DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

ATP-dependent DNA helicase, putative

Species:

Leishmania mexicana

UniProt:

E9AMR0_LEIMU

TriTrypDb:

LmxM.09.0590

Length:

984

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMR0

Function

Biological processes
Term	Name	Level	Count
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003678	DNA helicase activity	3	8
GO:0003824	catalytic activity	1	8
GO:0004386	helicase activity	2	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0008094	ATP-dependent activity, acting on DNA	2	8
GO:0016787	hydrolase activity	2	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:0140657	ATP-dependent activity	1	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0043138	3'-5' DNA helicase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.455
CLV_NRD_NRD_1	353	355	PF00675	0.420
CLV_NRD_NRD_1	371	373	PF00675	0.245
CLV_NRD_NRD_1	454	456	PF00675	0.606
CLV_NRD_NRD_1	685	687	PF00675	0.786
CLV_NRD_NRD_1	94	96	PF00675	0.376
CLV_PCSK_FUR_1	368	372	PF00082	0.376
CLV_PCSK_KEX2_1	116	118	PF00082	0.455
CLV_PCSK_KEX2_1	285	287	PF00082	0.508
CLV_PCSK_KEX2_1	352	354	PF00082	0.423
CLV_PCSK_KEX2_1	370	372	PF00082	0.242
CLV_PCSK_KEX2_1	454	456	PF00082	0.604
CLV_PCSK_KEX2_1	545	547	PF00082	0.526
CLV_PCSK_KEX2_1	608	610	PF00082	0.735
CLV_PCSK_KEX2_1	685	687	PF00082	0.791
CLV_PCSK_KEX2_1	902	904	PF00082	0.376
CLV_PCSK_KEX2_1	94	96	PF00082	0.376
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.508
CLV_PCSK_PC1ET2_1	545	547	PF00082	0.526
CLV_PCSK_PC1ET2_1	608	610	PF00082	0.706
CLV_PCSK_PC1ET2_1	902	904	PF00082	0.402
CLV_PCSK_PC7_1	898	904	PF00082	0.430
CLV_PCSK_SKI1_1	143	147	PF00082	0.362
CLV_PCSK_SKI1_1	326	330	PF00082	0.326
CLV_PCSK_SKI1_1	388	392	PF00082	0.392
CLV_PCSK_SKI1_1	402	406	PF00082	0.354
CLV_PCSK_SKI1_1	424	428	PF00082	0.628
CLV_PCSK_SKI1_1	441	445	PF00082	0.466
CLV_PCSK_SKI1_1	454	458	PF00082	0.595
CLV_PCSK_SKI1_1	562	566	PF00082	0.596
CLV_PCSK_SKI1_1	577	581	PF00082	0.635
CLV_PCSK_SKI1_1	596	600	PF00082	0.722
CLV_PCSK_SKI1_1	605	609	PF00082	0.743
CLV_PCSK_SKI1_1	7	11	PF00082	0.430
CLV_PCSK_SKI1_1	902	906	PF00082	0.376
CLV_PCSK_SKI1_1	911	915	PF00082	0.376
DEG_APCC_DBOX_1	401	409	PF00400	0.376
DEG_APCC_DBOX_1	714	722	PF00400	0.691
DEG_Nend_UBRbox_2	1	3	PF02207	0.488
DEG_SCF_FBW7_1	598	603	PF00400	0.610
DEG_SPOP_SBC_1	791	795	PF00917	0.737
DEG_SPOP_SBC_1	856	860	PF00917	0.800
DOC_ANK_TNKS_1	610	617	PF00023	0.619
DOC_CKS1_1	194	199	PF01111	0.210
DOC_CYCLIN_RxL_1	439	449	PF00134	0.591
DOC_CYCLIN_RxL_1	556	569	PF00134	0.698
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.430
DOC_CYCLIN_yCln2_LP_2	804	810	PF00134	0.678
DOC_MAPK_gen_1	368	375	PF00069	0.430
DOC_MAPK_gen_1	441	447	PF00069	0.626
DOC_MAPK_gen_1	463	471	PF00069	0.687
DOC_MAPK_gen_1	549	559	PF00069	0.614
DOC_MAPK_gen_1	911	919	PF00069	0.376
DOC_MAPK_MEF2A_6	552	559	PF00069	0.681
DOC_MAPK_MEF2A_6	876	885	PF00069	0.376
DOC_PP2B_LxvP_1	804	807	PF13499	0.686
DOC_USP7_MATH_1	198	202	PF00917	0.276
DOC_USP7_MATH_1	44	48	PF00917	0.399
DOC_USP7_MATH_1	484	488	PF00917	0.742
DOC_USP7_MATH_1	497	501	PF00917	0.708
DOC_USP7_MATH_1	566	570	PF00917	0.618
DOC_USP7_MATH_1	610	614	PF00917	0.771
DOC_USP7_MATH_1	663	667	PF00917	0.812
DOC_USP7_MATH_1	756	760	PF00917	0.639
DOC_USP7_MATH_1	764	768	PF00917	0.530
DOC_USP7_MATH_1	782	786	PF00917	0.738
DOC_USP7_MATH_1	98	102	PF00917	0.384
DOC_USP7_UBL2_3	545	549	PF12436	0.601
DOC_WW_Pin1_4	193	198	PF00397	0.303
DOC_WW_Pin1_4	410	415	PF00397	0.440
DOC_WW_Pin1_4	508	513	PF00397	0.798
DOC_WW_Pin1_4	596	601	PF00397	0.778
DOC_WW_Pin1_4	759	764	PF00397	0.815
DOC_WW_Pin1_4	857	862	PF00397	0.704
DOC_WW_Pin1_4	952	957	PF00397	0.528
LIG_14-3-3_CanoR_1	141	146	PF00244	0.378
LIG_14-3-3_CanoR_1	258	265	PF00244	0.346
LIG_14-3-3_CanoR_1	286	295	PF00244	0.419
LIG_14-3-3_CanoR_1	326	331	PF00244	0.424
LIG_14-3-3_CanoR_1	454	462	PF00244	0.644
LIG_14-3-3_CanoR_1	609	617	PF00244	0.753
LIG_14-3-3_CanoR_1	629	637	PF00244	0.465
LIG_14-3-3_CanoR_1	64	70	PF00244	0.381
LIG_14-3-3_CanoR_1	7	12	PF00244	0.430
LIG_14-3-3_CanoR_1	715	723	PF00244	0.762
LIG_14-3-3_CanoR_1	854	864	PF00244	0.788
LIG_Actin_WH2_2	568	583	PF00022	0.639
LIG_Actin_WH2_2	958	976	PF00022	0.542
LIG_APCC_ABBA_1	373	378	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	372	378	PF00400	0.430
LIG_APCC_ABBAyCdc20_2	466	472	PF00400	0.768
LIG_BIR_III_4	838	842	PF00653	0.766
LIG_BRCT_BRCA1_1	517	521	PF00533	0.666
LIG_Clathr_ClatBox_1	444	448	PF01394	0.593
LIG_FHA_1	101	107	PF00498	0.501
LIG_FHA_1	131	137	PF00498	0.464
LIG_FHA_1	142	148	PF00498	0.381
LIG_FHA_1	229	235	PF00498	0.376
LIG_FHA_1	288	294	PF00498	0.398
LIG_FHA_1	427	433	PF00498	0.603
LIG_FHA_1	457	463	PF00498	0.734
LIG_FHA_1	466	472	PF00498	0.673
LIG_FHA_1	509	515	PF00498	0.669
LIG_FHA_1	795	801	PF00498	0.689
LIG_FHA_1	953	959	PF00498	0.510
LIG_FHA_1	973	979	PF00498	0.272
LIG_FHA_2	58	64	PF00498	0.404
LIG_FHA_2	778	784	PF00498	0.758
LIG_LIR_Apic_2	159	164	PF02991	0.430
LIG_LIR_Gen_1	229	238	PF02991	0.392
LIG_LIR_Gen_1	240	249	PF02991	0.347
LIG_LIR_Gen_1	520	530	PF02991	0.566
LIG_LIR_Gen_1	725	733	PF02991	0.667
LIG_LIR_Gen_1	816	822	PF02991	0.620
LIG_LIR_Gen_1	84	93	PF02991	0.376
LIG_LIR_Nem_3	178	182	PF02991	0.357
LIG_LIR_Nem_3	229	233	PF02991	0.392
LIG_LIR_Nem_3	236	241	PF02991	0.355
LIG_LIR_Nem_3	518	524	PF02991	0.593
LIG_LIR_Nem_3	527	533	PF02991	0.551
LIG_LIR_Nem_3	536	541	PF02991	0.529
LIG_LIR_Nem_3	725	729	PF02991	0.671
LIG_LIR_Nem_3	816	821	PF02991	0.615
LIG_LIR_Nem_3	84	88	PF02991	0.376
LIG_LIR_Nem_3	879	883	PF02991	0.376
LIG_NRBOX	247	253	PF00104	0.430
LIG_PCNA_APIM_2	575	581	PF02747	0.632
LIG_PCNA_PIPBox_1	401	410	PF02747	0.430
LIG_PCNA_yPIPBox_3	245	258	PF02747	0.404
LIG_PCNA_yPIPBox_3	545	555	PF02747	0.632
LIG_PCNA_yPIPBox_3	629	643	PF02747	0.777
LIG_Pex14_1	283	287	PF04695	0.445
LIG_Pex14_1	889	893	PF04695	0.430
LIG_SH2_CRK	187	191	PF00017	0.410
LIG_SH2_CRK	726	730	PF00017	0.668
LIG_SH2_GRB2like	138	141	PF00017	0.376
LIG_SH2_GRB2like	530	533	PF00017	0.621
LIG_SH2_NCK_1	667	671	PF00017	0.527
LIG_SH2_STAP1	230	234	PF00017	0.376
LIG_SH2_STAT3	37	40	PF00017	0.501
LIG_SH2_STAT5	138	141	PF00017	0.376
LIG_SH2_STAT5	161	164	PF00017	0.368
LIG_SH2_STAT5	230	233	PF00017	0.362
LIG_SH2_STAT5	270	273	PF00017	0.479
LIG_SH2_STAT5	37	40	PF00017	0.430
LIG_SH2_STAT5	376	379	PF00017	0.430
LIG_SH2_STAT5	578	581	PF00017	0.558
LIG_SH2_STAT5	906	909	PF00017	0.376
LIG_SH2_STAT5	957	960	PF00017	0.502
LIG_SH2_STAT5	977	980	PF00017	0.278
LIG_SH3_1	191	197	PF00018	0.210
LIG_SH3_3	145	151	PF00018	0.430
LIG_SH3_3	191	197	PF00018	0.210
LIG_SH3_3	259	265	PF00018	0.374
LIG_SH3_3	411	417	PF00018	0.430
LIG_SH3_3	698	704	PF00018	0.838
LIG_SH3_3	880	886	PF00018	0.376
LIG_SH3_3	891	897	PF00018	0.376
LIG_SH3_3	937	943	PF00018	0.639
LIG_SUMO_SIM_anti_2	247	253	PF11976	0.344
LIG_SUMO_SIM_anti_2	362	367	PF11976	0.378
LIG_SUMO_SIM_anti_2	816	826	PF11976	0.660
LIG_SUMO_SIM_par_1	343	348	PF11976	0.397
LIG_SUMO_SIM_par_1	443	449	PF11976	0.592
LIG_TRAF2_1	334	337	PF00917	0.287
LIG_TRAF2_1	703	706	PF00917	0.752
LIG_TRAF2_1	728	731	PF00917	0.618
LIG_TRAF2_1	897	900	PF00917	0.350
LIG_TYR_ITIM	358	363	PF00017	0.376
LIG_TYR_ITIM	968	973	PF00017	0.597
LIG_UBA3_1	537	545	PF00899	0.633
LIG_WRC_WIRS_1	82	87	PF05994	0.376
MOD_CK1_1	25	31	PF00069	0.376
MOD_CK1_1	400	406	PF00069	0.501
MOD_CK1_1	446	452	PF00069	0.606
MOD_CK1_1	550	556	PF00069	0.470
MOD_CK1_1	601	607	PF00069	0.795
MOD_CK1_1	627	633	PF00069	0.725
MOD_CK1_1	657	663	PF00069	0.691
MOD_CK1_1	666	672	PF00069	0.804
MOD_CK1_1	684	690	PF00069	0.763
MOD_CK1_1	759	765	PF00069	0.748
MOD_CK1_1	777	783	PF00069	0.797
MOD_CK1_1	787	793	PF00069	0.720
MOD_CK1_1	820	826	PF00069	0.668
MOD_CK2_1	484	490	PF00069	0.729
MOD_CK2_1	57	63	PF00069	0.348
MOD_CK2_1	725	731	PF00069	0.722
MOD_GlcNHglycan	24	27	PF01048	0.359
MOD_GlcNHglycan	40	43	PF01048	0.376
MOD_GlcNHglycan	435	438	PF01048	0.605
MOD_GlcNHglycan	600	603	PF01048	0.808
MOD_GlcNHglycan	612	615	PF01048	0.688
MOD_GlcNHglycan	624	629	PF01048	0.660
MOD_GlcNHglycan	630	633	PF01048	0.607
MOD_GlcNHglycan	661	664	PF01048	0.810
MOD_GlcNHglycan	668	671	PF01048	0.698
MOD_GlcNHglycan	686	689	PF01048	0.741
MOD_GlcNHglycan	690	693	PF01048	0.747
MOD_GlcNHglycan	764	767	PF01048	0.799
MOD_GlcNHglycan	789	792	PF01048	0.800
MOD_GlcNHglycan	851	854	PF01048	0.704
MOD_GlcNHglycan	927	930	PF01048	0.698
MOD_GlcNHglycan	948	951	PF01048	0.657
MOD_GlcNHglycan	96	99	PF01048	0.210
MOD_GSK3_1	126	133	PF00069	0.455
MOD_GSK3_1	217	224	PF00069	0.498
MOD_GSK3_1	287	294	PF00069	0.435
MOD_GSK3_1	422	429	PF00069	0.623
MOD_GSK3_1	461	468	PF00069	0.766
MOD_GSK3_1	594	601	PF00069	0.788
MOD_GSK3_1	624	631	PF00069	0.783
MOD_GSK3_1	65	72	PF00069	0.429
MOD_GSK3_1	654	661	PF00069	0.719
MOD_GSK3_1	684	691	PF00069	0.774
MOD_GSK3_1	762	769	PF00069	0.816
MOD_GSK3_1	787	794	PF00069	0.763
MOD_GSK3_1	817	824	PF00069	0.643
MOD_GSK3_1	845	852	PF00069	0.740
MOD_GSK3_1	94	101	PF00069	0.269
MOD_GSK3_1	944	951	PF00069	0.668
MOD_GSK3_1	972	979	PF00069	0.498
MOD_N-GLC_1	472	477	PF02516	0.717
MOD_N-GLC_1	531	536	PF02516	0.622
MOD_N-GLC_1	716	721	PF02516	0.758
MOD_N-GLC_1	787	792	PF02516	0.761
MOD_N-GLC_2	266	268	PF02516	0.376
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	366	371	PF00069	0.376
MOD_NEK2_1	38	43	PF00069	0.447
MOD_NEK2_1	426	431	PF00069	0.398
MOD_NEK2_1	541	546	PF00069	0.561
MOD_NEK2_2	465	470	PF00069	0.766
MOD_NEK2_2	57	62	PF00069	0.430
MOD_PIKK_1	1	7	PF00454	0.531
MOD_PIKK_1	198	204	PF00454	0.424
MOD_PIKK_1	25	31	PF00454	0.430
MOD_PIKK_1	313	319	PF00454	0.422
MOD_PIKK_1	379	385	PF00454	0.501
MOD_PIKK_1	646	652	PF00454	0.763
MOD_PIKK_1	944	950	PF00454	0.753
MOD_PK_1	391	397	PF00069	0.382
MOD_PKA_1	353	359	PF00069	0.210
MOD_PKA_1	454	460	PF00069	0.611
MOD_PKA_1	94	100	PF00069	0.210
MOD_PKA_2	257	263	PF00069	0.346
MOD_PKA_2	353	359	PF00069	0.390
MOD_PKA_2	433	439	PF00069	0.547
MOD_PKA_2	454	460	PF00069	0.643
MOD_PKA_2	465	471	PF00069	0.721
MOD_PKA_2	610	616	PF00069	0.737
MOD_PKA_2	628	634	PF00069	0.748
MOD_PKA_2	65	71	PF00069	0.410
MOD_PKA_2	684	690	PF00069	0.778
MOD_PKA_2	94	100	PF00069	0.210
MOD_PKB_1	62	70	PF00069	0.430
MOD_Plk_1	1	7	PF00069	0.603
MOD_Plk_1	228	234	PF00069	0.411
MOD_Plk_1	782	788	PF00069	0.758
MOD_Plk_4	326	332	PF00069	0.424
MOD_Plk_4	44	50	PF00069	0.424
MOD_Plk_4	497	503	PF00069	0.708
MOD_Plk_4	517	523	PF00069	0.492
MOD_Plk_4	796	802	PF00069	0.706
MOD_Plk_4	817	823	PF00069	0.625
MOD_Plk_4	935	941	PF00069	0.717
MOD_ProDKin_1	193	199	PF00069	0.303
MOD_ProDKin_1	410	416	PF00069	0.440
MOD_ProDKin_1	508	514	PF00069	0.798
MOD_ProDKin_1	596	602	PF00069	0.779
MOD_ProDKin_1	759	765	PF00069	0.816
MOD_ProDKin_1	857	863	PF00069	0.700
MOD_ProDKin_1	952	958	PF00069	0.521
MOD_SUMO_for_1	539	542	PF00179	0.729
MOD_SUMO_rev_2	899	904	PF00179	0.430
MOD_SUMO_rev_2	966	976	PF00179	0.532
TRG_DiLeu_BaEn_1	247	252	PF01217	0.376
TRG_DiLeu_BaEn_1	307	312	PF01217	0.210
TRG_DiLeu_BaEn_1	817	822	PF01217	0.597
TRG_DiLeu_BaEn_2	228	234	PF01217	0.430
TRG_ENDOCYTIC_2	187	190	PF00928	0.430
TRG_ENDOCYTIC_2	230	233	PF00928	0.376
TRG_ENDOCYTIC_2	360	363	PF00928	0.376
TRG_ENDOCYTIC_2	376	379	PF00928	0.376
TRG_ENDOCYTIC_2	530	533	PF00928	0.532
TRG_ENDOCYTIC_2	726	729	PF00928	0.669
TRG_ENDOCYTIC_2	827	830	PF00928	0.718
TRG_ENDOCYTIC_2	906	909	PF00928	0.376
TRG_ENDOCYTIC_2	970	973	PF00928	0.595
TRG_ER_diArg_1	116	118	PF00400	0.455
TRG_ER_diArg_1	351	354	PF00400	0.376
TRG_ER_diArg_1	368	371	PF00400	0.376
TRG_ER_diArg_1	758	761	PF00400	0.769
TRG_ER_diArg_1	895	898	PF00400	0.395
TRG_ER_diArg_1	93	95	PF00400	0.376
TRG_NLS_MonoExtC_3	283	288	PF00514	0.503
TRG_NLS_MonoExtN_4	605	612	PF00514	0.748
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	813	817	PF00026	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P480	Leptomonas seymouri	65%	85%
A0A3Q8I8J3	Leishmania donovani	90%	99%
A0A3R7MPV2	Trypanosoma rangeli	40%	100%
A4H5P1	Leishmania braziliensis	82%	100%
A4HTY0	Leishmania infantum	90%	99%
Q4QHW5	Leishmania major	90%	100%