TYR_PHOSPHATASE_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dual specificity phosphatase, catalytic domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMQ6_LEIMU

TriTrypDb:

LmxM.09.0550

Length:

594

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0044237	cellular metabolic process	2	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	306	310	PF00656	0.511
CLV_NRD_NRD_1	152	154	PF00675	0.573
CLV_NRD_NRD_1	197	199	PF00675	0.518
CLV_NRD_NRD_1	202	204	PF00675	0.611
CLV_NRD_NRD_1	25	27	PF00675	0.329
CLV_NRD_NRD_1	337	339	PF00675	0.529
CLV_NRD_NRD_1	456	458	PF00675	0.614
CLV_NRD_NRD_1	476	478	PF00675	0.496
CLV_NRD_NRD_1	549	551	PF00675	0.484
CLV_NRD_NRD_1	556	558	PF00675	0.405
CLV_NRD_NRD_1	569	571	PF00675	0.323
CLV_NRD_NRD_1	62	64	PF00675	0.530
CLV_PCSK_FUR_1	150	154	PF00082	0.350
CLV_PCSK_FUR_1	23	27	PF00082	0.312
CLV_PCSK_FUR_1	567	571	PF00082	0.420
CLV_PCSK_KEX2_1	152	154	PF00082	0.573
CLV_PCSK_KEX2_1	196	198	PF00082	0.538
CLV_PCSK_KEX2_1	202	204	PF00082	0.588
CLV_PCSK_KEX2_1	25	27	PF00082	0.329
CLV_PCSK_KEX2_1	337	339	PF00082	0.532
CLV_PCSK_KEX2_1	456	458	PF00082	0.614
CLV_PCSK_KEX2_1	548	550	PF00082	0.517
CLV_PCSK_KEX2_1	556	558	PF00082	0.405
CLV_PCSK_KEX2_1	567	569	PF00082	0.519
CLV_PCSK_KEX2_1	62	64	PF00082	0.549
CLV_PCSK_PC7_1	193	199	PF00082	0.495
CLV_PCSK_SKI1_1	172	176	PF00082	0.483
CLV_PCSK_SKI1_1	508	512	PF00082	0.418
DEG_APCC_DBOX_1	409	417	PF00400	0.417
DEG_Kelch_Keap1_1	155	160	PF01344	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.539
DEG_SCF_FBW7_1	424	431	PF00400	0.474
DEG_SPOP_SBC_1	274	278	PF00917	0.494
DEG_SPOP_SBC_1	310	314	PF00917	0.603
DEG_SPOP_SBC_1	341	345	PF00917	0.644
DEG_SPOP_SBC_1	536	540	PF00917	0.530
DEG_SPOP_SBC_1	97	101	PF00917	0.689
DOC_MAPK_gen_1	23	31	PF00069	0.384
DOC_MAPK_gen_1	407	415	PF00069	0.519
DOC_MAPK_gen_1	567	577	PF00069	0.412
DOC_MAPK_MEF2A_6	183	192	PF00069	0.441
DOC_MAPK_MEF2A_6	23	31	PF00069	0.480
DOC_MAPK_MEF2A_6	407	415	PF00069	0.519
DOC_MAPK_MEF2A_6	493	500	PF00069	0.388
DOC_MAPK_MEF2A_6	567	575	PF00069	0.409
DOC_PP1_RVXF_1	506	513	PF00149	0.349
DOC_PP2B_LxvP_1	115	118	PF13499	0.658
DOC_PP2B_LxvP_1	204	207	PF13499	0.507
DOC_PP2B_LxvP_1	411	414	PF13499	0.417
DOC_PP2B_LxvP_1	473	476	PF13499	0.494
DOC_USP7_MATH_1	166	170	PF00917	0.485
DOC_USP7_MATH_1	259	263	PF00917	0.507
DOC_USP7_MATH_1	310	314	PF00917	0.650
DOC_USP7_MATH_1	341	345	PF00917	0.577
DOC_USP7_MATH_1	428	432	PF00917	0.443
DOC_USP7_MATH_1	50	54	PF00917	0.789
DOC_USP7_MATH_1	504	508	PF00917	0.398
DOC_USP7_MATH_1	536	540	PF00917	0.530
DOC_USP7_MATH_1	98	102	PF00917	0.573
DOC_WW_Pin1_4	212	217	PF00397	0.578
DOC_WW_Pin1_4	312	317	PF00397	0.555
DOC_WW_Pin1_4	327	332	PF00397	0.627
DOC_WW_Pin1_4	337	342	PF00397	0.589
DOC_WW_Pin1_4	351	356	PF00397	0.632
DOC_WW_Pin1_4	374	379	PF00397	0.678
DOC_WW_Pin1_4	397	402	PF00397	0.484
DOC_WW_Pin1_4	415	420	PF00397	0.479
DOC_WW_Pin1_4	424	429	PF00397	0.431
DOC_WW_Pin1_4	93	98	PF00397	0.542
LIG_14-3-3_CanoR_1	26	32	PF00244	0.449
LIG_14-3-3_CanoR_1	410	414	PF00244	0.454
LIG_14-3-3_CanoR_1	508	513	PF00244	0.340
LIG_Actin_WH2_2	137	154	PF00022	0.494
LIG_Actin_WH2_2	179	195	PF00022	0.516
LIG_BRCT_BRCA1_1	508	512	PF00533	0.364
LIG_deltaCOP1_diTrp_1	357	361	PF00928	0.541
LIG_deltaCOP1_diTrp_1	520	524	PF00928	0.366
LIG_EVH1_1	115	119	PF00568	0.590
LIG_EVH1_2	119	123	PF00568	0.601
LIG_FHA_1	140	146	PF00498	0.423
LIG_FHA_1	199	205	PF00498	0.657
LIG_FHA_1	206	212	PF00498	0.680
LIG_FHA_1	401	407	PF00498	0.528
LIG_FHA_1	410	416	PF00498	0.434
LIG_FHA_1	419	425	PF00498	0.436
LIG_FHA_1	428	434	PF00498	0.349
LIG_FHA_1	536	542	PF00498	0.500
LIG_FHA_1	89	95	PF00498	0.667
LIG_FHA_1	98	104	PF00498	0.513
LIG_FHA_2	19	25	PF00498	0.337
LIG_FHA_2	250	256	PF00498	0.634
LIG_FHA_2	343	349	PF00498	0.619
LIG_FHA_2	352	358	PF00498	0.480
LIG_FHA_2	400	406	PF00498	0.420
LIG_FHA_2	437	443	PF00498	0.537
LIG_GBD_Chelix_1	27	35	PF00786	0.422
LIG_LIR_Gen_1	136	145	PF02991	0.422
LIG_LIR_Gen_1	167	177	PF02991	0.357
LIG_LIR_Gen_1	264	275	PF02991	0.331
LIG_LIR_Gen_1	357	365	PF02991	0.463
LIG_LIR_Gen_1	581	591	PF02991	0.428
LIG_LIR_LC3C_4	24	29	PF02991	0.487
LIG_LIR_Nem_3	136	140	PF02991	0.417
LIG_LIR_Nem_3	167	173	PF02991	0.384
LIG_LIR_Nem_3	357	361	PF02991	0.532
LIG_LIR_Nem_3	405	411	PF02991	0.431
LIG_PCNA_yPIPBox_3	260	271	PF02747	0.408
LIG_Pex14_1	521	525	PF04695	0.374
LIG_Pex14_2	34	38	PF04695	0.439
LIG_Pex14_2	512	516	PF04695	0.355
LIG_SH2_STAT5	107	110	PF00017	0.513
LIG_SH2_STAT5	133	136	PF00017	0.413
LIG_SH2_STAT5	205	208	PF00017	0.504
LIG_SH2_STAT5	426	429	PF00017	0.413
LIG_SH2_STAT5	565	568	PF00017	0.476
LIG_SH3_2	116	121	PF14604	0.613
LIG_SH3_3	110	116	PF00018	0.635
LIG_SH3_3	325	331	PF00018	0.510
LIG_SH3_3	395	401	PF00018	0.506
LIG_SH3_CIN85_PxpxPR_1	116	121	PF14604	0.677
LIG_SUMO_SIM_par_1	27	32	PF11976	0.521
LIG_TRAF2_1	439	442	PF00917	0.540
LIG_TYR_ITIM	406	411	PF00017	0.522
LIG_WRC_WIRS_1	587	592	PF05994	0.256
LIG_WW_3	111	115	PF00397	0.557
LIG_WW_3	118	122	PF00397	0.422
MOD_CDC14_SPxK_1	334	337	PF00782	0.736
MOD_CDK_SPxK_1	331	337	PF00069	0.719
MOD_CDK_SPxxK_3	331	338	PF00069	0.681
MOD_CDK_SPxxK_3	415	422	PF00069	0.595
MOD_CK1_1	155	161	PF00069	0.663
MOD_CK1_1	162	168	PF00069	0.594
MOD_CK1_1	215	221	PF00069	0.522
MOD_CK1_1	311	317	PF00069	0.625
MOD_CK1_1	340	346	PF00069	0.585
MOD_CK1_1	351	357	PF00069	0.509
MOD_CK1_1	374	380	PF00069	0.604
MOD_CK1_1	399	405	PF00069	0.510
MOD_CK1_1	418	424	PF00069	0.593
MOD_CK1_1	461	467	PF00069	0.622
MOD_CK1_1	53	59	PF00069	0.666
MOD_CK1_1	88	94	PF00069	0.692
MOD_CK1_1	96	102	PF00069	0.604
MOD_CK2_1	18	24	PF00069	0.367
MOD_CK2_1	259	265	PF00069	0.520
MOD_CK2_1	399	405	PF00069	0.519
MOD_CK2_1	436	442	PF00069	0.531
MOD_CK2_1	536	542	PF00069	0.607
MOD_CMANNOS	521	524	PF00535	0.363
MOD_DYRK1A_RPxSP_1	397	401	PF00069	0.496
MOD_GlcNHglycan	2	5	PF01048	0.534
MOD_GlcNHglycan	212	215	PF01048	0.540
MOD_GlcNHglycan	294	297	PF01048	0.737
MOD_GlcNHglycan	303	306	PF01048	0.681
MOD_GlcNHglycan	316	319	PF01048	0.456
MOD_GlcNHglycan	373	376	PF01048	0.399
MOD_GlcNHglycan	52	55	PF01048	0.667
MOD_GSK3_1	135	142	PF00069	0.405
MOD_GSK3_1	14	21	PF00069	0.523
MOD_GSK3_1	155	162	PF00069	0.695
MOD_GSK3_1	205	212	PF00069	0.632
MOD_GSK3_1	245	252	PF00069	0.533
MOD_GSK3_1	301	308	PF00069	0.703
MOD_GSK3_1	310	317	PF00069	0.608
MOD_GSK3_1	327	334	PF00069	0.551
MOD_GSK3_1	337	344	PF00069	0.584
MOD_GSK3_1	367	374	PF00069	0.433
MOD_GSK3_1	396	403	PF00069	0.632
MOD_GSK3_1	424	431	PF00069	0.537
MOD_GSK3_1	49	56	PF00069	0.684
MOD_GSK3_1	5	12	PF00069	0.664
MOD_GSK3_1	504	511	PF00069	0.380
MOD_GSK3_1	586	593	PF00069	0.258
MOD_GSK3_1	93	100	PF00069	0.750
MOD_N-GLC_1	461	466	PF02516	0.730
MOD_NEK2_1	192	197	PF00069	0.618
MOD_NEK2_1	558	563	PF00069	0.368
MOD_NEK2_1	586	591	PF00069	0.304
MOD_PIKK_1	228	234	PF00454	0.684
MOD_PIKK_1	578	584	PF00454	0.431
MOD_PK_1	506	512	PF00069	0.352
MOD_PK_1	550	556	PF00069	0.478
MOD_PKA_1	152	158	PF00069	0.454
MOD_PKA_2	152	158	PF00069	0.474
MOD_PKA_2	192	198	PF00069	0.478
MOD_PKA_2	396	402	PF00069	0.667
MOD_PKA_2	409	415	PF00069	0.472
MOD_PKB_1	150	158	PF00069	0.558
MOD_PKB_1	196	204	PF00069	0.543
MOD_PKB_1	548	556	PF00069	0.496
MOD_Plk_1	461	467	PF00069	0.487
MOD_Plk_4	428	434	PF00069	0.388
MOD_Plk_4	508	514	PF00069	0.338
MOD_Plk_4	558	564	PF00069	0.374
MOD_Plk_4	586	592	PF00069	0.253
MOD_ProDKin_1	212	218	PF00069	0.578
MOD_ProDKin_1	312	318	PF00069	0.539
MOD_ProDKin_1	327	333	PF00069	0.630
MOD_ProDKin_1	337	343	PF00069	0.582
MOD_ProDKin_1	351	357	PF00069	0.625
MOD_ProDKin_1	374	380	PF00069	0.683
MOD_ProDKin_1	397	403	PF00069	0.475
MOD_ProDKin_1	415	421	PF00069	0.477
MOD_ProDKin_1	424	430	PF00069	0.425
MOD_ProDKin_1	93	99	PF00069	0.543
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.608
TRG_ENDOCYTIC_2	267	270	PF00928	0.426
TRG_ENDOCYTIC_2	408	411	PF00928	0.397
TRG_ENDOCYTIC_2	426	429	PF00928	0.432
TRG_ER_diArg_1	150	153	PF00400	0.576
TRG_ER_diArg_1	196	198	PF00400	0.609
TRG_ER_diArg_1	202	204	PF00400	0.659
TRG_ER_diArg_1	25	27	PF00400	0.319
TRG_ER_diArg_1	336	338	PF00400	0.529
TRG_ER_diArg_1	548	550	PF00400	0.516
TRG_ER_diArg_1	556	558	PF00400	0.404
TRG_ER_diArg_1	566	569	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	324	329	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	569	574	PF00026	0.259

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5F1	Leptomonas seymouri	34%	100%
A0A3S7WQM8	Leishmania donovani	81%	100%
A4H5N2	Leishmania braziliensis	64%	97%
A4HTX6	Leishmania infantum	80%	100%
Q4QHW9	Leishmania major	79%	100%