF2_1	466	469	PF00917	0.359
MOD_CDC14_SPxK_1	415	418	PF00782	0.445
MOD_CDK_SPK_2	155	160	PF00069	0.622
MOD_CDK_SPK_2	254	259	PF00069	0.660
MOD_CDK_SPK_2	412	417	PF00069	0.458
MOD_CDK_SPxK_1	412	418	PF00069	0.459
MOD_CDK_SPxxK_3	191	198	PF00069	0.512
MOD_CK1_1	12	18	PF00069	0.693
MOD_CK1_1	140	146	PF00069	0.767
MOD_CK1_1	22	28	PF00069	0.732
MOD_CK1_1	221	227	PF00069	0.751
MOD_CK1_1	231	237	PF00069	0.508
MOD_CK1_1	333	339	PF00069	0.592
MOD_CK1_1	70	76	PF00069	0.747
MOD_CK2_1	119	125	PF00069	0.731
MOD_CK2_1	20	26	PF00069	0.768
MOD_CK2_1	254	260	PF00069	0.666
MOD_CK2_1	346	352	PF00069	0.666
MOD_CK2_1	384	390	PF00069	0.727
MOD_CK2_1	430	436	PF00069	0.588
MOD_CK2_1	438	444	PF00069	0.615
MOD_CK2_1	463	469	PF00069	0.490
MOD_CK2_1	70	76	PF00069	0.750
MOD_Cter_Amidation	196	199	PF01082	0.520
MOD_DYRK1A_RPxSP_1	155	159	PF00069	0.713
MOD_GlcNHglycan	11	14	PF01048	0.770
MOD_GlcNHglycan	121	124	PF01048	0.677
MOD_GlcNHglycan	138	142	PF01048	0.733
MOD_GlcNHglycan	220	223	PF01048	0.697
MOD_GlcNHglycan	272	276	PF01048	0.704
MOD_GlcNHglycan	280	283	PF01048	0.702
MOD_GlcNHglycan	285	288	PF01048	0.618
MOD_GlcNHglycan	332	335	PF01048	0.601
MOD_GlcNHglycan	38	41	PF01048	0.642
MOD_GlcNHglycan	432	435	PF01048	0.431
MOD_GSK3_1	217	224	PF00069	0.555
MOD_GSK3_1	234	241	PF00069	0.706
MOD_GSK3_1	254	261	PF00069	0.542
MOD_GSK3_1	276	283	PF00069	0.704
MOD_GSK3_1	3	10	PF00069	0.679
MOD_GSK3_1	364	371	PF00069	0.653
MOD_GSK3_1	374	381	PF00069	0.721
MOD_GSK3_1	94	101	PF00069	0.492
MOD_N-GLC_1	19	24	PF02516	0.703
MOD_NEK2_1	1	6	PF00069	0.639
MOD_NEK2_1	145	150	PF00069	0.596
MOD_NEK2_1	94	99	PF00069	0.492
MOD_NEK2_2	351	356	PF00069	0.512
MOD_PKA_1	31	37	PF00069	0.588
MOD_PKA_1	450	456	PF00069	0.576
MOD_PKA_2	1	7	PF00069	0.550
MOD_PKA_2	31	37	PF00069	0.588
MOD_PKB_1	187	195	PF00069	0.623
MOD_Plk_1	137	143	PF00069	0.735
MOD_Plk_1	351	357	PF00069	0.556
MOD_Plk_2-3	180	186	PF00069	0.537
MOD_Plk_4	231	237	PF00069	0.628
MOD_Plk_4	239	245	PF00069	0.608
MOD_Plk_4	258	264	PF00069	0.500
MOD_Plk_4	369	375	PF00069	0.548
MOD_Plk_4	400	406	PF00069	0.437
MOD_Plk_4	99	105	PF00069	0.367
MOD_ProDKin_1	155	161	PF00069	0.690
MOD_ProDKin_1	191	197	PF00069	0.510
MOD_ProDKin_1	254	260	PF00069	0.567
MOD_ProDKin_1	374	380	PF00069	0.691
MOD_ProDKin_1	384	390	PF00069	0.739
MOD_ProDKin_1	412	418	PF00069	0.459
MOD_ProDKin_1	49	55	PF00069	0.678
MOD_ProDKin_1	67	73	PF00069	0.654
MOD_ProDKin_1	7	13	PF00069	0.673
MOD_SUMO_for_1	355	358	PF00179	0.756
MOD_SUMO_rev_2	60	68	PF00179	0.544
TRG_DiLeu_BaEn_4	315	321	PF01217	0.683
TRG_DiLeu_LyEn_5	503	508	PF01217	0.620
TRG_ENDOCYTIC_2	456	459	PF00928	0.488
TRG_ER_diArg_1	116	118	PF00400	0.523
TRG_ER_diArg_1	187	190	PF00400	0.622
TRG_ER_diArg_1	302	304	PF00400	0.641
TRG_ER_diArg_1	31	33	PF00400	0.597
TRG_ER_diArg_1	312	314	PF00400	0.569
TRG_ER_diArg_1	416	418	PF00400	0.448
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.696
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.520
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILK1	Leptomonas seymouri	37%	98%
A0A3S7WQP0	Leishmania donovani	88%	100%
A4H5Q2	Leishmania braziliensis	71%	100%
A4HTZ2	Leishmania infantum	88%	100%
Q4QHV3	Leishmania major	85%	100%