CULT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMQ8_LEIMU

TriTrypDb:

LmxM.09.0570

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6	1
GO:0032991	protein-containing complex	1	1
GO:0080008	Cul4-RING E3 ubiquitin ligase complex	5	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AMQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ8

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	107	111	PF00656	0.555
CLV_C14_Caspase3-7	226	230	PF00656	0.579
CLV_C14_Caspase3-7	317	321	PF00656	0.714
CLV_C14_Caspase3-7	432	436	PF00656	0.558
CLV_NRD_NRD_1	213	215	PF00675	0.580
CLV_NRD_NRD_1	233	235	PF00675	0.501
CLV_NRD_NRD_1	245	247	PF00675	0.514
CLV_NRD_NRD_1	384	386	PF00675	0.453
CLV_NRD_NRD_1	393	395	PF00675	0.430
CLV_NRD_NRD_1	81	83	PF00675	0.539
CLV_PCSK_FUR_1	381	385	PF00082	0.472
CLV_PCSK_KEX2_1	213	215	PF00082	0.580
CLV_PCSK_KEX2_1	245	247	PF00082	0.478
CLV_PCSK_KEX2_1	383	385	PF00082	0.463
CLV_PCSK_KEX2_1	386	388	PF00082	0.434
CLV_PCSK_KEX2_1	393	395	PF00082	0.423
CLV_PCSK_KEX2_1	81	83	PF00082	0.543
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.439
DEG_APCC_DBOX_1	81	89	PF00400	0.528
DEG_SCF_FBW7_2	97	103	PF00400	0.625
DEG_SPOP_SBC_1	117	121	PF00917	0.572
DEG_SPOP_SBC_1	157	161	PF00917	0.632
DEG_SPOP_SBC_1	263	267	PF00917	0.698
DOC_ANK_TNKS_1	281	288	PF00023	0.663
DOC_CDC14_PxL_1	422	430	PF14671	0.514
DOC_CKS1_1	97	102	PF01111	0.552
DOC_MAPK_gen_1	393	399	PF00069	0.449
DOC_MAPK_gen_1	81	88	PF00069	0.515
DOC_MAPK_MEF2A_6	87	94	PF00069	0.542
DOC_MIT_MIM_1	389	398	PF04212	0.401
DOC_PP1_RVXF_1	371	378	PF00149	0.579
DOC_PP2B_LxvP_1	162	165	PF13499	0.635
DOC_PP2B_LxvP_1	299	302	PF13499	0.691
DOC_PP2B_LxvP_1	397	400	PF13499	0.448
DOC_USP7_MATH_1	104	108	PF00917	0.555
DOC_USP7_MATH_1	109	113	PF00917	0.609
DOC_USP7_MATH_1	117	121	PF00917	0.599
DOC_USP7_MATH_1	257	261	PF00917	0.706
DOC_USP7_MATH_1	262	266	PF00917	0.824
DOC_USP7_MATH_1	294	298	PF00917	0.691
DOC_USP7_MATH_1	3	7	PF00917	0.646
DOC_USP7_MATH_1	302	306	PF00917	0.603
DOC_USP7_MATH_1	367	371	PF00917	0.520
DOC_WW_Pin1_4	1	6	PF00397	0.792
DOC_WW_Pin1_4	15	20	PF00397	0.576
DOC_WW_Pin1_4	264	269	PF00397	0.626
DOC_WW_Pin1_4	280	285	PF00397	0.709
DOC_WW_Pin1_4	346	351	PF00397	0.507
DOC_WW_Pin1_4	64	69	PF00397	0.536
DOC_WW_Pin1_4	96	101	PF00397	0.710
LIG_14-3-3_CanoR_1	155	165	PF00244	0.620
LIG_14-3-3_CanoR_1	393	398	PF00244	0.454
LIG_14-3-3_CanoR_1	456	462	PF00244	0.403
LIG_14-3-3_CanoR_1	96	100	PF00244	0.723
LIG_BIR_II_1	1	5	PF00653	0.685
LIG_BRCT_BRCA1_1	433	437	PF00533	0.553
LIG_EH1_1	365	373	PF00400	0.597
LIG_EH1_1	415	423	PF00400	0.486
LIG_eIF4E_1	366	372	PF01652	0.521
LIG_FHA_1	20	26	PF00498	0.504
LIG_FHA_1	325	331	PF00498	0.558
LIG_FHA_1	390	396	PF00498	0.500
LIG_FHA_1	55	61	PF00498	0.393
LIG_FHA_2	315	321	PF00498	0.715
LIG_FHA_2	458	464	PF00498	0.399
LIG_LIR_Gen_1	414	423	PF02991	0.479
LIG_LIR_Nem_3	180	185	PF02991	0.495
LIG_LIR_Nem_3	349	355	PF02991	0.499
LIG_LIR_Nem_3	410	415	PF02991	0.493
LIG_PTAP_UEV_1	271	276	PF05743	0.667
LIG_SH2_PTP2	423	426	PF00017	0.390
LIG_SH2_STAP1	185	189	PF00017	0.405
LIG_SH2_STAP1	56	60	PF00017	0.498
LIG_SH2_STAT5	423	426	PF00017	0.409
LIG_SH2_STAT5	56	59	PF00017	0.424
LIG_SH3_1	423	429	PF00018	0.572
LIG_SH3_3	2	8	PF00018	0.577
LIG_SH3_3	266	272	PF00018	0.664
LIG_SH3_3	361	367	PF00018	0.608
LIG_SH3_3	423	429	PF00018	0.572
LIG_SH3_3	94	100	PF00018	0.576
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.494
LIG_TRAF2_1	238	241	PF00917	0.668
LIG_TRAF2_1	429	432	PF00917	0.517
LIG_TRAF2_1	460	463	PF00917	0.395
MOD_CK1_1	225	231	PF00069	0.552
MOD_CK1_1	305	311	PF00069	0.631
MOD_CK1_1	314	320	PF00069	0.598
MOD_CK1_1	4	10	PF00069	0.792
MOD_CK1_1	478	484	PF00069	0.628
MOD_CK1_1	98	104	PF00069	0.630
MOD_CK2_1	163	169	PF00069	0.567
MOD_CK2_1	201	207	PF00069	0.384
MOD_CK2_1	280	286	PF00069	0.535
MOD_CK2_1	457	463	PF00069	0.315
MOD_CK2_1	483	489	PF00069	0.669
MOD_DYRK1A_RPxSP_1	96	100	PF00069	0.545
MOD_GlcNHglycan	1	4	PF01048	0.658
MOD_GlcNHglycan	100	103	PF01048	0.626
MOD_GlcNHglycan	106	109	PF01048	0.580
MOD_GlcNHglycan	15	18	PF01048	0.542
MOD_GlcNHglycan	203	206	PF01048	0.393
MOD_GlcNHglycan	220	223	PF01048	0.648
MOD_GlcNHglycan	272	275	PF01048	0.696
MOD_GlcNHglycan	291	294	PF01048	0.629
MOD_GlcNHglycan	337	340	PF01048	0.628
MOD_GlcNHglycan	475	480	PF01048	0.571
MOD_GlcNHglycan	485	488	PF01048	0.549
MOD_GlcNHglycan	73	76	PF01048	0.493
MOD_GlcNHglycan	78	81	PF01048	0.564
MOD_GSK3_1	15	22	PF00069	0.541
MOD_GSK3_1	169	176	PF00069	0.575
MOD_GSK3_1	218	225	PF00069	0.667
MOD_GSK3_1	3	10	PF00069	0.624
MOD_GSK3_1	302	309	PF00069	0.659
MOD_GSK3_1	310	317	PF00069	0.634
MOD_GSK3_1	389	396	PF00069	0.452
MOD_GSK3_1	431	438	PF00069	0.570
MOD_GSK3_1	471	478	PF00069	0.529
MOD_N-GLC_1	170	175	PF02516	0.424
MOD_N-GLC_1	64	69	PF02516	0.514
MOD_NEK2_1	27	32	PF00069	0.377
MOD_NEK2_1	402	407	PF00069	0.457
MOD_NEK2_2	158	163	PF00069	0.670
MOD_NEK2_2	170	175	PF00069	0.404
MOD_NEK2_2	90	95	PF00069	0.524
MOD_PIKK_1	257	263	PF00454	0.629
MOD_PKA_1	393	399	PF00069	0.449
MOD_PKA_2	216	222	PF00069	0.755
MOD_PKA_2	393	399	PF00069	0.476
MOD_PKA_2	402	408	PF00069	0.553
MOD_PKA_2	95	101	PF00069	0.648
MOD_Plk_1	170	176	PF00069	0.470
MOD_Plk_1	177	183	PF00069	0.456
MOD_Plk_1	311	317	PF00069	0.576
MOD_Plk_2-3	306	312	PF00069	0.692
MOD_Plk_4	163	169	PF00069	0.598
MOD_Plk_4	170	176	PF00069	0.458
MOD_Plk_4	177	183	PF00069	0.418
MOD_Plk_4	367	373	PF00069	0.521
MOD_Plk_4	393	399	PF00069	0.399
MOD_ProDKin_1	1	7	PF00069	0.791
MOD_ProDKin_1	15	21	PF00069	0.567
MOD_ProDKin_1	264	270	PF00069	0.628
MOD_ProDKin_1	280	286	PF00069	0.710
MOD_ProDKin_1	346	352	PF00069	0.505
MOD_ProDKin_1	64	70	PF00069	0.527
MOD_ProDKin_1	96	102	PF00069	0.710
TRG_DiLeu_BaLyEn_6	423	428	PF01217	0.515
TRG_ENDOCYTIC_2	415	418	PF00928	0.457
TRG_ER_diArg_1	213	215	PF00400	0.585
TRG_ER_diArg_1	244	246	PF00400	0.465
TRG_ER_diArg_1	381	384	PF00400	0.472
TRG_ER_diArg_1	385	388	PF00400	0.431
TRG_ER_diArg_1	393	395	PF00400	0.406
TRG_ER_diArg_1	81	83	PF00400	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5U2	Leptomonas seymouri	39%	100%
A0A3S7WQQ0	Leishmania donovani	88%	100%
A4H5N4	Leishmania braziliensis	69%	100%
A4HTX8	Leishmania infantum	88%	100%
Q4QHW7	Leishmania major	88%	100%