Zeta_toxin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zeta toxin, putative

Species:

Leishmania mexicana

UniProt:

E9AMR6_LEIMU

TriTrypDb:

LmxM.09.0650

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMR6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	567	571	PF00656	0.650
CLV_NRD_NRD_1	210	212	PF00675	0.218
CLV_NRD_NRD_1	327	329	PF00675	0.483
CLV_NRD_NRD_1	477	479	PF00675	0.658
CLV_NRD_NRD_1	480	482	PF00675	0.660
CLV_PCSK_FUR_1	475	479	PF00082	0.578
CLV_PCSK_KEX2_1	210	212	PF00082	0.218
CLV_PCSK_KEX2_1	327	329	PF00082	0.505
CLV_PCSK_KEX2_1	346	348	PF00082	0.423
CLV_PCSK_KEX2_1	477	479	PF00082	0.663
CLV_PCSK_KEX2_1	480	482	PF00082	0.666
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.423
CLV_PCSK_PC7_1	323	329	PF00082	0.447
CLV_PCSK_SKI1_1	249	253	PF00082	0.487
CLV_PCSK_SKI1_1	425	429	PF00082	0.487
CLV_PCSK_SKI1_1	481	485	PF00082	0.633
CLV_PCSK_SKI1_1	551	555	PF00082	0.720
CLV_PCSK_SKI1_1	81	85	PF00082	0.397
DEG_APCC_DBOX_1	75	83	PF00400	0.469
DEG_COP1_1	9	18	PF00400	0.633
DEG_SCF_FBW7_1	127	134	PF00400	0.673
DEG_SPOP_SBC_1	529	533	PF00917	0.600
DOC_CKS1_1	132	137	PF01111	0.467
DOC_CKS1_1	15	20	PF01111	0.607
DOC_CYCLIN_RxL_1	548	555	PF00134	0.616
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.538
DOC_CYCLIN_yCln2_LP_2	139	145	PF00134	0.530
DOC_MAPK_DCC_7	137	147	PF00069	0.534
DOC_MAPK_gen_1	210	218	PF00069	0.218
DOC_MAPK_gen_1	327	333	PF00069	0.413
DOC_MAPK_gen_1	346	352	PF00069	0.403
DOC_MAPK_gen_1	539	548	PF00069	0.647
DOC_MAPK_MEF2A_6	137	145	PF00069	0.547
DOC_MAPK_MEF2A_6	210	218	PF00069	0.381
DOC_MAPK_RevD_3	312	328	PF00069	0.429
DOC_MAPK_RevD_3	331	347	PF00069	0.397
DOC_PP2B_LxvP_1	115	118	PF13499	0.497
DOC_PP2B_LxvP_1	139	142	PF13499	0.533
DOC_PP2B_LxvP_1	169	172	PF13499	0.447
DOC_PP2B_LxvP_1	237	240	PF13499	0.391
DOC_PP4_FxxP_1	132	135	PF00568	0.629
DOC_USP7_MATH_1	206	210	PF00917	0.479
DOC_USP7_MATH_1	224	228	PF00917	0.193
DOC_USP7_MATH_1	528	532	PF00917	0.694
DOC_USP7_MATH_1	603	607	PF00917	0.665
DOC_WW_Pin1_4	110	115	PF00397	0.394
DOC_WW_Pin1_4	123	128	PF00397	0.599
DOC_WW_Pin1_4	131	136	PF00397	0.592
DOC_WW_Pin1_4	152	157	PF00397	0.441
DOC_WW_Pin1_4	3	8	PF00397	0.745
DOC_WW_Pin1_4	45	50	PF00397	0.728
DOC_WW_Pin1_4	524	529	PF00397	0.651
DOC_WW_Pin1_4	597	602	PF00397	0.531
DOC_WW_Pin1_4	608	613	PF00397	0.594
DOC_WW_Pin1_4	9	14	PF00397	0.640
LIG_14-3-3_CanoR_1	152	156	PF00244	0.456
LIG_14-3-3_CanoR_1	379	384	PF00244	0.517
LIG_14-3-3_CanoR_1	40	49	PF00244	0.661
LIG_14-3-3_CanoR_1	478	488	PF00244	0.620
LIG_14-3-3_CanoR_1	539	548	PF00244	0.614
LIG_14-3-3_CanoR_1	607	611	PF00244	0.524
LIG_14-3-3_CanoR_1	76	80	PF00244	0.365
LIG_14-3-3_CanoR_1	92	101	PF00244	0.486
LIG_BIR_II_1	1	5	PF00653	0.579
LIG_FAT_LD_1	317	325	PF03623	0.401
LIG_FHA_1	114	120	PF00498	0.558
LIG_FHA_1	243	249	PF00498	0.306
LIG_FHA_1	457	463	PF00498	0.569
LIG_FHA_2	419	425	PF00498	0.441
LIG_FHA_2	431	437	PF00498	0.364
LIG_GBD_Chelix_1	312	320	PF00786	0.247
LIG_HP1_1	118	122	PF01393	0.510
LIG_LIR_Apic_2	130	135	PF02991	0.620
LIG_LIR_Gen_1	199	206	PF02991	0.420
LIG_LIR_Gen_1	393	402	PF02991	0.244
LIG_LIR_Gen_1	424	435	PF02991	0.442
LIG_LIR_Gen_1	437	448	PF02991	0.459
LIG_LIR_Gen_1	623	633	PF02991	0.654
LIG_LIR_Nem_3	199	204	PF02991	0.422
LIG_LIR_Nem_3	260	266	PF02991	0.419
LIG_LIR_Nem_3	29	34	PF02991	0.473
LIG_LIR_Nem_3	393	397	PF02991	0.364
LIG_LIR_Nem_3	424	430	PF02991	0.456
LIG_LIR_Nem_3	437	443	PF02991	0.500
LIG_LIR_Nem_3	509	515	PF02991	0.593
LIG_LIR_Nem_3	623	628	PF02991	0.660
LIG_LIR_Nem_3	73	77	PF02991	0.420
LIG_NRBOX	100	106	PF00104	0.470
LIG_NRBOX	320	326	PF00104	0.473
LIG_OCRL_FandH_1	426	438	PF00620	0.404
LIG_Pex14_2	263	267	PF04695	0.412
LIG_SH2_NCK_1	109	113	PF00017	0.488
LIG_SH2_PTP2	440	443	PF00017	0.299
LIG_SH2_STAT3	306	309	PF00017	0.346
LIG_SH2_STAT5	109	112	PF00017	0.625
LIG_SH2_STAT5	167	170	PF00017	0.415
LIG_SH2_STAT5	342	345	PF00017	0.409
LIG_SH2_STAT5	390	393	PF00017	0.403
LIG_SH2_STAT5	440	443	PF00017	0.299
LIG_SH3_3	10	16	PF00018	0.764
LIG_SH3_3	138	144	PF00018	0.536
LIG_SH3_3	215	221	PF00018	0.197
LIG_SH3_3	288	294	PF00018	0.487
LIG_SH3_3	359	365	PF00018	0.403
LIG_SH3_3	505	511	PF00018	0.639
LIG_SH3_3	571	577	PF00018	0.502
LIG_SH3_3	595	601	PF00018	0.531
LIG_SH3_3	625	631	PF00018	0.635
LIG_SUMO_SIM_par_1	116	124	PF11976	0.536
LIG_SUMO_SIM_par_1	143	149	PF11976	0.504
LIG_SUMO_SIM_par_1	412	419	PF11976	0.441
LIG_WRC_WIRS_1	391	396	PF05994	0.447
MOD_CDK_SPxK_1	127	133	PF00069	0.620
MOD_CK1_1	244	250	PF00069	0.484
MOD_CK1_1	45	51	PF00069	0.673
MOD_CK1_1	489	495	PF00069	0.693
MOD_CK1_1	562	568	PF00069	0.666
MOD_CK1_1	587	593	PF00069	0.621
MOD_CK1_1	6	12	PF00069	0.684
MOD_CK1_1	606	612	PF00069	0.632
MOD_CK2_1	266	272	PF00069	0.432
MOD_CK2_1	293	299	PF00069	0.718
MOD_CK2_1	366	372	PF00069	0.472
MOD_CK2_1	430	436	PF00069	0.449
MOD_CK2_1	47	53	PF00069	0.674
MOD_DYRK1A_RPxSP_1	597	601	PF00069	0.490
MOD_GlcNHglycan	105	108	PF01048	0.528
MOD_GlcNHglycan	185	188	PF01048	0.364
MOD_GlcNHglycan	221	224	PF01048	0.254
MOD_GlcNHglycan	295	298	PF01048	0.485
MOD_GlcNHglycan	481	484	PF01048	0.651
MOD_GlcNHglycan	49	52	PF01048	0.652
MOD_GlcNHglycan	491	494	PF01048	0.642
MOD_GlcNHglycan	496	499	PF01048	0.809
MOD_GlcNHglycan	541	544	PF01048	0.642
MOD_GlcNHglycan	570	573	PF01048	0.787
MOD_GlcNHglycan	577	580	PF01048	0.655
MOD_GSK3_1	103	110	PF00069	0.507
MOD_GSK3_1	123	130	PF00069	0.564
MOD_GSK3_1	172	179	PF00069	0.474
MOD_GSK3_1	224	231	PF00069	0.292
MOD_GSK3_1	41	48	PF00069	0.590
MOD_GSK3_1	430	437	PF00069	0.442
MOD_GSK3_1	487	494	PF00069	0.655
MOD_GSK3_1	524	531	PF00069	0.819
MOD_GSK3_1	564	571	PF00069	0.675
MOD_GSK3_1	580	587	PF00069	0.660
MOD_GSK3_1	606	613	PF00069	0.605
MOD_GSK3_1	629	636	PF00069	0.592
MOD_N-GLC_1	159	164	PF02516	0.510
MOD_N-GLC_1	486	491	PF02516	0.706
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	121	126	PF00069	0.515
MOD_NEK2_1	151	156	PF00069	0.544
MOD_NEK2_1	232	237	PF00069	0.306
MOD_NEK2_1	266	271	PF00069	0.421
MOD_NEK2_1	350	355	PF00069	0.451
MOD_NEK2_1	416	421	PF00069	0.411
MOD_NEK2_1	430	435	PF00069	0.307
MOD_NEK2_1	488	493	PF00069	0.504
MOD_PIKK_1	159	165	PF00454	0.704
MOD_PIKK_1	232	238	PF00454	0.366
MOD_PIKK_1	564	570	PF00454	0.593
MOD_PK_1	327	333	PF00069	0.413
MOD_PKA_1	327	333	PF00069	0.444
MOD_PKA_2	151	157	PF00069	0.444
MOD_PKA_2	327	333	PF00069	0.444
MOD_PKA_2	479	485	PF00069	0.657
MOD_PKA_2	562	568	PF00069	0.709
MOD_PKA_2	596	602	PF00069	0.649
MOD_PKA_2	606	612	PF00069	0.614
MOD_PKA_2	75	81	PF00069	0.394
MOD_PKA_2	93	99	PF00069	0.486
MOD_PKB_1	377	385	PF00069	0.548
MOD_Plk_1	423	429	PF00069	0.384
MOD_Plk_4	228	234	PF00069	0.352
MOD_Plk_4	26	32	PF00069	0.482
MOD_Plk_4	327	333	PF00069	0.416
MOD_Plk_4	430	436	PF00069	0.401
MOD_Plk_4	570	576	PF00069	0.712
MOD_Plk_4	629	635	PF00069	0.650
MOD_ProDKin_1	110	116	PF00069	0.393
MOD_ProDKin_1	123	129	PF00069	0.606
MOD_ProDKin_1	131	137	PF00069	0.587
MOD_ProDKin_1	14	20	PF00069	0.617
MOD_ProDKin_1	152	158	PF00069	0.444
MOD_ProDKin_1	3	9	PF00069	0.745
MOD_ProDKin_1	45	51	PF00069	0.732
MOD_ProDKin_1	524	530	PF00069	0.652
MOD_ProDKin_1	597	603	PF00069	0.533
MOD_ProDKin_1	608	614	PF00069	0.594
TRG_DiLeu_BaEn_1	334	339	PF01217	0.363
TRG_DiLeu_BaEn_1	629	634	PF01217	0.677
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.313
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.427
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.457
TRG_ENDOCYTIC_2	440	443	PF00928	0.441
TRG_ER_diArg_1	210	212	PF00400	0.197
TRG_ER_diArg_1	252	255	PF00400	0.422
TRG_ER_diArg_1	376	379	PF00400	0.527
TRG_ER_diArg_1	474	477	PF00400	0.636
TRG_ER_diArg_1	478	481	PF00400	0.687
TRG_ER_diArg_1	538	541	PF00400	0.687
TRG_Pf-PMV_PEXEL_1	551	555	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	99	103	PF00026	0.284

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I622	Leptomonas seymouri	46%	96%
A0A3S5H6D7	Leishmania donovani	88%	99%
A4H5P6	Leishmania braziliensis	78%	100%
A4HTY6	Leishmania infantum	88%	100%
D0A9E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	81%
Q4QHV9	Leishmania major	85%	97%