Glucosidase 2 subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Glucosidase II beta subunit-like, putative

Species:

Leishmania mexicana

UniProt:

E9AMR2_LEIMU

TriTrypDb:

LmxM.09.0610

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0017177	glucosidase II complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140534	endoplasmic reticulum protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AMR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMR2

Function

Biological processes
Term	Name	Level	Count
GO:0006491	N-glycan processing	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009100	glycoprotein metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.461
CLV_C14_Caspase3-7	651	655	PF00656	0.614
CLV_C14_Caspase3-7	67	71	PF00656	0.808
CLV_C14_Caspase3-7	702	706	PF00656	0.586
CLV_NRD_NRD_1	108	110	PF00675	0.595
CLV_NRD_NRD_1	131	133	PF00675	0.660
CLV_NRD_NRD_1	261	263	PF00675	0.680
CLV_NRD_NRD_1	354	356	PF00675	0.665
CLV_NRD_NRD_1	422	424	PF00675	0.484
CLV_NRD_NRD_1	46	48	PF00675	0.834
CLV_NRD_NRD_1	522	524	PF00675	0.606
CLV_NRD_NRD_1	549	551	PF00675	0.621
CLV_NRD_NRD_1	671	673	PF00675	0.445
CLV_NRD_NRD_1	710	712	PF00675	0.514
CLV_PCSK_KEX2_1	131	133	PF00082	0.678
CLV_PCSK_KEX2_1	263	265	PF00082	0.641
CLV_PCSK_KEX2_1	354	356	PF00082	0.667
CLV_PCSK_KEX2_1	421	423	PF00082	0.536
CLV_PCSK_KEX2_1	46	48	PF00082	0.834
CLV_PCSK_KEX2_1	522	524	PF00082	0.606
CLV_PCSK_KEX2_1	549	551	PF00082	0.621
CLV_PCSK_KEX2_1	671	673	PF00082	0.447
CLV_PCSK_KEX2_1	710	712	PF00082	0.494
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.699
CLV_PCSK_PC7_1	127	133	PF00082	0.525
CLV_PCSK_PC7_1	418	424	PF00082	0.533
CLV_PCSK_SKI1_1	132	136	PF00082	0.647
CLV_PCSK_SKI1_1	166	170	PF00082	0.542
CLV_PCSK_SKI1_1	289	293	PF00082	0.598
CLV_PCSK_SKI1_1	381	385	PF00082	0.513
CLV_PCSK_SKI1_1	522	526	PF00082	0.304
CLV_PCSK_SKI1_1	552	556	PF00082	0.691
CLV_PCSK_SKI1_1	711	715	PF00082	0.623
CLV_PCSK_SKI1_1	825	829	PF00082	0.556
DEG_APCC_DBOX_1	188	196	PF00400	0.536
DEG_SCF_FBW7_1	731	737	PF00400	0.581
DEG_SPOP_SBC_1	86	90	PF00917	0.729
DOC_ANK_TNKS_1	765	772	PF00023	0.551
DOC_CKS1_1	168	173	PF01111	0.599
DOC_CKS1_1	219	224	PF01111	0.663
DOC_CKS1_1	314	319	PF01111	0.766
DOC_CKS1_1	553	558	PF01111	0.697
DOC_CKS1_1	731	736	PF01111	0.621
DOC_CKS1_1	813	818	PF01111	0.431
DOC_CYCLIN_RxL_1	286	295	PF00134	0.602
DOC_CYCLIN_RxL_1	520	530	PF00134	0.309
DOC_MAPK_MEF2A_6	439	446	PF00069	0.600
DOC_MAPK_NFAT4_5	439	447	PF00069	0.600
DOC_MAPK_RevD_3	407	423	PF00069	0.517
DOC_PP1_RVXF_1	685	691	PF00149	0.630
DOC_PP1_RVXF_1	795	802	PF00149	0.385
DOC_PP2B_LxvP_1	291	294	PF13499	0.595
DOC_PP4_FxxP_1	104	107	PF00568	0.496
DOC_PP4_FxxP_1	38	41	PF00568	0.632
DOC_USP7_MATH_1	475	479	PF00917	0.565
DOC_USP7_MATH_1	494	498	PF00917	0.300
DOC_USP7_MATH_1	642	646	PF00917	0.553
DOC_USP7_MATH_1	84	88	PF00917	0.758
DOC_USP7_UBL2_3	714	718	PF12436	0.646
DOC_USP7_UBL2_3	832	836	PF12436	0.608
DOC_WW_Pin1_4	167	172	PF00397	0.595
DOC_WW_Pin1_4	218	223	PF00397	0.643
DOC_WW_Pin1_4	313	318	PF00397	0.724
DOC_WW_Pin1_4	319	324	PF00397	0.736
DOC_WW_Pin1_4	364	369	PF00397	0.616
DOC_WW_Pin1_4	534	539	PF00397	0.625
DOC_WW_Pin1_4	552	557	PF00397	0.607
DOC_WW_Pin1_4	621	626	PF00397	0.641
DOC_WW_Pin1_4	730	735	PF00397	0.615
DOC_WW_Pin1_4	736	741	PF00397	0.514
DOC_WW_Pin1_4	755	760	PF00397	0.576
DOC_WW_Pin1_4	78	83	PF00397	0.797
DOC_WW_Pin1_4	812	817	PF00397	0.405
LIG_14-3-3_CanoR_1	109	114	PF00244	0.623
LIG_14-3-3_CanoR_1	227	232	PF00244	0.644
LIG_14-3-3_CanoR_1	325	333	PF00244	0.563
LIG_14-3-3_CanoR_1	354	361	PF00244	0.679
LIG_14-3-3_CanoR_1	439	443	PF00244	0.350
LIG_14-3-3_CanoR_1	536	542	PF00244	0.635
LIG_14-3-3_CanoR_1	592	596	PF00244	0.546
LIG_14-3-3_CanoR_1	676	682	PF00244	0.625
LIG_14-3-3_CanoR_1	710	717	PF00244	0.403
LIG_14-3-3_CanoR_1	780	785	PF00244	0.610
LIG_14-3-3_CanoR_1	85	95	PF00244	0.612
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_BRCT_BRCA1_1	100	104	PF00533	0.454
LIG_BRCT_BRCA1_1	678	682	PF00533	0.708
LIG_deltaCOP1_diTrp_1	7	12	PF00928	0.659
LIG_EH_1	632	636	PF12763	0.360
LIG_eIF4E_1	515	521	PF01652	0.530
LIG_FHA_1	119	125	PF00498	0.590
LIG_FHA_1	162	168	PF00498	0.517
LIG_FHA_1	204	210	PF00498	0.455
LIG_FHA_1	219	225	PF00498	0.592
LIG_FHA_1	439	445	PF00498	0.519
LIG_FHA_1	448	454	PF00498	0.515
LIG_FHA_1	622	628	PF00498	0.625
LIG_FHA_1	723	729	PF00498	0.678
LIG_FHA_1	737	743	PF00498	0.459
LIG_FHA_1	747	753	PF00498	0.593
LIG_FHA_2	168	174	PF00498	0.561
LIG_FHA_2	392	398	PF00498	0.619
LIG_FHA_2	537	543	PF00498	0.686
LIG_FHA_2	553	559	PF00498	0.563
LIG_FHA_2	649	655	PF00498	0.494
LIG_FHA_2	65	71	PF00498	0.754
LIG_FHA_2	710	716	PF00498	0.673
LIG_Integrin_RGD_1	264	266	PF01839	0.695
LIG_LIR_Apic_2	101	107	PF02991	0.491
LIG_LIR_Apic_2	37	41	PF02991	0.630
LIG_LIR_Gen_1	391	398	PF02991	0.575
LIG_LIR_Nem_3	226	231	PF02991	0.646
LIG_LIR_Nem_3	386	392	PF02991	0.557
LIG_LIR_Nem_3	454	459	PF02991	0.598
LIG_LIR_Nem_3	513	518	PF02991	0.470
LIG_LIR_Nem_3	582	588	PF02991	0.297
LIG_LIR_Nem_3	643	649	PF02991	0.539
LIG_LIR_Nem_3	7	11	PF02991	0.689
LIG_LIR_Nem_3	729	735	PF02991	0.681
LIG_LYPXL_yS_3	518	521	PF13949	0.529
LIG_RPA_C_Fungi	705	717	PF08784	0.416
LIG_SH2_SRC	413	416	PF00017	0.553
LIG_SH2_STAP1	369	373	PF00017	0.596
LIG_SH2_STAT3	257	260	PF00017	0.787
LIG_SH2_STAT3	567	570	PF00017	0.702
LIG_SH2_STAT5	199	202	PF00017	0.465
LIG_SH2_STAT5	231	234	PF00017	0.570
LIG_SH2_STAT5	272	275	PF00017	0.701
LIG_SH2_STAT5	393	396	PF00017	0.644
LIG_SH2_STAT5	459	462	PF00017	0.595
LIG_SH2_STAT5	623	626	PF00017	0.647
LIG_SH2_STAT5	732	735	PF00017	0.662
LIG_SH2_STAT5	748	751	PF00017	0.463
LIG_SH2_STAT5	790	793	PF00017	0.415
LIG_SH2_STAT5	95	98	PF00017	0.446
LIG_SH3_1	255	261	PF00018	0.709
LIG_SH3_1	57	63	PF00018	0.573
LIG_SH3_2	258	263	PF14604	0.733
LIG_SH3_3	165	171	PF00018	0.587
LIG_SH3_3	216	222	PF00018	0.652
LIG_SH3_3	255	261	PF00018	0.723
LIG_SH3_3	42	48	PF00018	0.707
LIG_SH3_3	569	575	PF00018	0.689
LIG_SH3_3	57	63	PF00018	0.805
LIG_SH3_3	636	642	PF00018	0.563
LIG_SH3_3	692	698	PF00018	0.751
LIG_SH3_3	728	734	PF00018	0.580
LIG_SH3_3	810	816	PF00018	0.493
LIG_SUMO_SIM_par_1	121	130	PF11976	0.632
LIG_SUMO_SIM_par_1	699	705	PF11976	0.672
LIG_SUMO_SIM_par_1	757	763	PF11976	0.478
LIG_TRAF2_1	170	173	PF00917	0.535
LIG_TRAF2_1	455	458	PF00917	0.554
LIG_TRFH_1	257	261	PF08558	0.717
LIG_TYR_ITIM	583	588	PF00017	0.413
LIG_WRC_WIRS_1	453	458	PF05994	0.292
MOD_CDC14_SPxK_1	322	325	PF00782	0.764
MOD_CDK_SPxK_1	319	325	PF00069	0.768
MOD_CDK_SPxxK_3	78	85	PF00069	0.674
MOD_CK1_1	118	124	PF00069	0.611
MOD_CK1_1	19	25	PF00069	0.689
MOD_CK1_1	274	280	PF00069	0.407
MOD_CK1_1	391	397	PF00069	0.536
MOD_CK1_1	447	453	PF00069	0.526
MOD_CK1_1	503	509	PF00069	0.617
MOD_CK1_1	621	627	PF00069	0.603
MOD_CK1_1	758	764	PF00069	0.487
MOD_CK1_1	817	823	PF00069	0.458
MOD_CK1_1	87	93	PF00069	0.655
MOD_CK2_1	167	173	PF00069	0.491
MOD_CK2_1	364	370	PF00069	0.635
MOD_CK2_1	391	397	PF00069	0.631
MOD_CK2_1	452	458	PF00069	0.549
MOD_CK2_1	552	558	PF00069	0.626
MOD_CK2_1	718	724	PF00069	0.625
MOD_GlcNHglycan	100	103	PF01048	0.511
MOD_GlcNHglycan	149	153	PF01048	0.745
MOD_GlcNHglycan	216	219	PF01048	0.579
MOD_GlcNHglycan	356	359	PF01048	0.643
MOD_GlcNHglycan	378	381	PF01048	0.541
MOD_GlcNHglycan	57	60	PF01048	0.842
MOD_GlcNHglycan	620	623	PF01048	0.617
MOD_GlcNHglycan	72	75	PF01048	0.706
MOD_GlcNHglycan	720	723	PF01048	0.667
MOD_GlcNHglycan	816	819	PF01048	0.390
MOD_GSK3_1	157	164	PF00069	0.590
MOD_GSK3_1	17	24	PF00069	0.685
MOD_GSK3_1	208	215	PF00069	0.478
MOD_GSK3_1	223	230	PF00069	0.596
MOD_GSK3_1	360	367	PF00069	0.620
MOD_GSK3_1	388	395	PF00069	0.560
MOD_GSK3_1	51	58	PF00069	0.801
MOD_GSK3_1	532	539	PF00069	0.590
MOD_GSK3_1	66	73	PF00069	0.628
MOD_GSK3_1	718	725	PF00069	0.665
MOD_GSK3_1	726	733	PF00069	0.661
MOD_GSK3_1	734	741	PF00069	0.493
MOD_GSK3_1	96	103	PF00069	0.528
MOD_N-GLC_1	437	442	PF02516	0.545
MOD_N-GLC_1	447	452	PF02516	0.483
MOD_N-GLC_1	579	584	PF02516	0.488
MOD_N-GLC_1	618	623	PF02516	0.545
MOD_N-GLC_2	212	214	PF02516	0.542
MOD_NEK2_1	16	21	PF00069	0.627
MOD_NEK2_1	232	237	PF00069	0.417
MOD_NEK2_1	271	276	PF00069	0.678
MOD_NEK2_1	281	286	PF00069	0.603
MOD_NEK2_1	444	449	PF00069	0.562
MOD_NEK2_1	527	532	PF00069	0.631
MOD_NEK2_1	53	58	PF00069	0.767
MOD_NEK2_1	541	546	PF00069	0.664
MOD_NEK2_1	591	596	PF00069	0.502
MOD_NEK2_1	628	633	PF00069	0.630
MOD_NEK2_1	760	765	PF00069	0.746
MOD_NEK2_2	388	393	PF00069	0.606
MOD_NEK2_2	677	682	PF00069	0.702
MOD_NEK2_2	722	727	PF00069	0.428
MOD_PIKK_1	184	190	PF00454	0.640
MOD_PIKK_1	232	238	PF00454	0.418
MOD_PIKK_1	726	732	PF00454	0.609
MOD_PIKK_1	760	766	PF00454	0.728
MOD_PKA_1	109	115	PF00069	0.509
MOD_PKA_1	354	360	PF00069	0.703
MOD_PKA_2	108	114	PF00069	0.674
MOD_PKA_2	274	280	PF00069	0.600
MOD_PKA_2	324	330	PF00069	0.719
MOD_PKA_2	354	360	PF00069	0.672
MOD_PKA_2	438	444	PF00069	0.350
MOD_PKA_2	591	597	PF00069	0.503
MOD_PKA_2	629	635	PF00069	0.648
MOD_PKA_2	709	715	PF00069	0.418
MOD_PKA_2	84	90	PF00069	0.487
MOD_PKB_1	778	786	PF00069	0.526
MOD_Plk_1	437	443	PF00069	0.439
MOD_Plk_1	527	533	PF00069	0.636
MOD_Plk_1	579	585	PF00069	0.470
MOD_Plk_1	618	624	PF00069	0.609
MOD_Plk_2-3	125	131	PF00069	0.624
MOD_Plk_2-3	452	458	PF00069	0.581
MOD_Plk_4	100	106	PF00069	0.575
MOD_Plk_4	157	163	PF00069	0.599
MOD_Plk_4	227	233	PF00069	0.660
MOD_Plk_4	274	280	PF00069	0.666
MOD_Plk_4	292	298	PF00069	0.540
MOD_Plk_4	388	394	PF00069	0.514
MOD_Plk_4	581	587	PF00069	0.512
MOD_Plk_4	591	597	PF00069	0.553
MOD_Plk_4	677	683	PF00069	0.690
MOD_Plk_4	738	744	PF00069	0.560
MOD_ProDKin_1	167	173	PF00069	0.594
MOD_ProDKin_1	218	224	PF00069	0.643
MOD_ProDKin_1	313	319	PF00069	0.727
MOD_ProDKin_1	364	370	PF00069	0.613
MOD_ProDKin_1	534	540	PF00069	0.627
MOD_ProDKin_1	552	558	PF00069	0.603
MOD_ProDKin_1	621	627	PF00069	0.636
MOD_ProDKin_1	730	736	PF00069	0.606
MOD_ProDKin_1	755	761	PF00069	0.725
MOD_ProDKin_1	78	84	PF00069	0.795
MOD_ProDKin_1	812	818	PF00069	0.408
MOD_SUMO_rev_2	367	373	PF00179	0.583
MOD_SUMO_rev_2	73	81	PF00179	0.784
TRG_DiLeu_BaEn_1	157	162	PF01217	0.656
TRG_DiLeu_BaEn_1	528	533	PF01217	0.650
TRG_ENDOCYTIC_2	389	392	PF00928	0.615
TRG_ENDOCYTIC_2	393	396	PF00928	0.584
TRG_ENDOCYTIC_2	517	520	PF00928	0.429
TRG_ENDOCYTIC_2	585	588	PF00928	0.295
TRG_ER_diArg_1	261	264	PF00400	0.623
TRG_ER_diArg_1	421	423	PF00400	0.563
TRG_ER_diArg_1	45	47	PF00400	0.791
TRG_ER_diArg_1	521	523	PF00400	0.590
TRG_ER_diArg_1	549	552	PF00400	0.465
TRG_ER_diArg_1	777	780	PF00400	0.725
TRG_Pf-PMV_PEXEL_1	522	526	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	806	810	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC1	Leptomonas seymouri	53%	89%
A0A1X0NMP0	Trypanosomatidae	27%	99%
A0A3Q8I8J4	Leishmania donovani	90%	100%
A0A422NV59	Trypanosoma rangeli	29%	100%
A4HTY2	Leishmania infantum	90%	86%
D0A9D8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AI37	Leishmania braziliensis	80%	98%
Q4QHW3	Leishmania major	90%	100%
V5B314	Trypanosoma cruzi	29%	100%