Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMQ2_LEIMU

TriTrypDb:

LmxM.09.0510

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	239	243	PF00656	0.693
CLV_NRD_NRD_1	106	108	PF00675	0.632
CLV_NRD_NRD_1	164	166	PF00675	0.548
CLV_NRD_NRD_1	167	169	PF00675	0.550
CLV_NRD_NRD_1	188	190	PF00675	0.671
CLV_NRD_NRD_1	197	199	PF00675	0.683
CLV_NRD_NRD_1	55	57	PF00675	0.424
CLV_NRD_NRD_1	81	83	PF00675	0.523
CLV_PCSK_KEX2_1	108	110	PF00082	0.710
CLV_PCSK_KEX2_1	164	166	PF00082	0.547
CLV_PCSK_KEX2_1	188	190	PF00082	0.671
CLV_PCSK_KEX2_1	55	57	PF00082	0.413
CLV_PCSK_KEX2_1	81	83	PF00082	0.523
CLV_PCSK_PC1ET2_1	108	110	PF00082	0.744
CLV_PCSK_PC7_1	104	110	PF00082	0.751
CLV_PCSK_SKI1_1	136	140	PF00082	0.377
CLV_PCSK_SKI1_1	283	287	PF00082	0.749
CLV_PCSK_SKI1_1	388	392	PF00082	0.623
DEG_ODPH_VHL_1	111	122	PF01847	0.515
DOC_CYCLIN_RxL_1	133	143	PF00134	0.475
DOC_MAPK_gen_1	55	63	PF00069	0.382
DOC_MAPK_gen_1	81	88	PF00069	0.498
DOC_MAPK_MEF2A_6	19	26	PF00069	0.396
DOC_MAPK_MEF2A_6	56	65	PF00069	0.412
DOC_PP1_RVXF_1	134	140	PF00149	0.411
DOC_PP2B_LxvP_1	63	66	PF13499	0.401
DOC_PP4_FxxP_1	32	35	PF00568	0.525
DOC_PP4_FxxP_1	84	87	PF00568	0.427
DOC_USP7_MATH_1	15	19	PF00917	0.497
DOC_USP7_MATH_1	206	210	PF00917	0.701
DOC_USP7_MATH_1	294	298	PF00917	0.739
DOC_USP7_MATH_1	317	321	PF00917	0.572
DOC_USP7_MATH_1	45	49	PF00917	0.470
DOC_WW_Pin1_4	146	151	PF00397	0.448
DOC_WW_Pin1_4	274	279	PF00397	0.747
DOC_WW_Pin1_4	34	39	PF00397	0.568
LIG_14-3-3_CanoR_1	198	203	PF00244	0.721
LIG_14-3-3_CanoR_1	205	213	PF00244	0.715
LIG_14-3-3_CanoR_1	44	50	PF00244	0.470
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BRCT_BRCA1_1	175	179	PF00533	0.735
LIG_BRCT_BRCA1_1	84	88	PF00533	0.248
LIG_CtBP_PxDLS_1	237	241	PF00389	0.675
LIG_EH_1	176	180	PF12763	0.691
LIG_FHA_1	115	121	PF00498	0.544
LIG_FHA_1	132	138	PF00498	0.540
LIG_FHA_1	151	157	PF00498	0.413
LIG_FHA_1	222	228	PF00498	0.645
LIG_FHA_2	128	134	PF00498	0.618
LIG_FHA_2	268	274	PF00498	0.719
LIG_FHA_2	275	281	PF00498	0.658
LIG_FHA_2	378	384	PF00498	0.677
LIG_FHA_2	65	71	PF00498	0.568
LIG_LIR_Apic_2	29	35	PF02991	0.501
LIG_LIR_Apic_2	83	87	PF02991	0.430
LIG_LIR_Gen_1	117	127	PF02991	0.506
LIG_LIR_Gen_1	305	315	PF02991	0.414
LIG_LIR_Nem_3	117	122	PF02991	0.474
LIG_LIR_Nem_3	157	162	PF02991	0.498
LIG_LIR_Nem_3	176	182	PF02991	0.723
LIG_LIR_Nem_3	305	310	PF02991	0.422
LIG_LIR_Nem_3	85	91	PF02991	0.411
LIG_Pex14_2	84	88	PF04695	0.464
LIG_PTB_Apo_2	74	81	PF02174	0.505
LIG_PTB_Phospho_1	74	80	PF10480	0.501
LIG_REV1ctd_RIR_1	388	392	PF16727	0.698
LIG_SH2_CRK	175	179	PF00017	0.658
LIG_SH2_CRK	307	311	PF00017	0.398
LIG_SH2_GRB2like	175	178	PF00017	0.654
LIG_SH2_GRB2like	90	93	PF00017	0.555
LIG_SH2_NCK_1	175	179	PF00017	0.736
LIG_SH2_NCK_1	307	311	PF00017	0.384
LIG_SH2_STAP1	116	120	PF00017	0.532
LIG_SH2_STAP1	223	227	PF00017	0.593
LIG_SH2_STAP1	307	311	PF00017	0.398
LIG_SH2_STAP1	46	50	PF00017	0.421
LIG_SH2_STAT5	116	119	PF00017	0.472
LIG_SH2_STAT5	223	226	PF00017	0.613
LIG_SH2_STAT5	329	332	PF00017	0.459
LIG_SH2_STAT5	349	352	PF00017	0.408
LIG_SH2_STAT5	39	42	PF00017	0.492
LIG_SH2_STAT5	49	52	PF00017	0.321
LIG_SH2_STAT5	90	93	PF00017	0.513
LIG_SH3_3	231	237	PF00018	0.632
LIG_SH3_3	32	38	PF00018	0.503
LIG_SH3_3	336	342	PF00018	0.565
LIG_SUMO_SIM_anti_2	2	9	PF11976	0.512
LIG_SUMO_SIM_anti_2	356	362	PF11976	0.574
LIG_SUMO_SIM_par_1	152	157	PF11976	0.411
LIG_SUMO_SIM_par_1	308	314	PF11976	0.495
LIG_TRAF2_1	229	232	PF00917	0.670
LIG_TRAF2_1	380	383	PF00917	0.666
LIG_TYR_ITSM	115	122	PF00017	0.547
MOD_CK1_1	263	269	PF00069	0.667
MOD_CK1_1	322	328	PF00069	0.558
MOD_CK2_1	267	273	PF00069	0.523
MOD_CK2_1	317	323	PF00069	0.541
MOD_CK2_1	377	383	PF00069	0.685
MOD_CK2_1	64	70	PF00069	0.555
MOD_GlcNHglycan	101	104	PF01048	0.664
MOD_GlcNHglycan	2	5	PF01048	0.523
MOD_GlcNHglycan	208	211	PF01048	0.720
MOD_GlcNHglycan	318	322	PF01048	0.565
MOD_GSK3_1	127	134	PF00069	0.574
MOD_GSK3_1	146	153	PF00069	0.439
MOD_GSK3_1	260	267	PF00069	0.667
MOD_GSK3_1	317	324	PF00069	0.594
MOD_GSK3_1	377	384	PF00069	0.643
MOD_GSK3_1	45	52	PF00069	0.536
MOD_N-GLC_1	114	119	PF02516	0.571
MOD_N-GLC_1	127	132	PF02516	0.578
MOD_NEK2_1	26	31	PF00069	0.365
MOD_NEK2_1	260	265	PF00069	0.501
MOD_NEK2_1	50	55	PF00069	0.377
MOD_PIKK_1	216	222	PF00454	0.551
MOD_PK_1	82	88	PF00069	0.254
MOD_PKA_1	198	204	PF00069	0.670
MOD_PKA_2	197	203	PF00069	0.597
MOD_PKA_2	261	267	PF00069	0.579
MOD_PKB_1	196	204	PF00069	0.668
MOD_Plk_1	132	138	PF00069	0.562
MOD_Plk_1	305	311	PF00069	0.419
MOD_Plk_1	322	328	PF00069	0.515
MOD_Plk_1	82	88	PF00069	0.371
MOD_Plk_4	150	156	PF00069	0.424
MOD_Plk_4	305	311	PF00069	0.419
MOD_Plk_4	45	51	PF00069	0.465
MOD_ProDKin_1	146	152	PF00069	0.443
MOD_ProDKin_1	274	280	PF00069	0.750
MOD_ProDKin_1	34	40	PF00069	0.567
MOD_SUMO_for_1	285	288	PF00179	0.795
MOD_SUMO_for_1	330	333	PF00179	0.558
MOD_SUMO_rev_2	382	390	PF00179	0.666
TRG_DiLeu_BaEn_1	305	310	PF01217	0.422
TRG_DiLeu_BaLyEn_6	16	21	PF01217	0.412
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.563
TRG_ENDOCYTIC_2	119	122	PF00928	0.543
TRG_ENDOCYTIC_2	159	162	PF00928	0.525
TRG_ENDOCYTIC_2	223	226	PF00928	0.613
TRG_ENDOCYTIC_2	307	310	PF00928	0.398
TRG_ER_diArg_1	188	190	PF00400	0.661
TRG_ER_diArg_1	202	205	PF00400	0.662
TRG_ER_diArg_1	54	56	PF00400	0.422
TRG_ER_diArg_1	80	82	PF00400	0.517
TRG_Pf-PMV_PEXEL_1	136	141	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB46	Leptomonas seymouri	63%	98%
A0A1X0NNC7	Trypanosomatidae	33%	100%
A0A3Q8IAS3	Leishmania donovani	86%	94%
A4H5M8	Leishmania braziliensis	79%	99%
A4HTW5	Leishmania infantum	84%	97%
D0A9C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QHX3	Leishmania major	85%	100%
V5DJG9	Trypanosoma cruzi	34%	100%