Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AMP0_LEIMU

TriTrypDb:

LmxM.09.0380

Length:

360

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AMP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AMP0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	205	209	PF00656	0.666
CLV_C14_Caspase3-7	338	342	PF00656	0.621
CLV_NRD_NRD_1	117	119	PF00675	0.673
CLV_NRD_NRD_1	196	198	PF00675	0.631
CLV_NRD_NRD_1	311	313	PF00675	0.461
CLV_PCSK_KEX2_1	117	119	PF00082	0.673
CLV_PCSK_KEX2_1	179	181	PF00082	0.634
CLV_PCSK_KEX2_1	195	197	PF00082	0.771
CLV_PCSK_KEX2_1	311	313	PF00082	0.445
CLV_PCSK_KEX2_1	332	334	PF00082	0.558
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.645
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.771
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.578
CLV_PCSK_SKI1_1	146	150	PF00082	0.462
CLV_PCSK_SKI1_1	243	247	PF00082	0.436
CLV_PCSK_SKI1_1	254	258	PF00082	0.463
CLV_PCSK_SKI1_1	287	291	PF00082	0.525
CLV_PCSK_SKI1_1	71	75	PF00082	0.416
DEG_APCC_DBOX_1	145	153	PF00400	0.452
DOC_CKS1_1	344	349	PF01111	0.530
DOC_CYCLIN_RxL_1	240	250	PF00134	0.497
DOC_MAPK_gen_1	143	151	PF00069	0.548
DOC_MAPK_gen_1	266	273	PF00069	0.392
DOC_MAPK_gen_1	28	37	PF00069	0.514
DOC_MAPK_MEF2A_6	143	151	PF00069	0.509
DOC_MAPK_MEF2A_6	71	78	PF00069	0.405
DOC_USP7_MATH_1	23	27	PF00917	0.558
DOC_USP7_MATH_1	289	293	PF00917	0.522
DOC_USP7_MATH_1	46	50	PF00917	0.793
DOC_USP7_UBL2_3	40	44	PF12436	0.604
DOC_WW_Pin1_4	343	348	PF00397	0.582
LIG_14-3-3_CanoR_1	117	122	PF00244	0.660
LIG_FHA_1	13	19	PF00498	0.555
LIG_FHA_1	156	162	PF00498	0.626
LIG_FHA_1	166	172	PF00498	0.510
LIG_FHA_1	227	233	PF00498	0.526
LIG_FHA_2	108	114	PF00498	0.489
LIG_FHA_2	201	207	PF00498	0.649
LIG_FHA_2	344	350	PF00498	0.519
LIG_FHA_2	94	100	PF00498	0.444
LIG_LIR_Gen_1	291	300	PF02991	0.312
LIG_LIR_Nem_3	291	296	PF02991	0.313
LIG_LIR_Nem_3	318	323	PF02991	0.405
LIG_MAD2	33	41	PF02301	0.474
LIG_NRBOX	241	247	PF00104	0.430
LIG_RPA_C_Plants	146	157	PF08784	0.481
LIG_SH2_CRK	320	324	PF00017	0.516
LIG_SH2_STAT5	213	216	PF00017	0.571
LIG_SH2_STAT5	77	80	PF00017	0.431
LIG_SH3_3	11	17	PF00018	0.499
LIG_SH3_3	341	347	PF00018	0.604
LIG_SH3_3	35	41	PF00018	0.479
LIG_SH3_4	40	47	PF00018	0.627
LIG_TYR_ITSM	316	323	PF00017	0.515
LIG_UBA3_1	350	358	PF00899	0.538
MOD_CK1_1	106	112	PF00069	0.537
MOD_CK1_1	292	298	PF00069	0.581
MOD_CK2_1	107	113	PF00069	0.504
MOD_CK2_1	199	205	PF00069	0.772
MOD_CK2_1	93	99	PF00069	0.430
MOD_GlcNHglycan	105	108	PF01048	0.372
MOD_GlcNHglycan	130	133	PF01048	0.607
MOD_GlcNHglycan	175	178	PF01048	0.572
MOD_GlcNHglycan	333	336	PF01048	0.431
MOD_GlcNHglycan	52	55	PF01048	0.733
MOD_GlcNHglycan	87	90	PF01048	0.482
MOD_GSK3_1	103	110	PF00069	0.481
MOD_GSK3_1	113	120	PF00069	0.581
MOD_GSK3_1	195	202	PF00069	0.624
MOD_GSK3_1	46	53	PF00069	0.619
MOD_LATS_1	50	56	PF00433	0.600
MOD_NEK2_1	103	108	PF00069	0.345
MOD_NEK2_1	134	139	PF00069	0.615
MOD_NEK2_1	331	336	PF00069	0.460
MOD_NEK2_1	85	90	PF00069	0.575
MOD_PIKK_1	121	127	PF00454	0.601
MOD_PIKK_1	217	223	PF00454	0.594
MOD_PIKK_1	23	29	PF00454	0.543
MOD_PK_1	117	123	PF00069	0.620
MOD_PKA_1	117	123	PF00069	0.659
MOD_PKA_1	195	201	PF00069	0.677
MOD_PKA_2	117	123	PF00069	0.659
MOD_PKA_2	12	18	PF00069	0.626
MOD_PKA_2	173	179	PF00069	0.642
MOD_PKA_2	195	201	PF00069	0.677
MOD_PKA_2	226	232	PF00069	0.555
MOD_Plk_2-3	93	99	PF00069	0.546
MOD_Plk_4	117	123	PF00069	0.668
MOD_Plk_4	209	215	PF00069	0.624
MOD_ProDKin_1	343	349	PF00069	0.577
MOD_SUMO_for_1	276	279	PF00179	0.477
MOD_SUMO_rev_2	250	256	PF00179	0.503
TRG_DiLeu_BaEn_2	98	104	PF01217	0.541
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.531
TRG_ENDOCYTIC_2	320	323	PF00928	0.516
TRG_ER_diArg_1	310	312	PF00400	0.497
TRG_ER_diLys_1	357	360	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N2	Leptomonas seymouri	61%	77%
A0A1X0NPB5	Trypanosomatidae	26%	81%
A0A3R7K7T1	Trypanosoma rangeli	31%	89%
A0A3S7WQL0	Leishmania donovani	89%	78%
A4H5L4	Leishmania braziliensis	80%	100%
D0A9B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	87%
Q4QHY6	Leishmania major	89%	100%