Surface antigen-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

surface antigen-like protein

Species:

Leishmania mexicana

UniProt:

E9AMQ9_LEIMU

TriTrypDb:

LmxM.09.0580

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 9, no: 5
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15
GO:0016020	membrane	2	5

Expansion

Sequence features

E9AMQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.418
CLV_PCSK_KEX2_1	6	8	PF00082	0.418
CLV_PCSK_SKI1_1	13	17	PF00082	0.251
CLV_PCSK_SKI1_1	219	223	PF00082	0.524
CLV_PCSK_SKI1_1	6	10	PF00082	0.235
DEG_APCC_DBOX_1	167	175	PF00400	0.258
DEG_MDM2_SWIB_1	118	125	PF02201	0.276
DOC_MAPK_gen_1	6	12	PF00069	0.384
DOC_MAPK_MEF2A_6	6	14	PF00069	0.407
DOC_PP1_RVXF_1	127	134	PF00149	0.251
DOC_USP7_MATH_1	148	152	PF00917	0.266
DOC_USP7_MATH_1	162	166	PF00917	0.250
DOC_USP7_MATH_1	249	253	PF00917	0.416
DOC_USP7_MATH_1	35	39	PF00917	0.318
DOC_USP7_MATH_1	67	71	PF00917	0.317
DOC_USP7_MATH_1	96	100	PF00917	0.418
DOC_WW_Pin1_4	209	214	PF00397	0.284
DOC_WW_Pin1_4	252	257	PF00397	0.333
DOC_WW_Pin1_4	261	266	PF00397	0.320
LIG_14-3-3_CanoR_1	150	156	PF00244	0.264
LIG_14-3-3_CanoR_1	168	172	PF00244	0.348
LIG_14-3-3_CanoR_1	219	229	PF00244	0.336
LIG_14-3-3_CanoR_1	29	39	PF00244	0.288
LIG_14-3-3_CanoR_1	6	11	PF00244	0.411
LIG_Actin_WH2_2	145	160	PF00022	0.301
LIG_Actin_WH2_2	170	187	PF00022	0.291
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_deltaCOP1_diTrp_1	60	66	PF00928	0.295
LIG_EH1_1	15	23	PF00400	0.196
LIG_FHA_1	152	158	PF00498	0.386
LIG_FHA_1	179	185	PF00498	0.297
LIG_FHA_1	220	226	PF00498	0.373
LIG_FHA_1	272	278	PF00498	0.365
LIG_FHA_1	7	13	PF00498	0.384
LIG_FHA_1	76	82	PF00498	0.282
LIG_FHA_1	85	91	PF00498	0.264
LIG_FHA_2	57	63	PF00498	0.331
LIG_GBD_Chelix_1	275	283	PF00786	0.510
LIG_LIR_Gen_1	145	152	PF02991	0.291
LIG_LIR_Gen_1	223	234	PF02991	0.341
LIG_LIR_Gen_1	278	284	PF02991	0.321
LIG_LIR_Nem_3	121	125	PF02991	0.264
LIG_LIR_Nem_3	136	142	PF02991	0.269
LIG_LIR_Nem_3	191	195	PF02991	0.277
LIG_Pex14_1	280	284	PF04695	0.313
LIG_Pex14_2	118	122	PF04695	0.279
LIG_Pex14_2	43	47	PF04695	0.235
LIG_PTB_Apo_2	80	87	PF02174	0.269
LIG_SH2_STAT5	194	197	PF00017	0.282
LIG_SH2_STAT5	68	71	PF00017	0.326
LIG_SH3_3	230	236	PF00018	0.369
LIG_SH3_3	46	52	PF00018	0.258
LIG_SUMO_SIM_anti_2	73	82	PF11976	0.266
LIG_SUMO_SIM_par_1	268	274	PF11976	0.342
LIG_SUMO_SIM_par_1	77	82	PF11976	0.263
LIG_WRC_WIRS_1	44	49	PF05994	0.258
MOD_CK1_1	151	157	PF00069	0.300
MOD_CK1_1	212	218	PF00069	0.356
MOD_CK1_1	252	258	PF00069	0.386
MOD_CK1_1	56	62	PF00069	0.326
MOD_CK1_1	70	76	PF00069	0.463
MOD_CK2_1	86	92	PF00069	0.347
MOD_CMANNOS	63	66	PF00535	0.465
MOD_GlcNHglycan	160	163	PF01048	0.530
MOD_GlcNHglycan	98	101	PF01048	0.566
MOD_GSK3_1	138	145	PF00069	0.270
MOD_GSK3_1	158	165	PF00069	0.299
MOD_GSK3_1	184	191	PF00069	0.302
MOD_GSK3_1	215	222	PF00069	0.337
MOD_GSK3_1	271	278	PF00069	0.340
MOD_GSK3_1	43	50	PF00069	0.317
MOD_N-GLC_1	131	136	PF02516	0.467
MOD_N-GLC_1	158	163	PF02516	0.543
MOD_N-GLC_1	199	204	PF02516	0.470
MOD_N-GLC_1	75	80	PF02516	0.478
MOD_N-GLC_2	207	209	PF02516	0.492
MOD_NEK2_1	118	123	PF00069	0.284
MOD_NEK2_1	131	136	PF00069	0.268
MOD_NEK2_1	138	143	PF00069	0.281
MOD_NEK2_1	157	162	PF00069	0.305
MOD_NEK2_1	184	189	PF00069	0.308
MOD_NEK2_1	275	280	PF00069	0.308
MOD_NEK2_1	43	48	PF00069	0.260
MOD_NEK2_1	86	91	PF00069	0.297
MOD_OFUCOSY	64	71	PF10250	0.515
MOD_PKA_1	6	12	PF00069	0.408
MOD_PKA_2	167	173	PF00069	0.279
MOD_PKA_2	184	190	PF00069	0.296
MOD_PKA_2	28	34	PF00069	0.306
MOD_PKA_2	6	12	PF00069	0.438
MOD_Plk_1	199	205	PF00069	0.297
MOD_Plk_1	75	81	PF00069	0.259
MOD_Plk_4	151	157	PF00069	0.303
MOD_Plk_4	199	205	PF00069	0.285
MOD_Plk_4	212	218	PF00069	0.304
MOD_Plk_4	271	277	PF00069	0.369
MOD_Plk_4	53	59	PF00069	0.291
MOD_ProDKin_1	209	215	PF00069	0.279
MOD_ProDKin_1	252	258	PF00069	0.331
MOD_ProDKin_1	261	267	PF00069	0.311
TRG_ER_diArg_1	5	7	PF00400	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2E6	Leptomonas seymouri	29%	100%
A0A0N0P2L4	Leptomonas seymouri	28%	96%
A0A0N0P4M2	Leptomonas seymouri	35%	100%
A0A0S4IZ03	Bodo saltans	25%	100%
A0A0S4J0K0	Bodo saltans	25%	99%
A0A1X0NKN8	Trypanosomatidae	32%	99%
A0A3Q8I9A6	Leishmania donovani	29%	74%
A0A3Q8I9D0	Leishmania donovani	31%	100%
A0A3Q8IIJ9	Leishmania donovani	26%	94%
A0A3S5H6D6	Leishmania donovani	88%	100%
A0A3S7WP69	Leishmania donovani	29%	100%
A0A3S7WPB2	Leishmania donovani	28%	100%
A0A3S7X4J4	Leishmania donovani	26%	94%
A4H4D2	Leishmania braziliensis	29%	100%
A4H4G6	Leishmania braziliensis	27%	100%
A4H5P0	Leishmania braziliensis	66%	100%
A4HJC8	Leishmania braziliensis	27%	100%
A4HSL2	Leishmania infantum	29%	100%
A4HTX9	Leishmania infantum	88%	100%
A4HVB0	Leishmania infantum	26%	71%
A4I6S4	Leishmania infantum	27%	94%
E8NHP8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9ACQ0	Leishmania major	28%	100%
E9AG65	Leishmania infantum	28%	100%
E9AGG5	Leishmania infantum	29%	68%
E9AGH0	Leishmania infantum	28%	76%
E9AKJ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	99%
E9AKM8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	84%
E9AP03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	73%
E9AP07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	78%
E9AP08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	68%
E9B1U4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	83%
E9B1U5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	68%
E9B1U6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
Q25331	Leishmania major	29%	100%
Q4Q6B6	Leishmania major	28%	100%
Q4Q6B7	Leishmania major	27%	100%
Q4QGJ4	Leishmania major	29%	100%
Q4QGJ7	Leishmania major	29%	100%
Q4QGK6	Leishmania major	29%	100%
Q4QGL4	Leishmania major	30%	72%
Q4QHW6	Leishmania major	87%	100%
Q4QJB2	Leishmania major	28%	100%
Q6NQP4	Arabidopsis thaliana	30%	100%
Q8GT95	Oryza sativa subsp. japonica	26%	86%