Serine/arginine repetitive matrix protein 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMS1_LEIMU

TriTrypDb:

LmxM.09.0700

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.491
CLV_C14_Caspase3-7	76	80	PF00656	0.474
CLV_NRD_NRD_1	198	200	PF00675	0.588
CLV_NRD_NRD_1	236	238	PF00675	0.521
CLV_NRD_NRD_1	243	245	PF00675	0.578
CLV_NRD_NRD_1	256	258	PF00675	0.465
CLV_NRD_NRD_1	275	277	PF00675	0.526
CLV_NRD_NRD_1	356	358	PF00675	0.775
CLV_PCSK_FUR_1	196	200	PF00082	0.660
CLV_PCSK_FUR_1	234	238	PF00082	0.589
CLV_PCSK_FUR_1	257	261	PF00082	0.476
CLV_PCSK_KEX2_1	180	182	PF00082	0.644
CLV_PCSK_KEX2_1	198	200	PF00082	0.631
CLV_PCSK_KEX2_1	236	238	PF00082	0.521
CLV_PCSK_KEX2_1	243	245	PF00082	0.578
CLV_PCSK_KEX2_1	256	258	PF00082	0.467
CLV_PCSK_KEX2_1	259	261	PF00082	0.694
CLV_PCSK_KEX2_1	265	267	PF00082	0.637
CLV_PCSK_KEX2_1	275	277	PF00082	0.602
CLV_PCSK_KEX2_1	350	352	PF00082	0.713
CLV_PCSK_KEX2_1	356	358	PF00082	0.763
CLV_PCSK_KEX2_1	416	418	PF00082	0.561
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.614
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.636
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.771
CLV_PCSK_PC1ET2_1	350	352	PF00082	0.564
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.561
CLV_PCSK_PC7_1	412	418	PF00082	0.556
CLV_PCSK_SKI1_1	180	184	PF00082	0.586
CLV_PCSK_SKI1_1	259	263	PF00082	0.519
CLV_PCSK_SKI1_1	275	279	PF00082	0.766
CLV_PCSK_SKI1_1	288	292	PF00082	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.697
DEG_SPOP_SBC_1	21	25	PF00917	0.754
DEG_SPOP_SBC_1	457	461	PF00917	0.661
DOC_CKS1_1	126	131	PF01111	0.656
DOC_CKS1_1	220	225	PF01111	0.457
DOC_MAPK_gen_1	188	195	PF00069	0.559
DOC_MAPK_gen_1	196	203	PF00069	0.518
DOC_MAPK_gen_1	256	263	PF00069	0.674
DOC_MAPK_gen_1	265	272	PF00069	0.556
DOC_MAPK_gen_1	288	297	PF00069	0.530
DOC_MAPK_gen_1	416	427	PF00069	0.558
DOC_MAPK_MEF2A_6	188	195	PF00069	0.559
DOC_PP2B_LxvP_1	106	109	PF13499	0.540
DOC_PP2B_LxvP_1	473	476	PF13499	0.684
DOC_PP4_FxxP_1	3	6	PF00568	0.483
DOC_PP4_MxPP_1	367	370	PF00568	0.737
DOC_SPAK_OSR1_1	308	312	PF12202	0.755
DOC_USP7_MATH_1	161	165	PF00917	0.566
DOC_USP7_MATH_1	325	329	PF00917	0.753
DOC_USP7_MATH_1	339	343	PF00917	0.628
DOC_USP7_MATH_1	401	405	PF00917	0.744
DOC_USP7_MATH_1	69	73	PF00917	0.569
DOC_WW_Pin1_4	125	130	PF00397	0.652
DOC_WW_Pin1_4	2	7	PF00397	0.698
DOC_WW_Pin1_4	219	224	PF00397	0.749
DOC_WW_Pin1_4	264	269	PF00397	0.533
DOC_WW_Pin1_4	298	303	PF00397	0.750
DOC_WW_Pin1_4	335	340	PF00397	0.798
DOC_WW_Pin1_4	377	382	PF00397	0.555
DOC_WW_Pin1_4	418	423	PF00397	0.751
DOC_WW_Pin1_4	466	471	PF00397	0.710
LIG_14-3-3_CanoR_1	138	144	PF00244	0.620
LIG_14-3-3_CanoR_1	163	167	PF00244	0.779
LIG_14-3-3_CanoR_1	260	264	PF00244	0.570
LIG_14-3-3_CanoR_1	341	345	PF00244	0.839
LIG_14-3-3_CanoR_1	456	464	PF00244	0.550
LIG_14-3-3_CanoR_1	478	482	PF00244	0.782
LIG_BRCT_BRCA1_1	273	277	PF00533	0.735
LIG_BRCT_BRCA1_1	448	452	PF00533	0.648
LIG_CtBP_PxDLS_1	174	178	PF00389	0.537
LIG_CtBP_PxDLS_1	506	510	PF00389	0.679
LIG_FHA_1	280	286	PF00498	0.741
LIG_FHA_1	432	438	PF00498	0.735
LIG_FHA_2	10	16	PF00498	0.522
LIG_FHA_2	225	231	PF00498	0.630
LIG_FHA_2	431	437	PF00498	0.657
LIG_LIR_Apic_2	218	223	PF02991	0.449
LIG_LIR_Apic_2	376	381	PF02991	0.713
LIG_LIR_Apic_2	500	506	PF02991	0.699
LIG_LIR_Apic_2	97	101	PF02991	0.748
LIG_LIR_Gen_1	141	150	PF02991	0.628
LIG_LIR_Nem_3	141	147	PF02991	0.625
LIG_LIR_Nem_3	374	378	PF02991	0.792
LIG_SH2_CRK	144	148	PF00017	0.632
LIG_SH2_CRK	220	224	PF00017	0.456
LIG_SH2_CRK	292	296	PF00017	0.532
LIG_SH2_CRK	379	383	PF00017	0.821
LIG_SH2_CRK	98	102	PF00017	0.748
LIG_SH2_NCK_1	220	224	PF00017	0.456
LIG_SH2_NCK_1	292	296	PF00017	0.532
LIG_SH2_NCK_1	405	409	PF00017	0.533
LIG_SH2_PTP2	503	506	PF00017	0.691
LIG_SH2_SRC	292	295	PF00017	0.537
LIG_SH2_SRC	444	447	PF00017	0.533
LIG_SH2_STAP1	375	379	PF00017	0.745
LIG_SH2_STAT5	2	5	PF00017	0.479
LIG_SH2_STAT5	375	378	PF00017	0.528
LIG_SH2_STAT5	444	447	PF00017	0.533
LIG_SH2_STAT5	503	506	PF00017	0.691
LIG_SH3_1	416	422	PF00018	0.557
LIG_SH3_3	126	132	PF00018	0.642
LIG_SH3_3	363	369	PF00018	0.726
LIG_SH3_3	416	422	PF00018	0.597
LIG_SH3_3	485	491	PF00018	0.668
LIG_SH3_3	80	86	PF00018	0.728
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.678
LIG_SUMO_SIM_par_1	505	510	PF11976	0.677
LIG_TRAF2_1	227	230	PF00917	0.628
LIG_TRFH_1	98	102	PF08558	0.534
LIG_TYR_ITIM	290	295	PF00017	0.535
LIG_WW_3	108	112	PF00397	0.528
MOD_CDK_SPxK_1	298	304	PF00069	0.655
MOD_CDK_SPxK_1	335	341	PF00069	0.774
MOD_CK1_1	148	154	PF00069	0.769
MOD_CK1_1	22	28	PF00069	0.737
MOD_CK1_1	298	304	PF00069	0.752
MOD_CK1_1	428	434	PF00069	0.643
MOD_CK1_1	459	465	PF00069	0.670
MOD_CK1_1	84	90	PF00069	0.731
MOD_CK2_1	224	230	PF00069	0.643
MOD_CK2_1	69	75	PF00069	0.604
MOD_CK2_1	9	15	PF00069	0.572
MOD_Cter_Amidation	196	199	PF01082	0.626
MOD_GlcNHglycan	147	150	PF01048	0.745
MOD_GlcNHglycan	27	30	PF01048	0.545
MOD_GlcNHglycan	297	300	PF01048	0.763
MOD_GlcNHglycan	325	328	PF01048	0.630
MOD_GlcNHglycan	389	392	PF01048	0.760
MOD_GlcNHglycan	422	425	PF01048	0.751
MOD_GlcNHglycan	448	451	PF01048	0.646
MOD_GlcNHglycan	464	467	PF01048	0.549
MOD_GSK3_1	19	26	PF00069	0.680
MOD_GSK3_1	271	278	PF00069	0.801
MOD_GSK3_1	335	342	PF00069	0.807
MOD_GSK3_1	373	380	PF00069	0.738
MOD_GSK3_1	385	392	PF00069	0.632
MOD_GSK3_1	425	432	PF00069	0.676
MOD_GSK3_1	458	465	PF00069	0.712
MOD_GSK3_1	486	493	PF00069	0.823
MOD_LATS_1	410	416	PF00433	0.647
MOD_N-GLC_1	161	166	PF02516	0.814
MOD_N-GLC_1	224	229	PF02516	0.724
MOD_N-GLC_1	335	340	PF02516	0.848
MOD_N-GLC_1	371	376	PF02516	0.589
MOD_NEK2_1	191	196	PF00069	0.459
MOD_NEK2_1	20	25	PF00069	0.808
MOD_NEK2_1	464	469	PF00069	0.561
MOD_NEK2_1	486	491	PF00069	0.556
MOD_NEK2_1	507	512	PF00069	0.677
MOD_NEK2_2	340	345	PF00069	0.671
MOD_PIKK_1	459	465	PF00454	0.670
MOD_PIKK_1	497	503	PF00454	0.716
MOD_PKA_1	259	265	PF00069	0.476
MOD_PKA_1	275	281	PF00069	0.524
MOD_PKA_2	137	143	PF00069	0.780
MOD_PKA_2	145	151	PF00069	0.717
MOD_PKA_2	162	168	PF00069	0.575
MOD_PKA_2	259	265	PF00069	0.478
MOD_PKA_2	275	281	PF00069	0.524
MOD_PKA_2	340	346	PF00069	0.865
MOD_PKA_2	359	365	PF00069	0.769
MOD_PKA_2	477	483	PF00069	0.685
MOD_Plk_1	161	167	PF00069	0.853
MOD_Plk_1	224	230	PF00069	0.720
MOD_Plk_1	371	377	PF00069	0.621
MOD_Plk_1	486	492	PF00069	0.831
MOD_Plk_1	507	513	PF00069	0.680
MOD_Plk_2-3	436	442	PF00069	0.660
MOD_Plk_4	507	513	PF00069	0.680
MOD_ProDKin_1	125	131	PF00069	0.655
MOD_ProDKin_1	2	8	PF00069	0.700
MOD_ProDKin_1	219	225	PF00069	0.750
MOD_ProDKin_1	264	270	PF00069	0.536
MOD_ProDKin_1	298	304	PF00069	0.752
MOD_ProDKin_1	335	341	PF00069	0.801
MOD_ProDKin_1	377	383	PF00069	0.555
MOD_ProDKin_1	418	424	PF00069	0.749
MOD_ProDKin_1	466	472	PF00069	0.712
MOD_SUMO_rev_2	28	38	PF00179	0.599
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.590
TRG_ENDOCYTIC_2	144	147	PF00928	0.631
TRG_ENDOCYTIC_2	242	245	PF00928	0.638
TRG_ENDOCYTIC_2	252	255	PF00928	0.484
TRG_ENDOCYTIC_2	292	295	PF00928	0.557
TRG_ENDOCYTIC_2	379	382	PF00928	0.822
TRG_ER_diArg_1	168	171	PF00400	0.625
TRG_ER_diArg_1	195	198	PF00400	0.600
TRG_ER_diArg_1	234	237	PF00400	0.520
TRG_ER_diArg_1	242	244	PF00400	0.564
TRG_ER_diArg_1	255	257	PF00400	0.460
TRG_ER_diArg_1	275	277	PF00400	0.526
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQN7	Leishmania donovani	79%	100%
A4H5Q1	Leishmania braziliensis	43%	98%
A4HTZ1	Leishmania infantum	79%	100%
Q4QHV4	Leishmania major	64%	89%