Putative cyclin 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative cyclin 1

Gene product:

cyclin 1

Species:

Leishmania mexicana

UniProt:

E9AMR1_LEIMU

TriTrypDb:

LmxM.09.0600

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMR1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	283	287	PF00656	0.404
CLV_C14_Caspase3-7	84	88	PF00656	0.384
CLV_NRD_NRD_1	112	114	PF00675	0.234
CLV_NRD_NRD_1	219	221	PF00675	0.301
CLV_PCSK_KEX2_1	112	114	PF00082	0.223
CLV_PCSK_KEX2_1	163	165	PF00082	0.233
CLV_PCSK_KEX2_1	219	221	PF00082	0.261
CLV_PCSK_KEX2_1	229	231	PF00082	0.213
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.233
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.234
CLV_PCSK_SKI1_1	164	168	PF00082	0.328
CLV_PCSK_SKI1_1	226	230	PF00082	0.229
DEG_SPOP_SBC_1	325	329	PF00917	0.491
DOC_CKS1_1	34	39	PF01111	0.528
DOC_CYCLIN_yCln2_LP_2	304	310	PF00134	0.390
DOC_MAPK_DCC_7	68	77	PF00069	0.528
DOC_MAPK_gen_1	163	171	PF00069	0.433
DOC_PP4_FxxP_1	21	24	PF00568	0.460
DOC_USP7_MATH_1	134	138	PF00917	0.441
DOC_USP7_MATH_1	325	329	PF00917	0.581
DOC_WW_Pin1_4	263	268	PF00397	0.571
DOC_WW_Pin1_4	33	38	PF00397	0.507
LIG_14-3-3_CanoR_1	263	267	PF00244	0.572
LIG_14-3-3_CanoR_1	68	73	PF00244	0.452
LIG_AP2alpha_2	314	316	PF02296	0.399
LIG_APCC_ABBA_1	206	211	PF00400	0.434
LIG_FHA_1	253	259	PF00498	0.276
LIG_FHA_1	271	277	PF00498	0.581
LIG_FHA_1	295	301	PF00498	0.490
LIG_FHA_1	37	43	PF00498	0.445
LIG_FHA_1	49	55	PF00498	0.505
LIG_FHA_1	60	66	PF00498	0.530
LIG_FHA_2	178	184	PF00498	0.563
LIG_FHA_2	264	270	PF00498	0.584
LIG_FHA_2	82	88	PF00498	0.380
LIG_FHA_2	93	99	PF00498	0.524
LIG_LIR_Apic_2	156	160	PF02991	0.475
LIG_LIR_Apic_2	19	24	PF02991	0.433
LIG_LIR_Gen_1	188	199	PF02991	0.427
LIG_LIR_Gen_1	221	232	PF02991	0.451
LIG_LIR_Gen_1	240	247	PF02991	0.442
LIG_LIR_Gen_1	314	322	PF02991	0.531
LIG_LIR_Nem_3	188	194	PF02991	0.439
LIG_LIR_Nem_3	240	245	PF02991	0.433
LIG_LIR_Nem_3	314	319	PF02991	0.405
LIG_NRBOX	118	124	PF00104	0.528
LIG_NRBOX	299	305	PF00104	0.422
LIG_SH2_NCK_1	253	257	PF00017	0.390
LIG_SH2_NCK_1	52	56	PF00017	0.464
LIG_SH2_PTP2	193	196	PF00017	0.434
LIG_SH2_STAP1	253	257	PF00017	0.432
LIG_SH2_STAT5	157	160	PF00017	0.528
LIG_SH2_STAT5	193	196	PF00017	0.446
LIG_SH2_STAT5	46	49	PF00017	0.423
LIG_SH3_3	304	310	PF00018	0.436
LIG_SH3_3	31	37	PF00018	0.528
LIG_SUMO_SIM_anti_2	98	103	PF11976	0.490
LIG_SUMO_SIM_par_1	280	286	PF11976	0.470
LIG_SUMO_SIM_par_1	309	314	PF11976	0.348
LIG_SUMO_SIM_par_1	98	103	PF11976	0.434
LIG_TRAF2_2	74	79	PF00917	0.460
LIG_UBA3_1	244	248	PF00899	0.497
LIG_UBA3_1	30	38	PF00899	0.493
MOD_CDK_SPK_2	33	38	PF00069	0.528
MOD_CK1_1	146	152	PF00069	0.464
MOD_CK1_1	328	334	PF00069	0.643
MOD_CK2_1	175	181	PF00069	0.517
MOD_CK2_1	54	60	PF00069	0.473
MOD_DYRK1A_RPxSP_1	263	267	PF00069	0.483
MOD_GlcNHglycan	102	105	PF01048	0.238
MOD_GlcNHglycan	136	139	PF01048	0.233
MOD_GlcNHglycan	145	148	PF01048	0.226
MOD_GlcNHglycan	15	18	PF01048	0.221
MOD_GlcNHglycan	150	153	PF01048	0.207
MOD_GlcNHglycan	328	331	PF01048	0.627
MOD_GSK3_1	100	107	PF00069	0.434
MOD_GSK3_1	142	149	PF00069	0.447
MOD_GSK3_1	185	192	PF00069	0.500
MOD_GSK3_1	19	26	PF00069	0.530
MOD_GSK3_1	259	266	PF00069	0.613
MOD_GSK3_1	268	275	PF00069	0.586
MOD_GSK3_1	29	36	PF00069	0.512
MOD_GSK3_1	294	301	PF00069	0.546
MOD_GSK3_1	324	331	PF00069	0.505
MOD_GSK3_1	56	63	PF00069	0.455
MOD_GSK3_1	81	88	PF00069	0.376
MOD_N-GLC_1	85	90	PF02516	0.192
MOD_NEK2_1	13	18	PF00069	0.295
MOD_NEK2_1	187	192	PF00069	0.528
MOD_NEK2_1	210	215	PF00069	0.489
MOD_NEK2_1	54	59	PF00069	0.433
MOD_NEK2_1	92	97	PF00069	0.433
MOD_NEK2_2	104	109	PF00069	0.434
MOD_PIKK_1	210	216	PF00454	0.498
MOD_PIKK_1	54	60	PF00454	0.533
MOD_PKA_2	262	268	PF00069	0.509
MOD_Plk_1	59	65	PF00069	0.460
MOD_Plk_2-3	23	29	PF00069	0.528
MOD_Plk_4	104	110	PF00069	0.423
MOD_Plk_4	153	159	PF00069	0.528
MOD_Plk_4	29	35	PF00069	0.507
MOD_Plk_4	328	334	PF00069	0.638
MOD_Plk_4	60	66	PF00069	0.503
MOD_ProDKin_1	263	269	PF00069	0.578
MOD_ProDKin_1	33	39	PF00069	0.507
TRG_DiLeu_BaEn_1	60	65	PF01217	0.460
TRG_ENDOCYTIC_2	193	196	PF00928	0.423
TRG_ER_diArg_1	111	113	PF00400	0.434
TRG_ER_diArg_1	218	220	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I426	Leptomonas seymouri	72%	100%
A0A0S4KJ65	Bodo saltans	40%	93%
A0A1X0NMP2	Trypanosomatidae	47%	99%
A0A3S7WQM7	Leishmania donovani	92%	100%
A0A422NV72	Trypanosoma rangeli	50%	99%
A4H5P2	Leishmania braziliensis	84%	100%
A4HTY1	Leishmania infantum	92%	100%
D0A9D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
P41179	Trypanosoma brucei brucei	33%	100%
Q4QHW4	Leishmania major	93%	100%
V5BII1	Trypanosoma cruzi	49%	95%