Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMR3_LEIMU

TriTrypDb:

LmxM.09.0620

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMR3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	169	173	PF00656	0.669
CLV_C14_Caspase3-7	377	381	PF00656	0.404
CLV_C14_Caspase3-7	645	649	PF00656	0.445
CLV_C14_Caspase3-7	83	87	PF00656	0.684
CLV_NRD_NRD_1	2	4	PF00675	0.734
CLV_NRD_NRD_1	229	231	PF00675	0.593
CLV_NRD_NRD_1	356	358	PF00675	0.409
CLV_NRD_NRD_1	387	389	PF00675	0.431
CLV_NRD_NRD_1	472	474	PF00675	0.492
CLV_NRD_NRD_1	515	517	PF00675	0.494
CLV_NRD_NRD_1	636	638	PF00675	0.543
CLV_NRD_NRD_1	65	67	PF00675	0.736
CLV_PCSK_FUR_1	402	406	PF00082	0.583
CLV_PCSK_KEX2_1	2	4	PF00082	0.734
CLV_PCSK_KEX2_1	229	231	PF00082	0.593
CLV_PCSK_KEX2_1	29	31	PF00082	0.621
CLV_PCSK_KEX2_1	356	358	PF00082	0.409
CLV_PCSK_KEX2_1	387	389	PF00082	0.431
CLV_PCSK_KEX2_1	404	406	PF00082	0.655
CLV_PCSK_KEX2_1	472	474	PF00082	0.492
CLV_PCSK_KEX2_1	515	517	PF00082	0.494
CLV_PCSK_KEX2_1	638	640	PF00082	0.432
CLV_PCSK_KEX2_1	64	66	PF00082	0.745
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.621
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.583
CLV_PCSK_PC1ET2_1	638	640	PF00082	0.427
CLV_PCSK_SKI1_1	108	112	PF00082	0.495
CLV_PCSK_SKI1_1	139	143	PF00082	0.459
CLV_PCSK_SKI1_1	328	332	PF00082	0.444
DEG_Nend_UBRbox_1	1	4	PF02207	0.663
DOC_ANK_TNKS_1	356	363	PF00023	0.361
DOC_CKS1_1	317	322	PF01111	0.673
DOC_CKS1_1	492	497	PF01111	0.456
DOC_CKS1_1	98	103	PF01111	0.464
DOC_PP1_RVXF_1	636	643	PF00149	0.464
DOC_PP4_FxxP_1	243	246	PF00568	0.338
DOC_PP4_FxxP_1	612	615	PF00568	0.644
DOC_USP7_MATH_1	301	305	PF00917	0.621
DOC_USP7_MATH_1	519	523	PF00917	0.607
DOC_USP7_UBL2_3	125	129	PF12436	0.510
DOC_WW_Pin1_4	204	209	PF00397	0.582
DOC_WW_Pin1_4	242	247	PF00397	0.584
DOC_WW_Pin1_4	316	321	PF00397	0.636
DOC_WW_Pin1_4	416	421	PF00397	0.573
DOC_WW_Pin1_4	491	496	PF00397	0.462
DOC_WW_Pin1_4	56	61	PF00397	0.686
DOC_WW_Pin1_4	6	11	PF00397	0.727
DOC_WW_Pin1_4	97	102	PF00397	0.465
LIG_14-3-3_CanoR_1	118	124	PF00244	0.558
LIG_14-3-3_CanoR_1	276	285	PF00244	0.533
LIG_14-3-3_CanoR_1	328	335	PF00244	0.435
LIG_14-3-3_CanoR_1	405	414	PF00244	0.555
LIG_14-3-3_CanoR_1	440	446	PF00244	0.494
LIG_14-3-3_CanoR_1	604	608	PF00244	0.627
LIG_Actin_WH2_2	123	141	PF00022	0.507
LIG_Actin_WH2_2	590	606	PF00022	0.447
LIG_BRCT_BRCA1_1	407	411	PF00533	0.428
LIG_BRCT_BRCA1_1	567	571	PF00533	0.560
LIG_Clathr_ClatBox_1	22	26	PF01394	0.475
LIG_deltaCOP1_diTrp_1	583	586	PF00928	0.447
LIG_FHA_1	130	136	PF00498	0.526
LIG_FHA_1	140	146	PF00498	0.395
LIG_FHA_1	259	265	PF00498	0.370
LIG_FHA_1	346	352	PF00498	0.535
LIG_FHA_1	430	436	PF00498	0.616
LIG_FHA_1	475	481	PF00498	0.381
LIG_FHA_1	501	507	PF00498	0.353
LIG_FHA_1	98	104	PF00498	0.456
LIG_FHA_2	109	115	PF00498	0.452
LIG_FHA_2	167	173	PF00498	0.622
LIG_FHA_2	332	338	PF00498	0.360
LIG_FHA_2	81	87	PF00498	0.669
LIG_LIR_Apic_2	611	615	PF02991	0.650
LIG_LIR_Apic_2	95	101	PF02991	0.569
LIG_LIR_Gen_1	100	110	PF02991	0.551
LIG_LIR_Gen_1	245	255	PF02991	0.498
LIG_LIR_Gen_1	263	273	PF02991	0.243
LIG_LIR_Gen_1	369	379	PF02991	0.380
LIG_LIR_Gen_1	408	417	PF02991	0.454
LIG_LIR_Nem_3	100	105	PF02991	0.554
LIG_LIR_Nem_3	245	251	PF02991	0.502
LIG_LIR_Nem_3	263	268	PF02991	0.231
LIG_LIR_Nem_3	408	414	PF02991	0.452
LIG_MYND_3	270	274	PF01753	0.469
LIG_NRP_CendR_1	650	653	PF00754	0.590
LIG_Pex14_2	265	269	PF04695	0.253
LIG_PTB_Apo_2	259	266	PF02174	0.266
LIG_PTB_Apo_2	482	489	PF02174	0.402
LIG_PTB_Phospho_1	482	488	PF10480	0.403
LIG_SH2_CRK	195	199	PF00017	0.438
LIG_SH2_CRK	218	222	PF00017	0.511
LIG_SH2_CRK	98	102	PF00017	0.550
LIG_SH2_GRB2like	260	263	PF00017	0.263
LIG_SH2_NCK_1	98	102	PF00017	0.550
LIG_SH2_STAP1	260	264	PF00017	0.375
LIG_SH2_STAP1	367	371	PF00017	0.452
LIG_SH2_STAP1	567	571	PF00017	0.560
LIG_SH2_STAT3	335	338	PF00017	0.368
LIG_SH2_STAT5	260	263	PF00017	0.387
LIG_SH2_STAT5	344	347	PF00017	0.446
LIG_SH2_STAT5	488	491	PF00017	0.471
LIG_SH2_STAT5	517	520	PF00017	0.569
LIG_SH3_3	187	193	PF00018	0.588
LIG_SH3_3	284	290	PF00018	0.524
LIG_SH3_3	487	493	PF00018	0.342
LIG_SUMO_SIM_anti_2	18	24	PF11976	0.483
LIG_SUMO_SIM_anti_2	503	508	PF11976	0.330
LIG_SUMO_SIM_par_1	21	27	PF11976	0.475
LIG_SUMO_SIM_par_1	452	458	PF11976	0.338
LIG_TRAF2_1	320	323	PF00917	0.586
LIG_TRAF2_1	334	337	PF00917	0.321
LIG_UBA3_1	22	29	PF00899	0.470
LIG_WRC_WIRS_1	94	99	PF05994	0.483
MOD_CDK_SPxK_1	491	497	PF00069	0.456
MOD_CK1_1	153	159	PF00069	0.578
MOD_CK1_1	18	24	PF00069	0.630
MOD_CK1_1	316	322	PF00069	0.526
MOD_CK1_1	412	418	PF00069	0.590
MOD_CK1_1	424	430	PF00069	0.704
MOD_CK1_1	438	444	PF00069	0.555
MOD_CK1_1	80	86	PF00069	0.653
MOD_CK2_1	108	114	PF00069	0.424
MOD_CK2_1	331	337	PF00069	0.372
MOD_Cter_Amidation	402	405	PF01082	0.585
MOD_GlcNHglycan	155	158	PF01048	0.602
MOD_GlcNHglycan	177	180	PF01048	0.676
MOD_GlcNHglycan	305	308	PF01048	0.614
MOD_GlcNHglycan	311	314	PF01048	0.607
MOD_GlcNHglycan	414	417	PF01048	0.717
MOD_GlcNHglycan	423	426	PF01048	0.644
MOD_GlcNHglycan	437	440	PF01048	0.542
MOD_GlcNHglycan	572	575	PF01048	0.439
MOD_GlcNHglycan	578	581	PF01048	0.340
MOD_GSK3_1	125	132	PF00069	0.470
MOD_GSK3_1	146	153	PF00069	0.605
MOD_GSK3_1	260	267	PF00069	0.455
MOD_GSK3_1	295	302	PF00069	0.512
MOD_GSK3_1	309	316	PF00069	0.549
MOD_GSK3_1	405	412	PF00069	0.561
MOD_GSK3_1	419	426	PF00069	0.632
MOD_GSK3_1	441	448	PF00069	0.544
MOD_GSK3_1	474	481	PF00069	0.471
MOD_GSK3_1	566	573	PF00069	0.504
MOD_GSK3_1	93	100	PF00069	0.609
MOD_N-GLC_1	409	414	PF02516	0.516
MOD_NEK2_1	1	6	PF00069	0.768
MOD_NEK2_1	119	124	PF00069	0.467
MOD_NEK2_1	146	151	PF00069	0.488
MOD_NEK2_1	203	208	PF00069	0.574
MOD_NEK2_1	295	300	PF00069	0.487
MOD_NEK2_1	382	387	PF00069	0.456
MOD_NEK2_1	423	428	PF00069	0.624
MOD_NEK2_1	435	440	PF00069	0.607
MOD_NEK2_1	474	479	PF00069	0.398
MOD_NEK2_1	603	608	PF00069	0.601
MOD_NEK2_2	260	265	PF00069	0.377
MOD_NEK2_2	93	98	PF00069	0.501
MOD_PIKK_1	147	153	PF00454	0.535
MOD_PIKK_1	313	319	PF00454	0.613
MOD_PIKK_1	382	388	PF00454	0.462
MOD_PIKK_1	438	444	PF00454	0.533
MOD_PKA_2	1	7	PF00069	0.724
MOD_PKA_2	119	125	PF00069	0.544
MOD_PKA_2	173	179	PF00069	0.626
MOD_PKA_2	435	441	PF00069	0.588
MOD_PKA_2	603	609	PF00069	0.600
MOD_Plk_1	409	415	PF00069	0.448
MOD_Plk_4	18	24	PF00069	0.483
MOD_Plk_4	260	266	PF00069	0.372
MOD_Plk_4	445	451	PF00069	0.436
MOD_Plk_4	608	614	PF00069	0.639
MOD_Plk_4	93	99	PF00069	0.654
MOD_ProDKin_1	204	210	PF00069	0.590
MOD_ProDKin_1	242	248	PF00069	0.620
MOD_ProDKin_1	316	322	PF00069	0.702
MOD_ProDKin_1	416	422	PF00069	0.574
MOD_ProDKin_1	491	497	PF00069	0.458
MOD_ProDKin_1	56	62	PF00069	0.683
MOD_ProDKin_1	6	12	PF00069	0.727
MOD_ProDKin_1	97	103	PF00069	0.461
TRG_DiLeu_BaLyEn_6	540	545	PF01217	0.620
TRG_ENDOCYTIC_2	195	198	PF00928	0.438
TRG_ENDOCYTIC_2	488	491	PF00928	0.507
TRG_ER_diArg_1	1	3	PF00400	0.747
TRG_ER_diArg_1	118	121	PF00400	0.482
TRG_ER_diArg_1	471	473	PF00400	0.496
TRG_ER_diArg_1	514	516	PF00400	0.485
TRG_ER_diArg_1	63	66	PF00400	0.740
TRG_ER_diArg_1	637	640	PF00400	0.530
TRG_NES_CRM1_1	124	136	PF08389	0.562
TRG_Pf-PMV_PEXEL_1	388	392	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC90	Leptomonas seymouri	58%	88%
A0A3R7NXN4	Trypanosoma rangeli	34%	100%
A0A3S7WQN2	Leishmania donovani	91%	100%
A4H5P3	Leishmania braziliensis	81%	100%
A4HTY3	Leishmania infantum	92%	100%
D0A9D9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4QHW2	Leishmania major	93%	100%
V5DJH4	Trypanosoma cruzi	33%	100%