LeishMANIAdb
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Putative prefoldin subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative prefoldin subunit 2
Gene product:
prefoldin subunit 2, putative
Species:
Leishmania mexicana
UniProt:
E9AMR8_LEIMU
TriTrypDb:
LmxM.09.0670
Length:
138

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016272 prefoldin complex 2 11
GO:0032991 protein-containing complex 1 11
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AMR8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMR8

Function

Biological processes
Term Name Level Count
GO:0006457 protein folding 2 11
GO:0009987 cellular process 1 11
Molecular functions
Term Name Level Count
GO:0005488 binding 1 11
GO:0005515 protein binding 2 11
GO:0051082 unfolded protein binding 3 11
GO:0044183 protein folding chaperone 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 134 138 PF00082 0.631
CLV_PCSK_SKI1_1 89 93 PF00082 0.326
DEG_APCC_DBOX_1 88 96 PF00400 0.574
DOC_USP7_MATH_1 126 130 PF00917 0.629
DOC_USP7_MATH_1 3 7 PF00917 0.711
DOC_USP7_MATH_1 30 34 PF00917 0.549
LIG_Actin_WH2_2 81 98 PF00022 0.529
LIG_FHA_2 71 77 PF00498 0.488
LIG_PDZ_Class_2 133 138 PF00595 0.616
LIG_SUMO_SIM_par_1 68 73 PF11976 0.591
MOD_CK1_1 10 16 PF00069 0.564
MOD_CK2_1 3 9 PF00069 0.663
MOD_CK2_1 70 76 PF00069 0.528
MOD_GlcNHglycan 27 31 PF01048 0.374
MOD_GlcNHglycan 5 8 PF01048 0.670
MOD_GlcNHglycan 9 12 PF01048 0.612
MOD_GSK3_1 122 129 PF00069 0.702
MOD_GSK3_1 26 33 PF00069 0.563
MOD_GSK3_1 3 10 PF00069 0.667
MOD_N-GLC_1 126 131 PF02516 0.725
MOD_N-GLC_1 3 8 PF02516 0.655
MOD_N-GLC_1 39 44 PF02516 0.374
MOD_Plk_1 26 32 PF00069 0.524
MOD_Plk_1 70 76 PF00069 0.488
TRG_ENDOCYTIC_2 21 24 PF00928 0.488
TRG_Pf-PMV_PEXEL_1 53 58 PF00026 0.313
TRG_Pf-PMV_PEXEL_1 97 101 PF00026 0.299

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7J2 Leptomonas seymouri 90% 99%
A0A0S4JE59 Bodo saltans 48% 97%
A0A1X0NMS2 Trypanosomatidae 51% 93%
A0A3S7WQR3 Leishmania donovani 94% 100%
A0A422NV63 Trypanosoma rangeli 48% 94%
A1A4P5 Bos taurus 38% 90%
A4HTY8 Leishmania infantum 94% 100%
A8WVJ9 Caenorhabditis briggsae 32% 97%
B0BN18 Rattus norvegicus 41% 90%
D0A9E4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 95%
O70591 Mus musculus 42% 90%
Q4QHV7 Leishmania major 97% 100%
Q55GN3 Dictyostelium discoideum 40% 100%
Q9LJ98 Arabidopsis thaliana 36% 93%
Q9N5M2 Caenorhabditis elegans 32% 98%
Q9UHV9 Homo sapiens 39% 90%
Q9UTC9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
Q9VTE5 Drosophila melanogaster 32% 97%
V5DJI3 Trypanosoma cruzi 56% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS