Hypothetical tetratricopeptide repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bardet-Biedl syndrome 8 protein

Species:

Leishmania mexicana

UniProt:

E9AMP5_LEIMU

TriTrypDb:

LmxM.09.0440

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0034464	BBSome	2	12
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	1
GO:0012506	vesicle membrane	4	1
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0030662	coated vesicle membrane	5	1
GO:0030665	clathrin-coated vesicle membrane	6	1
GO:0030666	endocytic vesicle membrane	5	1
GO:0030669	clathrin-coated endocytic vesicle membrane	6	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0036064	ciliary basal body	3	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0060170	ciliary membrane	5	1
GO:0097730	non-motile cilium	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AMP5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMP5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030030	cell projection organization	4	12
GO:0030031	cell projection assembly	5	12
GO:0044782	cilium organization	5	12
GO:0060271	cilium assembly	6	12
GO:0070925	organelle assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0120031	plasma membrane bounded cell projection assembly	6	12
GO:0120036	plasma membrane bounded cell projection organization	5	12
GO:1905515	non-motile cilium assembly	7	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	390	392	PF00675	0.309
CLV_NRD_NRD_1	484	486	PF00675	0.456
CLV_NRD_NRD_1	491	493	PF00675	0.441
CLV_PCSK_KEX2_1	390	392	PF00082	0.309
CLV_PCSK_KEX2_1	484	486	PF00082	0.520
CLV_PCSK_KEX2_1	491	493	PF00082	0.464
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.386
CLV_PCSK_SKI1_1	110	114	PF00082	0.519
CLV_PCSK_SKI1_1	166	170	PF00082	0.335
CLV_PCSK_SKI1_1	177	181	PF00082	0.449
CLV_PCSK_SKI1_1	237	241	PF00082	0.393
CLV_PCSK_SKI1_1	256	260	PF00082	0.214
CLV_PCSK_SKI1_1	390	394	PF00082	0.315
CLV_PCSK_SKI1_1	491	495	PF00082	0.479
DEG_Nend_UBRbox_2	1	3	PF02207	0.379
DEG_SPOP_SBC_1	40	44	PF00917	0.347
DOC_ANK_TNKS_1	100	107	PF00023	0.657
DOC_CYCLIN_RxL_1	485	496	PF00134	0.486
DOC_MAPK_gen_1	164	171	PF00069	0.360
DOC_MAPK_gen_1	237	247	PF00069	0.374
DOC_MAPK_gen_1	387	397	PF00069	0.322
DOC_MAPK_gen_1	547	555	PF00069	0.492
DOC_MAPK_MEF2A_6	164	171	PF00069	0.360
DOC_MAPK_MEF2A_6	180	189	PF00069	0.548
DOC_MAPK_MEF2A_6	379	386	PF00069	0.352
DOC_PP2B_LxvP_1	499	502	PF13499	0.406
DOC_PP4_FxxP_1	260	263	PF00568	0.525
DOC_USP7_MATH_1	178	182	PF00917	0.460
DOC_USP7_MATH_1	188	192	PF00917	0.549
DOC_USP7_MATH_1	215	219	PF00917	0.696
DOC_USP7_MATH_1	39	43	PF00917	0.601
DOC_USP7_MATH_1	47	51	PF00917	0.456
DOC_USP7_MATH_1	80	84	PF00917	0.529
DOC_USP7_UBL2_3	305	309	PF12436	0.261
DOC_USP7_UBL2_3	484	488	PF12436	0.438
DOC_WW_Pin1_4	273	278	PF00397	0.637
LIG_14-3-3_CanoR_1	177	183	PF00244	0.410
LIG_14-3-3_CanoR_1	421	429	PF00244	0.399
LIG_14-3-3_CanoR_1	46	52	PF00244	0.461
LIG_14-3-3_CanoR_1	503	509	PF00244	0.197
LIG_14-3-3_CanoR_1	70	80	PF00244	0.501
LIG_Actin_WH2_2	112	127	PF00022	0.554
LIG_Actin_WH2_2	164	179	PF00022	0.489
LIG_Actin_WH2_2	241	258	PF00022	0.461
LIG_BRCT_BRCA1_1	3	7	PF00533	0.444
LIG_BRCT_BRCA1_1	451	455	PF00533	0.217
LIG_Clathr_ClatBox_1	158	162	PF01394	0.336
LIG_deltaCOP1_diTrp_1	231	234	PF00928	0.337
LIG_eIF4E_1	254	260	PF01652	0.408
LIG_FHA_1	119	125	PF00498	0.532
LIG_FHA_1	171	177	PF00498	0.497
LIG_FHA_1	295	301	PF00498	0.451
LIG_FHA_1	397	403	PF00498	0.328
LIG_FHA_1	494	500	PF00498	0.441
LIG_FHA_1	503	509	PF00498	0.371
LIG_FHA_2	313	319	PF00498	0.289
LIG_FHA_2	347	353	PF00498	0.434
LIG_FHA_2	467	473	PF00498	0.507
LIG_GBD_Chelix_1	150	158	PF00786	0.307
LIG_LIR_Gen_1	113	124	PF02991	0.568
LIG_LIR_Gen_1	352	360	PF02991	0.382
LIG_LIR_Gen_1	400	411	PF02991	0.294
LIG_LIR_Gen_1	522	532	PF02991	0.365
LIG_LIR_Gen_1	550	555	PF02991	0.452
LIG_LIR_Nem_3	113	119	PF02991	0.554
LIG_LIR_Nem_3	156	160	PF02991	0.349
LIG_LIR_Nem_3	349	354	PF02991	0.361
LIG_LIR_Nem_3	438	443	PF02991	0.303
LIG_LIR_Nem_3	522	528	PF02991	0.335
LIG_LIR_Nem_3	550	555	PF02991	0.452
LIG_PDZ_Class_2	550	555	PF00595	0.500
LIG_PTAP_UEV_1	189	194	PF05743	0.552
LIG_SH2_CRK	354	358	PF00017	0.333
LIG_SH2_CRK	389	393	PF00017	0.299
LIG_SH2_CRK	525	529	PF00017	0.340
LIG_SH2_CRK	87	91	PF00017	0.514
LIG_SH2_NCK_1	19	23	PF00017	0.522
LIG_SH2_NCK_1	87	91	PF00017	0.614
LIG_SH2_SRC	160	163	PF00017	0.375
LIG_SH2_SRC	19	22	PF00017	0.514
LIG_SH2_STAP1	320	324	PF00017	0.389
LIG_SH2_STAP1	412	416	PF00017	0.314
LIG_SH2_STAT3	412	415	PF00017	0.321
LIG_SH2_STAT5	157	160	PF00017	0.362
LIG_SH2_STAT5	254	257	PF00017	0.464
LIG_SH2_STAT5	307	310	PF00017	0.389
LIG_SH2_STAT5	412	415	PF00017	0.464
LIG_SH3_1	125	131	PF00018	0.480
LIG_SH3_3	125	131	PF00018	0.480
LIG_SH3_3	179	185	PF00018	0.635
LIG_SH3_3	187	193	PF00018	0.681
LIG_SH3_3	533	539	PF00018	0.364
LIG_TRAF2_1	219	222	PF00917	0.668
LIG_TYR_ITIM	523	528	PF00017	0.343
LIG_WRC_WIRS_1	411	416	PF05994	0.378
MOD_CK1_1	123	129	PF00069	0.640
MOD_CK2_1	312	318	PF00069	0.281
MOD_CK2_1	360	366	PF00069	0.325
MOD_CK2_1	466	472	PF00069	0.487
MOD_Cter_Amidation	489	492	PF01082	0.476
MOD_GlcNHglycan	190	193	PF01048	0.658
MOD_GlcNHglycan	217	220	PF01048	0.653
MOD_GlcNHglycan	464	467	PF01048	0.344
MOD_GlcNHglycan	73	76	PF01048	0.568
MOD_GSK3_1	211	218	PF00069	0.686
MOD_GSK3_1	279	286	PF00069	0.584
MOD_GSK3_1	312	319	PF00069	0.409
MOD_GSK3_1	397	404	PF00069	0.390
MOD_GSK3_1	462	469	PF00069	0.488
MOD_N-GLC_1	295	300	PF02516	0.388
MOD_N-GLC_1	47	52	PF02516	0.623
MOD_NEK2_1	1	6	PF00069	0.475
MOD_NEK2_1	360	365	PF00069	0.341
MOD_NEK2_1	416	421	PF00069	0.303
MOD_NEK2_1	493	498	PF00069	0.401
MOD_NEK2_1	508	513	PF00069	0.370
MOD_NEK2_1	521	526	PF00069	0.454
MOD_NEK2_1	7	12	PF00069	0.381
MOD_NEK2_1	71	76	PF00069	0.574
MOD_NEK2_2	120	125	PF00069	0.692
MOD_NEK2_2	47	52	PF00069	0.569
MOD_PIKK_1	283	289	PF00454	0.416
MOD_PIKK_1	431	437	PF00454	0.417
MOD_PK_1	96	102	PF00069	0.658
MOD_PKA_2	502	508	PF00069	0.203
MOD_Plk_1	1	7	PF00069	0.532
MOD_Plk_1	295	301	PF00069	0.384
MOD_Plk_1	416	422	PF00069	0.420
MOD_Plk_1	47	53	PF00069	0.514
MOD_Plk_1	521	527	PF00069	0.361
MOD_Plk_4	1	7	PF00069	0.517
MOD_Plk_4	14	20	PF00069	0.430
MOD_Plk_4	295	301	PF00069	0.384
MOD_ProDKin_1	273	279	PF00069	0.638
MOD_SUMO_rev_2	156	165	PF00179	0.448
TRG_DiLeu_BaEn_2	2	8	PF01217	0.409
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.315
TRG_DiLeu_BaLyEn_6	489	494	PF01217	0.466
TRG_ENDOCYTIC_2	307	310	PF00928	0.340
TRG_ENDOCYTIC_2	354	357	PF00928	0.370
TRG_ENDOCYTIC_2	389	392	PF00928	0.301
TRG_ENDOCYTIC_2	525	528	PF00928	0.316
TRG_ER_diArg_1	389	391	PF00400	0.310
TRG_ER_diArg_1	491	493	PF00400	0.485
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.479
TRG_Pf-PMV_PEXEL_1	530	535	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKM3	Leptomonas seymouri	70%	83%
A0A0S4IWH2	Bodo saltans	40%	100%
A0A1X0NMP5	Trypanosomatidae	46%	92%
A0A3S5H6D1	Leishmania donovani	92%	98%
A0A422NV89	Trypanosoma rangeli	45%	100%
A4H5M0	Leishmania braziliensis	85%	100%
A4HTV8	Leishmania infantum	92%	87%
D0A9C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	98%
Q23049	Caenorhabditis elegans	28%	100%
Q4QHY0	Leishmania major	89%	100%
Q8TAM2	Homo sapiens	33%	100%
Q8VD72	Mus musculus	33%	100%
V5DJG5	Trypanosoma cruzi	44%	87%