Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum attachment zone protein 3

Species:

Leishmania mexicana

UniProt:

E9AMQ3_LEIMU

TriTrypDb:

LmxM.09.0520

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AMQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0071889	14-3-3 protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.733
CLV_NRD_NRD_1	265	267	PF00675	0.635
CLV_NRD_NRD_1	410	412	PF00675	0.536
CLV_NRD_NRD_1	463	465	PF00675	0.599
CLV_NRD_NRD_1	696	698	PF00675	0.602
CLV_NRD_NRD_1	715	717	PF00675	0.745
CLV_PCSK_KEX2_1	214	216	PF00082	0.498
CLV_PCSK_KEX2_1	239	241	PF00082	0.521
CLV_PCSK_KEX2_1	410	412	PF00082	0.536
CLV_PCSK_KEX2_1	463	465	PF00082	0.599
CLV_PCSK_KEX2_1	617	619	PF00082	0.606
CLV_PCSK_KEX2_1	696	698	PF00082	0.545
CLV_PCSK_KEX2_1	715	717	PF00082	0.745
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.498
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.521
CLV_PCSK_PC1ET2_1	617	619	PF00082	0.623
CLV_PCSK_SKI1_1	112	116	PF00082	0.586
CLV_PCSK_SKI1_1	229	233	PF00082	0.483
CLV_PCSK_SKI1_1	342	346	PF00082	0.526
CLV_PCSK_SKI1_1	451	455	PF00082	0.454
CLV_PCSK_SKI1_1	466	470	PF00082	0.495
CLV_PCSK_SKI1_1	542	546	PF00082	0.526
CLV_PCSK_SKI1_1	58	62	PF00082	0.458
CLV_PCSK_SKI1_1	632	636	PF00082	0.725
DOC_CKS1_1	725	730	PF01111	0.595
DOC_CYCLIN_yCln2_LP_2	725	731	PF00134	0.612
DOC_MAPK_gen_1	239	247	PF00069	0.520
DOC_MAPK_gen_1	436	444	PF00069	0.434
DOC_MAPK_HePTP_8	526	538	PF00069	0.522
DOC_MAPK_MEF2A_6	436	444	PF00069	0.510
DOC_MAPK_MEF2A_6	529	538	PF00069	0.507
DOC_PP4_FxxP_1	384	387	PF00568	0.611
DOC_USP7_MATH_1	387	391	PF00917	0.631
DOC_USP7_MATH_1	543	547	PF00917	0.567
DOC_USP7_MATH_1	562	566	PF00917	0.759
DOC_USP7_MATH_1	645	649	PF00917	0.771
DOC_USP7_MATH_1	709	713	PF00917	0.646
DOC_USP7_MATH_1	753	757	PF00917	0.779
DOC_USP7_UBL2_3	183	187	PF12436	0.696
DOC_USP7_UBL2_3	529	533	PF12436	0.582
DOC_WW_Pin1_4	417	422	PF00397	0.419
DOC_WW_Pin1_4	627	632	PF00397	0.739
DOC_WW_Pin1_4	641	646	PF00397	0.701
DOC_WW_Pin1_4	648	653	PF00397	0.716
DOC_WW_Pin1_4	674	679	PF00397	0.711
DOC_WW_Pin1_4	698	703	PF00397	0.605
DOC_WW_Pin1_4	724	729	PF00397	0.601
LIG_14-3-3_CanoR_1	158	164	PF00244	0.609
LIG_14-3-3_CanoR_1	259	264	PF00244	0.545
LIG_14-3-3_CanoR_1	400	404	PF00244	0.459
LIG_14-3-3_CanoR_1	484	490	PF00244	0.587
LIG_14-3-3_CanoR_1	542	548	PF00244	0.546
LIG_14-3-3_CanoR_1	646	652	PF00244	0.775
LIG_14-3-3_CanoR_1	696	700	PF00244	0.638
LIG_14-3-3_CanoR_1	92	101	PF00244	0.601
LIG_Actin_WH2_2	44	60	PF00022	0.510
LIG_APCC_ABBA_1	729	734	PF00400	0.562
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.492
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BIR_III_2	743	747	PF00653	0.805
LIG_EVH1_2	548	552	PF00568	0.510
LIG_FHA_1	151	157	PF00498	0.520
LIG_FHA_1	310	316	PF00498	0.438
LIG_FHA_1	357	363	PF00498	0.571
LIG_FHA_1	435	441	PF00498	0.593
LIG_FHA_1	46	52	PF00498	0.615
LIG_FHA_1	655	661	PF00498	0.649
LIG_FHA_1	762	768	PF00498	0.731
LIG_FHA_2	160	166	PF00498	0.658
LIG_FHA_2	189	195	PF00498	0.657
LIG_FHA_2	374	380	PF00498	0.550
LIG_FHA_2	499	505	PF00498	0.498
LIG_HCF-1_HBM_1	289	292	PF13415	0.543
LIG_IBAR_NPY_1	567	569	PF08397	0.636
LIG_LIR_Apic_2	698	702	PF02991	0.710
LIG_LIR_Gen_1	217	226	PF02991	0.582
LIG_LIR_Gen_1	242	252	PF02991	0.500
LIG_LIR_Gen_1	312	320	PF02991	0.541
LIG_LIR_Gen_1	321	327	PF02991	0.594
LIG_LIR_Gen_1	515	526	PF02991	0.572
LIG_LIR_Gen_1	572	578	PF02991	0.715
LIG_LIR_Gen_1	701	709	PF02991	0.706
LIG_LIR_Nem_3	242	247	PF02991	0.457
LIG_LIR_Nem_3	250	255	PF02991	0.445
LIG_LIR_Nem_3	308	314	PF02991	0.521
LIG_LIR_Nem_3	349	355	PF02991	0.502
LIG_LIR_Nem_3	379	384	PF02991	0.536
LIG_LIR_Nem_3	490	496	PF02991	0.598
LIG_LIR_Nem_3	514	520	PF02991	0.569
LIG_LIR_Nem_3	572	576	PF02991	0.751
LIG_LIR_Nem_3	59	64	PF02991	0.585
LIG_LIR_Nem_3	701	707	PF02991	0.708
LIG_Pex14_2	350	354	PF04695	0.467
LIG_PTB_Apo_2	246	253	PF02174	0.547
LIG_REV1ctd_RIR_1	91	101	PF16727	0.461
LIG_RPA_C_Fungi	27	39	PF08784	0.423
LIG_SH2_CRK	301	305	PF00017	0.537
LIG_SH2_GRB2like	311	314	PF00017	0.547
LIG_SH2_GRB2like	489	492	PF00017	0.626
LIG_SH2_NCK_1	573	577	PF00017	0.750
LIG_SH2_SRC	314	317	PF00017	0.558
LIG_SH2_SRC	392	395	PF00017	0.589
LIG_SH2_SRC	573	576	PF00017	0.753
LIG_SH2_STAP1	311	315	PF00017	0.291
LIG_SH2_STAP1	489	493	PF00017	0.616
LIG_SH2_STAP1	763	767	PF00017	0.673
LIG_SH2_STAT3	189	192	PF00017	0.711
LIG_SH2_STAT3	489	492	PF00017	0.596
LIG_SH2_STAT3	527	530	PF00017	0.728
LIG_SH2_STAT5	168	171	PF00017	0.675
LIG_SH2_STAT5	189	192	PF00017	0.716
LIG_SH2_STAT5	292	295	PF00017	0.669
LIG_SH2_STAT5	311	314	PF00017	0.275
LIG_SH2_STAT5	392	395	PF00017	0.589
LIG_SH2_STAT5	505	508	PF00017	0.538
LIG_SH2_STAT5	518	521	PF00017	0.568
LIG_SH2_STAT5	551	554	PF00017	0.504
LIG_SH2_STAT5	704	707	PF00017	0.632
LIG_SH2_STAT5	763	766	PF00017	0.673
LIG_SH2_STAT5	83	86	PF00017	0.502
LIG_SH3_3	531	537	PF00018	0.601
LIG_SH3_3	625	631	PF00018	0.498
LIG_SH3_3	672	678	PF00018	0.634
LIG_SH3_3	681	687	PF00018	0.546
LIG_Sin3_3	479	486	PF02671	0.458
LIG_SUMO_SIM_anti_2	450	457	PF11976	0.477
LIG_SUMO_SIM_par_1	452	457	PF11976	0.526
LIG_TRAF2_1	162	165	PF00917	0.632
LIG_TRAF2_1	231	234	PF00917	0.495
LIG_TRAF2_1	472	475	PF00917	0.549
LIG_TRAF2_1	669	672	PF00917	0.679
LIG_TYR_ITSM	310	317	PF00017	0.294
LIG_UBA3_1	180	187	PF00899	0.735
LIG_WW_1	548	551	PF00397	0.506
LIG_WW_3	547	551	PF00397	0.517
MOD_CDK_SPK_2	627	632	PF00069	0.769
MOD_CDK_SPK_2	641	646	PF00069	0.701
MOD_CK1_1	150	156	PF00069	0.497
MOD_CK1_1	170	176	PF00069	0.435
MOD_CK1_1	262	268	PF00069	0.681
MOD_CK1_1	356	362	PF00069	0.560
MOD_CK1_1	395	401	PF00069	0.547
MOD_CK1_1	41	47	PF00069	0.658
MOD_CK1_1	420	426	PF00069	0.439
MOD_CK1_1	485	491	PF00069	0.594
MOD_CK1_1	561	567	PF00069	0.722
MOD_CK1_1	648	654	PF00069	0.748
MOD_CK1_1	698	704	PF00069	0.608
MOD_CK1_1	748	754	PF00069	0.699
MOD_CK1_1	761	767	PF00069	0.669
MOD_CK2_1	159	165	PF00069	0.586
MOD_CK2_1	170	176	PF00069	0.605
MOD_CK2_1	188	194	PF00069	0.605
MOD_CK2_1	30	36	PF00069	0.633
MOD_CK2_1	373	379	PF00069	0.580
MOD_CK2_1	456	462	PF00069	0.561
MOD_CK2_1	498	504	PF00069	0.469
MOD_CK2_1	601	607	PF00069	0.555
MOD_GlcNHglycan	1	4	PF01048	0.705
MOD_GlcNHglycan	149	152	PF01048	0.497
MOD_GlcNHglycan	332	335	PF01048	0.610
MOD_GlcNHglycan	484	487	PF01048	0.568
MOD_GlcNHglycan	560	563	PF01048	0.609
MOD_GlcNHglycan	747	750	PF01048	0.696
MOD_GlcNHglycan	751	754	PF01048	0.665
MOD_GSK3_1	136	143	PF00069	0.609
MOD_GSK3_1	166	173	PF00069	0.617
MOD_GSK3_1	394	401	PF00069	0.642
MOD_GSK3_1	41	48	PF00069	0.688
MOD_GSK3_1	558	565	PF00069	0.672
MOD_GSK3_1	641	648	PF00069	0.724
MOD_GSK3_1	7	14	PF00069	0.558
MOD_GSK3_1	745	752	PF00069	0.658
MOD_GSK3_1	759	766	PF00069	0.612
MOD_LATS_1	202	208	PF00433	0.542
MOD_N-GLC_1	398	403	PF02516	0.590
MOD_N-GLC_1	457	462	PF02516	0.669
MOD_NEK2_1	136	141	PF00069	0.574
MOD_NEK2_1	147	152	PF00069	0.489
MOD_NEK2_1	30	35	PF00069	0.580
MOD_NEK2_1	327	332	PF00069	0.530
MOD_NEK2_1	39	44	PF00069	0.723
MOD_NEK2_1	454	459	PF00069	0.631
MOD_NEK2_1	593	598	PF00069	0.620
MOD_NEK2_1	634	639	PF00069	0.750
MOD_PIKK_1	140	146	PF00454	0.662
MOD_PIKK_1	188	194	PF00454	0.645
MOD_PIKK_1	204	210	PF00454	0.408
MOD_PIKK_1	92	98	PF00454	0.575
MOD_PKA_2	399	405	PF00069	0.468
MOD_PKA_2	635	641	PF00069	0.692
MOD_PKA_2	645	651	PF00069	0.725
MOD_PKA_2	695	701	PF00069	0.714
MOD_PKA_2	709	715	PF00069	0.650
MOD_PKA_2	753	759	PF00069	0.741
MOD_PKB_1	90	98	PF00069	0.602
MOD_Plk_1	279	285	PF00069	0.616
MOD_Plk_1	398	404	PF00069	0.585
MOD_Plk_4	136	142	PF00069	0.605
MOD_Plk_4	185	191	PF00069	0.727
MOD_Plk_4	21	27	PF00069	0.621
MOD_Plk_4	322	328	PF00069	0.417
MOD_Plk_4	7	13	PF00069	0.576
MOD_Plk_4	700	706	PF00069	0.583
MOD_ProDKin_1	417	423	PF00069	0.419
MOD_ProDKin_1	627	633	PF00069	0.739
MOD_ProDKin_1	641	647	PF00069	0.702
MOD_ProDKin_1	648	654	PF00069	0.711
MOD_ProDKin_1	674	680	PF00069	0.711
MOD_ProDKin_1	698	704	PF00069	0.608
MOD_ProDKin_1	724	730	PF00069	0.599
MOD_SUMO_rev_2	379	384	PF00179	0.531
TRG_DiLeu_BaEn_1	127	132	PF01217	0.507
TRG_DiLeu_BaEn_1	450	455	PF01217	0.465
TRG_DiLeu_BaEn_4	109	115	PF01217	0.586
TRG_DiLeu_BaEn_4	671	677	PF01217	0.657
TRG_ENDOCYTIC_2	160	163	PF00928	0.571
TRG_ENDOCYTIC_2	218	221	PF00928	0.584
TRG_ENDOCYTIC_2	314	317	PF00928	0.446
TRG_ENDOCYTIC_2	352	355	PF00928	0.453
TRG_ENDOCYTIC_2	381	384	PF00928	0.531
TRG_ENDOCYTIC_2	493	496	PF00928	0.572
TRG_ENDOCYTIC_2	517	520	PF00928	0.572
TRG_ENDOCYTIC_2	551	554	PF00928	0.488
TRG_ENDOCYTIC_2	573	576	PF00928	0.753
TRG_ENDOCYTIC_2	704	707	PF00928	0.725
TRG_ER_diArg_1	32	35	PF00400	0.633
TRG_ER_diArg_1	463	466	PF00400	0.602
TRG_ER_diArg_1	707	710	PF00400	0.665
TRG_ER_diArg_1	714	716	PF00400	0.677
TRG_ER_diArg_1	90	93	PF00400	0.609
TRG_NES_CRM1_1	227	242	PF08389	0.295
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3D7	Leptomonas seymouri	77%	100%
A0A1X0NMP1	Trypanosomatidae	56%	96%
A0A3R7MX09	Trypanosoma rangeli	56%	97%
A0A3S5H6D5	Leishmania donovani	95%	100%
A4H5M9	Leishmania braziliensis	88%	100%
A4HTW6	Leishmania infantum	95%	100%
D0A9D0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	96%
Q4QHX2	Leishmania major	94%	100%
V5BSM8	Trypanosoma cruzi	55%	96%