Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMP9_LEIMU

TriTrypDb:

LmxM.09.0480

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AMP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMP9

Function

Biological processes
Term	Name	Level	Count
GO:0032879	regulation of localization	3	7
GO:0034762	regulation of transmembrane transport	4	7
GO:0034765	regulation of monoatomic ion transmembrane transport	5	7
GO:0043269	regulation of monoatomic ion transport	5	7
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	7
GO:0051049	regulation of transport	4	7
GO:0065007	biological regulation	1	7
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006813	potassium ion transport	7	1
GO:0009987	cellular process	1	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0071805	potassium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098657	import into cell	4	1
GO:0098659	inorganic cation import across plasma membrane	5	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:0098739	import across plasma membrane	3	1
GO:0099587	inorganic ion import across plasma membrane	4	1
GO:1990573	potassium ion import across plasma membrane	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005216	monoatomic ion channel activity	4	7
GO:0005242	inward rectifier potassium channel activity	7	7
GO:0005244	voltage-gated monoatomic ion channel activity	4	7
GO:0005249	voltage-gated potassium channel activity	6	7
GO:0005261	monoatomic cation channel activity	5	7
GO:0005267	potassium channel activity	6	7
GO:0008324	monoatomic cation transmembrane transporter activity	4	7
GO:0015075	monoatomic ion transmembrane transporter activity	3	7
GO:0015079	potassium ion transmembrane transporter activity	6	7
GO:0015267	channel activity	4	7
GO:0015276	ligand-gated monoatomic ion channel activity	5	7
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	7
GO:0022803	passive transmembrane transporter activity	3	7
GO:0022832	voltage-gated channel activity	6	7
GO:0022834	ligand-gated channel activity	6	7
GO:0022836	gated channel activity	5	7
GO:0022843	voltage-gated monoatomic cation channel activity	5	7
GO:0022857	transmembrane transporter activity	2	7
GO:0022890	inorganic cation transmembrane transporter activity	4	7
GO:0046873	metal ion transmembrane transporter activity	5	7
GO:0099094	ligand-gated monoatomic cation channel activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	192	196	PF00656	0.373
CLV_C14_Caspase3-7	406	410	PF00656	0.684
CLV_C14_Caspase3-7	498	502	PF00656	0.679
CLV_C14_Caspase3-7	518	522	PF00656	0.616
CLV_NRD_NRD_1	357	359	PF00675	0.477
CLV_NRD_NRD_1	412	414	PF00675	0.533
CLV_NRD_NRD_1	418	420	PF00675	0.513
CLV_NRD_NRD_1	439	441	PF00675	0.445
CLV_NRD_NRD_1	480	482	PF00675	0.540
CLV_NRD_NRD_1	644	646	PF00675	0.357
CLV_PCSK_KEX2_1	356	358	PF00082	0.561
CLV_PCSK_KEX2_1	412	414	PF00082	0.533
CLV_PCSK_KEX2_1	418	420	PF00082	0.513
CLV_PCSK_KEX2_1	439	441	PF00082	0.462
CLV_PCSK_KEX2_1	644	646	PF00082	0.357
CLV_PCSK_KEX2_1	673	675	PF00082	0.340
CLV_PCSK_PC1ET2_1	356	358	PF00082	0.561
CLV_PCSK_PC1ET2_1	673	675	PF00082	0.340
CLV_PCSK_SKI1_1	12	16	PF00082	0.606
CLV_PCSK_SKI1_1	239	243	PF00082	0.307
CLV_PCSK_SKI1_1	259	263	PF00082	0.422
CLV_PCSK_SKI1_1	305	309	PF00082	0.481
CLV_PCSK_SKI1_1	358	362	PF00082	0.521
CLV_PCSK_SKI1_1	482	486	PF00082	0.429
CLV_PCSK_SKI1_1	84	88	PF00082	0.478
DEG_APCC_DBOX_1	649	657	PF00400	0.470
DEG_Nend_Nbox_1	1	3	PF02207	0.736
DEG_SPOP_SBC_1	473	477	PF00917	0.715
DOC_CYCLIN_yCln2_LP_2	600	606	PF00134	0.518
DOC_MAPK_gen_1	202	210	PF00069	0.295
DOC_MAPK_gen_1	592	600	PF00069	0.596
DOC_MAPK_MEF2A_6	25	33	PF00069	0.675
DOC_PP1_RVXF_1	237	243	PF00149	0.523
DOC_PP1_RVXF_1	257	263	PF00149	0.518
DOC_PP4_FxxP_1	34	37	PF00568	0.721
DOC_USP7_MATH_1	346	350	PF00917	0.722
DOC_USP7_MATH_1	372	376	PF00917	0.805
DOC_USP7_MATH_1	425	429	PF00917	0.713
DOC_USP7_MATH_1	473	477	PF00917	0.684
DOC_USP7_MATH_1	508	512	PF00917	0.786
DOC_USP7_MATH_1	51	55	PF00917	0.701
DOC_USP7_MATH_1	551	555	PF00917	0.837
DOC_USP7_MATH_1	556	560	PF00917	0.636
DOC_USP7_MATH_1	696	700	PF00917	0.597
DOC_USP7_MATH_1	73	77	PF00917	0.751
DOC_WW_Pin1_4	407	412	PF00397	0.731
DOC_WW_Pin1_4	458	463	PF00397	0.613
DOC_WW_Pin1_4	488	493	PF00397	0.718
DOC_WW_Pin1_4	52	57	PF00397	0.744
DOC_WW_Pin1_4	521	526	PF00397	0.695
DOC_WW_Pin1_4	541	546	PF00397	0.624
DOC_WW_Pin1_4	558	563	PF00397	0.673
DOC_WW_Pin1_4	611	616	PF00397	0.558
DOC_WW_Pin1_4	71	76	PF00397	0.575
LIG_14-3-3_CanoR_1	118	123	PF00244	0.616
LIG_14-3-3_CanoR_1	202	210	PF00244	0.295
LIG_14-3-3_CanoR_1	239	248	PF00244	0.508
LIG_14-3-3_CanoR_1	3	8	PF00244	0.680
LIG_14-3-3_CanoR_1	366	373	PF00244	0.738
LIG_14-3-3_CanoR_1	463	468	PF00244	0.626
LIG_14-3-3_CanoR_1	495	503	PF00244	0.622
LIG_14-3-3_CanoR_1	581	589	PF00244	0.575
LIG_14-3-3_CanoR_1	595	601	PF00244	0.555
LIG_14-3-3_CanoR_1	81	90	PF00244	0.700
LIG_APCC_ABBA_1	616	621	PF00400	0.625
LIG_APCC_ABBA_1	692	697	PF00400	0.594
LIG_BRCT_BRCA1_1	79	83	PF00533	0.637
LIG_deltaCOP1_diTrp_1	256	262	PF00928	0.515
LIG_EH1_1	143	151	PF00400	0.388
LIG_eIF4E_1	144	150	PF01652	0.388
LIG_FHA_1	107	113	PF00498	0.529
LIG_FHA_1	136	142	PF00498	0.297
LIG_FHA_1	203	209	PF00498	0.278
LIG_FHA_1	231	237	PF00498	0.639
LIG_FHA_1	644	650	PF00498	0.537
LIG_FHA_1	93	99	PF00498	0.690
LIG_FHA_2	190	196	PF00498	0.382
LIG_FHA_2	586	592	PF00498	0.614
LIG_FHA_2	660	666	PF00498	0.556
LIG_FHA_2	675	681	PF00498	0.523
LIG_FHA_2	720	726	PF00498	0.773
LIG_GBD_Chelix_1	141	149	PF00786	0.327
LIG_KLC1_Yacidic_2	587	591	PF13176	0.631
LIG_LIR_Apic_2	32	37	PF02991	0.592
LIG_LIR_Gen_1	130	141	PF02991	0.506
LIG_LIR_Gen_1	212	221	PF02991	0.348
LIG_LIR_Gen_1	243	252	PF02991	0.520
LIG_LIR_Gen_1	461	471	PF02991	0.660
LIG_LIR_Gen_1	704	713	PF02991	0.530
LIG_LIR_Nem_3	116	122	PF02991	0.623
LIG_LIR_Nem_3	123	128	PF02991	0.517
LIG_LIR_Nem_3	130	136	PF02991	0.436
LIG_LIR_Nem_3	138	142	PF02991	0.312
LIG_LIR_Nem_3	170	176	PF02991	0.314
LIG_LIR_Nem_3	212	216	PF02991	0.352
LIG_LIR_Nem_3	243	248	PF02991	0.506
LIG_LIR_Nem_3	256	261	PF02991	0.555
LIG_LIR_Nem_3	461	467	PF02991	0.657
LIG_LIR_Nem_3	704	708	PF02991	0.533
LIG_Pex14_1	258	262	PF04695	0.516
LIG_Pex14_1	515	519	PF04695	0.616
LIG_PTB_Apo_2	212	219	PF02174	0.312
LIG_SH2_CRK	139	143	PF00017	0.291
LIG_SH2_GRB2like	213	216	PF00017	0.312
LIG_SH2_GRB2like	676	679	PF00017	0.573
LIG_SH2_GRB2like	707	710	PF00017	0.517
LIG_SH2_PTP2	213	216	PF00017	0.388
LIG_SH2_SRC	144	147	PF00017	0.388
LIG_SH2_SRC	213	216	PF00017	0.312
LIG_SH2_SRC	519	522	PF00017	0.616
LIG_SH2_STAP1	139	143	PF00017	0.312
LIG_SH2_STAT5	126	129	PF00017	0.585
LIG_SH2_STAT5	144	147	PF00017	0.312
LIG_SH2_STAT5	173	176	PF00017	0.363
LIG_SH2_STAT5	213	216	PF00017	0.388
LIG_SH2_STAT5	232	235	PF00017	0.494
LIG_SH2_STAT5	464	467	PF00017	0.619
LIG_SH2_STAT5	519	522	PF00017	0.616
LIG_SH2_STAT5	589	592	PF00017	0.634
LIG_SH2_STAT5	676	679	PF00017	0.534
LIG_SH2_STAT5	707	710	PF00017	0.517
LIG_SH3_2	408	413	PF14604	0.632
LIG_SH3_3	11	17	PF00018	0.697
LIG_SH3_3	405	411	PF00018	0.629
LIG_SH3_3	456	462	PF00018	0.614
LIG_SH3_3	50	56	PF00018	0.693
LIG_SH3_3	532	538	PF00018	0.627
LIG_SH3_3	550	556	PF00018	0.699
LIG_SH3_3	612	618	PF00018	0.618
LIG_SH3_5	287	291	PF00018	0.491
LIG_SH3_5	99	103	PF00018	0.578
LIG_Sin3_3	223	230	PF02671	0.381
LIG_SUMO_SIM_par_1	146	152	PF11976	0.388
LIG_SUMO_SIM_par_1	205	212	PF11976	0.388
LIG_SUMO_SIM_par_1	654	660	PF11976	0.574
LIG_TYR_ITIM	137	142	PF00017	0.291
LIG_ULM_U2AF65_1	412	417	PF00076	0.550
LIG_WRC_WIRS_1	114	119	PF05994	0.563
LIG_WW_1	37	40	PF00397	0.520
MOD_CDC14_SPxK_1	410	413	PF00782	0.676
MOD_CDK_SPK_2	407	412	PF00069	0.603
MOD_CDK_SPK_2	458	463	PF00069	0.506
MOD_CDK_SPK_2	488	493	PF00069	0.653
MOD_CDK_SPxK_1	407	413	PF00069	0.672
MOD_CDK_SPxxK_3	488	495	PF00069	0.581
MOD_CK1_1	106	112	PF00069	0.352
MOD_CK1_1	313	319	PF00069	0.626
MOD_CK1_1	349	355	PF00069	0.526
MOD_CK1_1	375	381	PF00069	0.726
MOD_CK1_1	385	391	PF00069	0.592
MOD_CK1_1	433	439	PF00069	0.657
MOD_CK1_1	441	447	PF00069	0.760
MOD_CK1_1	450	456	PF00069	0.568
MOD_CK1_1	458	464	PF00069	0.532
MOD_CK1_1	466	472	PF00069	0.538
MOD_CK1_1	476	482	PF00069	0.550
MOD_CK1_1	491	497	PF00069	0.648
MOD_CK1_1	510	516	PF00069	0.512
MOD_CK1_1	628	634	PF00069	0.684
MOD_CK1_1	666	672	PF00069	0.425
MOD_CK1_1	74	80	PF00069	0.626
MOD_CK2_1	225	231	PF00069	0.376
MOD_CK2_1	510	516	PF00069	0.634
MOD_CK2_1	659	665	PF00069	0.411
MOD_CK2_1	717	723	PF00069	0.606
MOD_Cter_Amidation	437	440	PF01082	0.553
MOD_Cter_Amidation	479	482	PF01082	0.592
MOD_GlcNHglycan	169	172	PF01048	0.473
MOD_GlcNHglycan	315	318	PF01048	0.683
MOD_GlcNHglycan	342	345	PF01048	0.514
MOD_GlcNHglycan	351	354	PF01048	0.518
MOD_GlcNHglycan	367	370	PF01048	0.675
MOD_GlcNHglycan	374	377	PF01048	0.719
MOD_GlcNHglycan	382	387	PF01048	0.594
MOD_GlcNHglycan	398	401	PF01048	0.821
MOD_GlcNHglycan	435	438	PF01048	0.828
MOD_GlcNHglycan	440	443	PF01048	0.766
MOD_GlcNHglycan	447	450	PF01048	0.621
MOD_GlcNHglycan	469	472	PF01048	0.614
MOD_GlcNHglycan	49	52	PF01048	0.593
MOD_GlcNHglycan	497	500	PF01048	0.607
MOD_GlcNHglycan	634	637	PF01048	0.572
MOD_GlcNHglycan	639	642	PF01048	0.456
MOD_GlcNHglycan	665	668	PF01048	0.454
MOD_GlcNHglycan	84	87	PF01048	0.616
MOD_GlcNHglycan	90	93	PF01048	0.537
MOD_GSK3_1	240	247	PF00069	0.358
MOD_GSK3_1	361	368	PF00069	0.766
MOD_GSK3_1	39	46	PF00069	0.636
MOD_GSK3_1	398	405	PF00069	0.689
MOD_GSK3_1	440	447	PF00069	0.644
MOD_GSK3_1	450	457	PF00069	0.751
MOD_GSK3_1	463	470	PF00069	0.565
MOD_GSK3_1	47	54	PF00069	0.589
MOD_GSK3_1	472	479	PF00069	0.552
MOD_GSK3_1	491	498	PF00069	0.618
MOD_GSK3_1	507	514	PF00069	0.620
MOD_GSK3_1	539	546	PF00069	0.689
MOD_GSK3_1	556	563	PF00069	0.521
MOD_GSK3_1	625	632	PF00069	0.536
MOD_GSK3_1	659	666	PF00069	0.436
MOD_GSK3_1	668	675	PF00069	0.460
MOD_GSK3_1	67	74	PF00069	0.586
MOD_GSK3_1	717	724	PF00069	0.620
MOD_GSK3_1	88	95	PF00069	0.578
MOD_LATS_1	359	365	PF00433	0.645
MOD_N-GLC_1	103	108	PF02516	0.389
MOD_N-GLC_1	508	513	PF02516	0.629
MOD_NEK2_1	127	132	PF00069	0.522
MOD_NEK2_1	149	154	PF00069	0.342
MOD_NEK2_1	209	214	PF00069	0.312
MOD_NEK2_1	225	230	PF00069	0.378
MOD_NEK2_1	24	29	PF00069	0.648
MOD_NEK2_1	301	306	PF00069	0.672
MOD_NEK2_1	310	315	PF00069	0.668
MOD_NEK2_1	396	401	PF00069	0.735
MOD_NEK2_1	455	460	PF00069	0.773
MOD_NEK2_1	465	470	PF00069	0.600
MOD_NEK2_1	580	585	PF00069	0.503
MOD_NEK2_1	62	67	PF00069	0.532
MOD_NEK2_1	629	634	PF00069	0.444
MOD_NEK2_2	113	118	PF00069	0.525
MOD_NEK2_2	346	351	PF00069	0.519
MOD_PIKK_1	127	133	PF00454	0.465
MOD_PIKK_1	60	66	PF00454	0.524
MOD_PK_1	463	469	PF00069	0.514
MOD_PKA_2	301	307	PF00069	0.588
MOD_PKA_2	365	371	PF00069	0.573
MOD_PKA_2	438	444	PF00069	0.652
MOD_PKA_2	494	500	PF00069	0.518
MOD_PKA_2	580	586	PF00069	0.428
MOD_PKA_2	643	649	PF00069	0.518
MOD_PKA_2	88	94	PF00069	0.672
MOD_PKB_1	118	126	PF00069	0.529
MOD_Plk_1	194	200	PF00069	0.451
MOD_Plk_1	346	352	PF00069	0.521
MOD_Plk_1	450	456	PF00069	0.650
MOD_Plk_1	508	514	PF00069	0.675
MOD_Plk_2-3	189	195	PF00069	0.458
MOD_Plk_4	120	126	PF00069	0.446
MOD_Plk_4	137	143	PF00069	0.321
MOD_Plk_4	209	215	PF00069	0.388
MOD_Plk_4	24	30	PF00069	0.658
MOD_Plk_4	3	9	PF00069	0.495
MOD_Plk_4	515	521	PF00069	0.611
MOD_Plk_4	585	591	PF00069	0.552
MOD_Plk_4	596	602	PF00069	0.372
MOD_Plk_4	74	80	PF00069	0.576
MOD_ProDKin_1	407	413	PF00069	0.672
MOD_ProDKin_1	458	464	PF00069	0.507
MOD_ProDKin_1	488	494	PF00069	0.653
MOD_ProDKin_1	52	58	PF00069	0.689
MOD_ProDKin_1	521	527	PF00069	0.620
MOD_ProDKin_1	541	547	PF00069	0.520
MOD_ProDKin_1	558	564	PF00069	0.587
MOD_ProDKin_1	611	617	PF00069	0.427
MOD_ProDKin_1	71	77	PF00069	0.446
MOD_SUMO_rev_2	19	27	PF00179	0.661
MOD_SUMO_rev_2	378	385	PF00179	0.580
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.609
TRG_ENDOCYTIC_2	139	142	PF00928	0.291
TRG_ENDOCYTIC_2	144	147	PF00928	0.312
TRG_ENDOCYTIC_2	173	176	PF00928	0.359
TRG_ENDOCYTIC_2	213	216	PF00928	0.348
TRG_ENDOCYTIC_2	464	467	PF00928	0.513
TRG_ER_diArg_1	201	204	PF00400	0.404
TRG_ER_diArg_1	411	413	PF00400	0.611
TRG_NLS_MonoExtN_4	354	360	PF00514	0.658

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NMR1	Trypanosomatidae	40%	100%
A0A3S7WQM3	Leishmania donovani	83%	98%
A4H5M5	Leishmania braziliensis	59%	92%
A4HTW2	Leishmania infantum	83%	98%
Q4QHX6	Leishmania major	82%	100%