Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania mexicana

UniProt:

E9AMQ4_LEIMU

TriTrypDb:

LmxM.09.0530

Length:

985

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	8
GO:0042995	cell projection	2	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	8
GO:0000151	ubiquitin ligase complex	3	1
GO:0005930	axoneme	2	1
GO:0019005	SCF ubiquitin ligase complex	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9AMQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ4

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	7	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.632
CLV_C14_Caspase3-7	3	7	PF00656	0.526
CLV_C14_Caspase3-7	356	360	PF00656	0.486
CLV_C14_Caspase3-7	714	718	PF00656	0.684
CLV_NRD_NRD_1	126	128	PF00675	0.662
CLV_NRD_NRD_1	515	517	PF00675	0.618
CLV_PCSK_KEX2_1	126	128	PF00082	0.706
CLV_PCSK_KEX2_1	515	517	PF00082	0.618
CLV_PCSK_KEX2_1	578	580	PF00082	0.593
CLV_PCSK_KEX2_1	926	928	PF00082	0.797
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.593
CLV_PCSK_PC1ET2_1	926	928	PF00082	0.797
CLV_PCSK_SKI1_1	142	146	PF00082	0.776
CLV_PCSK_SKI1_1	164	168	PF00082	0.583
CLV_PCSK_SKI1_1	229	233	PF00082	0.486
CLV_PCSK_SKI1_1	488	492	PF00082	0.552
CLV_PCSK_SKI1_1	596	600	PF00082	0.570
CLV_PCSK_SKI1_1	604	608	PF00082	0.509
CLV_PCSK_SKI1_1	691	695	PF00082	0.724
CLV_PCSK_SKI1_1	723	727	PF00082	0.622
CLV_Separin_Metazoa	512	516	PF03568	0.531
DEG_APCC_DBOX_1	453	461	PF00400	0.525
DEG_APCC_DBOX_1	487	495	PF00400	0.602
DEG_SPOP_SBC_1	353	357	PF00917	0.437
DOC_CDC14_PxL_1	282	290	PF14671	0.570
DOC_CYCLIN_RxL_1	313	322	PF00134	0.583
DOC_CYCLIN_RxL_1	439	447	PF00134	0.448
DOC_CYCLIN_RxL_1	727	740	PF00134	0.706
DOC_CYCLIN_yCln2_LP_2	393	396	PF00134	0.573
DOC_CYCLIN_yCln2_LP_2	823	829	PF00134	0.732
DOC_CYCLIN_yCln2_LP_2	862	865	PF00134	0.725
DOC_CYCLIN_yCln2_LP_2	894	900	PF00134	0.516
DOC_MAPK_DCC_7	316	325	PF00069	0.580
DOC_MAPK_DCC_7	476	485	PF00069	0.595
DOC_MAPK_gen_1	411	420	PF00069	0.567
DOC_MAPK_gen_1	476	485	PF00069	0.506
DOC_MAPK_HePTP_8	473	485	PF00069	0.589
DOC_MAPK_MEF2A_6	316	325	PF00069	0.580
DOC_MAPK_MEF2A_6	476	485	PF00069	0.550
DOC_PP2B_LxvP_1	318	321	PF13499	0.432
DOC_PP2B_LxvP_1	392	395	PF13499	0.497
DOC_PP2B_LxvP_1	481	484	PF13499	0.531
DOC_PP2B_LxvP_1	494	497	PF13499	0.495
DOC_PP2B_LxvP_1	818	821	PF13499	0.712
DOC_PP2B_LxvP_1	823	826	PF13499	0.673
DOC_PP2B_LxvP_1	862	865	PF13499	0.725
DOC_PP4_FxxP_1	979	982	PF00568	0.616
DOC_USP7_MATH_1	205	209	PF00917	0.662
DOC_USP7_MATH_1	222	226	PF00917	0.297
DOC_USP7_MATH_1	272	276	PF00917	0.487
DOC_USP7_MATH_1	30	34	PF00917	0.593
DOC_USP7_MATH_1	353	357	PF00917	0.715
DOC_USP7_MATH_1	472	476	PF00917	0.572
DOC_USP7_MATH_1	680	684	PF00917	0.736
DOC_USP7_MATH_1	705	709	PF00917	0.623
DOC_USP7_MATH_1	846	850	PF00917	0.743
DOC_USP7_MATH_1	935	939	PF00917	0.677
DOC_USP7_MATH_1	940	944	PF00917	0.579
DOC_USP7_MATH_1	953	957	PF00917	0.805
DOC_USP7_MATH_2	352	358	PF00917	0.436
DOC_WW_Pin1_4	231	236	PF00397	0.590
DOC_WW_Pin1_4	240	245	PF00397	0.649
DOC_WW_Pin1_4	34	39	PF00397	0.785
DOC_WW_Pin1_4	852	857	PF00397	0.753
DOC_WW_Pin1_4	867	872	PF00397	0.827
DOC_WW_Pin1_4	883	888	PF00397	0.728
DOC_WW_Pin1_4	893	898	PF00397	0.688
DOC_WW_Pin1_4	949	954	PF00397	0.684
LIG_14-3-3_CanoR_1	10	18	PF00244	0.675
LIG_14-3-3_CanoR_1	102	106	PF00244	0.466
LIG_14-3-3_CanoR_1	186	194	PF00244	0.613
LIG_14-3-3_CanoR_1	229	238	PF00244	0.573
LIG_14-3-3_CanoR_1	261	266	PF00244	0.524
LIG_14-3-3_CanoR_1	414	419	PF00244	0.348
LIG_14-3-3_CanoR_1	425	433	PF00244	0.386
LIG_14-3-3_CanoR_1	498	504	PF00244	0.557
LIG_14-3-3_CanoR_1	532	537	PF00244	0.573
LIG_14-3-3_CanoR_1	554	562	PF00244	0.382
LIG_14-3-3_CanoR_1	596	603	PF00244	0.563
LIG_14-3-3_CanoR_1	90	99	PF00244	0.655
LIG_14-3-3_CanoR_1	957	967	PF00244	0.674
LIG_APCC_Cbox_2	61	67	PF00515	0.354
LIG_BIR_II_1	1	5	PF00653	0.769
LIG_BRCT_BRCA1_1	263	267	PF00533	0.541
LIG_BRCT_BRCA1_1	534	538	PF00533	0.455
LIG_BRCT_BRCA1_1	794	798	PF00533	0.774
LIG_BRCT_BRCA1_1	937	941	PF00533	0.704
LIG_FAT_LD_1	460	468	PF03623	0.498
LIG_FHA_1	241	247	PF00498	0.443
LIG_FHA_1	260	266	PF00498	0.547
LIG_FHA_1	304	310	PF00498	0.495
LIG_FHA_1	346	352	PF00498	0.713
LIG_FHA_1	353	359	PF00498	0.641
LIG_FHA_1	365	371	PF00498	0.535
LIG_FHA_1	399	405	PF00498	0.524
LIG_FHA_1	415	421	PF00498	0.261
LIG_FHA_1	587	593	PF00498	0.519
LIG_FHA_1	652	658	PF00498	0.590
LIG_FHA_1	744	750	PF00498	0.534
LIG_FHA_1	815	821	PF00498	0.768
LIG_FHA_2	535	541	PF00498	0.567
LIG_FHA_2	595	601	PF00498	0.534
LIG_FHA_2	868	874	PF00498	0.791
LIG_GBD_Chelix_1	657	665	PF00786	0.507
LIG_Integrin_isoDGR_2	518	520	PF01839	0.661
LIG_LIR_Apic_2	905	911	PF02991	0.525
LIG_LIR_Apic_2	977	982	PF02991	0.616
LIG_LIR_LC3C_4	322	325	PF02991	0.505
LIG_LIR_Nem_3	268	274	PF02991	0.587
LIG_LIR_Nem_3	546	552	PF02991	0.568
LIG_LIR_Nem_3	938	944	PF02991	0.711
LIG_MAD2	442	450	PF02301	0.443
LIG_NRBOX	226	232	PF00104	0.577
LIG_NRBOX	332	338	PF00104	0.559
LIG_NRBOX	404	410	PF00104	0.269
LIG_PCNA_yPIPBox_3	178	186	PF02747	0.516
LIG_Pex14_2	263	267	PF04695	0.541
LIG_Pex14_2	979	983	PF04695	0.620
LIG_SH2_CRK	271	275	PF00017	0.488
LIG_SH2_CRK	908	912	PF00017	0.599
LIG_SH2_NCK_1	908	912	PF00017	0.531
LIG_SH2_STAT3	125	128	PF00017	0.555
LIG_SH2_STAT5	184	187	PF00017	0.479
LIG_SH2_STAT5	190	193	PF00017	0.466
LIG_SH2_STAT5	63	66	PF00017	0.347
LIG_SH2_STAT5	908	911	PF00017	0.744
LIG_SH3_1	868	874	PF00018	0.745
LIG_SH3_3	140	146	PF00018	0.674
LIG_SH3_3	188	194	PF00018	0.588
LIG_SH3_3	35	41	PF00018	0.761
LIG_SH3_3	53	59	PF00018	0.633
LIG_SH3_3	650	656	PF00018	0.616
LIG_SH3_3	822	828	PF00018	0.721
LIG_SH3_3	868	874	PF00018	0.553
LIG_SUMO_SIM_anti_2	117	124	PF11976	0.710
LIG_SUMO_SIM_anti_2	388	393	PF11976	0.442
LIG_SUMO_SIM_anti_2	458	466	PF11976	0.526
LIG_SUMO_SIM_anti_2	589	594	PF11976	0.560
LIG_SUMO_SIM_par_1	117	124	PF11976	0.682
LIG_SUMO_SIM_par_1	366	371	PF11976	0.573
LIG_SUMO_SIM_par_1	416	421	PF11976	0.422
LIG_SUMO_SIM_par_1	442	447	PF11976	0.572
LIG_SUMO_SIM_par_1	816	822	PF11976	0.705
LIG_TRAF2_1	870	873	PF00917	0.790
LIG_TRAF2_1	912	915	PF00917	0.834
LIG_TRAF2_1	982	985	PF00917	0.799
LIG_WRC_WIRS_1	200	205	PF05994	0.425
LIG_WRC_WIRS_1	260	265	PF05994	0.457
MOD_CK1_1	11	17	PF00069	0.689
MOD_CK1_1	275	281	PF00069	0.457
MOD_CK1_1	284	290	PF00069	0.438
MOD_CK1_1	357	363	PF00069	0.408
MOD_CK1_1	500	506	PF00069	0.599
MOD_CK1_1	539	545	PF00069	0.508
MOD_CK1_1	624	630	PF00069	0.593
MOD_CK1_1	685	691	PF00069	0.596
MOD_CK1_1	706	712	PF00069	0.626
MOD_CK1_1	754	760	PF00069	0.643
MOD_CK1_1	768	774	PF00069	0.720
MOD_CK1_1	813	819	PF00069	0.762
MOD_CK1_1	896	902	PF00069	0.733
MOD_CK1_1	903	909	PF00069	0.699
MOD_CK1_1	917	923	PF00069	0.691
MOD_CK1_1	925	931	PF00069	0.661
MOD_CK1_1	952	958	PF00069	0.744
MOD_CK1_1	959	965	PF00069	0.579
MOD_CK2_1	204	210	PF00069	0.660
MOD_CK2_1	316	322	PF00069	0.433
MOD_CK2_1	534	540	PF00069	0.573
MOD_CK2_1	866	872	PF00069	0.810
MOD_CK2_1	909	915	PF00069	0.775
MOD_GlcNHglycan	207	210	PF01048	0.659
MOD_GlcNHglycan	248	252	PF01048	0.615
MOD_GlcNHglycan	369	373	PF01048	0.583
MOD_GlcNHglycan	419	423	PF01048	0.453
MOD_GlcNHglycan	435	438	PF01048	0.471
MOD_GlcNHglycan	520	523	PF01048	0.666
MOD_GlcNHglycan	687	690	PF01048	0.709
MOD_GlcNHglycan	697	700	PF01048	0.680
MOD_GlcNHglycan	703	706	PF01048	0.694
MOD_GlcNHglycan	739	742	PF01048	0.693
MOD_GlcNHglycan	779	784	PF01048	0.791
MOD_GlcNHglycan	812	815	PF01048	0.756
MOD_GlcNHglycan	902	905	PF01048	0.659
MOD_GlcNHglycan	919	922	PF01048	0.611
MOD_GlcNHglycan	937	940	PF01048	0.719
MOD_GlcNHglycan	958	961	PF01048	0.756
MOD_GSK3_1	247	254	PF00069	0.564
MOD_GSK3_1	30	37	PF00069	0.599
MOD_GSK3_1	353	360	PF00069	0.631
MOD_GSK3_1	364	371	PF00069	0.474
MOD_GSK3_1	394	401	PF00069	0.574
MOD_GSK3_1	414	421	PF00069	0.232
MOD_GSK3_1	532	539	PF00069	0.542
MOD_GSK3_1	701	708	PF00069	0.693
MOD_GSK3_1	810	817	PF00069	0.616
MOD_GSK3_1	896	903	PF00069	0.797
MOD_GSK3_1	9	16	PF00069	0.716
MOD_GSK3_1	906	913	PF00069	0.720
MOD_GSK3_1	949	956	PF00069	0.775
MOD_LATS_1	259	265	PF00433	0.559
MOD_LATS_1	566	572	PF00433	0.596
MOD_N-GLC_2	572	574	PF02516	0.394
MOD_NEK2_1	101	106	PF00069	0.597
MOD_NEK2_1	199	204	PF00069	0.452
MOD_NEK2_1	281	286	PF00069	0.459
MOD_NEK2_1	368	373	PF00069	0.434
MOD_NEK2_1	400	405	PF00069	0.428
MOD_NEK2_1	418	423	PF00069	0.353
MOD_NEK2_1	433	438	PF00069	0.464
MOD_NEK2_1	463	468	PF00069	0.454
MOD_NEK2_1	474	479	PF00069	0.490
MOD_NEK2_1	552	557	PF00069	0.480
MOD_NEK2_1	770	775	PF00069	0.805
MOD_NEK2_1	8	13	PF00069	0.625
MOD_NEK2_1	866	871	PF00069	0.793
MOD_NEK2_1	898	903	PF00069	0.643
MOD_PIKK_1	229	235	PF00454	0.612
MOD_PIKK_1	310	316	PF00454	0.531
MOD_PIKK_1	497	503	PF00454	0.590
MOD_PIKK_1	552	558	PF00454	0.588
MOD_PIKK_1	604	610	PF00454	0.596
MOD_PIKK_1	906	912	PF00454	0.799
MOD_PK_1	261	267	PF00069	0.554
MOD_PK_1	532	538	PF00069	0.568
MOD_PKA_2	101	107	PF00069	0.521
MOD_PKA_2	185	191	PF00069	0.609
MOD_PKA_2	339	345	PF00069	0.557
MOD_PKA_2	424	430	PF00069	0.564
MOD_PKA_2	497	503	PF00069	0.554
MOD_PKA_2	531	537	PF00069	0.498
MOD_PKA_2	9	15	PF00069	0.757
MOD_PKA_2	956	962	PF00069	0.665
MOD_Plk_1	247	253	PF00069	0.561
MOD_Plk_1	30	36	PF00069	0.596
MOD_Plk_1	316	322	PF00069	0.533
MOD_Plk_1	353	359	PF00069	0.429
MOD_Plk_1	539	545	PF00069	0.479
MOD_Plk_1	627	633	PF00069	0.580
MOD_Plk_1	858	864	PF00069	0.692
MOD_Plk_2-3	354	360	PF00069	0.419
MOD_Plk_2-3	364	370	PF00069	0.258
MOD_Plk_4	199	205	PF00069	0.430
MOD_Plk_4	222	228	PF00069	0.537
MOD_Plk_4	272	278	PF00069	0.384
MOD_Plk_4	400	406	PF00069	0.554
MOD_Plk_4	490	496	PF00069	0.564
MOD_Plk_4	539	545	PF00069	0.503
MOD_Plk_4	560	566	PF00069	0.492
MOD_Plk_4	707	713	PF00069	0.647
MOD_Plk_4	765	771	PF00069	0.753
MOD_Plk_4	858	864	PF00069	0.678
MOD_ProDKin_1	231	237	PF00069	0.603
MOD_ProDKin_1	240	246	PF00069	0.646
MOD_ProDKin_1	34	40	PF00069	0.783
MOD_ProDKin_1	852	858	PF00069	0.756
MOD_ProDKin_1	867	873	PF00069	0.829
MOD_ProDKin_1	883	889	PF00069	0.727
MOD_ProDKin_1	893	899	PF00069	0.688
MOD_ProDKin_1	949	955	PF00069	0.687
MOD_SUMO_for_1	65	68	PF00179	0.505
TRG_DiLeu_BaEn_1	117	122	PF01217	0.658
TRG_DiLeu_BaEn_4	117	123	PF01217	0.709
TRG_DiLeu_BaEn_4	68	74	PF01217	0.493
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.572
TRG_DiLeu_BaLyEn_6	332	337	PF01217	0.473
TRG_ENDOCYTIC_2	271	274	PF00928	0.573
TRG_ER_diArg_1	125	127	PF00400	0.715
TRG_ER_diArg_1	514	516	PF00400	0.618
TRG_NES_CRM1_1	639	651	PF08389	0.559
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	442	447	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.599
TRG_Pf-PMV_PEXEL_1	604	608	PF00026	0.464
TRG_Pf-PMV_PEXEL_1	632	636	PF00026	0.470
TRG_Pf-PMV_PEXEL_1	732	737	PF00026	0.701
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	927	931	PF00026	0.788

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NN23	Trypanosomatidae	28%	76%
A0A3S7WQP1	Leishmania donovani	88%	99%
A0A422NV64	Trypanosoma rangeli	26%	91%
A4H5N0	Leishmania braziliensis	68%	98%
A4HTW7	Leishmania infantum	88%	99%
D0A9D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	94%
Q4QHX1	Leishmania major	88%	100%