RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania mexicana

UniProt:

E9AMP4_LEIMU

TriTrypDb:

LmxM.09.0430

Length:

477

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMP4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	229	233	PF00656	0.644
CLV_C14_Caspase3-7	255	259	PF00656	0.521
CLV_C14_Caspase3-7	343	347	PF00656	0.590
CLV_MEL_PAP_1	272	278	PF00089	0.516
CLV_NRD_NRD_1	207	209	PF00675	0.665
CLV_PCSK_FUR_1	205	209	PF00082	0.612
CLV_PCSK_KEX2_1	14	16	PF00082	0.312
CLV_PCSK_KEX2_1	207	209	PF00082	0.665
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.312
CLV_PCSK_SKI1_1	136	140	PF00082	0.452
CLV_PCSK_SKI1_1	325	329	PF00082	0.728
CLV_PCSK_SKI1_1	360	364	PF00082	0.678
CLV_PCSK_SKI1_1	42	46	PF00082	0.312
DEG_APCC_DBOX_1	114	122	PF00400	0.285
DEG_COP1_1	124	132	PF00400	0.421
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SCF_TRCP1_1	337	343	PF00400	0.528
DEG_SPOP_SBC_1	352	356	PF00917	0.639
DOC_CYCLIN_RxL_1	39	49	PF00134	0.312
DOC_CYCLIN_yCln2_LP_2	219	222	PF00134	0.601
DOC_CYCLIN_yCln2_LP_2	87	93	PF00134	0.388
DOC_MAPK_MEF2A_6	122	129	PF00069	0.476
DOC_PP2B_LxvP_1	127	130	PF13499	0.489
DOC_PP2B_LxvP_1	219	222	PF13499	0.601
DOC_PP2B_LxvP_1	328	331	PF13499	0.529
DOC_PP2B_LxvP_1	45	48	PF13499	0.312
DOC_PP2B_LxvP_1	453	456	PF13499	0.312
DOC_PP2B_LxvP_1	85	88	PF13499	0.312
DOC_USP7_MATH_1	16	20	PF00917	0.416
DOC_USP7_MATH_1	212	216	PF00917	0.569
DOC_USP7_MATH_1	263	267	PF00917	0.671
DOC_USP7_MATH_1	304	308	PF00917	0.620
DOC_USP7_MATH_1	342	346	PF00917	0.745
LIG_14-3-3_CanoR_1	20	27	PF00244	0.327
LIG_14-3-3_CanoR_1	207	212	PF00244	0.604
LIG_14-3-3_CanoR_1	240	246	PF00244	0.661
LIG_14-3-3_CanoR_1	325	331	PF00244	0.588
LIG_14-3-3_CanoR_1	360	365	PF00244	0.661
LIG_14-3-3_CanoR_1	465	474	PF00244	0.341
LIG_14-3-3_CanoR_1	58	68	PF00244	0.388
LIG_BIR_III_4	396	400	PF00653	0.491
LIG_BRCT_BRCA1_1	468	472	PF00533	0.255
LIG_BRCT_BRCA1_1	6	10	PF00533	0.398
LIG_FHA_1	124	130	PF00498	0.428
LIG_FHA_1	137	143	PF00498	0.454
LIG_FHA_1	215	221	PF00498	0.692
LIG_FHA_1	437	443	PF00498	0.312
LIG_FHA_1	458	464	PF00498	0.340
LIG_FHA_1	76	82	PF00498	0.321
LIG_FHA_2	47	53	PF00498	0.414
LIG_FHA_2	61	67	PF00498	0.235
LIG_LIR_Gen_1	116	125	PF02991	0.428
LIG_LIR_Gen_1	79	90	PF02991	0.312
LIG_LIR_Nem_3	66	71	PF02991	0.325
LIG_LIR_Nem_3	79	85	PF02991	0.350
LIG_PDZ_Class_3	472	477	PF00595	0.480
LIG_SH2_NCK_1	312	316	PF00017	0.708
LIG_SH2_STAT5	415	418	PF00017	0.481
LIG_SH2_STAT5	54	57	PF00017	0.312
LIG_SH2_STAT5	82	85	PF00017	0.312
LIG_SH3_3	388	394	PF00018	0.498
LIG_SH3_3	453	459	PF00018	0.501
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.312
MOD_CK1_1	105	111	PF00069	0.312
MOD_CK1_1	154	160	PF00069	0.584
MOD_CK1_1	19	25	PF00069	0.388
MOD_CK1_1	214	220	PF00069	0.604
MOD_CK1_1	307	313	PF00069	0.742
MOD_CK1_1	457	463	PF00069	0.366
MOD_CK1_1	466	472	PF00069	0.317
MOD_CK1_1	69	75	PF00069	0.312
MOD_CK2_1	105	111	PF00069	0.312
MOD_CK2_1	299	305	PF00069	0.708
MOD_CK2_1	315	321	PF00069	0.537
MOD_CK2_1	46	52	PF00069	0.418
MOD_CK2_1	60	66	PF00069	0.237
MOD_GlcNHglycan	156	159	PF01048	0.637
MOD_GlcNHglycan	198	201	PF01048	0.584
MOD_GlcNHglycan	232	235	PF01048	0.725
MOD_GlcNHglycan	241	244	PF01048	0.636
MOD_GlcNHglycan	250	253	PF01048	0.571
MOD_GlcNHglycan	258	262	PF01048	0.704
MOD_GlcNHglycan	305	309	PF01048	0.684
MOD_GlcNHglycan	337	340	PF01048	0.720
MOD_GlcNHglycan	68	71	PF01048	0.312
MOD_GlcNHglycan	74	77	PF01048	0.312
MOD_GSK3_1	100	107	PF00069	0.312
MOD_GSK3_1	145	152	PF00069	0.606
MOD_GSK3_1	207	214	PF00069	0.599
MOD_GSK3_1	226	233	PF00069	0.610
MOD_GSK3_1	248	255	PF00069	0.663
MOD_GSK3_1	259	266	PF00069	0.722
MOD_GSK3_1	295	302	PF00069	0.724
MOD_GSK3_1	352	359	PF00069	0.674
MOD_GSK3_1	66	73	PF00069	0.330
MOD_N-GLC_1	105	110	PF02516	0.312
MOD_N-GLC_1	30	35	PF02516	0.340
MOD_NEK2_1	211	216	PF00069	0.600
MOD_NEK2_1	238	243	PF00069	0.679
MOD_NEK2_1	351	356	PF00069	0.721
MOD_OFUCOSY	451	458	PF10250	0.388
MOD_PIKK_1	212	218	PF00454	0.644
MOD_PKA_1	207	213	PF00069	0.662
MOD_PKA_2	19	25	PF00069	0.312
MOD_PKA_2	207	213	PF00069	0.600
MOD_PKA_2	239	245	PF00069	0.735
MOD_PKB_1	149	157	PF00069	0.601
MOD_PKB_1	205	213	PF00069	0.609
MOD_Plk_1	105	111	PF00069	0.312
MOD_Plk_1	30	36	PF00069	0.340
MOD_Plk_1	4	10	PF00069	0.410
MOD_Plk_2-3	226	232	PF00069	0.506
MOD_Plk_4	214	220	PF00069	0.622
MOD_Plk_4	307	313	PF00069	0.712
MOD_Plk_4	353	359	PF00069	0.686
MOD_Plk_4	436	442	PF00069	0.312
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.504
TRG_DiLeu_BaLyEn_6	403	408	PF01217	0.457
TRG_ENDOCYTIC_2	68	71	PF00928	0.339
TRG_ENDOCYTIC_2	82	85	PF00928	0.312
TRG_ER_diArg_1	205	208	PF00400	0.676
TRG_ER_diArg_1	404	407	PF00400	0.477
TRG_Pf-PMV_PEXEL_1	406	411	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I698	Leptomonas seymouri	61%	99%
A0A3S5H6D0	Leishmania donovani	88%	100%
A4H5L9	Leishmania braziliensis	71%	96%
A4HTV7	Leishmania infantum	88%	100%
Q4QHY1	Leishmania major	88%	98%