Nucleotid_trans domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMS0_LEIMU

TriTrypDb:

LmxM.09.0690

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 12
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.561
CLV_NRD_NRD_1	180	182	PF00675	0.351
CLV_NRD_NRD_1	203	205	PF00675	0.497
CLV_NRD_NRD_1	286	288	PF00675	0.328
CLV_PCSK_KEX2_1	180	182	PF00082	0.380
CLV_PCSK_KEX2_1	203	205	PF00082	0.488
CLV_PCSK_KEX2_1	234	236	PF00082	0.470
CLV_PCSK_KEX2_1	286	288	PF00082	0.452
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.522
CLV_PCSK_SKI1_1	180	184	PF00082	0.417
DEG_APCC_DBOX_1	203	211	PF00400	0.517
DOC_MAPK_MEF2A_6	105	113	PF00069	0.405
DOC_MAPK_MEF2A_6	29	37	PF00069	0.364
DOC_PP4_FxxP_1	269	272	PF00568	0.486
DOC_SPAK_OSR1_1	235	239	PF12202	0.534
DOC_USP7_MATH_1	116	120	PF00917	0.586
DOC_USP7_MATH_1	261	265	PF00917	0.314
DOC_WW_Pin1_4	117	122	PF00397	0.540
DOC_WW_Pin1_4	145	150	PF00397	0.393
DOC_WW_Pin1_4	169	174	PF00397	0.369
DOC_WW_Pin1_4	240	245	PF00397	0.529
LIG_14-3-3_CanoR_1	180	189	PF00244	0.421
LIG_14-3-3_CanoR_1	26	32	PF00244	0.357
LIG_14-3-3_CanoR_1	97	103	PF00244	0.355
LIG_APCC_ABBA_1	253	258	PF00400	0.472
LIG_BIR_II_1	1	5	PF00653	0.555
LIG_BRCT_BRCA1_1	185	189	PF00533	0.393
LIG_deltaCOP1_diTrp_1	174	179	PF00928	0.483
LIG_Dynein_DLC8_1	179	185	PF01221	0.372
LIG_eIF4E_1	216	222	PF01652	0.379
LIG_FHA_1	1	7	PF00498	0.511
LIG_FHA_1	118	124	PF00498	0.433
LIG_FHA_1	170	176	PF00498	0.427
LIG_FHA_1	32	38	PF00498	0.431
LIG_FHA_1	54	60	PF00498	0.542
LIG_LIR_Apic_2	267	272	PF02991	0.488
LIG_LIR_Nem_3	157	163	PF02991	0.346
LIG_LIR_Nem_3	75	80	PF02991	0.479
LIG_MLH1_MIPbox_1	185	189	PF16413	0.393
LIG_PCNA_yPIPBox_3	279	289	PF02747	0.313
LIG_SH2_CRK	77	81	PF00017	0.464
LIG_SH2_STAT3	188	191	PF00017	0.382
LIG_SH2_STAT5	167	170	PF00017	0.437
LIG_SH2_STAT5	188	191	PF00017	0.382
LIG_SH2_STAT5	38	41	PF00017	0.440
LIG_SH3_1	134	140	PF00018	0.418
LIG_SH3_3	134	140	PF00018	0.350
LIG_SH3_3	269	275	PF00018	0.465
LIG_SH3_3	30	36	PF00018	0.365
LIG_SH3_3	89	95	PF00018	0.445
LIG_SUMO_SIM_anti_2	110	115	PF11976	0.363
LIG_SUMO_SIM_anti_2	129	135	PF11976	0.344
MOD_CK1_1	119	125	PF00069	0.546
MOD_CK1_1	243	249	PF00069	0.666
MOD_CK1_1	264	270	PF00069	0.311
MOD_CK2_1	168	174	PF00069	0.528
MOD_CK2_1	225	231	PF00069	0.424
MOD_CK2_1	79	85	PF00069	0.502
MOD_GSK3_1	112	119	PF00069	0.528
MOD_GSK3_1	27	34	PF00069	0.515
MOD_GSK3_1	50	57	PF00069	0.572
MOD_NEK2_2	261	266	PF00069	0.315
MOD_NEK2_2	27	32	PF00069	0.355
MOD_PIKK_1	180	186	PF00454	0.513
MOD_PIKK_1	54	60	PF00454	0.611
MOD_PK_1	225	231	PF00069	0.526
MOD_PK_1	234	240	PF00069	0.380
MOD_PKA_1	180	186	PF00069	0.339
MOD_PKA_1	234	240	PF00069	0.509
MOD_PKA_2	152	158	PF00069	0.458
MOD_PKA_2	180	186	PF00069	0.415
MOD_PKA_2	234	240	PF00069	0.504
MOD_PKA_2	96	102	PF00069	0.360
MOD_Plk_1	128	134	PF00069	0.419
MOD_Plk_2-3	190	196	PF00069	0.342
MOD_ProDKin_1	117	123	PF00069	0.528
MOD_ProDKin_1	145	151	PF00069	0.399
MOD_ProDKin_1	169	175	PF00069	0.366
MOD_ProDKin_1	240	246	PF00069	0.543
MOD_SUMO_rev_2	228	236	PF00179	0.506
TRG_DiLeu_BaEn_1	104	109	PF01217	0.349
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.446
TRG_ENDOCYTIC_2	77	80	PF00928	0.428
TRG_ER_diArg_1	179	181	PF00400	0.375
TRG_ER_diArg_1	285	287	PF00400	0.533
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.469
TRG_PTS1	303	306	PF00515	0.412

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P758	Leptomonas seymouri	65%	94%
A0A0S4J3K3	Bodo saltans	35%	78%
A0A0S4J3X3	Bodo saltans	35%	82%
A0A1X0NMM8	Trypanosomatidae	50%	89%
A0A3R7NP68	Trypanosoma rangeli	51%	92%
A0A3S7WQN6	Leishmania donovani	92%	100%
A4H5N9	Leishmania braziliensis	86%	100%
A4H5Q0	Leishmania braziliensis	86%	100%
A4HTZ0	Leishmania infantum	92%	100%
D0A8W8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	92%
Q4QHV5	Leishmania major	92%	100%
V5BSP2	Trypanosoma cruzi	47%	80%