Acyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acyltransferase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMQ0_LEIMU

TriTrypDb:

LmxM.09.0490

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AMQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	188	190	PF00675	0.341
CLV_NRD_NRD_1	209	211	PF00675	0.524
CLV_NRD_NRD_1	339	341	PF00675	0.337
CLV_NRD_NRD_1	380	382	PF00675	0.369
CLV_PCSK_KEX2_1	188	190	PF00082	0.341
CLV_PCSK_KEX2_1	380	382	PF00082	0.395
CLV_PCSK_SKI1_1	246	250	PF00082	0.323
CLV_PCSK_SKI1_1	38	42	PF00082	0.417
CLV_PCSK_SKI1_1	392	396	PF00082	0.351
CLV_PCSK_SKI1_1	399	403	PF00082	0.451
CLV_PCSK_SKI1_1	69	73	PF00082	0.313
CLV_PCSK_SKI1_1	81	85	PF00082	0.249
DEG_APCC_DBOX_1	37	45	PF00400	0.350
DEG_APCC_DBOX_1	68	76	PF00400	0.323
DEG_APCC_DBOX_1	80	88	PF00400	0.438
DEG_Nend_UBRbox_2	1	3	PF02207	0.600
DEG_ODPH_VHL_1	72	85	PF01847	0.376
DEG_SPOP_SBC_1	108	112	PF00917	0.545
DEG_SPOP_SBC_1	158	162	PF00917	0.649
DOC_CYCLIN_RxL_1	35	42	PF00134	0.394
DOC_CYCLIN_yCln2_LP_2	138	144	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	351	357	PF00134	0.582
DOC_MAPK_gen_1	188	195	PF00069	0.563
DOC_MAPK_gen_1	210	218	PF00069	0.521
DOC_MAPK_gen_1	380	388	PF00069	0.544
DOC_MAPK_MEF2A_6	211	220	PF00069	0.498
DOC_MAPK_MEF2A_6	380	388	PF00069	0.544
DOC_PP1_RVXF_1	169	175	PF00149	0.555
DOC_PP1_RVXF_1	79	86	PF00149	0.504
DOC_PP2B_LxvP_1	249	252	PF13499	0.584
DOC_PP2B_LxvP_1	351	354	PF13499	0.505
DOC_PP2B_LxvP_1	71	74	PF13499	0.308
DOC_USP7_MATH_1	108	112	PF00917	0.727
DOC_USP7_MATH_1	158	162	PF00917	0.587
DOC_USP7_MATH_1	259	263	PF00917	0.560
DOC_USP7_MATH_1	332	336	PF00917	0.679
DOC_WW_Pin1_4	276	281	PF00397	0.594
DOC_WW_Pin1_4	311	316	PF00397	0.552
DOC_WW_Pin1_4	330	335	PF00397	0.642
DOC_WW_Pin1_4	405	410	PF00397	0.633
LIG_14-3-3_CanoR_1	188	194	PF00244	0.483
LIG_14-3-3_CanoR_1	210	219	PF00244	0.577
LIG_14-3-3_CanoR_1	38	48	PF00244	0.400
LIG_14-3-3_CanoR_1	381	387	PF00244	0.619
LIG_BRCT_BRCA1_1	191	195	PF00533	0.559
LIG_BRCT_BRCA1_1	313	317	PF00533	0.539
LIG_DLG_GKlike_1	189	196	PF00625	0.545
LIG_FHA_1	188	194	PF00498	0.514
LIG_FHA_1	298	304	PF00498	0.584
LIG_FHA_1	317	323	PF00498	0.429
LIG_FHA_1	374	380	PF00498	0.670
LIG_FHA_1	50	56	PF00498	0.388
LIG_FHA_2	334	340	PF00498	0.627
LIG_Integrin_isoDGR_2	244	246	PF01839	0.394
LIG_LIR_Apic_2	274	280	PF02991	0.584
LIG_LIR_Gen_1	127	137	PF02991	0.561
LIG_LIR_Gen_1	291	302	PF02991	0.603
LIG_LIR_Gen_1	42	51	PF02991	0.481
LIG_LIR_LC3C_4	119	122	PF02991	0.509
LIG_LIR_Nem_3	127	132	PF02991	0.561
LIG_LIR_Nem_3	2	7	PF02991	0.586
LIG_LIR_Nem_3	291	297	PF02991	0.608
LIG_LIR_Nem_3	42	48	PF02991	0.424
LIG_LIR_Nem_3	54	60	PF02991	0.345
LIG_MLH1_MIPbox_1	313	317	PF16413	0.518
LIG_NRBOX	66	72	PF00104	0.343
LIG_NRBOX	79	85	PF00104	0.449
LIG_Pex14_1	312	316	PF04695	0.580
LIG_Pex14_1	57	61	PF04695	0.169
LIG_Pex14_2	294	298	PF04695	0.547
LIG_SH2_CRK	142	146	PF00017	0.554
LIG_SH2_CRK	277	281	PF00017	0.598
LIG_SH2_NCK_1	277	281	PF00017	0.562
LIG_SH2_STAT3	221	224	PF00017	0.553
LIG_SH2_STAT5	186	189	PF00017	0.567
LIG_SH2_STAT5	60	63	PF00017	0.328
LIG_SH3_3	169	175	PF00018	0.509
LIG_SH3_3	17	23	PF00018	0.585
LIG_SH3_3	312	318	PF00018	0.524
LIG_SH3_3	89	95	PF00018	0.570
LIG_SH3_3	96	102	PF00018	0.637
LIG_SH3_4	100	107	PF00018	0.670
LIG_SUMO_SIM_par_1	368	373	PF11976	0.548
LIG_SUMO_SIM_par_1	46	54	PF11976	0.358
LIG_TRAF2_1	102	105	PF00917	0.544
LIG_Vh1_VBS_1	40	58	PF01044	0.417
MOD_CK1_1	109	115	PF00069	0.671
MOD_CK1_1	262	268	PF00069	0.635
MOD_CK1_1	373	379	PF00069	0.556
MOD_CK1_1	404	410	PF00069	0.553
MOD_CK2_1	157	163	PF00069	0.722
MOD_CMANNOS	181	184	PF00535	0.309
MOD_GlcNHglycan	113	116	PF01048	0.467
MOD_GlcNHglycan	202	205	PF01048	0.417
MOD_GlcNHglycan	257	260	PF01048	0.347
MOD_GlcNHglycan	264	267	PF01048	0.456
MOD_GlcNHglycan	351	354	PF01048	0.320
MOD_GlcNHglycan	372	375	PF01048	0.492
MOD_GSK3_1	107	114	PF00069	0.598
MOD_GSK3_1	184	191	PF00069	0.526
MOD_GSK3_1	255	262	PF00069	0.595
MOD_GSK3_1	316	323	PF00069	0.569
MOD_GSK3_1	401	408	PF00069	0.581
MOD_N-GLC_1	262	267	PF02516	0.318
MOD_NEK2_1	297	302	PF00069	0.489
MOD_NEK2_1	304	309	PF00069	0.520
MOD_NEK2_1	370	375	PF00069	0.650
MOD_NEK2_1	39	44	PF00069	0.398
MOD_NEK2_1	401	406	PF00069	0.644
MOD_NEK2_1	83	88	PF00069	0.516
MOD_PK_1	28	34	PF00069	0.491
MOD_PKA_1	188	194	PF00069	0.483
MOD_PKA_1	210	216	PF00069	0.607
MOD_PKA_2	187	193	PF00069	0.582
MOD_PKA_2	324	330	PF00069	0.583
MOD_Plk_1	148	154	PF00069	0.591
MOD_Plk_1	320	326	PF00069	0.556
MOD_Plk_4	124	130	PF00069	0.490
MOD_Plk_4	51	57	PF00069	0.386
MOD_Plk_4	62	68	PF00069	0.302
MOD_ProDKin_1	276	282	PF00069	0.594
MOD_ProDKin_1	311	317	PF00069	0.551
MOD_ProDKin_1	330	336	PF00069	0.650
MOD_ProDKin_1	405	411	PF00069	0.642
MOD_SUMO_rev_2	335	343	PF00179	0.686
MOD_SUMO_rev_2	385	394	PF00179	0.563
TRG_DiLeu_BaEn_2	389	395	PF01217	0.541
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.394
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.341
TRG_ENDOCYTIC_2	142	145	PF00928	0.558
TRG_ENDOCYTIC_2	398	401	PF00928	0.628
TRG_ENDOCYTIC_2	63	66	PF00928	0.340
TRG_ER_diArg_1	379	381	PF00400	0.576

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK56	Leptomonas seymouri	64%	100%
A0A0S4IZ96	Bodo saltans	28%	100%
A0A1X0NMQ7	Trypanosomatidae	31%	97%
A0A3Q8IBV5	Leishmania donovani	90%	100%
A0A3S5IRZ0	Trypanosoma rangeli	33%	100%
A4H5M6	Leishmania braziliensis	78%	98%
A4HTW3	Leishmania infantum	89%	100%
D0A9C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QHX5	Leishmania major	91%	100%
V5BIH4	Trypanosoma cruzi	32%	100%